The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Regulation of ob gene mRNA levels in cultured adipocytes
Abstract
mRNA levels of the ob gene product, leptin, were investigated by quantitative competitive RT‐PCR in a mouse cell line (3T3‐L1) which can be induced to differentiate into adipocytes. During conversion to fat cells, the level of leptin mRNA increased several‐fold and in parallel to that for typical adipocyte markers like lipoprotein lipase, adipsin and glycerophosphate dehydrogenase. Leptin transcription, however, did not correlate with the size of the adipocytes measured as total triglycerides. On the other hand, mRNA levels for leptin in fully differentiated adipocytes were increased 2–3 fold by insulin. In contrast, free fatty acids exerted a concentration‐dependent inhibition of leptin transcription while the corticosteroid dexamethasone and an elevation of intracellular cAMP displayed only marginal inhibitory effects on leptin mRNA levels.
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Cites
Positional cloning of the mouse obese gene and its human homologue
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Increased obese mRNA expression in omental fat cells from massively obese humans
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Cited by
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Insulin stimulates both leptin secretion and production by rat white adipose tissue
Barr, V. A., Malide, D., Zarnowski, M. J., Taylor, S. I., & Cushman, S. W. (1997) · Endocrinology · doi:10.1210/endo.138.10.5451 · Cited by 297
Mantovani, G., Macciò, A., Mura, L., Massa, E., Mudu, M. C., Mulas, C., Lusso, M. R., Madeddu, C., & Dessì, A. (2000) · Journal of Molecular Medicine · doi:10.1007/s001090000137 · Cited by 232
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Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats
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The role of leptin-->STAT3 signaling in neuroendocrine function: an integrative perspective
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Insulin regulates leptin secretion from 3T3–L1 adipocytes by a PI 3 kinase independent mechanism
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No Relationship Between Leptin and Cortisol in Obese Children and Adolescents
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Metadata
- Authors
- Rentsch, J., & Chiesi, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-01-22
- Volume
- 379
- Issue
- 1
- Pages
- 55-59
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2062001615
- Cited by
- 259
- References
- 3
- FWCI
- 26.67
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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