Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

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Thumm, M., Egner, R., Koch, B., Schlumpberger, M., Straub, M., Veenhuis, M., Wolf, D.H.·1994·FEBS Letters

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Abstract

Protein degradation in the vacuole (lysosome) is an important event in cellular regulation. In yeast, as in mammalian cells, a major route of protein uptake for degradation into the vacuole (lysosome) has been found to be autophagocytosis. The discovery of this process in yeast enables the elucidation of its mechanisms via genetic and molecular biological investigations. Here we report the isolation of yeast mutants defective in autophagocytosis (aut mutants), using a rapid colony screening procedure.

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Authors: Thumm, M., Egner, R., Koch, B., Schlumpberger, M., Straub, M., Veenhuis, M., & Wolf, D. H.
Venue: FEBS Letters
Publisher: Wiley
Published: 1994-08
Volume: 349
Issue: 2
Pages: 275-280
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/0014-5793(94)00672-5
OpenAlex: W2093521208
Cited by: 560
References: 0
FWCI: 5.90
Type: journal article
Language: en
Open access: bronze

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Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

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