An immuno-electronmicroscopical study comparing vasopressin, oxytocin, substance P and enkephalin containing nerve terminals in the nucleus of the solitary tract of the rat
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Vasopressin, oxytocin, substance P and enkephalin fibers were demonstrated to terminate synaptically in the nucleus of the solitary tract. The detergent Triton X-100 proved to be indispensable for the demonstration of vasopressin and oxytocin while enkephalin and substance P could be visualized very well without it. The differences with respect to morphology between these 4 peptides disappeared when Triton X-100 was used in both groups.
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Electron microscopic analysis has revealed dense core vesicles containing AVP- and OT-ir in terminals located in synaptic regions of brain areas such as the habenula, lateral septum, amygdala, supraoptic nuclei, ventromedial hypothalamus, and the nucleus of the solitary tract.
“For example, electron microscopic analysis has revealed dense core vesicles containing AVP- and OT-ir in terminals located in synaptic regions of brain areas such as the habenula, lateral septum, amygdala, supraoptic nuclei, ventromedial hypothalamus and the nucleus of the solitary tract [98; 99; 100; 101; 102; 103; 104].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [103]
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- Authors
- Voorn, P., & Buijs, R. M.
- Corresponding author
- Buijs, R.M.
- ORCID
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1983-06
- Volume
- 270
- Issue
- 1
- Pages
- 169-173
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1996774439
- Cited by
- 112
- References
- 19
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
- pure.knaw.nl
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- vasopressin, oxytocin, substance P, enkephalin, nucleus tractus solitarius, synaptic terminals, Triton X-100, rats
- MeSH terms
- Animals, Axons, Enkephalins, Immunoassay, Medulla Oblongata, Microscopy, Electron, Neurons, Oxytocin, Substance P, Vasopressins, Rats
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