Oxytocin excites gastric-related neurones in rat dorsal vagal complex
Open accessAbstract
1. Dorsal medullary injections of oxytocin (OT) influence gastric motor and secretory function via a vagally mediated mechanism. Thus, it was hypothesized that OT altered the firing rate of brain stem vagal neurones that were specifically related to gastric function. 2. To study this, glass microelectrode/injection pipette arrays were used to record the activity of gastric-related neurones in the dorsal vagal complex (DVC), which includes vagal sensory neurones in the nucleus tractus solitarius (NTS) and motor neurones in the dorsal motor nucleus (DMN). After identifying such a neurone, spontaneous activity was monitored before and after micropressure injection of OT and vehicle solutions from the pipettes. 3. Two methods were used to identify neurones that were related to gastric function. One method employed a gastric balloon to identify DVC neurones that were responsive to gastric inflation. The second method employed a gastric vagal stimulating electrode, which permitted the identification of gastric-related NTS and DMN cells via orthodromic or antidromic activation, respectively. 4. Twenty-four of forty-two gastric-inflation-related neurones responded to administration of OT (100-400 fmol in 100-400 pl). The majority of those responding to OT were activated by this peptide (21/24). All the cells tested (n = 13) remained sensitive to gastric inflation after administration of OT. Also, OT was found to excite the majority of cells that were identified as gastric-related NTS (nine excited; one no effect) or DMN cells (eleven excited; two no effect). 5. These studies support the hypothesis that central oxytocinergic neurones influence gastric motility and secretion by increasing the excitability of central vagal neurones in the NTS and DMN that are related to gastric function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150 · see citing works
Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442 · see citing works
Oxytocin Secretion in Response to Cholecystokinin and Food: Differentiation of Nausea from Satiety
Verbalis, J. G., McCann, M. J., McHale, C. M., & Stricker, E. M. (1986) · Science · doi:10.1126/science.3715453 · Cited by 354 · see citing works
Self-citationDetermination of antidromic excitation by the collision test: Problems of interpretation
Fuller, J. H., & Schlag, J. D. (1976) · Brain Research · doi:10.1016/0006-8993(76)90284-5 · Cited by 341 · see citing works
Wakerley, J. B., Poulain, D. A., & Brown, D. A. (1978) · Brain Research · doi:10.1016/0006-8993(78)90730-8 · Cited by 229 · see citing works
Vasopressin and oxytocin release in the brain – a synaptic event
Buijs, R. M., & Heerikhuize, J. J. V. (1982) · Brain Research · doi:10.1016/0006-8993(82)90979-9 · Cited by 218 · see citing works
Cholecystokinin and gastric distension activate oxytocinergic cells in rat hypothalamus
Renaud, L. P., Tang, M., McCann, M. J., Stricker, E. M., & Verbalis, J. G. (1987) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1987.253.4.r661 · Cited by 190 · see citing works
Self-citationRogers, R. C., & Hermann, G. E. (1987) · Peptides · doi:10.1016/0196-9781(87)90017-9 · Cited by 168 · see citing works
Self-citationBrimble, M. J., Dyball, R. E. J., & Forsling, M. L. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012293 · Cited by 162 · see citing works
Palkovits, M., Mezey, É., Eskay, R. L., & Brownstein, M. (1986) · Brain Research · doi:10.1016/0006-8993(86)90338-0 · Cited by 145 · see citing works
Afferent projections to the dorsal motor nucleus of the vagus
Roges, R. C., Kita, H., Butcher, L. L., et al. (1980) · Brain Research Bulletin · doi:10.1016/s0361-9230(80)80006-2 · Cited by 126 · see citing works
Rogers, R. C., & Hermann, G. E. (1985) · Peptides · doi:10.1016/0196-9781(85)90441-3 · Cited by 116 · see citing works
Self-citationLiCl and CCK inhibit gastric emptying and feeding and stimulate OT secretion in rats
McCann, M. J., Verbalis, J. G., & Stricker, E. M. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.2.r463 · Cited by 110 · see citing works
Self-citationStimulatory action of oxytocin on neurones of the dorsal motor nucleus of the vagus nerve
Charpak, S., Armstrong, W. E., Mühlethaler, M., & Dreifuss, J. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91342-8 · Cited by 107 · see citing works
Thyrotropin-releasing hormone: effects on identified neurons of the dorsal vagal complex
McCann, M. J., Hermann, G. E., & Rogers, R. C. (1989) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(89)90158-6 · Cited by 88 · see citing works
Self-citationMarc, S., Leiber, D., & Harbon, S. (1988) · PubMed · Cited by 79 · see citing works
Rogers, R. C., & Hermann, G. E. (1986) · Peptides · doi:10.1016/0196-9781(86)90046-x · Cited by 79 · see citing works
Self-citationRelease of vasopressin and oxytocin by paraventricular stimulation in rats
Landgraf, R., Malkinson, T. J., Horn, T. F. W., Veale, W. L., Lederis, K. P., & Pittman, Q. J. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.1.r155 · Cited by 68 · see citing works
Gastric-vagal solitary neurons excited by paraventricular nucleus microstimulation
Rogers, R. C., & Hermann, G. E. (1985) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(85)90081-5 · Cited by 51 · see citing works
Self-citationRogers, R. C., & Nelson, D. O. (1984) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(84)90057-2 · Cited by 42 · see citing works
Self-citationEffects of anorexigenic treatments on gastric motility in rats
Flanagan, L. M., Verbalis, J. G., & Stricker, E. M. (1989) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1989.256.4.r955 · Cited by 40 · see citing works
Vagal afferent stimulation-evoked gastric secretion suppressed by paraventricular nucleus lesion
Rogers, R. C., & Hermann, G. E. (1985) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(85)90011-6 · Cited by 38 · see citing works
Self-citationRaggenbass, M., Charpak, S., Dubois‐Dauphin, M., & Dreifuss, J.-J. (1988) · Journal of Receptor Research · doi:10.3109/10799898809048992 · Cited by 37 · see citing works
Interaction between descending paraventricular neurons and vagal motor neurons
Lawrence, D., & Pittman, Q. J. (1985) · Brain Research · doi:10.1016/0006-8993(85)90399-3 · Cited by 34 · see citing works
Rogers, R. C., & McCann, M. J. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90331-5 · Cited by 28 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Surmeier, D. J., Guzman, J. N., Sanchez-Padilla, J., & Schumacker, P. T. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.045 · Cited by 236 · see citing works
Oxytocin and social motivation
Gordon, I., Martin, C., Feldman, R., & Leckman, J. F. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.007 · Cited by 211 · see citing works
Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208 · see citing works
Neuronal vulnerability, pathogenesis, and Parkinson's disease
Sulzer, D., & Surmeier, D. J. (2013) · Movement Disorders · doi:10.1002/mds.25187 · Cited by 184 · see citing works
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180 · see citing works
Zhang, G., & Cai, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2011 · Cited by 171 · see citing works
Oxytocin, feeding, and satiety
Sabatier, N., Leng, G., & Menzies, J. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00035 · Cited by 149 · see citing works
Oxytocin enhances cranial visceral afferent synaptic transmission to the solitary tract nucleus
Peters, J. H., McDougall, S. J., Kellett, D. O., Jordan, D., Llewellyn-Smith, I. J., & Andresen, M. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3419-08.2008 · Cited by 135 · see citing works
Gonadal steroids have paradoxical effects on brain oxytocin receptors
Insel, T. R., Young, L., Witt, D. M., & Crews, D. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00531.x · Cited by 113 · see citing works
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works
The pathology roadmap in Parkinson disease
Surmeier, D. J., & Sulzer, D. (2013) · Prion · doi:10.4161/pri.23582 · Cited by 74 · see citing works
Vila, G., Riedl, M., Resl, M., van der Lely, A. J., Hofland, L. J., Clodi, M., & Luger, A. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0227 · Cited by 31 · see citing works
Borg, J., Simrén, M., & Ohlsson, B. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01599.x · Cited by 26 · see citing works
McEwen (2004) · doi:10.1016/s1054-3589(04)50016-9 · Cited by 22 · see citing works
- Authors
- McCann, M. J., & Rogers, R. C.
- Affiliations
- The Ohio State University (US)
- ORCID
- Rogers, R C
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1990-09
- Volume
- 428
- Issue
- 1
- Pages
- 95-108
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1181637
- OpenAlex
- W1970498004
- Cited by
- 118
- References
- 25
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 6 · 2014: 2 · 2013: 8 · 2012: 5
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f32ns008690-02, 5r01ns024530-05)
- National Institute of Neurological Disorders and Stroke (NS24530, NSO8690)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- oxytocin, dorsal vagal complex, nucleus tractus solitarius, dorsal motor nucleus of the vagus, gastric inflation, gastric motility, gastric secretion, antidromic activation
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Male, Medulla Oblongata, Motor Neurons, Neurons, Oxytocin, Stomach, Vagus Nerve, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
