Cited by 112Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

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The anabolic response to resistance exercise and a protein-rich meal is not diminished by age

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Symonsi, T.B., Sheffield-Moore, M., Mamerow, M.M., Wolfe, R.R., Paddon-Jones, Douglas·2011·The Journal of nutrition, health and aging

DOI 10.1007/s12603-010-0319-zPMC PMC3280506

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Abstract

OBJECTIVES: The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age. SETTING: The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas. PARTICIPANTS: Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults. DESIGN: Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum). MEASUREMENTS: Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol∙kg(-1)min(-1)) of L- [ring-13C6] phenylalanine. RESULTS: Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073±0.008; post: 0.156±0.021(SE) %/h, p<0.001] and older adults (pre: 0.075±0.004; post: 0.152±0.017 %/h, p=0.003) following the meal and resistance exercise bout. CONCLUSION: Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.

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Authors: Symonsi, T. B., Sheffield-Moore, M., Mamerow, M. M., Wolfe, R. R., & Paddon-Jones, D.
Affiliations: The University of Texas Medical Branch at Galveston (US)
ORCID: Wolfe, R.R.
Venue: The Journal of nutrition, health and aging
Publisher: Elsevier BV
Published: 2011-05
Volume: 15
Issue: 5
Pages: 376-381
ISSN: 1279-7707 (ISSN-L)
DOI: 10.1007/s12603-010-0319-z
PMC: PMC3280506
OpenAlex: W2085792315
Cited by: 112
References: 36
Citations by year: 2026: 4 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 8 · 2013: 7 · 2012: 12
FWCI: 3.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 4619 d)
Locations: The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000071)
National Institute on Aging (P30 AG17231, P60AG017231, P30AG024832)
National Center for Research Resources (M01 RR-00073, UL1RR029876, M01RR000073)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: muscle protein synthesis, resistance training, protein intake, aging, older adults, sarcopenia, knee extension exercise, phenylalanine tracer, vastus lateralis
MeSH terms: Adult, Aged, Aging, Biopsy, Dietary Proteins, Female, Humans, Male, Meat, Muscle Proteins, Phenylalanine, Exercise, Quadriceps Muscle, Resistance Training

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The anabolic response to resistance exercise and a protein-rich meal is not diminished by age

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