The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats
Abstract
The effect of an intracerebroventricular (i.c.v.) injection of the oxytocin antagonist, d(CH2)5Tyr(Me)-Orn8-vasotocin, on the copulatory behaviour of vigorous male rats in the presence of females in estrus was studied. The peptide (2.5, 25 and 50 ng, 15 min before mating tests) decreased the number of mounts and intromissions, and abolished ejaculation almost completely at all doses tested. The peptide failed to significantly influence motor activity at the doses used. The results support the hypothesis that central oxytocin plays a physiological role in the expression of copulatory behaviour.
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In rats, central administration of OTA reduces intromission frequency in males.
“In rats, central administration of OTA reduces intromission frequency in males (Argiolas et al., 1988).”
From Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles (2016) · cites this paper as Argiolas et al., 1988
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- Authors
- Argiolas, A., Collu, M., Gessa, G. L., Melis, M. R., & Serra, G.
- Affiliations
- University of Cagliari (IT)
- Corresponding author
- Argiolas, Antonio
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 149
- Issue
- 3
- Pages
- 389-392
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2010624346
- Cited by
- 125
- References
- 10
- Citations by year
- 2021: 1 · 2020: 4 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 2
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin antagonist, arginine vasotocin, ejaculation, intromission, mounting behavior, intracerebroventricular administration, mating behavior, rats
- MeSH terms
- Animals, Copulation, Depression, Chemical, Male, Motor Activity, Oxytocin, Rats, Inbred Strains, Sexual Behavior, Animal, Rats
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