The Effects of Eight Weeks of Circuit Resistance Training on Serum METRNL Levels and Insulin Resistance in Individuals with Type 2 Diabetes
Open accessAbstract
Purpose The effects of exercise training on meteorin-like protein (METRNL), one of the newest factors involved, is one of the treatment strategies for diabetes. The present study aimed to investigate the effects of circuit resistance training on METRNL and insulin resistance in people with Type 2 Diabetes Mellitus (T2DM).Methods Twenty eligible diabetics volunteered to participate and were randomly divided into control (n = 10, age = 51 ± 1 years, BMI = 27.43 ± 0.98 kg/m 2) and experimental groups (n = 10, age = 51 ± 1 years, BMI = 30.12 ± 0.92 kg/m 2). The circuit resistance training (10 exercises) used in this study was performed for eight weeks (3 non-consecutive sessions/week, 2-4 circuits, 40%-80% 1RM, 15-6 repetitions). The rest period between each exercise was 20-30 s, and the rest between each circuit was 3 min. Participants in the control groups were asked to maintain their daily physical activities and not to engage in any systematic training program throughout the study.Results METRNL did not change significantly in the control group (0.66 ± 0.06 to 0.7 ± 0.04), but it increased significantly in the experimental group (0.3 ± 0.06 to 0.71 ± 0.03, p = 0.001); In contrast, FBS increased significantly in the control group (122.8 ± 7.5 to 192.8 ± 14.9) and decreased significantly in the experimental group (197.2 ± 7.1 to 135.00 ± 14.00, p = 0.001). Insulin in control and experimental groups did not change significantly (p = 0.96); However, the IR of the control group increased significantly (6.37 ± 1.46 to 9.6 ± 1.53), but its level was significantly attenuated in the experimental group (4.89 ± 1.37 to 4.38 ± 1.44, p = 0.028).Conclusion Eigth weeks of circuit resistance training with low to high intensities can increase the resting levels of METRNL in men with T2DM, which can be significantly associated with the improved fasting blood glucose levels and insulin resistance.
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Specific training regimens-HIIT, circuit resistance training, and interval resistance training-consistently elevate circulating Metrnl.
“Specific training regimens—such as high-intensity interval training (HIIT), circuit resistance training, and interval resistance training—consistently elevate circulating Metrnl [27,28,67,68].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [68]
The Meteorin-like protein (METRNL) results section (page not provided) reports a significant rise in serum METRNL after eight weeks of circuit resistance training. The Discussion reports increased resting METRNL after high-intensity intermittent training, but does not establish an increase in circulating METRNL from interval resistance training; it also describes a resistance-training regimen that did not raise serum METRNL. Thus, 'consistently' overstates the evidence in this paper. (LLM, conf=0.87)
Experimental — accuracy not yet measuredCircuit resistance training boosts plasma Metrnl in overweight and type 2 diabetic individuals.
“Circuit resistance training has been shown to boost plasma Metrnl in overweight and type 2 diabetic individuals [67,68].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [68]
The Discussion and Conclusion report that eight weeks of circuit resistance training significantly increased resting METRNL in men with type 2 diabetes. The study measured serum, not plasma, METRNL and does not establish the effect in a separate population of overweight individuals. Page numbers were not provided for these passages. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMyostatin levels rise with increasing obesity and correlate with insulin resistance, whereas Metrnl levels may progressively decrease as obesity worsens.
“Closely related is obesity severity: myostatin levels have been shown to rise with increasing obesity and to correlate with insulin resistance [55], whereas Metrnl levels may progressively decrease as obesity worsens [68].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [68]
The citation to this paper is attached to the Metrnl clause, not the myostatin clause. The Discussion (page unavailable) reports that exercise increased METRNL while reducing BMI in obese women, but it does not establish that Metrnl levels progressively decrease as obesity severity increases. (LLM, conf=0.78)
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“Specific training regimens—such as high-intensity interval training (HIIT), circuit resistance training, and interval resistance training—consistently elevate circulating Metrnl [27,28,67,68].”
- Authors
- Tayebi, S. M., Golmohammadi, M., Eslami, R., Shakiba, N., & Costa, P. B.
- Affiliations
- Allameh Tabataba'i University (IR)
- Kurdistan University of Medical Sciences (IR)
- California State University, Fullerton (US)
- Corresponding author
- Tayebi, Seyed Morteza
- Venue
- Journal of Diabetes & Metabolic Disorders
- Published
- 2023-05-09
- Volume
- 22
- Issue
- 2
- Pages
- 1151-1158
- ISSN
- 2251-6581 (ISSN-L)
- PMC
- PMC10638344
- OpenAlex
- W4376114718
- Cited by
- 23
- References
- 41
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 3
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Diabetes & Metabolic Disorders (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- circuit resistance training, meteorin-like protein, Metrnl, insulin resistance, type 2 diabetes, fasting blood glucose, exercise training
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