Hunger in humans induced by 2-deoxy-D-glucose: glucoprivic control of taste preference and food intake
Abstract
Intracellular glucopenia induced by 2-deoxy-D-glucose (2DG) administration in man produces increased hunger ratings and magnitude estimates of pleasantness for sucrose solutions. Augmented food intake substantiates these changes in affective behavior and relieves experimentally induced hunger. Intracellular glucopenia activates counterregulatory mechanisms to raise plasma glucose concentrations. Inducing hunger experimentally with 2DG provides a useful method for studying appetitive behavior in humans. The neurohumoral control of pituitary hormone release and other hypothalamic functions may be examined after 2DG infusion.
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The combination of these physiologic events may foster food cravings with a special preference for high-GI carbohydrates, thereby propagating cycles of overeating.
“This combination of physiologic events may foster food cravings with a special preference for high-GI carbohydrates (16, 17), thereby propagating cycles of overeating.”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [16]
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- Authors
- Thompson, D. A., & Campbell, R. G.
- Affiliations
- Monroe Community Hospital (US)
- ORCID
- Campbell, Robert G.
- Venue
- Science
- Published
- 1977-12-09
- Volume
- 198
- Issue
- 4321
- Pages
- 1065-1068
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047896991
- Cited by
- 170
- References
- 37
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 2-deoxyglucose, glucopenia, hunger, taste preference, dietary intake, sucrose, counter-regulatory mechanisms, plasma glucose, appetite, hypothalamus, pituitary hormone secretion, neurohumoral regulation
- MeSH terms
- Adult, Blood Glucose, Body Temperature, Deoxy Sugars, Deoxyglucose, Feeding Behavior, Hormones, Humans, Hunger, Male, Satiation, Taste
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