Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons
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Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not only from GABAergic interneurons, but also from multiple glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cells. Consistently, patch-clamp recordings from retrovirally labeled new granule cells at 7-8 days post retroviral injection (dpi) show that these cells respond to NMDA application with tonic currents, and that both electrical and optogenetic stimulation can evoke NMDA-mediated synaptic responses. Furthermore, new dentate granule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel running. Overall, glutamatergic and GABAergic innervation of newly born neurons in the adult hippocampus develops concurrently, and excitatory input is reorganized by exercise.
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Running increases the ratio of inhibitory interneuron versus excitatory mossy cell innervation onto new granule neurons and enhances the number of new axon fibers projecting to the CA3 and CA2 subregions.
“Using viral-based methods, running has been found to increase the ratio of inhibitory interneuron versus excitatory mossy cell innervation onto new granule neurons (Sah et al., 2017; Vivar et al., 2016) as well as to enhance the number of new axon fibers projecting to the CA3 and CA2 subregions (Llorens-Martín et al., 2015).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Sah et al., 2017
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- Authors
- Sah, N., Peterson, B. D., Lubejko, S. T., Vivar, C., & van Praag, H.
- Affiliations
- National Institutes of Health (US)
- Instituto Politécnico Nacional (MX)
- Corresponding author
- Vivar, Carmen
- Venue
- Scientific Reports
- Published
- 2017-09-07
- Volume
- 7
- Issue
- 1
- Pages
- 10903-10903
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5589841
- OpenAlex
- W2753463578
- Cited by
- 63
- References
- 74
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Consejo Nacional de Ciencia y Tecnología (INFR-2016 268247, INFR-2016)
- National Institute on Aging
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult hippocampal neurogenesis, voluntary wheel running, glutamatergic innervation, GABAergic interneurons, mossy cells, NMDA receptor currents, excitatory synaptic input, dentate gyrus
- MeSH terms
- Action Potentials, Adult, Animals, Hippocampus, Humans, Mice, Inbred C57BL, Nerve Net, Neurons, Running, Patch-Clamp Techniques, Neurogenesis
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