Familial Association in Adults With Functional Gastrointestinal Disorders
Abstract
Objective To evaluate the association between functional gastrointestinal (GI) symptoms and a family history of abdominal pain or bowel problems. Subjects and methods A valid self-report questionnaire that records GI symptoms and spouse's and first-degree relatives' history of abdominal pain or bowel troubles and includes the psychosomatic symptom checklist (a measure of somatization) was mailed to an age- and sex-stratified random sample of Olmsted County, Minnesota, residents aged 30 to 64 years. A logistic regression model that adjusted for age, sex, and somatic symptom score was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of a positive family history for each functional GI disorder. Results Six hundred forty-three (72%) of 892 eligible subjects returned the survey. Reporting a first-degree relative with abdominal pain or bowel problems was significantly associated with reporting of irritable bowel syndrome (OR, 2.3; 95% CI, 1.3-3.9) and dyspepsia (OR, 1.8; 95% CI, 1.05-3.0) but not constipation, diarrhea, or gastroesophageal reflux. The reporting of a spouse with abdominal pain or bowel problems was not associated with any of these disorders. Conclusions A history of abdominal pain or bowel troubles in first-degree relatives was significantly associated with irritable bowel syndrome and dyspepsia. Whether the familial associations represent similar exposures in a shared environment, heightened familial awareness of GI symptoms (reporting bias), o…
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Two population based studies in the United States and the United Kingdom reported 25% and 19% overlap between IBS and GERD, respectively.
“Two other population based studies in the United States and the United Kingdom reported 25% and 19% overlap between IBS and GERD, respectively.17,18”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [17]
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Gathaiya, N. W., Locke, G. R., Camilleri, M., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01320.x · Cited by 51 · see citing works
Self-citationCrowell, M. D., Harris, L. A., Jones, M. P., & Chang, L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0019-8 · Cited by 50 · see citing works
“Older studies supporting a genetic component in IBS come from data demonstrating a clustering of IBS in families [ 67 ] and twin studies that show a twofold increased frequency of IBS in monozygotic twins compared with dizygotic twins [68].”
BackgroundGenetic epidemiology of irritable bowel syndrome.
Makker, J., Chilimuri, S., & Bella, J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i40.11353 · Cited by 53 · see citing works
Genetic determination of irritable bowel syndrome.
Hoţoleanu, C., Popp, R., Trifa, A., Nedelcu, L., & Dumitrascu, D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6636 · Cited by 53 · see citing works
Familial Aggregation in Children Affected by Functional Gastrointestinal Disorders
Buonavolontà, R., Coccorullo, P., Turco, R., Boccia, G., Greco, L., & Staiano, A. (2010) · Journal of Pediatric Gastroenterology and Nutrition - JPGN · doi:10.1097/mpg.0b013e3181b182ef · Cited by 52 · see citing works
“Heredity has been suggested as an explanation of the finding that IBS tends to run in families (3,6).”
BackgroundHomozygous 825T Allele of the GNB3 Protein Influences the Susceptibility of Japanese to Dyspepsia
Tahara, T., Arisawa, T., Shibata, T., Wang, F.-Y., Nakamura, M., Sakata, M., Hirata, I., & Nakano, H. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9923-0 · Cited by 52 · see citing works
Mimidis, K., & Tack, J. F. (2008) · Digestive Diseases · doi:10.1159/000121346 · Cited by 49 · see citing works
“No correlation was found between the symptom pattern and the presence of findings on electrogastrography. A good correlation between the presence of delayed gastric emptying and abnormalities of gastric electrical rhythm has been reported, so it is conceivable that this abnormality identifies similar patients as the m…”
BackgroundInfluentialFoxx–Orenstein, A. E. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16633050 · Cited by 45 · see citing works
An update on irritable bowel syndrome: from diagnosis to emerging therapies
CHANG, J. Y., & Talley, N. J. (2010) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283414065 · Cited by 40 · see citing works
Self-citationPsychosocial factors at work and in every day life are associated with irritable bowel syndrome
Faresjö, Å., Grodzinsky, E., Johansson, S., Wallander, M.-A. A., Timpka, T., & Åkerlind, I. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9133-2 · Cited by 44 · see citing works
“Several studies have shown that patients who report a family member with abdominal pain or bowel problems have an increased risk of reporting IBS-like symptoms themselves [20–23].”
BackgroundMudipalli, R. S., Remes-Troche, J. M., Andersen, L., & Rao, S. S. C. (2007) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000225521.36160.1b · Cited by 48 · see citing works
Adam, B., Liebregts, T., & Holtmann, G. (2007) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0717 · Cited by 44 · see citing works
Eusebi, L., Ratnakumaran, R., Bazzoli, F., & Ford, A. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.07.041 · Cited by 44 · see citing works
Genetics and Genotypes in Irritable Bowel Syndrome: Implications for Diagnosis and Treatment
Park, M. I., & Camilleri, M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.009 · Cited by 46 · see citing works
“Locke et al [2] performed a cross-sectional study and observed that patients who reported a family member with abdominal pain or bowel problems had a twofold increased risk of reporting symptoms of IBS.”
BackgroundThe genetics of irritable bowel syndrome.
Saito, Y., Petersen, G., Locke, G., & Talley, N. J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00184-9 · Cited by 42 · see citing works
Self-citationLacy, B. E., & Lee, R. D. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000156110.69232.bb · Cited by 38 · see citing works
Irritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment
El‐Salhy, M., Hatlebakk, J. G., Gilja, O. H., & Hausken, T. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.888952 · Cited by 39 · see citing works
Irritable Bowel Syndrome: A Co-Twin Control Analysis
Wojczynski, M. K., North, K. E., Pedersen, N. L., & Sullivan, P. F. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01479.x · Cited by 42 · see citing works
“IBS is a complex trait with a demonstrated familial tendency (genetic or environmental), documented through family”
BackgroundFunctional gastrointestinal disorders: past and present
Ammoury, R., Pfefferkorn, M. D., & Croffie, J. M. B. (2009) · World Journal of Pediatrics · doi:10.1007/s12519-009-0021-6 · Cited by 29 · see citing works
Functional Abdominal Pain: Time to Get Together and Move Forward
Nurko, S., & Lorenzo, C. D. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31818936d1 · Cited by 38 · see citing works
Gastric Activity and Gut Peptides in Patients With Functional Dyspepsia
Russo, F., Chimienti, G., Clemente, C., Riezzo, G., D’Attoma, B., & Martulli, M. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000531 · Cited by 17 · see citing works
- Authors
- Locke, G. R., Zinsmeister, A. R., Talley, N. J., Fett, S. L., & Melton, L. J.
- Affiliations
- Mayo Clinic (US)
- The University of Sydney (AU)
- Corresponding author
- Locke, G. Richard
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 75
- Issue
- 9
- Pages
- 907-912
- ISSN
- 0025-6196 (ISSN-L)
- OpenAlex
- W1999734650
- Cited by
- 258
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 10 · 2015: 19 · 2014: 12 · 2013: 8 · 2012: 16
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 09440)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- functional gastrointestinal disorders, familial association, irritable bowel syndrome, dyspepsia, abdominal pain, bowel problems, family history (medicine), first-degree relatives, somatization, psychosomatic symptoms, genetic susceptibility, shared environment, reporting bias
- MeSH terms
- Adult, Colonic Diseases, Functional, Dyspepsia, Female, Humans, Male, Medical Record Linkage, Middle Aged, Minnesota, Pedigree, Population Surveillance, Surveys and Questionnaires, Risk Factors, Sampling Studies, Bias, Logistic Models, Odds Ratio, Databases, Factual
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