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A general method applicable to the search for similarities in the amino acid sequence of two proteins
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Metadata
- Authors
- Needleman, S. B., & Wunsch, C. D.
- Affiliations
- Northwestern University (US)
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1970-03
- Volume
- 48
- Issue
- 3
- Pages
- 443-453
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2074231493
- Cited by
- 11,288
- References
- 11
- Citations by year
- 2026: 212 · 2025: 270 · 2024: 379 · 2023: 369 · 2022: 358 · 2021: 420 · 2020: 415 · 2019: 356 · 2018: 403 · 2017: 359 · 2016: 380 · 2015: 383 · 2014: 436 · 2013: 441 · 2012: 423
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fractal and DNA sequence analysis
- Physical Sciences › Mathematics › Theoretical Computer Science › Algorithms and Data Compression
- Keywords
- protein sequence comparison, amino acid sequence similarity, protein homology, protein evolution, dynamic programming, two-dimensional arrays, computational algorithms
- MeSH terms
- Amino Acid Sequence, Computers, Hemoglobins, Methods, Muramidase, Myoglobin, Probability, Ribonucleases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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