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Cited by 61Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorPharmacology and Obesity Treatment

Central serotoninergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase

Squadrito, Francesco, Calapai, Gioacchino, Altavilla, Domenica, Cucinotta, Domenico, Zingarelli, Basilia, Arcoraci, Vincenzo, Campo, Giuseppe M., Caputi, Achille P.·1994·European Journal of Pharmacology
DOI 10.1016/0014-2999(94)90081-7
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Abstract

The effects of NG-nitro-L-arginine, an inhibitor of brain nitric oxide (NO) synthase, on central serotoninergic system were studied in male obese Zucker rats and in their lean age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute injection of NG-nitro-L-arginine (50 mg/kg i.p.) or repeated administration of NG-nitro-L-arginine (50 mg/kg i.p. daily, for 7 days) reduced food intake and body weight in obese rats. Acute administration of NG-nitro-L-arginine reduced food intake in lean rats. However, lean rats showed tolerance to the NG-nitro-L-arginine effects after repeated administration. NG-Nitro-L-arginine administration significantly increased serotonin metabolism in the cortex, diencephalon and medulla-pons of obese Zucker rats after either acute or repeated administration of NG-nitro-L-arginine. In contrast, NG-nitro-L-arginine increased serotonin metabolism in lean rats only after acute administration, and the appearance of tolerance to NG-nitro-L-arginine anorectic effects paralleled the failure of NG-nitro-L-arginine to increase serotonin metabolism. The present data extend our previous findings indicating that NG-nitro-L-arginine possesses anorectic activity in obese Zucker rats, and clearly suggest that the central serotoninergic system mediates the anorexia induced by inhibitors of brain NO synthase.

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Crossref · 10.1016/0014-2999(94)90081-7

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  • Systemic administration of NG-nitro-L-arginine reduces food intake in obese rats and increases serotonin metabolism in the cortex, diencephalon, and medulla pons.

    “Systemic administration of the NOS inhibitor, NG-nitro-L-arginine, reduced food intake in obese rats and increased serotonin metabolism in the cortex, diencephalon, and medulla pons, thereby implicating the central serotoninergic system in mediating the anorexic effect of NOS inhibitors [257].”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [257]

  • The central serotoninergic system mediates the anorexic effect of NOS inhibitors.

    “thereby implicating the central serotoninergic system in mediating the anorexic effect of NOS inhibitors [257]”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [257]

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Authors
Squadrito, F., Calapai, G., Altavilla, D., Cucinotta, D., Zingarelli, B., Arcoraci, V., Campo, G. M., & Caputi, A. P.
Affiliations
University of Messina (IT)
Corresponding author
Squadrito, Francesco
ORCID
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1994-04
Volume
255
Issue
1-3
Pages
51-55
ISSN
0014-2999 (ISSN-L)
DOI
10.1016/0014-2999(94)90081-7
OpenAlex
W2032336012
Cited by
61
References
25
Citations by year
2021: 1 · 2019: 1 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
2.38
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
L-NNA, nitric oxide synthase inhibition, serotonin, anorexia, dietary intake, obesity, Zucker rats, serotonin metabolism, tolerance (pharmacology and immunology)
MeSH terms
Amino Acid Oxidoreductases, Animals, Appetite Depressants, Arginine, Body Weight, Brain, Eating, Hydroxyindoleacetic Acid, Male, Obesity, Rats, Zucker, Serotonin, Tryptophan, Nitric Oxide Synthase, Nitroarginine, Rats

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