Stimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve
Open accessAbstract
Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.
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The vagus is densely populated with oxytocin receptors in rodents.
“The vagus is densely populated with oxytocin receptors in rodents19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [22]
The vagus nerve is densely populated by oxytocin receptors.
“The vagus nerve is densely populated by oxytocin receptors19,21–26”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [22]
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Neuromodulation by Oxytocin and Vasopressin
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Gonadal steroids have paradoxical effects on brain oxytocin receptors
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- Authors
- Charpak, S., Armstrong, W. E., Mühlethaler, M., & Dreifuss, J. J.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Dreifuss, J.J.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1984-05
- Volume
- 300
- Issue
- 1
- Pages
- 83-89
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2063020601
- Cited by
- 107
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2019: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2012: 3
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Keywords
- oxytocin, dorsal motor nucleus of the vagus, vagal motoneurons, oxytocin receptor, vasopressin, neurohypophysial peptides, brainstem, spontaneous neuronal activity, receptor antagonism
- MeSH terms
- Animals, Arginine Vasopressin, Male, Medulla Oblongata, Organ Specificity, Oxytocin, Rats, Inbred Strains, Receptors, Cell Surface, Stimulation, Chemical, Vagus Nerve, Receptors, Oxytocin, Rats
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