Cortical areas are revealed by distribution patterns of proteoglycan components and parvalbumin in the Mongolian gerbil and rat
Abstract
Cortical areas in rodents have been basically characterized by its cytoarchitecture, connectivity or by physiological parameters. In this study we show that they are revealed by distribution patterns of proteoglycans and parvalbumin-immunoreactivity. Brains of young adult Mongolian gerbils (Meriones unguiculatus) and Wistar rats were cut into series of transversal sections. Proteoglycan components were detected using the N-acetylgalactosamine binding Wisteria floribunda agglutinin (WFA) and antibodies against chondroitin sulphate proteoglycan (CSPG). Differences between cortical areas were found to exist with regard to the occurrence and the density of perineuronal nets, but were also expressed in varying staining intensities for WFA and CSPG of the neuropil. Primary neocortical areas (somatosensory, auditory, visual cortex) were characterized by an intense neuropil staining in layer IV and the upper part of layer VI. Using the same methods strong labelling was also typical of the neuropil in the retrosplenial cortex, of layer Ia in the prepiriform cortex and the hippocampal CA3 field. In tangential sections cut from gerbil cortical hemispheres, some of the heavily lectin-stained cortical areas were sharply delineated from adjacent faintly labelled regions, others showed more diffuse borders. In the rat, the area-specific staining for WFA was less clearly expressed than in the gerbil. Immunocytochemistry of the calcium-binding protein parvalbumin in alternate sections showed labelling patterns of neuropil which resembled those of WFA-binding and CSPG-immunoreactivity in the entire neocortex and hippocampus. From these results it can be concluded that functional peculiarities of cortical fields may not only be determined by neuronal network parameters but also by the spatial arrangement of extracellular matrix proteoglycans.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PNNs surround inhibitory fast spiking parvalbumin-positive GABAergic interneurons and are also associated with excitatory pyramidal neurons in the cerebral cortex.
“PNNs surround inhibitory fast spiking parvalbumin-positive GABAergic interneurons12–14, but are also associated with further subpopulations, for example excitatory pyramidal neurons in the cerebral cortex15,16.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [12]
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Calbindin D-28k and parvalbumin in the rat nervous system
Celio, M. R. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90091-h · Cited by 2,086 · see citing works
Cytochrome oxidase: an endogenous metabolic marker for neuronal activity
Wong-Riley, M. T. T. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90165-3 · Cited by 1,238 · see citing works
Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas
Krieg, W. J. S. (1946) · The Journal of Comparative Neurology · doi:10.1002/cne.900840205 · Cited by 1,018 · see citing works
Organization of motor and somatosensory neocortex in the albino rat
Hall, R. D., & Lindholm, E. P. (1974) · Brain Research · doi:10.1016/0006-8993(74)90076-6 · Cited by 897 · see citing works
Zilles, K. (1985) · Springer eBooks · doi:10.1007/978-3-642-70573-1 · Cited by 756 · see citing works
An autoradiographic study of the organization of intrahippocampal association pathways in the rat
Swanson, L. W., Wyss, J. M., & Cowan, W. M. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810402 · Cited by 704 · see citing works
A STUDY OF THALAMO-CORTICAL RELATIONS
Morison, R. S., & Dempsey, E. W. (1941) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1941.135.2.281 · Cited by 666 · see citing works
The Cortex of the Rat: A Stereotaxic Atlas
Zilles, K. (1985) · Medical Entomology and Zoology · Cited by 657 · see citing works
Mapping the body representation in the SI cortex of anesthetized and awake rats
Chapin, J. K., & Lin, C. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902290206 · Cited by 584 · see citing works
Laminar organization of thalamic projections to the rat neocortex.
Herkenham, M. (1980) · Science · doi:10.1126/science.7352263 · Cited by 579 · see citing works
Kosaka, T., Katsumaru, H., Hama, K., Wu, J.-Y., & Heizmann, C. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)90575-0 · Cited by 536 · see citing works
Price, J. L. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901500105 · Cited by 530 · see citing works
Receptive fields of barrels in the somatosensory neocortex of the rat
Welker, C. (1976) · Journal of Comparative Neurology · doi:10.1002/cne.901660205 · Cited by 519 · see citing works
Fast spiking cells in rat hippocampus (CA1 region) contain the calcium-binding protein parvalbumin
Kawaguchi, Y., Katsumaru, H., Kosaka, T., Heizmann, C. W., & Hama, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)90921-8 · Cited by 485 · see citing works
Swezy, O. (1928) · Science · doi:10.1126/science.68.1751.60 · Cited by 461 · see citing works
Connections of the cerebral cortex. I. The albino rat. B. Structure of the cortical areas
Krieg, W. J. S. (1946) · The Journal of Comparative Neurology · doi:10.1002/cne.900840302 · Cited by 443 · see citing works
Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons
Härtig, W., Brauer, K., & Brückner, G. (1992) · NeuroReport · doi:10.1097/00001756-199210000-00012 · Cited by 440 · see citing works
Self-citationMonoclonal antibodies directed against the calcium binding protein parvalbumin
Celio, M. R., Baier, W. K., Schärer, L., de Viragh, P. A., & Gerday, C. (1988) · Cell Calcium · doi:10.1016/0143-4160(88)90027-9 · Cited by 423 · see citing works
Perineuronal nets — a specialized form of extracellular matrix in the adult nervous system
Celio, M. R., & Blümcke, I. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90006-x · Cited by 386 · see citing works
Blackstad, T. W., Brink, K., Hem, J., & June, B. (1970) · The Journal of Comparative Neurology · doi:10.1002/cne.901380404 · Cited by 366 · see citing works
Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A. (1993) · Glia · doi:10.1002/glia.440080306 · Cited by 358 · see citing works
Self-citationPhysiology of the Nervous System
Fulton, J. F. (1939) · Science · doi:10.1126/science.90.2327.110.a · Cited by 355 · see citing works
Maturation and plasticity in the olfactory system of vertebrates
Brunjes, P. C., & Frazier, L. L. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90008-1 · Cited by 322 · see citing works
Hockfield, S., Kalb, R. G., Zaremba, S., & Fryer, H. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.049 · Cited by 271 · see citing works
Evidence for two complementary patterns of thalamic input to the rat somatosensory cortex
Koralek, K., Jensen, K. F., & Killackey, H. P. (1988) · Brain Research · doi:10.1016/0006-8993(88)90408-8 · Cited by 240 · see citing works
Thalamic Relationships of the Medial Cortex in the Rat (Part 1 of 2)
Domesick, V. B. (2008) · Brain Behavior and Evolution · doi:10.1159/000123727 · Cited by 226 · see citing works
Hendry, S., Jones, E. G., Hockfield, S. J., & McKay, R. D. G. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-02-00518.1988 · Cited by 205 · see citing works
White, E. L. (1979) · Brain Research Reviews · doi:10.1016/0165-0173(79)90008-0 · Cited by 188 · see citing works
The organization and development of the hippocampal mossy fiber system
Gaarskjaer, F. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90004-4 · Cited by 186 · see citing works
Connections of the cerebral cortex I. The Albino Rat. C. Extrinsic connections
Krieg, W. J. S. (1947) · The Journal of Comparative Neurology · doi:10.1002/cne.900860302 · Cited by 179 · see citing works
A surface antigen expressed by a subset of neurons in the vertebrate central nervous system.
Hockfield, S. J., & McKay, R. D. G. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.18.5758 · Cited by 175 · see citing works
A stereotaxic atlas of the Mongolian gerbil brain (Meriones unguiculatus)
Loskota, W. J., Lomax, P., & Verity, M. A. (1974) · Medical Entomology and Zoology · Cited by 169 · see citing works
The parvalbumin-containing nonpyramidal neurons in the rat hippocampus
Nitsch, R., Soriano, E., & Frotscher, M. (1990) · Anatomy and Embryology · doi:10.1007/bf02433788 · Cited by 162 · see citing works
New Perspectives on the Organization and Evolution of Nonspecific Thalamocortical Projections
Herkenham, M. A. (1986) · Cerebral cortex · doi:10.1007/978-1-4613-2149-1_11 · Cited by 155 · see citing works
Kosaka, T., & Heizmann, C. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)90048-6 · Cited by 153 · see citing works
Seeger, G., Brauer, K., Ha¨rtig, W., & Bru¨ckner, G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90044-2 · Cited by 150 · see citing works
Self-citationBraun, K. A. (1990) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(11)80044-6 · Cited by 147 · see citing works
Ha¨rtig, W., Brauer, K., Bigl, V., & Bru¨ckner, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)91452-4 · Cited by 147 · see citing works
Self-citationNakagawa, F., Schulte, B. A., & Spicer, S. S. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430210 · Cited by 140 · see citing works
Guimaraes, A., Zaremba, S., & Hockfield, S. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03014.1990 · Cited by 128 · see citing works
DeYoe, E. A., Hockfield, S. J., Garren, H., & Essen, D. C. V. (1990) · Visual Neuroscience · doi:10.1017/s0952523800000080 · Cited by 127 · see citing works
Montero, V. M., & Guillery, R. W. (1968) · The Journal of Comparative Neurology · doi:10.1002/cne.901340208 · Cited by 126 · see citing works
A stereotaxic atlas of the mongolian gerbil brain (meriones unguiculatus)
Hankinson, J. (1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90095-7 · Cited by 120 · see citing works
Proteoglycans in the nervous system
Lander, A. D. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90143-m · Cited by 114 · see citing works
An intercellular substance in rat cerebral cortex: Submicroscopic distribution of ruthenium red
Bondareff, W. (1967) · The Anatomical Record · doi:10.1002/ar.1091570312 · Cited by 111 · see citing works
Synaptic termination of thalamic and callosal afferents in cingulate cortex of the rat
Vogt, B. A., Rosene, D. L., & Peters, A. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902010210 · Cited by 110 · see citing works
Distribution of histochemically reactive zinc in the forebrain of the rat
Frederickson, C. J., Rampy, B. A., Reamy-Rampy, S., & Howell, G. A. (1992) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(92)90007-d · Cited by 102 · see citing works
Molecular determinants of GABAergic local-circuit neurons in the visual cortex
Naegele, J. R., & Barnstable, C. J. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90153-7 · Cited by 100 · see citing works
Miragall, F., Kadmon, G., Faissner, A., Antonicek, H., & Schachner, M. (1990) · Journal of Neurocytology · doi:10.1007/bf01186818 · Cited by 94 · see citing works
Naegele, J. R., & Katz, L. C. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-02-00540.1990 · Cited by 88 · see citing works
Tortosa, A., & Ferrer, I. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90452-l · Cited by 84 · see citing works
Chondroitin sulfate proteoglycan surrounds a subset of human and rat CNS neurons
Bertolotto, A., Rocca, G., Canavese, G., Migheli, A., & Schiffer, D. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490290213 · Cited by 81 · see citing works
Kosaka, T., Isogai, K., Barnstable, C. J., & Heizmann, C. W. (1990) · Experimental Brain Research · doi:10.1007/bf00228797 · Cited by 79 · see citing works
Abbott, N. J. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90003-2 · Cited by 77 · see citing works
Scheich, H., Heil, P. F., & Langner, G. D. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00941.x · Cited by 76 · see citing works
Brauer, K., Ha¨rtig, W., Bigl, V., & Bru¨ckner, G. (1993) · Brain Research · doi:10.1016/0006-8993(93)91205-7 · Cited by 75 · see citing works
Self-citationTermination of Thalamic Afferents in the Cerebral Cortex
White, E. L. (1986) · Cerebral cortex · doi:10.1007/978-1-4613-2149-1_8 · Cited by 74 · see citing works
Immunohistochemical localization of hyaluronic acid in rat and human brain
Yasuhara, O., Akiyama, H., McGeer, E. G., & McGeer, P. L. (1994) · Brain Research · doi:10.1016/0006-8993(94)91448-6 · Cited by 74 · see citing works
‘Perineuronal nets’ around cortical interneurons expressing parvalbumin are rich in tenascin
Celio, M. R., & Chiquet‐Ehrismann, R. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90579-a · Cited by 71 · see citing works
Hyaluronan and Hyaluronectin in the Nervous System
Delpech, B., DELPECH, A., Brückner, G., Girard, N., & Maingonnat, C. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513774.ch13 · Cited by 69 · see citing works
Self-citationLocalization of Hyaluronectin in the nervous system
DELPECH, A., Girard, N., & Delpech, B. (1982) · Brain Research · doi:10.1016/0006-8993(82)90807-1 · Cited by 67 · see citing works
Bertolotto, A., Rocca, G., & Schiffer, D. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90021-e · Cited by 65 · see citing works
Zaremba, S., Naegele, J. R., Barnstable, C. J., & Hockfield, S. J. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-09-02985.1990 · Cited by 64 · see citing works
L�th, H. J., Fischer, J., & Celio, M. R. (1992) · Journal of Neurocytology · doi:10.1007/bf01194979 · Cited by 63 · see citing works
Brauer, K., Werner, L., & Leibnitz, L. (1982) · PubMed · Cited by 59 · see citing works
Self-citationCo-localization of hyaluronic acid and chondroitin sulfate proteoglycan in rat cerebral cortex
Bignami, A., Asher, R., & Perides, G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90759-3 · Cited by 55 · see citing works
Margolis, R. U., & Margolis, R. K. (1989) · Developmental Neuroscience · doi:10.1159/000111906 · Cited by 55 · see citing works
Structural and cytochemical features of perineuronal glial nets in the rat brain
Brauer, K., Brückner, G., Leibnitz, L., & Werner, L. (1984) · Acta Histochemica · doi:10.1016/s0065-1281(84)80026-4 · Cited by 51 · see citing works
Self-citationSchweizer, M., Streit, W. J., & Müller, C. M. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903290303 · Cited by 47 · see citing works
An atlas of a rare neuronal surface antigen in the rat central nervous system
Stephenson, D., & Kushner, P. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-03035.1988 · Cited by 44 · see citing works
The perineuronal net in the fastigial nucleus of the rat cerebellum
Lafarga, M., Berciano, M. T., & Blanco, M. J. (1984) · Anatomy and Embryology · doi:10.1007/bf00319461 · Cited by 42 · see citing works
A brain extracellular matrix proteoglycan forms aggregates with hyaluronan
Iwata, M., Wight, T. N., & Carlson, S. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82438-3 · Cited by 38 · see citing works
Cell Surface Recognition and Neuron‐Glia Interactionsa
Schachner, M. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb15601.x · Cited by 35 · see citing works
Caird, D. M., Scheich, H., & Klinke, R. (1991) · Journal of Comparative Physiology A · doi:10.1007/bf00217100 · Cited by 34 · see citing works
Fujita, S. C., & Kudo, J. (1992) · Experimental Brain Research · doi:10.1007/bf02259110 · Cited by 28 · see citing works
The perforant path in the seizure sensitive gerbil contains the Ca2+-binding protein parvalbumin
Scotti, A. L., & Nitsch, C. (1991) · Experimental Brain Research · doi:10.1007/bf00229994 · Cited by 28 · see citing works
Bignami, A., Asher, R., Perides, G., & Rahemtulla, F. G. (1992) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(92)90018-u · Cited by 27 · see citing works
Kosaka, T., Heizmann, C., & Fujita, S. (1992) · Experimental Brain Research · doi:10.1007/bf00229007 · Cited by 27 · see citing works
Atoji, Y., & Suzuki, Y. (1992) · Brain Research · doi:10.1016/0006-8993(92)91220-9 · Cited by 21 · see citing works
Brückner, G., Delpech, B., DELPECH, A., & Girard, N. (1990) · PubMed · Cited by 20 · see citing works
Self-citationThe basal forebrain cholinergic system in the raccoon
Brückner, G., Schober, W., Härtig, W., Ostermann‐Latif, C., Webster, H. H., Dykes, R. W., Rasmusson, D. D., & Biesold, D. (1992) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(92)90001-7 · Cited by 18 · see citing works
Self-citationMulligan, K. A., van Brederode, J. F. M., Mehra, R., & Hendrickson, A. E. (1992) · Journal of Neurocytology · doi:10.1007/bf01224759 · Cited by 11 · see citing works
Brain cytochrome oxidase activity after kindled seizures: a quantitative histochemical mapping study
Nóbrega, J. N., Petrasek, J. S., Raymond, R., Dixon, L. M., & Burnham, W. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)90809-2 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 86 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575 · see citing works
DeFelipe, J. (1997) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(97)10013-8 · Cited by 550 · see citing works
Härtig, W., Derouiche, A., Welt, K., Brauer, K., Grosche, J., Mäder, M., Reichenbach, A., & Brückner, G. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01784-9 · Cited by 339 · see citing works
Self-citationChondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?
Rhodes, K. E., & Fawcett, J. W. (2003) · Journal of Anatomy · doi:10.1111/j.1469-7580.2004.00261.x · Cited by 296 · see citing works
Weber, P., Bartsch, U., Rasband, M. N., Czaniera, R., Lang, Y., Bluethmann, H., Margolis, R. U., Levinson, S. R., Shrager, P., Montag, D., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04245.1999 · Cited by 247 · see citing works
Laminar and columnar auditory cortex in avian brain
Wang, Y., Brzozowska-Prechtl, A., & Karten, H. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006645107 · Cited by 244 · see citing works
Bukalo, O., Schachner, M., & Dityatev, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00082-3 · Cited by 236 · see citing works
Brückner, G., Hausen, D., Härtig, W., Drlicek, M., Arendt, T., & Brauer, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00071-8 · Cited by 196 · see citing works
Self-citationCaggiano, A. O., Zimber, M. P., Ganguly, A., Blight, A. R., & Gruskin, E. A. (2005) · Journal of Neurotrauma · doi:10.1089/neu.2005.22.226 · Cited by 189 · see citing works
Extracellular matrix abnormalities in schizophrenia
Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179 · see citing works
Happel, M. F. K., Niekisch, H., Castiblanco Rivera, L. L., Ohl, F. W., Deliano, M., & Frischknecht, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310272111 · Cited by 176 · see citing works
Suttkus, A., Rohn, S., Weigel, S., Glöckner, P., Arendt, T., & Morawski, M. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.25 · Cited by 168 · see citing works
Brückner, G., Bringmann, A., Härtig, W., Köppe, G., Delpech, B., & Brauer, K. (1998) · Experimental Brain Research · doi:10.1007/s002210050463 · Cited by 162 · see citing works
Self-citationBurnside, E. R., & Bradbury, E. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12114 · Cited by 153 · see citing works
Ye, Q., & Miao, Q.-L. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.04.001 · Cited by 146 · see citing works
Hylin, M. J., Orsi, S. A., Moore, A. N., & Dash, P. K. (2013) · Learning & Memory · doi:10.1101/lm.030197.112 · Cited by 143 · see citing works
Budinger, E., Heil, P. F., & Scheich, H. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00142.x · Cited by 135 · see citing works
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works
Preuss, T. M. (2000) · Brain Behavior and Evolution · doi:10.1159/000006664 · Cited by 132 · see citing works
Köppe, G., Brückner, G., Brauer, K., Härtig, W., & Bigl, V. (1997) · Cell and Tissue Research · doi:10.1007/s004410050790 · Cited by 129 · see citing works
Self-citationGlycosaminoglycans and β-amyloid, prion and tau peptides in neurodegenerative diseases
Díaz‐Nido, J., Wandosell, F. G., & Ávila, J. (2002) · Peptides · doi:10.1016/s0196-9781(02)00068-2 · Cited by 128 · see citing works
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Pantazopoulos, H., & Berretta, S. (2015) · Neural Plasticity · doi:10.1155/2016/9847696 · Cited by 118 · see citing works
Brückner, G., Grosche, J., Hartlage‐Rübsamen, M., Schmidt, S., & Schachner, M. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(03)00036-x · Cited by 116 · see citing works
Self-citationHenschke, J. U., Noesselt, T., Scheich, H., & Budinger, E. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0694-4 · Cited by 114 · see citing works
Cruikshank, S. J., Killackey, H. P., & Metherate, R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00226-3 · Cited by 113 · see citing works
Gottschling, C., Wegrzyn, D., Denecke, B., & Faissner, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-50404-9 · Cited by 111 · see citing works
Extracellular matrix organization in various regions of rat brain grey matter
Brückner, G., Härtig, W., Kacza, J., Seeger, J., Welt, K., & Brauer, K. (1996) · Journal of Neurocytology · doi:10.1007/bf02284806 · Cited by 109 · see citing works
Self-citationWegner, F., Härtig, W., Bringmann, A., Grosche, J., Wohlfarth, K., Zuschratter, W., & Brückner, G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00313-3 · Cited by 107 · see citing works
Self-citationGuirado, R., Perez-Rando, M., Sanchez-Matarredona, D., Castrén, E., & Nacher, J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000406 · Cited by 103 · see citing works
Perineuronal nets protect against amyloid β-protein neurotoxicity in cultured cortical neurons
Miyata, S., Nishimura, Y., & Nakashima, T. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.066 · Cited by 101 · see citing works
Morris, N. P., & Henderson, Z. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00970.x · Cited by 98 · see citing works
Dzyubenko, E., Rozenberg, A., Hermann, D. M., & Faissner, A. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.09.001 · Cited by 98 · see citing works
Köppe, G., Brückner, G., Härtig, W., Delpech, B., & Bigl, V. (1997) · The Histochemical Journal · doi:10.1023/a:1026408716522 · Cited by 95 · see citing works
Self-citationLendvai, D., Morawski, M., Négyessy, L., Gáti, G., Jäger, C., Baksa, G., Glasz, T., Attems, J., Tanila, H., Arendt, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1042-0 · Cited by 93 · see citing works
Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat
Alpár, A., Gärtner, U., Härtig, W., & Brückner, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.069 · Cited by 93 · see citing works
Self-citationBaker, K., Gray, A. R., & Richardson, R. (2017) · Behavioral Neuroscience · doi:10.1037/bne0000203 · Cited by 89 · see citing works
Bertolotto, A., Manzardo, E., & Guglielmone, R. (1996) · Cell and Tissue Research · doi:10.1007/s004410050538 · Cited by 80 · see citing works
Diverse functions of perineuronal nets
Karetko, M., & Skangiel-Kramska, J. (2009) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2009-1766 · Cited by 76 · see citing works
Extracellular Matrix in Neural Plasticity and Regeneration
Chelyshev, Y. A., Kabdesh, I. M., & Mukhamedshina, Y. O. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00986-0 · Cited by 76 · see citing works
Diño, M. R., Harroch, S., Hockfield, S. J., & Matthews, R. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.054 · Cited by 76 · see citing works
Construction of perineuronal net-like structure by cortical neurons in culture
Miyata, S., Nishimura, Y., Hayashi, N., & Oohira, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.031 · Cited by 75 · see citing works
Bidmon, H.-J., Jancsik, V, Schleicher, A., Hagemann, G., Witte, O. W., Woodhams, P., & Zilles, K. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00289-3 · Cited by 74 · see citing works
Morikawa, S., Ikegaya, Y., Narita, M., & Tamura, H. (2017) · Scientific Reports · doi:10.1038/srep46024 · Cited by 74 · see citing works
Reduced extracellular space in the brain of tenascin‐R‐ and HNK‐1‐sulphotransferase deficient mice
Syková, E., Voříšek, I., Mazel, T., Antonova, T., & Schachner, M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04375.x · Cited by 73 · see citing works
Distler, C., Mustari, M. J., & Hoffmann, K. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10127 · Cited by 71 · see citing works
Harris, N. G., Mironova, Y. A., Hovda, D. A., & Sutton, R. L. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5bee · Cited by 70 · see citing works
Härtig, W., Singer, A., Grosche, J., Brauer, K., Ottersen, O. P., & Brückner, G. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02211-9 · Cited by 62 · see citing works
Self-citationIn vivo and in vitro labelling of perineuronal nets in rat brain
Brückner, G., Bringmann, A., Köppe, G., Härtig, W., & Brauer, K. (1996) · Brain Research · doi:10.1016/0006-8993(96)00152-7 · Cited by 62 · see citing works
Self-citationBlosa, M., Sonntag, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., Rübsamen, R., Arendt, T., & Morawski, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.003 · Cited by 59 · see citing works
Self-citationKing, A. E., Chung, R. S., Vickers, J. C., & Dickson, T. C. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21053 · Cited by 58 · see citing works
Slaker, M. L., Barnes, J., Sorg, B. A., & Grimm, J. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168256 · Cited by 57 · see citing works
Nakamura, M., Nakano, K., Morita, S., Nakashima, T., Oohira, A., & Miyata, S. (2009) · Brain Research · doi:10.1016/j.brainres.2008.11.022 · Cited by 54 · see citing works
Haunsø, A., Celio, M. R., Margolis, R. K., & Menoud, P.-A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01596-6 · Cited by 52 · see citing works
Kritzer, M. F., & Kohama, S. G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990705)409:3 · Cited by 125 · see citing works
Directional Asymmetry of Neurons in Cortical Areas MT and MST Projecting to the NOT-DTN in Macaques
Hoffmann, K.-P., Bremmer, F., Thiele, A., & Distler, C. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00488.2001 · Cited by 52 · see citing works
Gray, E., Thomas, T. L., Betmouni, S., Scolding, N., & Love, S. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318183d003 · Cited by 51 · see citing works
A Decline in Response Variability Improves Neural Signal Detection during Auditory Task Performance
von Trapp, G., Buran, B. N., Sen, K., Semple, M. N., & Sanes, D. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1302-16.2016 · Cited by 51 · see citing works
Arimatsu, Y., Kojima, M., & Ishida, M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00185-7 · Cited by 51 · see citing works
Hilbig, H., Bidmon, H. J., Oppermann, O. T., & Remmerbach, T. W. (2004) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2004.08.002 · Cited by 50 · see citing works
Grosche, J., & Br�ckner, G. (2001) · Experimental Brain Research · doi:10.1007/s002210000617 · Cited by 50 · see citing works
Self-citationPreuss, T. M., & Kaas, J. H. (1996) · Brain Research · doi:10.1016/0006-8993(95)01531-0 · Cited by 49 · see citing works
Perineuronal and perisynaptic extracellular matrix in the human spinal cord
Jäger, C., Lendvai, D., Seeger, G., Brückner, G., Matthews, R. T., Arendt, T., Alpár, A., & Morawski, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.014 · Cited by 48 · see citing works
Self-citationHorn, A. K. E., Brückner, G., Härtig, W., & Messoudi, A. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10495 · Cited by 48 · see citing works
Self-citationHof, P. R., Bogaert, Y. E., Rosenthal, R. E., & Fiskum, G. M. (1996) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(96)00126-3 · Cited by 48 · see citing works
Perineuronal nets in the auditory system
Sonntag, M., Blosa, M., Schmidt, S., Rübsamen, R., & Morawski, M. (2015) · Hearing Research · doi:10.1016/j.heares.2014.12.012 · Cited by 47 · see citing works
Härtig, W. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00179-2 · Cited by 46 · see citing works
Self-citationBidmon, H. J., Wu, J., Gödecke, A., Schleicher, A., Mayer, B., & Zilles, K. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00131-0 · Cited by 46 · see citing works
Karetko-Sysa, M., Skangiel-Kramska, J., & Nowicka, D. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.05.022 · Cited by 45 · see citing works
Hobohm, C., Härtig, W., Brauer, K., & Brückner, G. (1998) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(98)00044-1 · Cited by 41 · see citing works
Self-citationKirkcaldie, M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-369497-3.10004-4 · Cited by 40 · see citing works
Distler, C. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.572 · Cited by 39 · see citing works
Härtig, W., Brückner, G., Brauer, K., Schmidt, C., & Bigl, V. (1995) · Brain Research · doi:10.1016/0006-8993(95)01016-o · Cited by 39 · see citing works
Self-citationYamada, J., Nadanaka, S., Kitagawa, H., Takeuchi, K., & Jinno, S. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0632-18.2018 · Cited by 38 · see citing works
Nguyen, A., Khaleel, H. M., & Razak, K. A. (2017) · Hearing Research · doi:10.1016/j.heares.2017.04.015 · Cited by 36 · see citing works
Derouiche, A., Härtig, W., Brauer, K., & Brückner, G. (1996) · PubMed · Cited by 35 · see citing works
Self-citationPantazopoulos, H., Murray, E. A., & Berretta, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.036 · Cited by 34 · see citing works
Regional analysis of neurofilament protein immunoreactivity in the hamster's cortex
Boire, D., Desgent, S., Matteau, I., & Ptito, M. (2005) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2005.01.003 · Cited by 34 · see citing works
Brückner, G., Kacza, J., & Grosche, J. (2004) · Journal of Molecular Histology · doi:10.1023/b:hijo.0000023374.22298.50 · Cited by 33 · see citing works
Self-citationSu, J., Cole, J., & Fox, M. A. (2017) · ASN NEURO · doi:10.1177/1759091416689020 · Cited by 33 · see citing works
Wegrzyn, D., Freund, N., Faissner, A., & Juckel, G. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.637549 · Cited by 33 · see citing works
Morita, S., Oohira, A., & Miyata, S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.041 · Cited by 31 · see citing works
Hilbig, H., Bidmon, H. J., Blohm, U., & Zilles, K. (2001) · Anatomy and Embryology · doi:10.1007/s004290000135 · Cited by 31 · see citing works
Oermann, E., Bidmon, H. J., Mayer, B., & Zilles, K. (1999) · Anatomy and Embryology · doi:10.1007/s004290050256 · Cited by 31 · see citing works
Cyto-, myelo- and chemoarchitecture of the prefrontal cortex of the Cebus monkey
Cruz-Rizzolo, R. J., Lima, M. A. D., Ervolino, E., de Oliveira, J. A., & Casatti, C. A. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-6 · Cited by 30 · see citing works
Perirolandic Cortex of the Normal Brain: Low Signal Intensity on Turbo FLAIR MR Images
Karaarslan, E., & Arslan, A. (2003) · Radiology · doi:10.1148/radiol.2272020311 · Cited by 29 · see citing works
Hilbig, H., Bidmon, H. J., Steingrüber, S., Reinke, H., & Dinse, H. R. (2002) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00159-4 · Cited by 29 · see citing works
Brückner, G., Härtig, W., Seeger, J., Rübsamen, R., Reimer, K., & Brauer, K. (1998) · Anatomy and Embryology · doi:10.1007/s004290050135 · Cited by 29 · see citing works
Self-citationTranscriptional maturation of the mouse auditory forebrain
Hackett, T. A., Guo, Y. P., Clause, A. R., Hackett, N., Garbett, K. A., Zhang, P., Polley, D. B., & Mirnics, K. (2015) · BMC Genomics · doi:10.1186/s12864-015-1709-8 · Cited by 28 · see citing works
Broicher, T., Bidmon, H. J., Kamuf, B., Coulon, P., Gorji, A., Pape, H., Speckmann, E. ‐., & Budde, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.025 · Cited by 28 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., Künzle, H., & Arendt, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.018 · Cited by 28 · see citing works
Self-citationFader, S., Imaizumi, K., Yanagawa, Y., & Lee, C. C. (2016) · Brain Sciences · doi:10.3390/brainsci6020013 · Cited by 25 · see citing works
Cant, N. B., & Benson, C. G. (2006) · Hearing Research · doi:10.1016/j.heares.2006.01.008 · Cited by 24 · see citing works
A PET study on cortical and subcortical control of pelvic floor musculature in women
Blok, B. F. M., Sturms, L. M., & Holstege, G. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19971222)389:3 · Cited by 146 · see citing works
Riečanský, I., Thiele, A., Distler, C., & Hoffmann, K. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-0058-2 · Cited by 23 · see citing works
Neuronal cell death in the mammalian nervous system: the calmortin hypothesis
Bennett, M. R., & Huxlin, K. R. (1996) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)02069-1 · Cited by 23 · see citing works
Vidal, E., Bolea, R., Tortosa, R., Costa, C., Domènech, A., Monleón, E., Vargas, A., Badiola, J. J., & Pumarola, M. B. (2006) · Journal of Virological Methods · doi:10.1016/j.jviromet.2006.05.008 · Cited by 22 · see citing works
Preuss, T. M., Gray, D., & Cusick, C. G. (1998) · Somatosensory & Motor Research · doi:10.1080/08990229870772 · Cited by 22 · see citing works
Lee, H., Leamey, C. A., & Sawatari, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003020 · Cited by 21 · see citing works
Watakabe, A., Fujita, H., Hayashi, M., & Yamamori, T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00177.x · Cited by 21 · see citing works
Neuronal and glial structures of the superficial layers of the human superior colliculus
Hilbig, H., Bidmon, H. J., Zilles, K., & Busecke, K. (1999) · Anatomy and Embryology · doi:10.1007/s004290050264 · Cited by 20 · see citing works
- Authors
- Brückner, G., Seeger, G., Brauer, K., Härtig, W., Kacza, J., & Bigl, V.
- Affiliations
- Leipzig University (DE)
- Corresponding author
- Brückner, Gert
- ORCID
- Härtig, Wolfgang
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 658
- Issue
- 1-2
- Pages
- 67-86
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2002867031
- Cited by
- 132
- References
- 86
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 3
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cortical regions, proteoglycans, parvalbumin, chondroitin sulfate proteoglycans, perineuronal nets, Wisteria floribunda agglutinin, extracellular matrix, neocortex, hippocampus, somatosensory cortex, auditory cortex, visual cortex, retrosplenial cortex, piriform cortex, Mongolian gerbil, rats
- MeSH terms
- Animals, Cerebral Cortex, Gerbillinae, Immunoenzyme Techniques, Parvalbumins, Chondroitin Sulfate Proteoglycans, Species Specificity, Signal Transduction, Rats, Wistar, Receptors, N-Acetylglucosamine, Lectins, Plant Lectins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review