A nitric oxide synthase inhibitor, NG-nitro-l-arginine methyl ester, attenuates lipoprivic feeding in mice

Czech, Donald A.; Kazel, Melanie R.; Harris, John

doi:10.1016/s0031-9384(03)00220-8

Cited by 16Regulation of Appetite and ObesityNitric Oxide and Endothelin EffectsNeurotransmitter Receptor Influence on Behavior

A nitric oxide synthase inhibitor, NG-nitro-l-arginine methyl ester, attenuates lipoprivic feeding in mice

Czech, Donald A., Kazel, Melanie R., Harris, John·2003·Physiology & Behavior

DOI 10.1016/s0031-9384(03)00220-8

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Abstract

Possible involvement of nitric oxide (NO) in lipoprivic feeding was investigated in nondeprived male ICR mice adapted to a high-fat diet in a within-subjects design. Lipoprivation was induced by blocking fatty acid oxidation with Na-mercaptoacetate (MA), which produces a short-term increase in feeding in mice and rats. Food intake, measured at 1, 2, and 4 h following injection of 70 mg/kg of MA, was attenuated in a dose related manner with increasing pretreatment dose (1,10, 25 and 50 mg/kg sc) of the NO-synthase (NOS) inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), reaching statistical significance at 10 mg/kg of L-NAME at h1 when compared to vehicle control condition. The inactive isomer, D-NAME, was ineffective, thereby supporting stereospecific drug action and directly implicating NO. A control experiment measured general locomotor activity (grid crossings and rears) in an open arena under 10-50 mg/kg of L-NAME in the same mice; both measures were significantly different from vehicle condition only at the highest dose. These findings support involvement of NO in lipoprivic hyperphagia; they are consistent with and extend research linking NO and ingestive behaviors through use of NOS inhibitors. Possible influences of confounds were discussed.

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A Nitric Oxide Synthase Inhibitor NG-Nitro-?-Arginine, Attenuates Glucoprivic Feeding and Deprivation-Induced Drinking in the Mouse
Czech, D. A. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00016-1 · Cited by 17 · see citing works
Nitric oxide mediates hyperphagia of obese zucker rats: Relation to specific changes in the microstructure of feeding behavior
Stricker‐Krongrad, A., Beck, B., & Burlet, C. R. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02260-0 · Cited by 48 · see citing works
Nitric oxide synthase inhibition and food intake: Effects on motivation to eat and in female mice
Morley, J. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00276-o · Cited by 41 · see citing works
Evidence that nitric oxide stimulates feeding in the marsupial Sminthopsis crassicaudata
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Yamada, J., Sugimoto, Y., Yoshikawa, T., & Horisaka, K. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00657-7 · Cited by 16 · see citing works

Authors: Czech, D. A., Kazel, M. R., & Harris, J.
Affiliations: Marquette University (US)
Corresponding author: Czech, Donald A.
Venue: Physiology & Behavior
Publisher: Elsevier BV
Published: 2003-10
Volume: 80
Issue: 1
Pages: 75-79
ISSN: 0031-9384 (ISSN-L)
DOI: 10.1016/s0031-9384(03)00220-8
OpenAlex: W1993597424
Cited by: 16
References: 35
Citations by year: 2026: 1 · 2020: 1 · 2017: 2 · 2015: 1 · 2014: 2 · 2013: 2
FWCI: 0.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Physiology & Behavior (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: nitric oxide, nitric oxide synthase inhibition, L-NAME, D-NAME, fatty acid oxidation, dietary intake, locomotor activity, high-fat diet, ingestive behavior
MeSH terms: Animals, Dietary Fats, Dose-Response Relationship, Drug, Enzyme Inhibitors, Feeding Behavior, Food Deprivation, Lipids, Male, Mice, Inbred ICR, Motor Activity, Nitric Oxide, NG-Nitroarginine Methyl Ester, Mice

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A nitric oxide synthase inhibitor, NG-nitro-l-arginine methyl ester, attenuates lipoprivic feeding in mice

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