Cited by 225Nitric Oxide and Endothelin EffectsAtherosclerosis and Cardiovascular DiseasesCell Adhesion Molecules Research

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Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis.

Gimbrone, Michael A.·1995·The American Journal of Cardiology

DOI 10.1016/0002-9149(95)80016-l

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Abstract

Vascular endothelium, the single-cell-thick lining of the cardiovascular system, is an important functional component of the blood vessel wall, actively participating in normal vascular physiology as well as the pathogenesis of vascular diseases such as atherosclerosis. The localized modulation of vascular endothelium to a non-adaptive functional state can be termed "endothelial dysfunction." This article provides a brief overview of endothelial dysfunction, especially as it relates to mononuclear leukocyte recruitment during atherosclerotic lesion formation. Potential diagnostic and therapeutic implications are also considered.

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Authors: Gimbrone, M. A.
Affiliations: Brigham and Women's Hospital (US)
Corresponding author: Gimbrone, Michael A.
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 1995-02
Volume: 75
Issue: 6
Pages: 67B-70B
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/0002-9149(95)80016-l
OpenAlex: W2045786338
Cited by: 225
References: 31
Citations by year: 2026: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 9
FWCI: 1.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: vascular endothelium, endothelial dysfunction, atherosclerosis, atherosclerotic lesion formation, vascular physiology, vascular disease pathogenesis
MeSH terms: Animals, Arteriosclerosis, Endothelium, Vascular, Humans, Leukocytes, Mononuclear, Cell Adhesion Molecules, Vascular Cell Adhesion Molecule-1

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Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis.

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