Development of cholinergic innervation in the hippocampal formation of the rat

Matthews, Dee Ann; Nadler, J.Victor; Lynch, Gary S.; Cotman, Carl W.

doi:10.1016/0012-1606(74)90196-1

Cited by 201Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Development of cholinergic innervation in the hippocampal formation of the rat

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Matthews, Dee Ann, Nadler, J.Victor, Lynch, Gary S., Cotman, Carl W.·1974·Developmental Biology

DOI 10.1016/0012-1606(74)90196-1

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Around birth, the numerous cholinergic projections arising from the basal forebrain nuclei innervate the primary cortical regions where they influence cortical ultrastructure.
“Around birth, the numerous cholinergic projections arising from the basal forebrain nuclei innervate the primary cortical regions where they influence cortical ultrastructure [210–213].”
From Development of prefrontal cortex (2022) · cites this paper as [212]
The Introduction identifies a cholinergic pathway from the septum to the rat hippocampus, and the Histochemical section reports that its detectable innervation develops largely after birth. The paper studies the hippocampal formation, not primary cortical regions, and does not show that these projections influence cortical ultrastructure. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Authors: Matthews, D. A., Nadler, J. V., Lynch, G. S., & Cotman, C. W.
Affiliations: University of California, Irvine (US)
ORCID: Lynch, Gary S.
Cotman, Carl W.
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 1974-01
Volume: 36
Issue: 1
Pages: 130-141
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/0012-1606(74)90196-1
OpenAlex: W1569690226
Cited by: 201
References: 56
Citations by year: 2025: 3 · 2024: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1
FWCI: 2.57
Type: journal article
Language: en
Open access: green
www.escholarship.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Science Foundation
National Institutes of Health
National Institute of Mental Health (MH 19691)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: cholinergic innervation, hippocampal formation, acetylcholinesterase activity, postnatal development, fimbria, dentate gyrus, stratum oriens, rat brain development
MeSH terms: Acetylcholinesterase, Animals, Hippocampus, Histocytochemistry, Parasympathetic Nervous System, Rats

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