Oxytocin and neurophysin in plasma and CSF during suckling in the guinea-pig
Abstract
Cerebrospinal fluid (CSF) obtained from the cisterna magna of conscious unrestrained guinea-pigs was assayed for oxytocin (OT), vasopressin (AVP) and neurophysin (NP). Basal levels of OT and AVP were approximately 5 and 15 fmol/ml, respectively, whereas NP levels were considerably higher (around 1 pmol/ml); there was no significant differences between males, females and lactating females. In lactating females, simultaneous samples of blood and CSF were obtained during suckling episodes. Despite large increases in plasma OT and NP at milk ejection, CSF levels remained unchanged throughout. Intracerebroventricular injection of 100 fmol OT produced an 8-fold rise in the concentration of this peptide in cisternal fluid within 10 min. Since CSF levels of OT and NP do not change when these peptides are released from the pituitary, we conclude that the presence of these peptides in CSF reflects activity of extrapituitary terminals and that these terminals are not activated during suckling.
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In lactating rats, hypothalamic oxytocin release in response to suckling precedes peripheral secretion, but in guinea pigs simultaneous measurements showed a large plasma increase during suckling with no change in CSF, leading the authors to conclude that CSF oxytocin reflects secretion from centrally projecting neurons that are functionally independent of magnocellular neurosecretory neurons.
“In lactating rats, oxytocin is released in the hypothalamus in response to suckling before any peripheral secretion (84), but in guinea pigs, simultaneous measurements revealed a large increase in plasma during suckling but no change in CSF (85), leading the authors to conclude that CSF levels reflect secretion from centrally projecting neurons that are functionally independent of the magno”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [85]
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- Authors
- Robinson, I. C. A. F., & Jones, P. M.
- Corresponding author
- Robinson, I.C.A.F.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-03-26
- Volume
- 34
- Issue
- 1
- Pages
- 59-63
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1995617239
- Cited by
- 69
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, neurophysin, vasopressin, cerebrospinal fluid, plasma, suckling, lactation, milk ejection, guinea pig
- MeSH terms
- Animals, Female, Guinea Pigs, Lactation, Male, Neurophysins, Oxytocin, Pituitary Gland, Posterior, Pregnancy, Vasopressins
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