Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole
Open accessAbstract
The monogamous prairie vole displays developmental sensitivity to early pharmacological manipulation in a number of species-typical social behaviors. The long-term consequences of altering the neonatal dopamine system are not well characterized. This study examined whether early manipulation of the dopamine system, a known mediator of adult prairie vole social behavior, during neonatal development would affect adult aggressive and attachment behaviors. Eight-day-old pups were given a single treatment with either 1 mg/kg of SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, animals received tests for intrasexual aggression and partner preference. Activation of D1-like receptors in pups impaired partner preference formation, but had no effect on aggression. Other neonatal treatments had no effect on their behavior as adults. To determine whether D1 activation in pups induced changes in dopamine receptor expression, we performed autoradiography on striatal tissue from a second cohort of saline-treated and SKF38393-treated animals. Although sex differences were observed, we found no treatment differences in D1 or D2 receptor binding in any striatal subregion. This study shows that exposure to a single early pharmacological alteration of dopamine receptor activity may have long-term effects on the social behavior of prairie voles.
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Systemic administration of amphetamine or a selective D1 receptor agonist to male voles interfered with mating-induced pair bonding, and this disruption seems dependent on D1 receptor activation.
“when amphetamine or a selective D1 receptor agonist was administered systemically to male voles, this interfered with mating-induced pair bonding, and this disruption seems dependent on D1 receptor activation [542-544].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [542]
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- Authors
- Hostetler, C. M., Harkey, S. L., Krzywosinski, T. B., Aragona, B. J., & Bales, K. L.
- Affiliations
- Oregon Health & Science University (US)
- University of Michigan (US)
- University of California, Davis (US)
- Corresponding author
- Hostetler, Caroline M.
- Venue
- Behavioural Pharmacology
- Published
- 2011-10
- Volume
- 22
- Issue
- 7
- Pages
- 703-710
- ISSN
- 0955-8810 (ISSN-L)
- PMC
- PMC3174420
- OpenAlex
- W2038797004
- Cited by
- 19
- References
- 33
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute of Mental Health (R01MH073022, MH073022)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- dopamine D1 receptor, SKF 38393, Microtus ochrogaster, pair bonding, mate preferences, intrasexual aggression, monogamy, dopamine antagonists, quinpirole, eticlopride, sex differences, social behavior development
- MeSH terms
- Age Factors, Aggression, Animals, Animals, Newborn, Behavior, Animal, Benzazepines, Corpus Striatum, Arvicolinae, Dopamine, Female, Male, Salicylamides, Sexual Behavior, Animal, Sex Factors, Social Behavior, Cohort Studies, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Neostriatum, Receptors, Dopamine D1, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Quinpirole, Dopamine D2 Receptor Antagonists
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