Sex and Species Differences in the Vasopressin Innervation of Sexually Naive and Parental Prairie Voles, Microtus ochrogaster and Meadow Voles, Microtus pennsylvanicus
Abstract
To study whether central systems that are implicated in functions associated with reproduction show different changes in males and females that become parental, the central vasopressin (AVP) innervation was compared in two species of voles: prairie voles, in which males and females provide parental care, and meadow voles, in which only females provide parental care. For both species, the densities of AVP-immunoreactive (AVP-ir) fibers in the lateral septum, lateral habenular nucleus, medial preoptic area and paraventricular nucleus of the thalamus were compared in males and females that were sexually inexperienced or had become parents 6 days before sacrifice. The lateral septum and lateral habenular nucleus presumably receive their projections from the bed nucleus of the stria terminalis and medial amygdaloid nucleus, while the other two areas presumably receive their projections from the suprachiasmatic nucleus. Differences between sexually naive and parental animals were found only in the presumed projections of the bed nucleus of the stria terminalis and medial amygdaloid nucleus. In both species, AVP-ir fiber densities in the lateral habenular nucleus and the lateral septum were much greater in males than in females regardless of parental state. In prairie voles, AVP-ir fiber density in the lateral septum and lateral habenular nucleus was reduced in parental males, while no differences were found in females. In parental meadow voles, the AVP-ir fiber density in the lateral septum did not show changes, while the fiber density in the lateral habenular nucleus was increased.(ABSTRACT TRUNCATED AT 250 WORDS)
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In prairie voles, cohabitation with a female resulted in a decrease in AVP content in the lateral septum, coincident with an increase in paternal responsiveness.
“Early comparative studies discovered that in prairie voles, cohabitation with a female resulted in a decrease in AVP content in the lateral septum (likely reflecting a release of AVP from neuronal fibers in the region), which was coincident with an increase in paternal responsiveness.”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [37]
The decrease in AVP content in the lateral septum after cohabitation with a female was not observed in meadow voles.
“This phenomenon was not observed in meadow voles [36, 37].”
From The prairie vole: An emerging model organism for understanding the social brain (2010) · cites this paper as [37]
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- Authors
- Bamshad, M., Novak, M. A., & De Vries, G. J.
- Affiliations
- University of Massachusetts Amherst (US)
- ORCID
- Novak, Melinda A.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 1993-06
- Volume
- 5
- Issue
- 3
- Pages
- 247-255
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1993426397
- Cited by
- 175
- References
- 53
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 11 · 2013: 11 · 2012: 5
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- Microtus ochrogaster, Microtus pennsylvanicus, parental care, sex differences, lateral septum, medial preoptic area, paraventricular thalamus, bed nucleus of the stria terminalis, medial amygdala, suprachiasmatic nucleus, neuropeptide immunoreactivity
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Brain Chemistry, Arvicolinae, Female, Hypothalamus, Male, Nerve Fibers, Preoptic Area, Reproduction, Sex Characteristics, Species Specificity, Thalamus
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