Social isolation in animal models of relevance to neuropsychiatric disorders
Abstract
Animal models of social isolation have been suggested to be relevant to several neuropsychiatric disorders; however, social isolation is usually not purely an alteration of social environment, as it often involves such factors as decreased complexity of the environment, loss of tactile stimulation, and increased metabolic demands of temperature maintenance. In this study, female prairie voles (Microtus ochrogaster, a highly social rodent) were assigned to four experimental groups: continued housing with sibs, with or without nesting material; and individual housing, with or without nesting material. Isolation increased serum corticosterone but did not alter weight. There was no statistical interaction between these two factors. In animal models, factors other than specifically social variables may contribute to the physiological response to social isolation, and the various aspects of the stress response may respond differentially to these factors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Heightened HPA activity, shown by increased circulating corticosterone and ACTH, occurs after 1-5 days of isolation in juvenile or pair-bonded adult prairie voles.
“Heightened HPA axis activity (evidenced by a robust increase in circulating corticosterone and ACTH) is observed after 1–5 days of social isolation in juvenile (3–5 weeks old)68,69 or pair-bonded adult70–72 prairie voles.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [69]
Cites
The effects of an enriched environment on the histology of the rat cerebral cortex
Diamond, M. C., Krech, D., & Rosenzweig, M. R. (1964) · Journal of Comparative Neurology · doi:10.1002/cne.901230110 · Cited by 584 · see citing works
WILLIAMS, J. (1992) · Hormones and Behavior · doi:10.1016/0018-506x(92)90004-f · Cited by 471 · see citing works
Geyer, M. A., Wilkinson, L. S., Humby, T., & Robbins, T. W. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90180-l · Cited by 377 · see citing works
Jones, G. H., Hernandez, T. D., Kendall, D. A., Marsden, C. A., & Robbins, T. W. (1992) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(92)90635-s · Cited by 341 · see citing works
Wilkinson, L. S., Killcross, S., Humby, T., Hall, F. S., Geyer, M. A., & Robbins, T. W. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.8 · Cited by 267 · see citing works
Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats.
Stanton, M. E., Gutierrez, Y. R., & Levine, S. D. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.5.692 · Cited by 264 · see citing works
Carter, C. S., Getz, L. L., Gavish, L., Dermott, J. L. M., & Arnold, P. (1980) · Biology of Reproduction · doi:10.1095/biolreprod23.5.1038 · Cited by 242 · see citing works
Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats.
Stanton, M. E., Gutierrez, Y. R., & Levine, S. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.5.692 · Cited by 223 · see citing works
Jones, G. H., Marsden, C. A., & Robbins, T. W. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80050-6 · Cited by 172 · see citing works
“Isolation stress” revisited: isolation-rearing effects depend on animal care methods
Holson, R. R., Scallet, A. C., Ali, S. F., & Turner, B. B. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90338-o · Cited by 166 · see citing works
Animal models of depression: Parallels and correlates to severe depression in humans
Jesberger, J. A., & Richardson, J. S. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90156-8 · Cited by 156 · see citing works
The interpretation of physiological correlates of differential housing in laboratory rats
Brain, P. F., & Benton, D. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90119-x · Cited by 156 · see citing works
Effects of Imipramine Treatment of Separation-Induced Social Disorders in Rhesus Monkeys
Suomi, S. J. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770270071006 · Cited by 142 · see citing works
Shapiro, L. E., & Insel, T. R. (1990) · Developmental Psychobiology · doi:10.1002/dev.420230502 · Cited by 128 · see citing works
Animal models of depression: an overview.
Wt, M. (1984) · PubMed · Cited by 110 · see citing works
Social organization in Microtus ochrogaster populations
Porges, C. C., & Getz, L. (1979) · Cited by 108 · see citing works
Shapiro, L. E., & Dewsbury, D. A. (1990) · Journal of comparative psychology · doi:10.1037/0735-7036.104.3.268 · Cited by 95 · see citing works
Wallace, C. S., Kilman, V. L., Withers, G. S., & Greenough, W. T. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90937-y · Cited by 88 · see citing works
Environmental impoverishment, social isolation and changes in brain chemistry and anatomy
Krech, D., Rosenzweig, M. R., & Bennett, E. L. (1966) · Physiology & Behavior · doi:10.1016/0031-9384(66)90051-5 · Cited by 77 · see citing works
Isolation stress and volitional ethanol consumption in the rat
Parker, L. F., & Radow, B. L. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90060-2 · Cited by 76 · see citing works
McKinney, W. T., Suomi, S. J., & Harlow, H. F. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.127.10.1313 · Cited by 61 · see citing works
Suomi, S. J., Harlow, H. F., & McKinney, W. T. (1972) · American Journal of Psychiatry · doi:10.1176/ajp.128.8.927 · Cited by 53 · see citing works
Effects of gender and social isolation on electroencephalogram and neuroendocrine parameters in rats
Ehlers, C. L., Kaneko, W. M., Owens, M. J., & Nemeroff, C. B. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90325-8 · Cited by 42 · see citing works
Jaffe, E. H., Frías, V. D., & Ibarra, C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90584-8 · Cited by 42 · see citing works
Enhancement of rat lymphocyte proliferation after prolonged exposure to stress
Jessop, J. J., Gale, K., & Bayer, B. (1987) · Journal of Neuroimmunology · doi:10.1016/0165-5728(87)90080-4 · Cited by 39 · see citing works
Does a relationship exist between the quality of stress and the motivation to ingest alcohol?
Roske, I., Baeger, I., Frenzel, R., et al. (1994) · Alcohol · doi:10.1016/0741-8329(94)90052-3 · Cited by 34 · see citing works
Preproenkephalin RNA increases in the hypothalamus of rats stressed by social deprivation
Iglesias, T., Montero, S., Otero, M. J., et al. (1992) · Cellular and Molecular Neurobiology · doi:10.1007/bf00711234 · Cited by 29 · see citing works
Taste preferences, body weight gain, food and fluid intake in singly or group-housed rats
Scalera, G. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90374-b · Cited by 23 · see citing works
Changes in brain opiate receptors in rats with isolation syndrome
Petkov, V. V., Konstantinova, E., & Grachovska, T. (1985) · Pharmacological Research Communications · doi:10.1016/0031-6989(85)90130-4 · Cited by 20 · see citing works
Sánchez-Toscano, F., Sánchez, M. M., & Garzón, J. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90178-v · Cited by 20 · see citing works
Social isolation modifies the response of mice to experimental Mengo virus infection.
Clausing, P., Bocker, T., Diekgerdes, J., Gärtner, K., Güttner, J., Haemisch, A., Veckenstedt, A., & Weimer, A. (1994) · PubMed · Cited by 14 · see citing works
Thermal control of maternal contact bouts: The interbout interval
Bates, A., Adels, L. E., & Leon, M. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90386-5 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Neural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273 · see citing works
Bosch, O. J., Nair, H. P., Ahern, T. H., Neumann, I. D., & Young, L. J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.154 · Cited by 216 · see citing works
Grippo, A. J., Cushing, B. S., & Carter, C. S. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802f054b · Cited by 196 · see citing works
Ruscio, M. G., Sweeny, T., Hazelton, J., Suppatkul, P., & Sue Carter, C. (2007) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.08.004 · Cited by 81 · see citing works
Grippo, A. J., Pournajafi-Nazarloo, H., Sanzenbacher, L., Trahanas, D. M., McNeal, N., Clarke, D. A., Porges, S. W., & Sue Carter, C. (2012) · Stress · doi:10.3109/10253890.2011.605486 · Cited by 74 · see citing works
Pournajafi-Nazarloo, H., Partoo, L., Yee, J., Stevenson, J., Sanzenbacher, L., Kenkel, W., Mohsenpour, S. R., Hashimoto, K., & Carter, C. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.015 · Cited by 53 · see citing works
Social isolation stress exacerbates autoimmune disease in MRL/lpr mice
Chida, Y., Sudo, N., & Kubo, C. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.09.002 · Cited by 48 · see citing works
Curtis, J. T., Stowe, J. R., & Wang, Z. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00032-0 · Cited by 30 · see citing works
Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole
Hostetler, C. M., Harkey, S. L., Krzywosinski, T. B., Aragona, B. J., & Bales, K. L. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32834affd2 · Cited by 19 · see citing works
- Authors
- Kim, J. W., & Kirkpatrick, B.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Kirkpatrick, Brian
- ORCID
- Kirkpatrick, Brian
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 40
- Issue
- 9
- Pages
- 918-922
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2016209057
- Cited by
- 95
- References
- 32
- Citations by year
- 2024: 1 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1k20mh000925-01a1)
- National Institute of Mental Health (MH 00925)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- social isolation, Microtus ochrogaster, nesting material, corticosterone, stress response, residential environment, tactile stimulation, metabolic demand, social behavior
- MeSH terms
- Animals, Arousal, Body Weight, Corticosterone, Arvicolinae, Depressive Disorder, Disease Models, Animal, Female, Social Environment, Social Isolation, Neurocognitive Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
