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A general method applicable to the search for similarities in the amino acid sequence of two proteins

Needleman, Saul B., Wunsch, Christian D.·1970·Journal of Molecular Biology

DOI 10.1016/0022-2836(70)90057-4

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“The following templates were used: OF MCT1 with FucB (PDB 3O7Pa and 3O7Qa, 18% sequence identity calculated using Needleman Wunsch Needleman and Wunsch, 1970 ; Madeira et al., 2019 ); OF LAT1 with AdiC (3OB6a and 5J4Ib, 22%); IF LAT1 with b(0,+)AT1 (6LI9, 45%), KCC3 (6Y5Ra, 12%), GkApcT (6F34a,…”
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Authors: Needleman, S. B., & Wunsch, C. D.
Affiliations: Northwestern University (US)
Venue: Journal of Molecular Biology
Publisher: Elsevier BV
Published: 1970-03
Volume: 48
Issue: 3
Pages: 443-453
ISSN: 0022-2836 (ISSN-L)
DOI: 10.1016/0022-2836(70)90057-4
OpenAlex: W2074231493
Cited by: 11,288
References: 11
Citations by year: 2026: 212 · 2025: 270 · 2024: 379 · 2023: 369 · 2022: 358 · 2021: 420 · 2020: 415 · 2019: 356 · 2018: 403 · 2017: 359 · 2016: 380 · 2015: 383 · 2014: 436 · 2013: 441 · 2012: 423
FWCI: 4.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fractal and DNA sequence analysis
Physical Sciences › Mathematics › Theoretical Computer Science › Algorithms and Data Compression
Keywords: protein sequence comparison, amino acid sequence similarity, protein homology, protein evolution, dynamic programming, two-dimensional arrays, computational algorithms
MeSH terms: Amino Acid Sequence, Computers, Hemoglobins, Methods, Muramidase, Myoglobin, Probability, Ribonucleases

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A general method applicable to the search for similarities in the amino acid sequence of two proteins

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