The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Anti-cancer potential of flavonoids: recent trends and future perspectives
Open accessAbstract
Cancer is a major public health concern in both developed and developing countries. Several plant-derived anti-cancer agents including taxol, vinblastine, vincristine, the campothecin derivatives, topotecan, irinotecan and etoposide are in clinical use all over the world. Other promising anti-cancer agents include flavopiridol, roscovitine, combretastatin A-4, betulinic acid and silvestrol. From this list one can well imagine the predominance of polyphenols, flavonoids and their synthetic analogs in the treatment of ovarian, breast, cervical, pancreatic and prostate cancer. Flavonoids present in human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. A positive correlation between flavonoids-rich diet (from vegetables and fruits) and lower risk of colon, prostate and breast cancers lead to a question that whether flavonoids mediate the protective effects as chemopreventive agents or can interact with different genes and proteins to play role in chemotherapy. The current review emphasizes onto the therapeutic potential of flavonoids and their synthetic analogs as anti-cancer agents by providing new insights into the factors, regulation and molecular mechanisms along with their significant protein interactions.
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Citations
Cites
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“It is extremely difficult to estimate the daily human intake of flavonoids, especially because of the lack of standardized analytical methods (Scalbert and Williamson 2000).”
BackgroundAP-1 as a regulator of cell life and death
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BackgroundRole of oxygen radicals in DNA damage and cancer incidence
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Cited by
Flavonoids as natural phenolic compounds and their role in therapeutics: an overview
Mutha, R. E., Tatiya, A. U., & Surana, S. J. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-020-00161-8 · Cited by 626
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495
Kong, C., Liang, L., Liu, G., Du, L., Yang, Y., Liu, J., Shi, D., Li, X., & Ma, Y. (2023) · Gut · doi:10.1136/gutjnl-2022-327156 · Cited by 254
Skała, E., Kowalczyk, T., Toma, M., Szemraj, J., Radek, M., Pytel, D., Wieczfinska, J., Wysokińska, H., Śliwiński, T., & Sitarek, P. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3254-z · Cited by 18
Jang, B.-Y., Shin, M., Han, D.-H., & Sung, J.-S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15112627 · Cited by 19
Metadata
- Authors
- Batra, P., & Sharma, A. K.
- Venue
- 3 Biotech
- Published
- 2013-02-12
- Volume
- 3
- Issue
- 6
- Pages
- 439-459
- ISSN
- 2190-572X (ISSN-L)
- 2190-5738
- OpenAlex
- W2143626453
- Cited by
- 550
- References
- 11
- FWCI
- 11.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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