The DOI matches its Crossref record.
‘Ischemic tolerance’ phenomenon found in the brain
Abstract
We investigated the possibility that neuronal cells given a mild ischemic treatment sufficient to perturb the cellular metabolism acquired tolerance to a subsequent, and what would be lethal, ischemic stress in vivo. Cerebral ischemia was produced in the gerbils by occlusion of both common carotids for 5 min, which consistently resulted in delayed neuronal death in the CA1 region of the hippocampus. Minor 2-min ischemia in this model depletes high-energy phosphate compounds and perturbs the protein synthesis, but never causes neuronal necrosis, and therefore was chosen as mild ischemic treatment. Single 2-min ischemia 1 day or 2 days before 5 min ischemia exhibited only partial protective effects against delayed neuronal death. However, two 2-min ischemic treatments at 1 day intervals 2 days before 5 min ischemia exhibited drastically complete protection against neuronal death. The duration and intervals of ischemic treatment, enough to perturb cellular metabolism and cause protein synthesis, were needed respectively, because neither 1-min ischemia nor 2-min ischemia received twice at short intervals exhibited protective effects. This 'ischemic tolerance' phenomenon induced by ischemic stress--which is unquestionably important--and frequent stress in clinical medicine, is intriguing and may open a new approach to investigate the pathophysiology of ischemic neuronal damage.
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Citations
Cited by
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Jankauskas, S. S., Pevzner, I. B., Andrianova, N. V., Zorova, L. D., Popkov, V. A., Silachev, D. N., Kolosova, N. G., Plotnikov, E. Y., & Zorov, D. B. (2017) · Scientific Reports · doi:10.1038/srep44430 · Cited by 41
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Metadata
- Authors
- Kitagawa, K., Matsumoto, M., Tagaya, M., Hata, R., Ueda, H., Niinobe, M., Handa, N., Fukunaga, R., Kimura, K., Mikoshiba, K., & Kamada, T.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-09
- Volume
- 528
- Issue
- 1
- Pages
- 21-24
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2094164804
- Cited by
- 1,091
- References
- 0
- FWCI
- 15.86
- Type
- journal article
- Language
- en
- Open access
- closed
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