Cited by 427Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismTrace Elements in Health

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

Good, Paul F., Olanow, C.W., Perl, Daniel P.·1992·Brain Research

Abstract

The Laser Microprobe Mass Analyzer (LAMMA) is a sensitive instrument for identifying and localizing trace elements in tissue samples. Using LAMMA, we have examined melanin-containing neurons of the substantia nigra in patients with Parkinson's disease (PD) and controls. We found that iron significantly accumulates within neuromelanin granules of patients with PD compared to controls. Increased aluminum was found in the neuromelanin granules of 2 of 3 PD cases but in no controls. The accumulation of iron and aluminum, which are known to promote oxidant stress, may account for the selective degeneration of neuromelanin-containing neurons in PD.

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Crossref · 10.1016/0006-8993(92)91334-b

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23 of 23 references verified0 citation errors · 0 not checkable

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  • Investigations have shown an increase in redox-active iron associated with neuromelanin in substantia nigra neurons of patients with Parkinson's disease, probably as a result of decreased ferritin synthesis.

    “Investigations have shown an increase in redox-active iron associated with neuromelanin in substantia nigra neurons of patients with Parkinson’s disease, probably as a result of decreased ferritin synthesis.”
  • Increased redox-active iron is higher in patients with the most severe neuronal loss and is absent in neurons without neuromelanin.

    “Increased redox-active iron is higher in patients with the most severe neuronal loss and is absent in neurons without neuromelanin.122–124”

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Authors
Good, P. F., Olanow, C. W., & Perl, D. P.
Affiliations
  • Mount Sinai Hospital (US)
  • University of South Florida (US)
Corresponding author
Perl, Daniel P.
Venue
Brain Research
Publisher
Elsevier BV
Published
1992-10
Volume
593
Issue
2
Pages
343-346
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2076031180
Cited by
427
References
23
Citations by year
2026: 3 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 13 · 2021: 10 · 2020: 9 · 2019: 20 · 2018: 7 · 2017: 8 · 2016: 20 · 2015: 16 · 2014: 11 · 2013: 10 · 2012: 7
FWCI
13.96
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
Parkinson's disease, substantia nigra, neuromelanin, iron accumulation, aluminum accumulation, trace elements, laser microprobe mass analysis, oxidative stress, neurodegeneration, neurotoxicity
MeSH terms
Aluminum, Humans, Iron, Lasers, Melanins, Neurons, Parkinson Disease, Reference Values, Mass Spectrometry, Substantia Nigra, Trace Elements

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