Genetic Basis of Complex Genetic Disease: The Contribution of Disease Heterogeneity to Missing Heritability
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Our h2g estimate is lower than a prior report, likely reflecting a combination of differences in estimation method (GREML vs. LDSR) and greater heterogeneity in ascertainment strategy across samples.
“Our h2g estimate is lower than a prior report7, likely reflecting a combination of differences in estimation method (GREML vs. LDSR) and greater heterogeneity in ascertainment strategy across samples in the current study (see26–28).”
From Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders (2018) · cites this paper as [28]
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- Authors
- Wray, N. R., & Maier, R.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Wray, Naomi R.
- ORCID
- Wray, Naomi R.
- Venue
- Current Epidemiology Reports
- Published
- 2014-09-30
- Volume
- 1
- Issue
- 4
- Pages
- 220-227
- ISSN
- 2196-2995 (ISSN-L)
- OpenAlex
- W2067645578
- Cited by
- 67
- References
- 46
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 12 · 2016: 8 · 2015: 5
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Epidemiology Reports (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council (1050218)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- missing heritability, genetic heterogeneity, complex genetic disorders, heritability, common genetic variants, rare variants, risk alleles, effect size, genome-wide association study, exome sequencing
About these checks
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