The DOI matches its Crossref record; 55 of the 57 references it cites were found in a registry or an index.
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
Abstract
We have employed a method based on the Cre-loxP recombination system of bacteriophage P1 to generate a mouse strain in which the JH segments and the intron enhancer in the IgH locus are deleted. By analysis of immunoglobulin isotype switch recombination in heterozygous mutant B cells activated by lipopolysaccharide plus interleukin-4, we show that, on the mutant chromosome, switch recombination at the mu gene switch region is strongly suppressed, whereas the switch region of the gamma 1 gene is efficiently rearranged. These data demonstrate an independent control of switch recombination at individual switch regions and suggest that, in the process of switch recombination, the alignment of the recombining strands occurs independently of and probably after the introduction of double-strand breaks into the switch regions involved.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In JHT mice, functional B cells fail to develop due to deletion of the Ig JH locus, while μ MT mice lack B cells as a result of inactivation of the Ig heavy chain of the class M gene [112,113].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [112]
Citations
Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
A short amino acid sequence able to specify nuclear location
Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production
Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927
Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
Self-citationGeneration and Analysis of Interleukin-4 Deficient Mice
Kühn, R., Rajewsky, K., & Müller, W. (1991) · Science · doi:10.1126/science.1948049 · Cited by 1,229
Self-citationSite-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.
Sauer, B., & Henderson, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5166 · Cited by 1,213
Bacteriophage P1 site-specific recombination
Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 813
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.
Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796
Teratocarcinomas and embryonic stem cells: A practical approach
Krumlauf, R. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90286-1 · Cited by 779
Research works printed but not linked: 2
- Schüpple, 1987, Monoclonal anti-allotype antibodies towards Balbc IgM, Eur. J. Immunol., 17, 739
- Stavnezer, 1984, Ig H-chain switching in cultured 129 murine B lymphoma cells, commitment to an IgA or IgE switch, Curr. Topics Microbiol. Immunol., 113, 109
Cited by
Sorted by citations
Items 201–300 of 985
The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo
Moroishi, T., Nishiyama, M., Takeda, Y., Iwaï, K., & Nakayama, K. I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.011 · Cited by 165
Regulation of IL-4 Expression by Activation of Individual Alleles
Rivière, I., Sunshine, M. J., & Littman, D. R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80604-4 · Cited by 164
Reik, A., Telling, A., Zitnik, G., Cimbora, D., Epner, E., & Groudine, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5992 · Cited by 163
Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)
Hérault, Y., Rassoulzadegan, M., Cuzin, F., & Duboule, D. (1998) · Nature Genetics · doi:10.1038/3861 · Cited by 161
Esposito, G., Godin, I., Klein, U., Yaspo, M., Cumano, A., & Rajewsky, K. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00726-0 · Cited by 166
Self-citationCurrent issues in mouse genome engineering
Glaser, S., Anastassiadis, K., & Stewart, A. F. (2005) · Nature Genetics · doi:10.1038/ng1668 · Cited by 160
Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin
Wang, Y., Schnegelsberg, P. N. J., Dausman, J. A., & Jaenisch, R. (1996) · Nature · doi:10.1038/379823a0 · Cited by 159
EMPReSS: standardized phenotype screens for functional annotation of the mouse genome
Brown, S. D. M., Chambon, P., & de Angelis, M. H. (2005) · Nature Genetics · doi:10.1038/ng1105-1155 · Cited by 159
Linking class-switch recombination with somatic hypermutation
Kinoshita, K., & Honjo, T. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35080033 · Cited by 159
Gyurko, R., Leupen, S., & Huang, P. L. (2002) · Endocrinology · doi:10.1210/endo.143.7.8921 · Cited by 157
AID Targeting in Antibody Diversity
Pavri, R., & Nussenzweig, M. C. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387663-8.00005-3 · Cited by 156
Villey, I. J., Caillol, D. H., Selz, F., Ferrier, P., & de Villartay, J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80259-9 · Cited by 156
At the intersection of DNA damage and immune responses
Bednarski, J. J., & Sleckman, B. P. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0135-6 · Cited by 157
Isolated Lymphoid Follicles Can Function as Sites for Induction of Mucosal Immune Responses
Lorenz, R. G., & Newberry, R. D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1309.006 · Cited by 152
In Vivo Analysis of Growth Hormone Receptor Signaling Domains and Their Associated Transcripts
Rowland, J., Lichanska, A. M., Kerr, L. M., White, M. E., d’Aniello, E., Maher, S., Brown, R. J. P., Teasdale, R. D., Noakes, P. G., & Waters, M. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.66-77.2005 · Cited by 152
Deletion of DDB1 in Mouse Brain and Lens Leads to p53-Dependent Elimination of Proliferating Cells
Cang, Y., Zhang, J., Nicholas, S. A., Bastien, J., Li, B., Zhou, P., & Goff, S. P. (2006) · Cell · doi:10.1016/j.cell.2006.09.045 · Cited by 152
To be or not to be active: the stochastic nature of enhancer action
Fiering, S., Whitelaw, E., & Martin, D. I. K. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200004)22:4 · Cited by 161
The lac operator-repressor system is functional in the mousePreprint
Cronin, C. A., Gluba, W., & Scrable, H. J. (2001) · Genes & Development · doi:10.1101/gad.892001 · Cited by 150
Gustafsson, E., Brakebusch, C., Hietanen, K., & Fässler, R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.4.671 · Cited by 149
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice
Nishio, M., Hamada, K., Kawahara, K., Sasaki, M., Noguchi, F., Chiba, S., Mizuno, K., Suzuki, S. O., Dong, Y., Tokuda, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63735 · Cited by 147
Defining a mesenchymal progenitor niche at single-cell resolution
Kumar, M. E., Bogard, P. E., Espinoza, F. H., Menke, D. B., Kingsley, D. M., & Krasnow, M. A. (2014) · Science · doi:10.1126/science.1258810 · Cited by 145
Two Forms of Loops Generate the Chromatin Conformation of the Immunoglobulin Heavy-Chain Gene Locus
Guo, C., Gerasimova, T. I., Hao, H., Иванова, И., Chakraborty, T., Selimyan, R., Oltz, E. M., & Sen, R. (2011) · Cell · doi:10.1016/j.cell.2011.08.049 · Cited by 148
Nelson, R. D., Stricklett, P. K., Gustafson, C., Stevens, A. L., Ausiello, D. A., Brown, D., & Kohan, D. E. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.1.c216 · Cited by 147
Class Switching in B Cells Lacking 3′ Immunoglobulin Heavy Chain Enhancers
Manis, J. P., van der Stoep, N., Tian, M., Ferrini, R., Davidson, L., Bottaro, A., & Alt, F. W. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1421 · Cited by 147
The Flp Recombinase of th 2-μm Plasmid of Saccharomyces cerevisiae
Sadowski, P. D. (1995) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60876-4 · Cited by 146
Cre-mediated site-specific translocation between nonhomologous mouse chromosomes.
van Deursen, J., Fornerod, M. W. J., van Rees, B. P., & Grosveld, G. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7376 · Cited by 146
IgD can largely substitute for loss of IgM function in B cells
Lutz, C., Ledermann, B., Kosco‐Vilbois, M. H., Ochsenbein, A. F., Zinkernagel, R. M., Köhler, G., & Brombacher, F. (1998) · Nature · doi:10.1038/31716 · Cited by 145
Kumar, V. V., Scandella, E., Danuser, R., Onder, L., Nitschké, M., Fukui, Y., Halin, C., Ludewig, B., & Stein, J. V. (2010) · Blood · doi:10.1182/blood-2009-10-250118 · Cited by 148
Regulation of AID, the B-cell genome mutatorPreprint
Keim, C., Kazadi, D., Rothschild, G., & Basu, U. (2013) · Genes & Development · doi:10.1101/gad.200014.112 · Cited by 142
Mehling, A., Loser, K., Varga, G., Metze, D., Luger, T. A., Schwarz, T., Grabbe, S., & Beissert, S. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.615 · Cited by 143
Regulation of Immunoglobulin Class-Switch Recombination
Matthews, A. J., Zheng, S., DiMenna, L. J., & Chaudhuri, J. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800267-4.00001-8 · Cited by 159
Cre‐mediated recombination in the skin melanocyte lineage
Delmas, V., Martinozzi, S., Bourgeois, Y., Holzenberger, M., & Larue, L. (2003) · genesis · doi:10.1002/gene.10197 · Cited by 140
The Roles of γ1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses
Kaisho, T., Schwenk, F., & Rajewsky, K. (1997) · Science · doi:10.1126/science.276.5311.412 · Cited by 140
Self-citationSpitz, F., Gonzãlez, F., Peichel, C. L., Vogt, T., Duboule, D., & Zákány, J. (2001) · Genes & Development · doi:10.1101/gad.205701 · Cited by 138
Srivastava, M., Hsieh, S., Grinberg, A., Williams‐Simons, L., Huang, S.-P., & Pfeifer, K. E. (2000) · Genes & Development · doi:10.1101/gad.14.10.1186 · Cited by 140
Medvedovic, J., Ebert, A., Tagoh, H., Tamir, I., Schwickert, T. A., Novatchkova, M., Sun, Q., Veld, P. J. H. I. ’., Guo, C., Yoon, H. S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.011 · Cited by 136
Pelanda, R., Schaal, S., Torres, R. M., & Rajewsky, K. (1996) · Immunity · doi:10.1016/s1074-7613(00)80318-0 · Cited by 139
Self-citationEarly B‐Cell Development in the Mouse: Insights from Mutations Introduced by Gene Targeting
Löffert, D., Schaal, S., Ehlich, A., Hardy, R. R., Zou, Y.-R., Müller, W., & Rajewsky, K. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00662.x · Cited by 139
Self-citationThe IgH Locus 3′ Regulatory Region
Pinaud, E., Marquet, M., Fiancette, R., Péron, S., Vincent‐Fabert, C., Denizot, Y., & Cogné, M. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387663-8.00002-8 · Cited by 134
Wu, S., Ying, G., Wu, Q., & Capecchi, M. R. (2008) · Nature Protocols · doi:10.1038/nprot.2008.70 · Cited by 133
The Drosophila bendless gene encodes a neural protein related to ubiquitin-conjugating enzymes
Muralidhar, M. G., & Thomas, J. B. (1993) · Neuron · doi:10.1016/0896-6273(93)90182-q · Cited by 138
The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse development
Mascrez, B., Mark, M. P., Dierich, A., Ghyselinck, N. B., Kastner, P., & Chambon, P. (1998) · Development · doi:10.1242/dev.125.23.4691 · Cited by 139
Astrof, S., Crowley, D., & Hynes, R. O. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.07.005 · Cited by 136
Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4
Barrow, J. R., & Capecchi, M. R. (1996) · Development · doi:10.1242/dev.122.12.3817 · Cited by 135
Effect of Transmembrane and Cytoplasmic Domains of IgE on the IgE Response
Achatz, G., Nitschke, L., & Lamers, M. C. (1997) · Science · doi:10.1126/science.276.5311.409 · Cited by 132
Hanakahi, L. A., Dempsey, L. A., Li, M.-J., & Maizels, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3605 · Cited by 132
Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes
Dietrich, P., Dragatsis, I., Xuan, S., Zeitlin, S. O., & Efstratiadis, A. (2000) · Mammalian Genome · doi:10.1007/s003350010037 · Cited by 129
Temporal Cre‐mediated recombination exclusively in endothelial cells using Tie2 regulatory elements
Forde, A., Constien, R., Gröne, H., Hämmerling, G. J., & Arnold, B. (2002) · genesis · doi:10.1002/gene.10117 · Cited by 128
Engineering the mouse genome by site-specific recombination
METZGER, D., & Feil, R. (1999) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(99)00012-9 · Cited by 128
Contreras, C. M., Akbay, E. A., Gallardo, T. D., Haynie, J. M., Sharma, S. V., Tagao, O., Bardeesy, N. M., Takahashi, M., Settleman, J., Wong, K., et al. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004440 · Cited by 125
Araki, K. (2002) · Nucleic Acids Research · doi:10.1093/nar/gnf102 · Cited by 124
Hesser, B. A., Henschel, O., & Witzemann, V. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.020 · Cited by 123
Alexopoulou, L., Kranidioti, K., Xanthoulea, S., Denis, M. C., Kotanidou, A. N., Douni, E. K., Blackshear, P. J., Kontoyiannis, D. L., & Kollias, G. A. (2006) · European Journal of Immunology · doi:10.1002/eji.200635921 · Cited by 123
Andreas, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.11.2299 · Cited by 124
Normal limb development in conditional mutants of Fgf4
Moon, A., Boulet, A. M., & Capecchi, M. R. (2000) · Development · doi:10.1242/dev.127.5.989 · Cited by 123
Location of enhancers is essential for the imprinting of H19 and Igf2 genes
Webber, A. L., Ingram, R. S., Levorse, J. M., & Tilghman, S. M. (1998) · Nature · doi:10.1038/35655 · Cited by 122
Evidence for Distinct CD4 Silencer Functions at Different Stages of Thymocyte Differentiation
Taniuchi, I., Sunshine, M. J., Festenstein, R., & Littman, D. R. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00735-9 · Cited by 121
Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient inHoxb3andHoxb4
Bjürnsson, J. M., Larsson, N., Brun, A. C. M., Magnusson, M., Andersson, E., Lundstrüm, P., Larsson, J., Repetowska, E., Ehinger, M., Humphries, R. K., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.11.3872-3883.2003 · Cited by 120
Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche
Mondor, I., Baratin, M., Lagueyrie, M., Saro, L., Henri, S., Gentek, R., Suerinck, D., Kastenmüller, W., Jiang, J. X., & Bajénoff, M. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.002 · Cited by 125
Oxburgh, L. H., Chu, G. C., Michael, S. K., & Robertson, E. J. (2004) · Development · doi:10.1242/dev.01324 · Cited by 120
Efficient Generation of Recombinant Adenoviral Vectors by Cre-lox Recombination In Vitro
Aoki, K., Barker, C. S., Danthinne, X., Imperiale, M. J., & Nabel, G. J. (1999) · Molecular Medicine · doi:10.1007/bf03402119 · Cited by 120
Chapter 6 Interleukin 5 in the Link Between the Innate and Acquired Immune Response
Takatsu, K., Kouro, T., & Nagai, Y. (2009) · Advances in immunology · doi:10.1016/s0065-2776(08)01006-7 · Cited by 123
Kraus, M., Pao, L. I., Reichlin, A., Hu, Y., Canono, B. P., Cambier, J. C., Nussenzweig, M. C., & Rajewsky, K. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.455 · Cited by 119
Self-citationDavis, D. L., Edwards, A. V., Juraszek, A. L., Phelps, A. L., Wessels, A., & Burch, J. B. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00500-7 · Cited by 119
Therapeutic cloning in individual parkinsonian mice
Tabar, V. S., Tomishima, M. J., Panagiotakos, G., Wakayama, S., Menon, J., Chan, B., Mizutani, E., Al-Shamy, G., Ohta, H., Wakayama, T., et al. (2008) · Nature Medicine · doi:10.1038/nm1732 · Cited by 118
Developmental Changes in Histone macroH2A1-Mediated Gene Regulation
Changolkar, L. N., Costanzi, C., Leu, N. A., Chen, D., McLaughlin, K. J., & Pehrson, J. R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02334-06 · Cited by 118
Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in mice
Cheung, W. C., Kim, J. S., Linden, M. A., Peng, L., Ness, B. G. V., Polakiewicz, R. D., & Janz, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20369 · Cited by 118
Mingueneau, M., Roncagalli, R., Grégoire, C., Kissenpfennig, A., Miążek, A., Archambaud, C., Wang, Y., Perrin, P., Bertosio, E., Sansoni, A., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.013 · Cited by 116
Beta cell MHC class I is a late requirement for diabetes
Hamilton‐Williams, E. E., Palmer, S. E., Charlton, B., & Slattery, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1131954100 · Cited by 116
Modulation of T‐cell function by type I interferon
Tough, D. F. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2012.7 · Cited by 121
Fischer, A., Klattig, J., Kneitz, B., Diez, H., Maier, M., Holtmann, B., Englert, C., & Gessler, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.20.8960-8970.2005 · Cited by 115
zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila
Broihier, H. T., Moore, L. A., Doren, M. V., Newman, S., & Lehmann, R. (1998) · Development · doi:10.1242/dev.125.4.655 · Cited by 115
Stacey, A., Schnieke, A., McWhir, J., Cooper, J. D., Colman, A., & Melton, D. W. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.2.1009 · Cited by 115
Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance
Lesniewski, L. A., Hosch, S. E., Neels, J. G., de Luca, C., Pashmforoush, M., Lumeng, C. N.-K., Chiang, S.-H., Scadeng, M., Saltiel, A. R., & Olefsky, J. M. (2007) · Nature Medicine · doi:10.1038/nm1550 · Cited by 114
Hunker, A. C., Soden, M. E., Krayushkina, D., Heymann, G., Awatramani, R. B., & Zweifel, L. S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.092 · Cited by 124
Insertion of c- Myc into Igh Induces B-Cell and Plasma-Cell Neoplasms in Mice
Park, S. S., Kim, J. S., Tessarollo, L., Owens, J. D., Peng, L., Han, S. S., Chung, S. T., Torrey, T. A., Cheung, W. C., Polakiewicz, R. D., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-0268 · Cited by 112
Reinhardt, R. L., Hong, S., Kang, S., Wang, Z., & Locksley, R. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1618 · Cited by 113
A genetic screen identifies novel non-compatible loxP sites
Langer, S. J. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf421 · Cited by 112
Gene knock-out technology: a methodological overview for the interested novice
Galli-Taliadoros, L. A., Sedgwick, J. D., Wood, S. A., & Körner, H. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00017-5 · Cited by 112
Ellmeier, W., Sunshine, M. J., Losos, K., & Littman, D. R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80632-9 · Cited by 110
Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice
Ludwig, T. E., Fisher, P. E., Murty, V. V., & Efstratiadis, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204512 · Cited by 105
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration
Köhler, T., Reizis, B., Johnson, R. S., Weighardt, H., & Förster, I. (2012) · European Journal of Immunology · doi:10.1002/eji.201142053 · Cited by 108
Creation and Use of a Cre Recombinase Transgenic Database
Nagy, A., Mar, L., & Watts, G. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_19 · Cited by 107
The 3′ IgH regulatory region: A complex structure in a search for a function
Khamlichi, A. A., Pinaud, E., Decourt, C., Chauveau, C., & Cogné, M. (2000) · Advances in immunology · doi:10.1016/s0065-2776(00)75008-5 · Cited by 109
Prelle, K., Zink, N., & Wolf, E. (2002) · Anatomia Histologia Embryologia · doi:10.1046/j.1439-0264.2002.00388.x · Cited by 107
Kanegae, Y., Takamori, K., Sato, Y., Lee, G., Nakai, M., & Saito, I. (1996) · Gene · doi:10.1016/s0378-1119(96)00516-1 · Cited by 107
Genome engineering: the new mouse genetics
Rossant, J., & Nagy, A. (1995) · Nature Medicine · doi:10.1038/nm0695-592 · Cited by 107
Recent advances in gene mutagenesis by site-directed recombination.
Marth, J. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118634 · Cited by 107
Ahmed, B. Y., Chakravarthy, S., Eggers, R., Hermens, W. T., Zhang, J. Y., Niclou, S. P., Levelt, C. N., Sablitzky, F., Anderson, P. N., Lieberman, A. R., et al. (2004) · BMC Neuroscience · doi:10.1186/1471-2202-5-4 · Cited by 105
Pawlikowska, L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh100 · Cited by 105
Leitges, M., Neidhardt, L., Haenig, B., Herrmann, B. G., & Kispert, A. (2000) · Development · doi:10.1242/dev.127.11.2259 · Cited by 104
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies
Zou, Y.-R., Müller, W., Gu, H., & Rajewsky, K. (1994) · Current Biology · doi:10.1016/s0960-9822(00)00248-7 · Cited by 104
Self-citationKew, J. N. C., Köester, A., Moreau, J., Jenck, F., Ouagazzal, A., Mutel, V., Richards, J. G., Trube, G., Fischer, G., Montkowski, A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04037.2000 · Cited by 107
Human Antibodies from Transgenic Mice
Lönberg, N., & Huszar, D. (1995) · International Reviews of Immunology · doi:10.3109/08830189509061738 · Cited by 104
Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development
Leu, M., Bellmunt, E., Schwander, M., Fariñas, I., Brenner, H. R., & Müller, U. (2003) · Development · doi:10.1242/dev.00447 · Cited by 103
Gubbels, M., Striepen, B., Shastri, N., Turkoz, M., & Robey, E. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.703-711.2005 · Cited by 103
Buchholz, F. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.15.3118 · Cited by 103
He, L.-Z., Merghoub, T., & Pandolfi, P. P. (1999) · Oncogene · doi:10.1038/sj.onc.1203088 · Cited by 102
Stage-and tissue-specific expression of a Col2a1-Cre fusion gene in transgenic mice
Sakai, K., Hiripi, L., Glumoff, V., Brandau, O., Eerola, R., VUORIO, E. I., Bösze, Z., Fässler, R., & Aszódi, A. (2001) · Matrix Biology · doi:10.1016/s0945-053x(00)00122-0 · Cited by 102
Vekovischeva, O. Y., Zamanillo, D., Echenko, O., Seppälä, T., Uusi‐Oukari, M., Honkanen, A., Seeburg, P. H., Sprengel, R., & Korpi, E. R. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04451.2001 · Cited by 103
Metadata
- Authors
- Gu, H., Zou, Y.-R., & Rajewsky, K.
- Affiliations
- University of Cologne (DE)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 73
- Issue
- 6
- Pages
- 1155-1164
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2053200644
- Cited by
- 989
- References
- 57
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 22 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 17 · 2013: 24 · 2012: 31
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- switch regions, Cre-loxP recombination, intron enhancer, IGH locus, B cells, lipopolysaccharide, IL-4, DNA double-strand breaks
- MeSH terms
- Animals, Base Sequence, Female, Genes, Immunoglobulin, Genes, Switch, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Recombination, Genetic, Tumor Cells, Cultured, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review