The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The anabolic response to resistance exercise and a protein-rich meal is not diminished by age
Open accessAbstract
OBJECTIVES: The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age. SETTING: The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas. PARTICIPANTS: Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults. DESIGN: Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum). MEASUREMENTS: Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol∙kg(-1)min(-1)) of L- [ring-13C6] phenylalanine. RESULTS: Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073±0.008; post: 0.156±0.021(SE) %/h, p<0.001] and older adults (pre: 0.075±0.004; post: 0.152±0.017 %/h, p=0.003) following the meal and resistance exercise bout. CONCLUSION: Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.
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“However, this would seem to point more convincingly toward protein change theory; perhaps creating a more pronounced change from habitual intake in older populations is even more important than in younger populations. New related data support this [37].”
From Dietary protein to maximize resistance training: a review and examination of protein spread and change theories (2012) · cites this paper as [37]
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Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
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“For example, ingestion of more than approximately 30 g of protein in a single meal does not result in continued improvement in muscle protein synthesis (13, 16).”
BackgroundInfluentialPercutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
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“Certainly, a blunted response to these fundamental anabolic stimuli could contribute to the characteristic slow, progressive loss of muscle mass experienced by many older individuals (13, 34).”
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Self-citationPostexercise net protein synthesis in human muscle from orally administered amino acids
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“However, approximately 60 minutes post-exercise, the capacity for muscle protein synthesis is restored and ultimately increased via the activation of protein kinase B, mTOR, S6K1 and eEF2 (29).”
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Filho, J. C. J. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2018.tde-05112018-104212
Nutrients with Malnutrition-Sarcopenia
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The Role of Dietary Essential Amino Acids in Muscle and Health
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Self-citationEffects of Age on Exercise Metabolism
Hinkley, J. M., Coen, P. M., & Goodpaster, B. H. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-94305-9_14
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Exercise Considerations for Older Adults
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Metadata
- Authors
- Symonsi, T. B., Sheffield-Moore, M., Mamerow, M. M., Wolfe, R. R., & Paddon-Jones, D.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- ORCID
- Wolfe, R.R.
- Venue
- The Journal of nutrition, health and aging
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 15
- Issue
- 5
- Pages
- 376-381
- ISSN
- 1279-7707 (ISSN-L)
- PMC
- PMC3280506
- OpenAlex
- W2085792315
- Cited by
- 112
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 8 · 2013: 7 · 2012: 12
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000071)
- National Institute on Aging (P30 AG17231, P60AG017231, P30AG024832)
- National Center for Research Resources (M01 RR-00073, UL1RR029876, M01RR000073)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- muscle protein synthesis, resistance training, protein intake, aging, older adults, sarcopenia, knee extension exercise, phenylalanine tracer, vastus lateralis
- MeSH terms
- Adult, Aged, Aging, Biopsy, Dietary Proteins, Female, Humans, Male, Meat, Muscle Proteins, Phenylalanine, Exercise, Quadriceps Muscle, Resistance Training
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