Competitive antagonism of nitric oxide synthetase causes weight loss in mice
Abstract
These studies demonstrate that the competitive antagonist of nitric oxide synthesis, L-NG-nitro-arginine methyl ester (NO Arg ME), produces an L-arginine reversible decrease in food intake in mice. NO Arg ME also blocked the feeding effect of the potent orexigenic peptide, neuropeptide Y. NO Arg ME produced weight loss when administered over 5 days. The studies suggest that nitric oxide is a physiological modulator of food intake and that nitric oxide synthetase inhibitors may be useful in the management of obesity.
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In rodents, L-arginine increases food intake and NOS inhibitors decrease food intake.
“In rodents, L-arginine was shown to increase, and NOS inhibitors to decrease, food intake [155, 251-254].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [252]
Cites
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Regulation of obesity and insulin resistance by nitric oxide
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- Authors
- Morley, J. E., & Flood, J. F.
- Affiliations
- St. Louis VA Medical Center (US)
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 51
- Issue
- 16
- Pages
- 1285-1289
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W1993966683
- Cited by
- 103
- References
- 9
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2018: 1 · 2015: 2 · 2014: 2 · 2012: 2
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- nitric oxide synthase, nitric oxide, dietary intake, weight loss, neuropeptide Y, L-arginine, obesity, appetite regulation
- MeSH terms
- Amino Acid Oxidoreductases, Analysis of Variance, Animals, Appetite Depressants, Appetite Regulation, Arginine, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Mice, Inbred Strains, Neuropeptide Y, Weight Loss, Nitric Oxide Synthase, NG-Nitroarginine Methyl Ester, Mice
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