Differential effects of intraspecific interactions on the striatal dopamine system in social and non-social voles
Abstract
We used in vivo microdialysis to examine the responses to intraspecific social interactions in the striatal dopamine systems of females of two vole species displaying vastly different social structures. Both highly social prairie voles and asocial meadow voles had similar increases in extracellular dopamine associated with mating. There was a species-specific effect of social condition on extracellular dihydroxyphenylacetic acid (DOPAC). Exposure to a conspecific male significantly decreased extracellular DOPAC in female prairie voles isolated for approximately 18 h during surgical recovery. Such decrease in DOPAC was not seen if females experienced continued isolation or if they were housed with a sibling during surgical recovery. No changes in extracellular DOPAC were seen in meadow voles after manipulations of social environment. Together, our data indicate that mating-associated dopamine release is independent from mating systems. However, species-specific patterns of extracellular DOPAC suggest that social isolation may be a more stressful stimulus for the social prairie vole than for the asocial meadow vole.
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Manipulation of OT/AVP levels via direct exposures to exogenous hormones, agonists, or alteration of the social environment can significantly modify the number of OT, AVP, and TH neurons in the PVN, resulting in anxiety-like behavior and alterations of prototypical male and female sociosexual behavior.
“Manipulation of OT/AVP levels via direct exposures to exogenous hormones, agonists, or alteration of the social environment can significantly modify the number of OT, AVP, and TH neurons in the PVN, thereby resulting in anxiety-like behavior and alterations of prototypical male and female sociosexual behavior (123–127).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [126]
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- Authors
- Curtis, J. T., Stowe, J. R., & Wang, Z.
- Affiliations
- Florida State University (US)
- Corresponding author
- Curtis, J.T
- ORCID
- Curtis, J.T
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 118
- Issue
- 4
- Pages
- 1165-1173
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2154723325
- Cited by
- 30
- References
- 44
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29mh054554-06)
- National Institute of Mental Health (MH 58616, MH54554, R01MH058616)
- National Institute of Neurological Disorders and Stroke (NS07439, T32NS007439)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD040722, HD 40722)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- striatal dopamine, Microtus ochrogaster, Microtus pennsylvanicus, social isolation, mating behavior, DOPAC, social stress, social structure
- MeSH terms
- Animals, Behavior, Animal, Corpus Striatum, Arvicolinae, Dopamine, Extracellular Space, Female, Homovanillic Acid, Male, Sexual Behavior, Animal, Sibling Relations, Social Behavior, Species Specificity, Time Factors, 3,4-Dihydroxyphenylacetic Acid, Microdialysis
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