The heritability of human disease: estimation, uses and abuses.

Tenesa, Albert; Haley, Chris S.

doi:10.1038/nrg3377

Cited by 283Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestockGenomics and Rare Diseases

The heritability of human disease: estimation, uses and abuses.

Tenesa, Albert, Haley, Chris S.·2013·Nature Reviews Genetics

DOI 10.1038/nrg3377

Open this paper in CoChat — free account

Abstract

Relatives provide the basic material for the study of inheritance of human disease. However, the methodologies for the estimation of heritability and the interpretation of the results have been controversial. The debate arises from the plethora of methods used, the validity of the methodological assumptions and the inconsistent and sometimes erroneous genetic interpretations made. We will discuss how to estimate disease heritability, how to interpret it, how biases in heritability estimates arise and how heritability relates to other measures of familial disease aggregation.

Integrity signals

Registry

Crossref · 10.1038/nrg3377

Cites

91 of 91 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The study directly addresses the concern about lack of replication by replicating results across five countries and health systems.
“In addition to providing exceptional statistical power, the study directly addresses the concern of lack of replication in research findings 31,32 replicating results across 5 countries and health systems.”
From Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort (2019) · cites this paper as [32]

A new look at the statistical model identification
Akaike, H. (1974) · IEEE Transactions on Automatic Control · doi:10.1109/tac.1974.1100705 · Cited by 51,879 · see citing works
Introduction to Quantitative Genetics.
Edwards, A. W. F., & Falconer, D. S. (1982) · Biometrics · doi:10.2307/2529912 · Cited by 21,447 · see citing works
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works
Generalized Linear Models
Nelder, J. A., & Wedderburn, R. W. M. (1972) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344614 · Cited by 7,321 · see citing works
Genetics and Analysis of Quantitative Traits
(2002) · Journal of Animal Breeding and Genetics · doi:10.1046/j.1439-0388.2002.00356.x · Cited by 6,172 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
Lichtenstein, P., Holm, N. V., Verkasalo, P. K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A., & Hemminki, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007133430201 · Cited by 4,114 · see citing works
Recovery of Inter-Block Information when Block Sizes are Unequal
Patterson, H. D., & Thompson, R. (1971) · Biometrika · doi:10.1093/biomet/58.3.545 · Cited by 4,073 · see citing works
Methodology for Genetic Studies of Twins and Families
Neale, M. C., & Cardon, L. R. (1992) · doi:10.1007/978-94-015-8018-2 · Cited by 4,005 · see citing works
Introduction to Quantitative Genetics
J.-M., G., & Falconer, D. S. (1962) · Population · doi:10.2307/1525780 · Cited by 3,773 · see citing works
Asymptotic Properties of Maximum Likelihood Estimators and Likelihood Ratio Tests Under Nonstandard Conditions
Self, S. G., & Liang, K. (1987) · Journal of the American Statistical Association · doi:10.1080/01621459.1987.10478472 · Cited by 2,657 · see citing works
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544 · see citing works
How people make their own environments: a theory of genotype greater than environment effects.
Scarr, S., & Mccartney, K. (1983) · Child Development · doi:10.1111/j.1467-8624.1983.tb03884.x · Cited by 2,385 · see citing works
Heritability in the genomics era — concepts and misconceptions
Visscher, P. M., Hill, W. G., & Wray, N. R. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2322 · Cited by 1,921 · see citing works
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
Juma, S., Imrhan, V., Vijayagopal, P., & Prasad, C. (2014) · Lifestyle Genomics · doi:10.1159/000370213 · Cited by 1,905 · see citing works
Personal genomes: The case of the missing heritability
Maher, B. (2008) · Nature · doi:10.1038/456018a · Cited by 1,737 · see citing works
Missing heritability and strategies for finding the underlying causes of complex disease
Eichler, E. E., Flint, J., Gibson, G. C., Kong, A., Leal, S. M., Moore, J. H., & Nadeau, J. H. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2809 · Cited by 1,671 · see citing works
The inheritance of liability to certain diseases, estimated from the incidence among relatives
Falconer, D. (1965) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1965.tb00500.x · Cited by 1,662 · see citing works
The mystery of missing heritability: Genetic interactions create phantom heritability
Zuk, O., Hechter, E., Sunyaev, S. R., & Lander, E. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119675109 · Cited by 1,542 · see citing works
Genetic and Environmental Factors in Relative Body Weight and Human Adiposity
Maes, H. H. M., Neale, M. C., & Eaves, L. J. (1997) · Behavior Genetics · doi:10.1023/a:1025635913927 · Cited by 1,515 · see citing works
Estimating genetic parameters in natural populations using the ‘animal model’
Kruuk, L. E. B. (2004) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2003.1437 · Cited by 1,196 · see citing works
Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105 · see citing works
Variance components testing in the longitudinal mixed effects model
Stram, D. O., & Lee, J. W. (1994) · Biometrics · doi:10.2307/2533455 · Cited by 992 · see citing works
Fetal programming and adult health
Godfrey, K. M., & Barker, D. J. P. (2001) · Public Health Nutrition · doi:10.1079/phn2001145 · Cited by 987 · see citing works
Likelihood, Bayesian, and MCMC Methods in Quantitative Genetics
Sørensen, D., & Gianola, D. (2002) · Statistics for biology and health · doi:10.1007/b98952 · Cited by 925 · see citing works
HERITABILITY OF THRESHOLD CHARACTERS
Dempster, E. R., & Lerner, I. M. (1950) · Genetics · doi:10.1093/genetics/35.2.212 · Cited by 816 · see citing works
Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment
Wardle, J., Carnell, S., Haworth, C. M. A., & Plomin, R. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.398 · Cited by 771 · see citing works
Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature
Law, C., & Shiell, A. W. (1996) · Journal of Hypertension · doi:10.1097/00004872-199608000-00002 · Cited by 733 · see citing works
A twin-pronged attack on complex traits
Martin, N., Boomsma, D., & Machin, G. (1997) · Nature Genetics · doi:10.1038/ng1297-387 · Cited by 685 · see citing works
DNA methylation profiles in monozygotic and dizygotic twins
Kaminsky, Z. A., Tang, T., Wang, S.-C., Ptak, C., Oh, G., Wong, A. H. C., Feldcamp, L. A., Virtanen, C., Halfvarson, J., Tysk, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.286 · Cited by 662 · see citing works
The Assumptions Underlying the Analysis of Variance
Eisenhart, C. (1947) · Biometrics · doi:10.2307/3001534 · Cited by 643 · see citing works
Tobacco-smoking-related differential DNA methylation: 27K discovery and replication
Breitling, L. P., Yang, R., Korn, B., Burwinkel, B., & Brenner, H. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.03.003 · Cited by 640 · see citing works
Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), Lee, S. H., The International Schizophrenia Consortium (ISC), The Molecular Genetics of Schizophrenia Collaboration (MGS), DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., Keller, M. C., et al. (2012) · Nature Genetics · doi:10.1038/ng.1108 · Cited by 579 · see citing works
Statistics in human genetics
Sham, P. C. (1997) · The HKU Scholars Hub (University of Hong Kong) · Cited by 555 · see citing works
Annotation: the analysis of variance and the analysis of causes.
Lewontin, R. C. (1974) · Europe PMC (PubMed Central) · Cited by 533 · see citing works
Twin concordance and sibling recurrence rates in multiple sclerosis
Willer, C. J., Dyment, D. A., RISCH, N. J., Sadovnick, A. D., Ebers, G. C., & The Canadian Collaborative Study Group§§ (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932604100 · Cited by 532 · see citing works
Theory and Analysis of Threshold Characters
Gianola, D. (1982) · Journal of Animal Science · doi:10.2527/jas1982.5451079x · Cited by 507 · see citing works
A Mixed-Model Procedure for Analyzing Ordered Categorical Data
Harville, D. A., & Mee, R. W. (1984) · Biometrics · doi:10.2307/2531393 · Cited by 431 · see citing works
The use of multiple thresholds in determining the mode of transmission of semi‐continuous traits*
Reich, T., James, J. W., & Morris, C. A. (1972) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1972.tb00767.x · Cited by 420 · see citing works
A test of the equal-environment assumption in twin studies of psychiatric illness
Kendler, K., Neale, M., Kessler, R., Heath, A., & Eaves, L. (1993) · Behavior Genetics · doi:10.1007/bf01067551 · Cited by 420 · see citing works
Epigenetic Inheritance and the Missing Heritability Problem
Slatkin, M. (2009) · Genetics · doi:10.1534/genetics.109.102798 · Cited by 337 · see citing works
The genetic interpretation of area under the ROC curve in genomic profiling
Wray, N. R., Yang, J., Goddard, M. E., & Visscher, P. M. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000864 · Cited by 334 · see citing works
THE HERITABILITY OF ALL-OR-NONE TRAITS: VIABILITY OF POULTRY
Robertson, A., & Lerner, I. M. (1949) · Genetics · doi:10.1093/genetics/34.4.395 · Cited by 305 · see citing works
The analysis of binomial data by a generalized linear mixed model
GILMOUR, A. R., ANDERSON, R. D., & RAE, A. L. (1985) · Biometrika · doi:10.1093/biomet/72.3.593 · Cited by 304 · see citing works
The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus
Falconer, D. S. (1967) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1967.tb01249.x · Cited by 303 · see citing works
Cultural versus biological inheritance: phenotypic transmission from parents to children. (A theory of the effect of parental phenotypes on children's phenotypes).
Cavalli-Sforza, L. L., & Feldman, M. W. (1973) · Europe PMC (PubMed Central) · Cited by 296 · see citing works
The thrifty phenotype as an adaptive maternal effect
Wells, J. C. K. (2007) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2006.00007.x · Cited by 276 · see citing works
Concordance in twins: methods and interpretation.
Smith, C. S. (1974) · PubMed · Cited by 233 · see citing works
A MARKER-BASED METHOD FOR INFERENCES ABOUT QUANTITATIVE INHERITANCE IN NATURAL POPULATIONS
Ritland, K. (1996) · Evolution · doi:10.1111/j.1558-5646.1996.tb02347.x · Cited by 224 · see citing works
The inheritance of liability to diseases with variable age of onset, with particular reference to diabetes mellitus
Falconer, D. S. (1967) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1967.tb02015.x · Cited by 211 · see citing works
FAMILIAL PREDISPOSITION IN MAN
Edwards, J. (1969) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a070672 · Cited by 207 · see citing works
A Commentary on ‘Common SNPs Explain a Large Proportion of the Heritability for Human Height’ by Yang et al. (2010)
Visscher, P. M., Yang, J., & Goddard, M. E. (2010) · Twin Research and Human Genetics · doi:10.1375/twin.13.6.517 · Cited by 203 · see citing works
Primary biases in twin studies; a review of prenatal and natal difference-producing factors in monozygotic pairs.
Price, B. (1950) · PubMed · Cited by 193 · see citing works
Likelihood of Bayesian, and MCMC Methods in Quantitative Genetics
Jannink, J. (2003) · Crop Science · doi:10.2135/cropsci2003.1574 · Cited by 190 · see citing works
A note on the asymptotic distribution of likelihood ratio tests to test variance components
Visscher, P. M. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.4.490 · Cited by 169 · see citing works
The UK Biobank sample handling and storage validation studies
Peakman, T. C., & Elliott, P. (2008) · International Journal of Epidemiology · doi:10.1093/ije/dyn019 · Cited by 162 · see citing works
Estimation of Heritability of Threshold Characters
Vleck, L. D. V. (1972) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(72)85463-8 · Cited by 148 · see citing works
Genome Partitioning of Genetic Variation for Height from 11,214 Sibling Pairs
Visscher, P. M., MacGregor, S., Benyamin, B., Zhu, G., Gordon, S. D., Medland, S. E., Hill, W. G., Hottenga, J., Willemsen, G. A. H. M., Boomsma, D. I., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/522934 · Cited by 145 · see citing works
On the Genetic Interpretation of Disease Data
Bishop, S. C., & Woolliams, J. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008940 · Cited by 130 · see citing works
The Heritability of Resistance to Death in the Fowl
Lush, J. L., Lamoreux, W. F., & Hazel, L. N. (1948) · Poultry Science · doi:10.3382/ps.0270375 · Cited by 122 · see citing works
Measures of Twin Concordance
Allen, G., Harvald, B., & Shields, J. (1967) · Human Heredity · doi:10.1159/000152101 · Cited by 117 · see citing works
Mapping QTLs for binary traits in backcross and F2populations
Visscher, P. M., Haley, C., & Knott, S. (1996) · Genetics Research · doi:10.1017/s0016672300033887 · Cited by 111 · see citing works
Heritability of liability and concordance in monozygous twins
Smith, C. S. (1970) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1970.tb00223.x · Cited by 109 · see citing works
Epidemiology in a changing world: variation, causation and ubiquitous risk factors
Pearce, N. E. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyq257 · Cited by 105 · see citing works
An analysis of the genetics of schizophrenia
Kídd, K. K., & Cavalli-Sforza, L. L. (1973) · Social Biology · doi:10.1080/19485565.1973.9988051 · Cited by 87 · see citing works
Review papers : Variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health
Hopper, J. L. (1993) · Statistical Methods in Medical Research · doi:10.1177/096228029300200302 · Cited by 85 · see citing works
Recurrence risks for multifactorial inheritance.
Smith, C. S. (1971) · PubMed · Cited by 75 · see citing works
INFERENCES ABOUT QUANTITATIVE INHERITANCE BASED ON NATURAL POPULATION STRUCTURE IN THE YELLOW MONKEYFLOWER,MIMULUS GUTTATUS
Ritland, K., & Ritland, C. E. (1996) · Evolution · doi:10.1111/j.1558-5646.1996.tb02348.x · Cited by 74 · see citing works
Commentary: Heritability estimates—long past their sell-by date
Rose, S. P. R. (2006) · International Journal of Epidemiology · doi:10.1093/ije/dyl064 · Cited by 55 · see citing works
STATISTICAL MODELING AND ANALYSIS IN HUMAN GENETICS
Elston, R. C., & Rao, D. C. (1978) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.07.060178.001345 · Cited by 53 · see citing works
Path Analysis of Family Resemblance and Gene-Environment Interaction
Lathrope, G. M., Lalouel, J.-M., & Jacquard, A. (1984) · Biometrics · doi:10.2307/2530905 · Cited by 53 · see citing works
The Multifactorial Model for the Inheritance of Liability to Disease and Its Implications for Relatives at Risk
Curnow, R. N. (1972) · Biometrics · doi:10.2307/2528630 · Cited by 52 · see citing works
Exchangeable Models of Complex Inherited Diseases
Slatkin, M. (2008) · Genetics · doi:10.1534/genetics.107.077719 · Cited by 45 · see citing works
A statistical and genetical study of diabetes: II. Heritability of liability
Smith, C. S., Falconer, D. S., & Duncan, L. J. P. (1972) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1957.tb01402.x · Cited by 44 · see citing works
Multipoint linkage disequilibrium mapping with particular reference to the African-American population
Zheng, C., & Elston, R. C. (1999) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1999)17:2 · Cited by 42 · see citing works
Mx Scripts Library: Structural Equation Modeling Scripts for Twin and Family Data
Posthuma, D., & Boomsma, D. I. (2005) · Behavior Genetics · doi:10.1007/s10519-005-2791-5 · Cited by 34 · see citing works
Comparisons of dermatoglyphic patterns in monochorionic and dichorionic monozygotic twins.
Reed, T., Uchida, I. A., Norton, J. A., & Christian, J. C. (1978) · Europe PMC (PubMed Central) · Cited by 33 · see citing works
Path analysis of family resemblance in the presence of gene-environment interaction.
Rao, D. C., & Morton, N. E. (1974) · PubMed · Cited by 32 · see citing works
Detecting QTLs for uni- and bipolar disorder using a variance component method
Visscher, P. M., Haley, C., Heath, S. C., Muir, W. J., & Blackwood, D. (1999) · Psychiatric Genetics · doi:10.1097/00041444-199906000-00005 · Cited by 30 · see citing works
The effect of diagnostic ascertainment in twins on the assessment of the genetic factor in disease etiology.
Hrubec, Z. (1973) · PubMed · Cited by 24 · see citing works
Uses and limitations of twin studies
Bundey, S. (1991) · Journal of Neurology · doi:10.1007/bf00319852 · Cited by 23 · see citing works
Obesity—still highly heritable after all these years
Musani, S. K., Erickson, S. W., & Allison, D. B. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.275 · Cited by 21 · see citing works
On the Futility of Screening for Genes That Make You Fat
Veerman, L. J. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001114 · Cited by 20 · see citing works
The maximum likelihood approach to the estimate of liability
Thompson, R. (1972) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1972.tb00771.x · Cited by 16 · see citing works
Human Complex Trait Genetics: Lifting the Lid of the Genomics Toolbox - from Pathways to Prediction
Rowe, S. J., & Tenesa, A. (2012) · Current Genomics · doi:10.2174/138920212800543101 · Cited by 16 · see citing works
Commentary: Genes for osteoarthritis: interpreting twin data
Hopper, J. L. (1996) · BMJ · doi:10.1136/bmj.312.7036.943 · Cited by 13 · see citing works
Variance of plasma free and esterified cholesterol in adult twins.
Christian, J. C., Cheung, S. W., Kang, K.-W., Harmath, F., Huntzinger, D., & Rc, P. (1976) · Europe PMC (PubMed Central) · Cited by 11 · see citing works
Mathematical contributions to the theory of evolution. VII.—On the application of certain formulæ in the theory of correlation to the inheritance of characters not capabl of quantitative measurement
Pearson, K., & Lee, A. (1900) · Proceedings of the Royal Society of London · doi:10.1098/rspl.1899.0107 · Cited by 3 · see citing works
Abstracts of the 32nd annual meeting of the human biology association Philadelphia, Pennsylvania march 28–29, 2007
(2007) · American Journal of Human Biology · doi:10.1002/ajhb.20629 · Cited by 1 · see citing works
Untitled work
(1999) · doi:10.1002/(sici)1096-8644(199903)108:3

Flagged first, then by citations

Sorted by citations

Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort
Bai, D., Yip, B. H. K., Windham, G. C., Sourander, A., Francis, R., Yoffe, R., Glasson, E., Mahjani, B., Suominen, A., Leonard, H., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.1411 · Cited by 683 · see citing works
Pitfalls of predicting complex traits from SNPs
Wray, N. R., Yang, J., Hayes, B. J., Price, A. L., Goddard, M. E., & Visscher, P. M. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3457 · Cited by 672 · see citing works
Research Review: Polygenic methods and their application to psychiatric traits
Wray, N. R., Lee, S., Mehta, D., Vinkhuyzen, A. A. E., Dudbridge, F., & Middeldorp, C. M. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12295 · Cited by 657 · see citing works
Heritability of schizophrenia and schizophrenia spectrum based on the nationwide danish twin register
Hilker, R., Helenius, D., Fagerlund, B., Skytthe, A., Christensen, K., Werge, T. M., Nordentoft, M., & Glenthøj, B. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.017 · Cited by 615 · see citing works
Genetic architecture: the shape of the genetic contribution to human traits and disease
Timpson, N. J., Greenwood, C. M. T., Soranzo, N., Lawson, D. J., & Richards, J. B. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.101 · Cited by 434 · see citing works
Using genetic data to strengthen causal inference in observational research
Pingault, J.-B., O’Reilly, P. F., Schoeler, T., Ploubidis, G. B., Rijsdijk, F., & Dudbridge, F. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0020-3 · Cited by 444 · see citing works
Genetic correlations of polygenic disease traits: from theory to practice
van Rheenen, W., Peyrot, W. J., Schork, A. J., Lee, S., & Wray, N. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0137-z · Cited by 385 · see citing works
The genetics of human ageing
Melzer, D. R., Pilling, L. C., & Ferrucci, L. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0183-6 · Cited by 371 · see citing works
Familial Aggregation of Systemic Lupus Erythematosus and Coaggregation of Autoimmune Diseases in Affected Families
Kuo, C., Grainge, M. J., Valdes, A. M., See, L., Luo, S., Yu, K., Zhang, W., & Doherty, M. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.3528 · Cited by 311 · see citing works
TEOSINTE BRANCHED1 Regulates Inflorescence Architecture and Development in Bread Wheat ( Triticum aestivum )
Dixon, L. E., Greenwood, J. R., Bencivenga, S., Zhang, P., Cockram, J., Mellers, G., Ramm, K., Cavanagh, C. R., Swain, S. M., & Boden, S. A. (2018) · The Plant Cell · doi:10.1105/tpc.17.00961 · Cited by 254 · see citing works
Quantitative analysis of population-scale family trees with millions of relatives
Kaplanis, J., Gordon, A., Shor, T., Weissbrod, O., Geiger, D., Wahl, M., Gershovits, M., Markus, B., Sheikh, M., Gymrek, M., et al. (2018) · Science · doi:10.1126/science.aam9309 · Cited by 245 · see citing works
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits
Haplotype Reference Consortium, Evans, L. M., Tahmasbi, R., Vrieze, S. I., Abecasis, G. R., Das, S., Gazal, S., Bjelland, D. W., de Candia, T. R., Goddard, M. E., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0108-x · Cited by 239 · see citing works
The road to precision psychiatry: translating genetics into disease mechanisms
Gandal, M. J., Leppa, V., Won, H., Parikshak, N. N., & Geschwind, D. H. (2016) · Nature Neuroscience · doi:10.1038/nn.4409 · Cited by 223 · see citing works
Missing heritability of complex diseases: case solved?
Génin, E. (2019) · Human Genetics · doi:10.1007/s00439-019-02034-4 · Cited by 210 · see citing works
Delay discounting of different outcomes: Review and theory
Odum, A., Becker, R. J., Haynes, J. M., Galizio, A., Frye, C. C. J., Downey, H., Friedel, J. E., & Perez, D. (2020) · Journal of The Experimental Analysis of Behavior · doi:10.1002/jeab.589 · Cited by 163 · see citing works
The paradox of intelligence: Heritability and malleability coexist in hidden gene-environment interplay.
Sauce, B., & Matzel, L. D. (2017) · Psychological Bulletin · doi:10.1037/bul0000131 · Cited by 172 · see citing works
Estimation and Partition of Heritability in Human Populations Using Whole-Genome Analysis Methods
Vinkhuyzen, A. A. E., Wray, N. R., Yang, J., Goddard, M. E., & Visscher, P. M. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133258 · Cited by 167 · see citing works
The contribution of genetic variants to disease depends on the ruler
Witte, J. S., Visscher, P. M., & Wray, N. R. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3786 · Cited by 160 · see citing works
Assessing the Heritability of Complex Traits in Humans: Methodological Challenges and Opportunities
Mayhew, A., & Meyre, D. (2017) · Current Genomics · doi:10.2174/1389202918666170307161450 · Cited by 159 · see citing works
Genetic Architecture of Atherosclerosis in Mice: A Systems Genetics Analysis of Common Inbred Strains
Bennett, B. J., Davis, R. C., Civelek, M., Orozco, L. D., Wu, J., Qi, H., Pan, C., Packard, R. R. S., Eskin, E., Yan, M., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005711 · Cited by 135 · see citing works
The Genetic Basis of Vitiligo
Spritz, R. A., & Santorico, S. A. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.06.004 · Cited by 132 · see citing works
Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)
Fernandez-Pujals, A. M., Adams, M. J., Thomson, P. A., McKechanie, A. G., Blackwood, D., Smith, B. H., Dominiczak, A. F., Morris, A. D., Matthews, K., Campbell, A. I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142197 · Cited by 125 · see citing works
Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy
Marenholz, I., Grosche, S., Kalb, B., Rüschendorf, F., Blümchen, K., Schlags, R., Harandi, N., Price, M., Hansen, G., Seidenberg, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01220-0 · Cited by 117 · see citing works
Disease Heritability Inferred from Familial Relationships Reported in Medical Records
Polubriaginof, F. C. G., Vanguri, R. S., Quinnies, K. M., Belbin, G. M., Yahi, A., Salmasian, H., Lorberbaum, T., Nwankwo, V., Li, L., Shervey, M. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.04.032 · Cited by 111 · see citing works
Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank
Muñoz, M., Pong‐Wong, R., Canela‐Xandri, O., Rawlik, K., Haley, C., & Tenesa, A. (2016) · Nature Genetics · doi:10.1038/ng.3618 · Cited by 108 · see citing works
Genetic and molecular architecture of complex traits
Lappalainen, T., Li, Y., Ramachandran, S., & Gusev, A. (2024) · Cell · doi:10.1016/j.cell.2024.01.023 · Cited by 108 · see citing works
What Is the Heritability of Periodontitis? A Systematic Review
Nibali, L., Bayliss-Chapman, J., Almofareh, S. A., Zhou, Y., Divaris, K., & Vieira, A. R. (2019) · Journal of Dental Research · doi:10.1177/0022034519842510 · Cited by 103 · see citing works
Low-copper diet as a preventive strategy for Alzheimer's disease
Squitti, R., Siotto, M., & Polimanti, R. A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.031 · Cited by 101 · see citing works
Inference of the Genetic Architecture Underlying BMI and Height with the Use of 20,240 Sibling Pairs
Hemani, G., Yang, J., Vinkhuyzen, A. A. E., Powell, J. E., Willemsen, G. A. H. M., Hottenga, J., Abdellaoui, A., Mangino, M., Valdes, A. M., Medland, S. E., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.10.005 · Cited by 101 · see citing works
Polygenic Risk for Externalizing Disorders
Salvatore, J. E., Alıev, F., Bucholz, K. K., Arpana Agrawal, A., HESSELBROCK, V. M., Hesselbrock, M. N., Bauer, L. O., Kuperman, S., Schuckit, M. A., Kramer, J., et al. (2014) · Clinical Psychological Science · doi:10.1177/2167702614534211 · Cited by 101 · see citing works
Statistical methods for SNP heritability estimation and partition: A review
Zhu, H., & Zhou, X. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.06.011 · Cited by 95 · see citing works
Cultural evolution of genetic heritability
Uchiyama, R., Spicer, R., & Muthukrishna, M. (2021) · Behavioral and Brain Sciences · doi:10.1017/s0140525x21000893 · Cited by 97 · see citing works
Familial aggregation and heritability of sarcoidosis: a Swedish nested case−control study
Rossides, M., Grünewald, J., Eklúnd, A., Kullberg, S., Giuseppe, D. D., Askling, J., & Arkema, E. V. (2018) · European Respiratory Journal · doi:10.1183/13993003.00385-2018 · Cited by 90 · see citing works
Periodontal health and disease: The contribution of genetics
Shaddox, L. M., Morford, L. A., & Nibali, L. (2020) · Periodontology 2000 · doi:10.1111/prd.12357 · Cited by 85 · see citing works
Computational approaches for prioritizing candidate disease genes based on PPI networks
Lan, W., Wang, J., Li, M., Peng, W., & Wu, F. (2015) · Tsinghua Science & Technology · doi:10.1109/tst.2015.7297749 · Cited by 84 · see citing works
Variations of cingulate sulcal organization and link with cognitive performance
Amiez, C., Wilson, C. R. E., & Procyk, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-32088-9 · Cited by 81 · see citing works
Sexual dimorphisms in genetic loci linked to body fat distribution
Pulit, S. L., Karaderi, T., & Lindgren, C. M. (2017) · Bioscience Reports · doi:10.1042/bsr20160184 · Cited by 76 · see citing works
A Swedish Nationwide Adoption Study of the Heritability of Heart Failure
Lindgren, M. P., Pirouzifard, M., Smith, J. G., Sundquist, J., Sundquist, K., & Zöller, B. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2018.1919 · Cited by 69 · see citing works
The genetic architecture of vitiligo
Roberts, G. H. L., Santorico, S. A., & Spritz, R. A. (2019) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12848 · Cited by 75 · see citing works
Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways
Bossini‐Castillo, L., López‐Isac, E., & Martin, J. J. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.07.005 · Cited by 72 · see citing works
On the power of epigenome-wide association studies using a disease-discordant twin design
Li, W., Christiansen, L., Hjelmborg, J., Baumbach, J., & Tan, Q. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty532 · Cited by 73 · see citing works
Pedigree- and SNP-Associated Genetics and Recent Environment are the Major Contributors to Anthropometric and Cardiometabolic Trait Variation
Xia, C., Amador, C., Huffman, J. E., Trochet, H., Campbell, A., Porteous, D. J., Scotland, G., Hastie, N. D., Hayward, C., Vitart, V., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005804 · Cited by 68 · see citing works
Multidimensional heritability analysis of neuroanatomical shape
Ge, T., Reuter, M., Winkler, A. M., Holmes, A. J., Lee, P. H., Tirrell, L. S., Roffman, J. L., Buckner, R. L., Smoller, J. W., & Sabuncu, M. R. (2016) · Nature Communications · doi:10.1038/ncomms13291 · Cited by 73 · see citing works
The familial risk of autism spectrum disorder with and without intellectual disability
Xie, S., Karlsson, H., Dalman, C., Widman, L., Rai, D., Gardner, R. M., Magnusson, C., Sandin, S., Tabb, L. P., Newschaffer, C. J., et al. (2020) · Autism Research · doi:10.1002/aur.2417 · Cited by 64 · see citing works
Genetic Basis of Complex Genetic Disease: The Contribution of Disease Heterogeneity to Missing Heritability
Wray, N. R., & Maier, R. (2014) · Current Epidemiology Reports · doi:10.1007/s40471-014-0023-3 · Cited by 67 · see citing works
Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study
Chen, F., Childs, E. J., Mocci, E., Bracci, P. M., Gallinger, S., Li, D., Neale, R. Ε., Olson, S. H., Scélo, G., Bamlet, W. R., et al. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1235 · Cited by 65 · see citing works
Quantitative Genetic Variation in, and Environmental Effects on, Pathogen Resistance and Temperature-Dependent Disease Severity in a Wild Trout
Debes, P. V., Gross, R., & Vasemägi, A. (2017) · The American Naturalist · doi:10.1086/692536 · Cited by 59 · see citing works
Heritability of glaucoma and glaucoma-related endophenotypes: Systematic review and meta-analysis
Asefa, N. G., Neustaeter, A., Jansonius, N. M., & Snieder, H. (2019) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2019.06.002 · Cited by 59 · see citing works
Direct-to-Consumer Nutrigenetics Testing: An Overview
Floris, M., Cano, A., Porru, L., Addis, R., Cambedda, A., Idda, M. L., Steri, M., Ventura, C., & Maioli, M. (2020) · Nutrients · doi:10.3390/nu12020566 · Cited by 56 · see citing works
Dominant Genetic Variation and Missing Heritability for Human Complex Traits: Insights from Twin versus Genome-wide Common SNP Models
Chen, X., Kuja‐Halkola, R., Rahman, I., Arpegård, J., Viktorin, A., Karlsson, R., Hägg, S., Svensson, P., Pedersen, N. L., & Magnusson, P. K. E. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.10.004 · Cited by 53 · see citing works
Schizophrenia as a pseudogenetic disease: A call for more gene-environmental studies
Torrey, E. F., & Yolken, R. H. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.06.006 · Cited by 53 · see citing works
Assumption-free estimation of the genetic contribution to refractive error across childhood.
Guggenheim, J. A., Pourcain, B. S., McMahon, G., Timpson, N. J., Evans, D. M., & Williams, C. (2015) · PubMed Central · Cited by 52 · see citing works
Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics
Holland, D., Wang, Y., Thompson, W. K., Schork, A. J., Chen, C., Lo, M., Witoelar, A., Werge, T. M., O’Donovan, M. C., Andreassen, O. A., et al. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00015 · Cited by 49 · see citing works
Glaucoma Heritability: Molecular Mechanisms of Disease
Zukerman, R. J., Harris, A., Oddone, F., Siesky, B. A., Vercellin, A. C. V., & Ciulla, T. A. (2021) · Genes · doi:10.3390/genes12081135 · Cited by 50 · see citing works
The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth
Wu, W., Witherspoon, D. J., Fraser, A., Clark, E., Rogers, A. R., Stoddard, G. J., Manuck, T. A., Chen, K., Esplin, M. S., Smith, K. R., et al. (2015) · Human Genetics · doi:10.1007/s00439-015-1558-1 · Cited by 50 · see citing works
What does heritability of Alzheimer’s disease represent?
Baker, E. A., Leonenko, G., Schmidt, K. M., Hill, M., Myers, A., Shoai, M., de Rojas, I., Tesi, N., Holstege, H. H., van der Flier, W. M., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281440 · Cited by 50 · see citing works
Interpreting Mendelian-randomization estimates of the effects of categorical exposures such as disease status and educational attainment
Howe, L. J., Tudball, M., Davey Smith, G., & Davies, N. M. (2022) · International Journal of Epidemiology · doi:10.1093/ije/dyab208 · Cited by 48 · see citing works
An Evolutionary Genetic Perspective of Eating Disorders
Mayhew, A., Pigeyre, M., Couturier, J. L., & Meyre, D. (2017) · Neuroendocrinology · doi:10.1159/000484525 · Cited by 48 · see citing works
Genome-Wide Polygenic Score and the Risk of Ischemic Stroke in a Prospective Cohort
Hachiya, T., Hata, J., Hirakawa, Y., Yoshida, D., Furuta, Y., Kitazono, T., Shimizu, A., & Ninomiya, T. (2020) · Stroke · doi:10.1161/strokeaha.119.027520 · Cited by 44 · see citing works
Genetically transitional disease: a new concept in genomic medicine
Yao, Q., Gorevic, P. D., Shen, B., & Gibson, G. C. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.11.002 · Cited by 43 · see citing works
Endocrinology Meets Metabolomics: Achievements, Pitfalls, and Challenges
Tokarz, J., Haid, M., Cecil, A., Prehn, C. P., Artati, A., Möller, G., & Adamski, J. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.07.001 · Cited by 43 · see citing works
A review of SNP heritability estimation methods
Tang, M., Wang, T., & Zhang, X. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac067 · Cited by 43 · see citing works
A Decade in Review after Idiopathic Scoliosis Was First Called a Complex Trait—A Tribute to the Late Dr. Yves Cotrel for His Support in Studies of Etiology of Scoliosis
Tang, N. L. S., Dobbs, M. B., Gurnett, C. A., Qiu, Y., Lam, T. P., Cheng, J. C. Y., & Hadley-Miller, N. A. (2021) · Genes · doi:10.3390/genes12071033 · Cited by 41 · see citing works
Estimation of kinship coefficient in structured and admixed populations using sparse sequencing data
Dou, J., Sun, B., Sim, X., Hughes, J. D., Reilly, D. F., Tai, E. S., Liu, J., & Wang, C. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1007021 · Cited by 40 · see citing works
The impact of environmental interventions among mouse siblings on the heritability and malleability of general cognitive ability
Sauce, B., Bendrath, S. C., Herzfeld, M., Siegel, D., Style, C., Rab, S., Korabelnikov, J., & Matzel, L. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0289 · Cited by 38 · see citing works
Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression
Zeng, Y., Navarro, P., Xia, C., Amador, C., Fernandez-Pujals, A. M., Thomson, P. A., Campbell, A. I., Nagy, R., Clarke, T., Hafferty, J. D., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.003 · Cited by 37 · see citing works
Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder
Mahjani, B., Klei, L., Hultman, C. M., Larsson, H., Devlin, B., Buxbaum, J. D., Sandin, S., & Grice, D. E. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.006 · Cited by 36 · see citing works
Heritability of Sleep EEG Topography in Adolescence: Results from a Longitudinal Twin Study
Markovic, A., Achermann, P., Rusterholz, T., & Tarokh, L. (2018) · Scientific Reports · doi:10.1038/s41598-018-25590-7 · Cited by 36 · see citing works
Family-Based Association Analysis of Alcohol Dependence Criteria and Severity
Wetherill, L. F., Kapoor, M., Arpana Agrawal, A., Bucholz, K. K., Koller, D. L., Bertelsen, S. E., Le, N., Wang, J., Almasy, L. A., HESSELBROCK, V. M., et al. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12251 · Cited by 33 · see citing works
A Twin Study Examining Rumination as a Transdiagnostic Correlate of Psychopathology
Johnson, D. P., Rhee, S. H., Friedman, N. P., Corley, R. P., Munn‐Chernoff, M. A., Hewitt, J. K., & Whisman, M. A. (2016) · Clinical Psychological Science · doi:10.1177/2167702616638825 · Cited by 34 · see citing works
Individual differences: Case studies of rodent and primate intelligence.
Matzel, L. D., & Sauce, B. (2017) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000152 · Cited by 33 · see citing works
Familial risk and heritability of intellectual disability: a population‐based cohort study in Sweden
Lichtenstein, P., Tideman, M., Sullivan, P. F., Serlachius, E., Larsson, H., Kuja‐Halkola, R., & Butwicka, A. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13560 · Cited by 32 · see citing works
Genetic and environmental influences on rumination and its covariation with depression
Johnson, D. P., Whisman, M. A., Corley, R. P., Hewitt, J. K., & Friedman, N. P. (2014) · Cognition & Emotion · doi:10.1080/02699931.2014.881325 · Cited by 32 · see citing works
Heritability Estimation Approaches Utilizing Genome‐Wide Data
Srivastava, A. K., Williams, S. M., & Zhang, G. (2023) · Current Protocols · doi:10.1002/cpz1.734 · Cited by 31 · see citing works
Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits
Haljas, K., Amare, A. T., Alizadeh, B. Z., Hsu, Y., Mosley, T. H., Newman, A. B., Murabito, J. M., Tiemeier, H. W., Tanaka, T., van Duijn, C. M., et al. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000555 · Cited by 31 · see citing works
GenoMatrix: A Software Package for Pedigree-Based and Genomic Prediction Analyses on Complex Traits
Nazarian, A., & Gezan, S. A. (2016) · Journal of Heredity · doi:10.1093/jhered/esw020 · Cited by 33 · see citing works
Heritability of Choroidal Thickness in the Amish
Sardell, R. J., Nittala, M. G., Adams, L. D., Laux, R. A., Bailey, J. N. C., Fuzzell, D., Fuzzell, S. L., Reinhart‐Mercer, L., Caywood, L. J., Horst, V., et al. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.09.001 · Cited by 30 · see citing works
Familiality and SNP heritability of age at onset and episodicity in major depressive disorder
Ferentinos, P. P., Koukounari, A., Power, R. A., Rivera, M., Uher, R., Craddock, N. J., Owen, M. J., Korszun, A., Jones, L. A., Jones, I. R., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715000215 · Cited by 29 · see citing works
Deep genotype imputation captures virtually all heritability of autoimmune vitiligo
Roberts, G. H. L., Santorico, S. A., & Spritz, R. A. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa005 · Cited by 29 · see citing works
Genetic and environmental contributions to psychological resilience and coping
Navrady, L. B., Zeng, Y., Clarke, T., Adams, M. J., Howard, D. M., Deary, I. J., & McIntosh, A. M. (2018) · Wellcome Open Research · doi:10.12688/wellcomeopenres.13854.1 · Cited by 28 · see citing works
Testing the validity of value‐added measures of educational progress with genetic data
Morris, T., Davies, N. M., Dorling, D., Richmond, R. C., & Smith, G. D. (2018) · British Educational Research Journal · doi:10.1002/berj.3466 · Cited by 29 · see citing works
Narrow-sense heritability estimation of complex traits using identity-by-descent information
Evans, L. M., Tahmasbi, R., Jones, M., Vrieze, S. I., Abecasis, G. R., Das, S., Bjelland, D. W., de Candia, T. R., Abecasis, G., Altshuler, D., et al. (2018) · Heredity · doi:10.1038/s41437-018-0067-0 · Cited by 28 · see citing works
Did the human genome project affect research on Schizophrenia?
Torrey, Ε. F. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115691 · Cited by 32 · see citing works
Heritability of periodontal bone loss in mice
Hiyari, S., Atti, E., Camargo, P. M., Eskin, E., Lusis, A. J., Tetradis, S., & Pirih, F. Q. M. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12258 · Cited by 28 · see citing works
Familiality of Psychotic Disorders: A Polynosologic Study in Multiplex Families
Peralta, V., Goldberg, X., Ribeiro, M., Sánchez-Torres, A. M., Fañanás, L., & Cuesta, M. J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv192 · Cited by 28 · see citing works
A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR
Safarova, M. S., Satterfield, B. A., Fan, X., Austin, E. E., Ye, Z., Bastarache, L. A., Zheng, N. S., Ritchie, M. D., Borthwick, K. M., Williams, M. S., et al. (2019) · npj Genomic Medicine · doi:10.1038/s41525-019-0078-7 · Cited by 28 · see citing works
The Role and Sources of Individual Differences in Critical-Analytic Thinking: a Capsule Overview
Bolger, D. J., Mackey, A. P., Wang, M., & Grigorenko, E. L. (2014) · Educational Psychology Review · doi:10.1007/s10648-014-9279-x · Cited by 27 · see citing works
Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis
Hiyari, S., Green, E. B., Pan, C., Lari, S., Davar, M., Davis, R. C., Camargo, P. M., Tetradis, S., Lusis, A. J., & Pirih, F. Q. M. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3440 · Cited by 28 · see citing works
Genetics
State, M. W., & Thapar, A. (2015) · doi:10.1002/9781118381953.ch24 · Cited by 27 · see citing works
Peripheral Blood-Based Gene Expression Studies in Schizophrenia: A Systematic Review
Wagh, V. V., Vyas, P., Agrawal, S., Pachpor, T. A., Paralikar, V. P., & Khare, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.736483 · Cited by 24 · see citing works
A systematic heritability analysis of the human whole blood transcriptome
Huan, T., Liu, C., Joehanes, R., Zhang, X., Chen, B. H., Johnson, A. D., Yao, C., Courchesne, P. L., O’Donnell, C. J., Munson, P. J., et al. (2015) · Human Genetics · doi:10.1007/s00439-014-1524-3 · Cited by 24 · see citing works
Inequality in genetic cancer risk suggests bad genes rather than bad luck
Stensrud, M. J., & Valberg, M. (2017) · Nature Communications · doi:10.1038/s41467-017-01284-y · Cited by 22 · see citing works
The goldmine of GWAS summary statistics: a systematic review of methods and tools
Kontou, P. I., & Bagos, P. G. (2024) · BioData Mining · doi:10.1186/s13040-024-00385-x · Cited by 21 · see citing works
Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases
Gorlov, I. P., Gorlova, O. Y., & Amos, C. I. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005371 · Cited by 21 · see citing works
Fundamentals of Complex Trait Genetics and Association Studies
Alghamdi, J., & Padmanabhan, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386882-4.00012-8 · Cited by 22 · see citing works
Dissecting the catatonia phenotype in psychotic and mood disorders on the basis of familial-genetic factors
Peralta, V., Fañanás, L., Reyes, M. M., & Cuesta, M. J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.09.013 · Cited by 20 · see citing works
Heritability of a resting heart rate in a 20-year follow-up family cohort with GWAS data: Insights from the STANISLAS cohort
Xhaard, C., Dandine‐Roulland, C., de Villemereuil, P., Floch, É. L., Bacq‐Daian, D., Machu, J., Ferreira, J. P., Deleuze, J., Zannad, F. M., Rossignol, P., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487319890763 · Cited by 20 · see citing works
Revisiting heritability accounting for shared environmental effects and maternal inheritance
Liu, C., Dupuis, J., Larson, M. G., Cupples, L. A., Ordovás, J. M., Vasan, R. S., Meigs, J. B., Jacques, P. F., & Levy, D. A. (2014) · Human Genetics · doi:10.1007/s00439-014-1505-6 · Cited by 19 · see citing works
Genetic Influence on Accessory Navicular Bone in the Foot: A Korean Twin and Family Study
Cheong, I. Y., Kang, H. J., Ko, H., Sung, J., Song, Y., & Hwang, J. H. (2017) · Twin Research and Human Genetics · doi:10.1017/thg.2017.21 · Cited by 19 · see citing works
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants
Yang, C., Li, C., Kranzler, H. R., Farrer, L. A., Zhao, H., & Gelernter, J. E. (2013) · Human Genetics · doi:10.1007/s00439-013-1399-8 · Cited by 19 · see citing works

Authors: Tenesa, A., & Haley, C. S.
Affiliations: Roslin Institute (GB)
Corresponding author: Tenesa, Albert
ORCID: Tenesa, Albert
Haley, Chris S.
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2013-01-18
Volume: 14
Issue: 2
Pages: 139-149
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg3377
OpenAlex: W2040924786
Cited by: 283
References: 90
Citations by year: 2026: 10 · 2025: 13 · 2024: 13 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 22 · 2019: 30 · 2018: 35 · 2017: 20 · 2016: 23 · 2015: 27 · 2014: 22 · 2013: 9
FWCI: 3.27
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research UK (C12229/A13154, 13154)
Medical Research Council
Biotechnology and Biological Sciences Research Council (BBS/E/D/20211553, BB/K000195/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
Keywords: heritability, human disease, heritability estimation, genetic and environmental contributions, phenotypic variance, familial aggregation, relatives
MeSH terms: Disease, Environment, Female, Humans, Male, Models, Genetic, Pedigree, Models, Statistical, Bias, Linear Models, Twin Studies as Topic, Genetic Predisposition to Disease, Genetic Association Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The heritability of human disease: estimation, uses and abuses.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks