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Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention

Quartermain, David, Mower, Jay, Rafferty, Michael F., Herting, Robert L., Lanthorn, Thomas H.·1994·European Journal of Pharmacology

DOI 10.1016/0014-2999(94)90687-4

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Abstract

The memory-enhancing potential of D-cycloserine (cycloserine) a partial agonist at the glycine recognition site on the NMDA receptor, was evaluated in mice using a thirst-motivated linear maze learning task. Immediate acute post-training injections (10, 20 and 80 mg/kg) significantly improved retention relative to vehicle-injected controls. Retention was also facilitated if cycloserine (3 and 10 mg/kg but not 20 or 40 mg/kg) was administered 20 min before the retention test. Acquisition of the habit was accelerated if cycloserine (3 mg/kg) was injected 20 min before the training session. Acute post-training injections failed to facilitate retention if mice were pretreated with cycloserine (3 mg/kg) b.i.d. for 15 days before training on the maze. These results indicate that acute cycloserine administration can enhance consolidation and retrieval of memory but that desensitization may occur with chronic exposure to the drug.

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Authors: Quartermain, D., Mower, J., Rafferty, M. F., Herting, R. L., & Lanthorn, T. H.
Affiliations: NYU Langone Health (US)
Corresponding author: Quartermain, David
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 1994-05
Volume: 257
Issue: 1-2
Pages: 7-12
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/0014-2999(94)90687-4
OpenAlex: W1989766588
Cited by: 190
References: 26
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 12 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 10
FWCI: 3.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: D-cycloserine, NMDA receptor, glycine receptor, partial agonists, memory enhancement, learning and retention, memory consolidation, memory retrieval, desensitization, chronic drug exposure, acute drug administration
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Cycloserine, Drug Administration Schedule, Learning, Male, Memory, Receptors, N-Methyl-D-Aspartate, Receptors, Glycine, Mice

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Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention

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