Social environment regulates corticotropin releasing factor, corticosterone and vasopressin in juvenile prairie voles
Abstract
Stressful social conditions, such as isolation, that occur during sensitive developmental periods may alter present and future social behavior. Changes in the neuroendocrine mechanisms closely associated with affiliative behaviors and stress reactivity are likely to underlie these changes in behavior. In the present study, we assessed the effects of post-weaning social housing conditions on the neuropeptides arginine vasopressin (AVP) and oxytocin (OT), and components of the hypothalamic-pituitary-adrenal axis (corticotropin releasing factor: [CRF], and corticosterone: [CORT]) in the prairie vole (Microtus ochrogaster), a socially monogamous bi-parental rodent. Following weaning at 21 days of age, prairie voles were maintained in one of three housing conditions: social isolation (isolate), paired with a same sex sibling (sibling) or paired with a stranger (stranger) of the same sex and age. Housing conditions were maintained for either 4 or 21 days. Central CRF, AVP and OT immunoreactivity (ir) were quantified and circulating plasma CORT, AVP and OT were assayed. Isolated voles had higher CRF-ir in the paraventricular nucleus of the hypothalamus (PVN) compared with sibling and stranger housed voles. Plasma CORT was significantly higher in isolates. AVP-ir was significantly lower in the PVN of isolate females compared to either sibling females or stranger females. However, AVP-ir was significantly higher in the supraoptic nucleus (SON) of isolates compared to siblings. There were no differences in central OT-ir or plasma OT. These results identify neuroendocrine mechanisms which respond to isolation and potentially modulate behavior.
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Heightened HPA activity, shown by increased circulating corticosterone and ACTH, occurs after 1-5 days of isolation in juvenile or pair-bonded adult prairie voles.
“Heightened HPA axis activity (evidenced by a robust increase in circulating corticosterone and ACTH) is observed after 1–5 days of social isolation in juvenile (3–5 weeks old)68,69 or pair-bonded adult70–72 prairie voles.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [68]
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- Authors
- Ruscio, M. G., Sweeny, T., Hazelton, J., Suppatkul, P., & Sue Carter, C.
- Affiliations
- College of Charleston (US)
- University of Illinois Chicago (US)
- Corresponding author
- Ruscio, Michael G.
- ORCID
- Sweeny, Timothy
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 51
- Issue
- 1
- Pages
- 54-61
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2129988184
- Cited by
- 81
- References
- 72
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01 HD 38490, P01HD038490)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- Microtus ochrogaster, social isolation, social housing, corticotropin-releasing factor, corticosterone, vasopressin, oxytocin, hypothalamic-pituitary-adrenal axis, paraventricular nucleus, supraoptic nucleus, post-weaning development, stress reactivity, affiliative behavior, sensitive period, neuroendocrine regulation of behavior
- MeSH terms
- Animals, Brain Chemistry, Corticosterone, Corticotropin-Releasing Hormone, Arvicolinae, Female, Male, Paraventricular Hypothalamic Nucleus, Social Isolation, Supraoptic Nucleus, Vasopressins
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