Neuronal Pentraxin 2 Binds PNNs and Enhances PNN Formation
Open accessAbstract
The perineuronal net (PNN) is a mesh-like proteoglycan structure on the neuronal surface which is involved in regulating plasticity. The PNN regulates plasticity via multiple pathways, one of which is direct regulation of synapses through the control of AMPA receptor mobility. Since neuronal pentraxin 2 (Nptx2) is a known regulator of AMPA receptor mobility and Nptx2 can be removed from the neuronal surface by PNN removal, we investigated whether Nptx2 has a function in the PNN. We found that Nptx2 binds to the glycosaminoglycans hyaluronan and chondroitin sulphate E in the PNN. Furthermore, in primary cortical neuron cultures, the addition of NPTX2 to the culture medium enhances PNN formation during PNN development. These findings suggest Nptx2 as a novel PNN binding protein with a role in the mechanism of PNN formation.
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OTX2 and Sema3A bind to 4,6 disulphated GAGs in PNNs, while Nptx2 binds to both 4,6 sulphated GAGs and HA.
“While OTX2 and Sema3A bind to 4,6 disulphated GAGs in the PNNs [23, 28], Nptx2 binds to both 4,6 sulphated GAGs and HA [29].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [29]
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- Authors
- Van’t Spijker, H. M., Rowlands, D., Rossier, J., Haenzi, B., Fawcett, J. W., & Kwok, J. C. F.
- Affiliations
- John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, UK
- University of Cambridge (GB)
- Neurosciences Paris-Seine (FR)
- University of Leeds (GB)
- Venue
- Neural Plasticity
- Publisher
- Wiley
- Published
- 2019-10-20
- Volume
- 2019
- Pages
- 1-13
- ISSN
- 1687-5443 (ISSN-L)
- 2090-5904
- PMC
- PMC6854953
- OpenAlex
- W2981078527
- Cited by
- 31
- References
- 52
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 3
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Neural Plasticity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Apollo
- Apollo (cc-by)
- Funders
- European Union
- Leverhulme Trust
- Royal Society
- Pinsent Darwin scholarship
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- NPTX2, perineuronal nets, hyaluronic acid, glycosaminoglycans, synaptic plasticity, cortical neurons, proteoglycan binding
- MeSH terms
- Pentraxins, Animals, C-Reactive Protein, Cells, Cultured, Female, Nerve Net, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Protein Binding, Visual Cortex, Rats, Sprague-Dawley, Satellite Cells, Perineuronal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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