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Cited by 221Neuroendocrine regulation and behaviorHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Release of oxytocin within the supraoptic nucleus during the milk ejection reflex in rats

Moos, F., Poulain, D. A., Rodriguez, F., Guern�, Y., Vincent, J. -D., Richard, Ph.·1989·Experimental Brain Research
DOI 10.1007/bf00248916
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Abstract

To investigate the hypothesis that oxytocin may be released within the magnocellular nuclei in vivo, push-pull cannula perfusions were performed in anaesthetized lactating rats in one supraoptic nucleus of the hypothalamus while recording the intramammary pressure and/or the electrical activity of oxytocin cells in the contralateral supraoptic nucleus. Oxytocin content was measured in samples collected over 15 min, under various conditions: 1) with no stimulation; 2) during suckling and suckling-induced reflex milk ejections; 3) during electrical stimulation of the neuro-hypophysis by trains of pulses that mimicked oxytocin cell bursts; 4) under osmotic stimulation by i.p. injection of 2 ml of 1.5 M NaCl to evoke a tonic and sustained oxytocin release from the neurohypophysis. Oxytocin release within the supraoptic nucleus increased significantly during the milk ejection reflex and, to a lesser extent, during burst-like electrical stimulation of the neurohypophysis. In suckled rats, the increase started before the first reflex milk ejection occurred. There was no apparent correlation between the amount of oxytocin in the perfusates and the number of milk ejections and oxytocin cell bursts occurring during each perfusion period. The amount of oxytocin in the perfusates further increased-during facilitation of the milk ejection reflex by intraventricular injections of oxytocin or its analogue, isotocin. When suckling failed to evoke the milk ejection reflex, there was no change in intra-supraoptic oxytocin release. There was also no change after osmotic stimulation. When the push-pull cannula was positioned outside the supraoptic nucleus, there was no increase in the amount of oxytocin during the three types of stimulation tested. These results provide evidence for an endogenous release of oxytocin within the magnocellular nuclei in lactating rats. It is suggested that the increase in such a release induced by suckling is likely to be a prerequisite for the onset and the maintenance of the characteristic intermittent bursting electrical activity of oxytocin cells leading to milk ejections.

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Crossref · 10.1007/bf00248916

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  • In lactating rats, hypothalamic oxytocin release in response to suckling precedes peripheral secretion, but in guinea pigs simultaneous measurements showed a large plasma increase during suckling with no change in CSF, leading the authors to conclude that CSF oxytocin reflects secretion from centrally projecting neurons that are functionally independent of magnocellular neurosecretory neurons.

    “In lactating rats, oxytocin is released in the hypothalamus in response to suckling before any peripheral secretion (84), but in guinea pigs, simultaneous measurements revealed a large increase in plasma during suckling but no change in CSF (85), leading the authors to conclude that CSF levels reflect secretion from centrally projecting neurons that are functionally independent of the magno”

    From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [84]

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Authors
Moos, F., Poulain, D. A., Rodriguez, F., Guern�, Y., Vincent, J. D., & Richard, P.
Affiliations
  • Université de Strasbourg (FR)
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
Venue
Experimental Brain Research
Publisher
Springer Science and Business Media LLC
Published
1989
Volume
76
Issue
3
Pages
593-602
ISSN
  • 0014-4819 (ISSN-L)
  • 1432-1106
DOI
10.1007/bf00248916
OpenAlex
W2045157991
Cited by
221
References
30
Citations by year
2026: 6 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 15 · 2013: 6 · 2012: 3
FWCI
8.14
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Experimental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin release, supraoptic nucleus, milk ejection reflex, magnocellular neurons, lactation, suckling, neurohypophysis, osmotic stimulation, isotocin, intramammary pressure, hypothalamus
MeSH terms
Animals, Animals, Suckling, Electric Stimulation, Electrophysiology, Female, Lactation, Osmolar Concentration, Oxytocin, Pregnancy, Rats, Inbred Strains, Reflex, Saline Solution, Hypertonic, Supraoptic Nucleus, Rats

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