Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741

A short amino acid sequence able to specify nuclear location

Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783

Generation and Analysis of Interleukin-4 Deficient Mice

Kühn, R., Rajewsky, K., & Müller, W. (1991) · Science · doi:10.1126/science.1948049 · Cited by 1,229

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

Sauer, B., & Henderson, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5166 · Cited by 1,213

Bacteriophage P1 site-specific recombination

Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 813

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796

Teratocarcinomas and embryonic stem cells: A practical approach

Krumlauf, R. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90286-1 · Cited by 779

Evidence for recombinatorial hot spots at the T cell receptor Jα locus

Rytkönen-Nissinen, M. A., Hurwitz, J. L., Tolonen, K., & Pelkonen, J. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240117 · Cited by 23

The Nobel Prize in Physiology or Medicine 2007

Hansen, T. (2007) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2007.02041.x · Cited by 23

Regulatory T Cells and IL-10 Independently Counterregulate Cytotoxic T Lymphocyte Responses Induced by Transcutaneous Immunization

Stein, P., Weber, M., Prüfer, S., Schmid, B., Schmitt, E., Probst, H. C., Waisman, A., Langguth, P., Schild, H., & Radsak, M. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027911 · Cited by 23

Activation of Cre Recombinase Alone Can Induce Complete Tumor Regression

Li, Y., Choi, P. S., Casey, S. C., & Felsher, D. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107589 · Cited by 22

Knockin of Cre Gene at Ins2 Locus Reveals No Cre Activity in Mouse Hypothalamic Neurons

Li, L., Gao, L., Wang, K., Ma, X., Chang, X., Shi, J.-H., Zhang, Y., Yin, K., Liu, Z., Shi, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep20438 · Cited by 22

Transcriptional and posttranslational regulation of cre recombinase by ru486 as the basis for an enhanced inducible expression system

Kyrkanides, S., Miller, J.-N. H., Bowers, W. J., & Federoff, H. J. (2003) · Molecular Therapy · doi:10.1016/j.ymthe.2003.07.005 · Cited by 22

CD8+ T cells specific for β cells encounter their cognate antigens in the islets of NOD mice

Pang, S., Zhang, L., Wang, H., Yi, Z., Li, L., Gao, L., Zhao, J., Tisch, R., Katz, J. D., & Wang, B. (2009) · European Journal of Immunology · doi:10.1002/eji.200939408 · Cited by 22

Efficient gene-specific expression of Cre recombinase in the mouse embryo by targeted insertion of a novel IRES-Cre cassette into endogenous loci

Michael, S. K., Brennan, J., & Robertson, E. J. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00052-0 · Cited by 22

Mouse models as a tool to unravel the genetic basis for human otitis media

Zheng, Q. Y., Hardisty-Hughes, R. E., & Brown, S. D. M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.046 · Cited by 22

Targeted Ablation of Par-4 Reveals a Cell Type–Specific Susceptibility to Apoptosis-Inducing Agents

Affar, E. B., Luke, M. P.-S., Gay, F., Calvo, D., Sui, G., Weiss, R. S., Li, E., & Shi, Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0964 · Cited by 22

GENETICALLY MODIFIED MICE IN NEUROPHARMACOLOGY

Brusa, R. (1999) · Pharmacological Research · doi:10.1006/phrs.1998.0457 · Cited by 23

Aging-related changes in calcium oscillations in fertilized mouse oocytes

Igarashi, H., Takahashi, E., Hiroi, M., & Doi, K. (1997) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199711)48:3 · Cited by 94

TKO'ed: Lox, stock and barrel

Chambers, C. A. (1994) · BioEssays · doi:10.1002/bies.950161202 · Cited by 22

Developmental specificity of immunoglobulin heavy chain switch region recombination activities

Li, M.-J., Chung, W.-S., & Maizels, N. (1997) · Molecular Immunology · doi:10.1016/s0161-5890(97)00028-x · Cited by 22

High frequency recombination betweenloxP sites in human chromosomes mediated by an adenovirus vector expressing Cre recombinase

Wang, P., Anton, M., Graham, F. L., & Bacchetti, S. (1995) · Somatic Cell and Molecular Genetics · doi:10.1007/bf02310209 · Cited by 22

Fate of transient catecholaminergic cell types revealed by site‐specific recombination in transgenic mice

Matsushita, N., Kobayashi, K., Miyazaki, J., & Kobayashi, K. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20229 · Cited by 21

A Novel Molecular Switch

Daber, R. D., & Lewis, M. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.06.039 · Cited by 21

Genetic manipulation of specific neural circuits by use of a viral vector system

Kobayashi, K., Kato, S., & Kobayashi, K. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-016-1674-7 · Cited by 20

Generation of Human Embryonic Stem Cell Reporter Knock‐In Lines by Homologous Recombination

Davis, R. P., Grandela, C., Sourris, K., Hatzistavrou, T., Dottori, M., Elefanty, A. G., Stanley, E. G., & Costa, M. (2009) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc05b01s11 · Cited by 21

Generation of a conditional null allele for Dmp1 in mouse

Feng, J. Q., Scott, G. J., Guo, D., Jiang, B., Harris, M. A., Ward, T., Ray, M. K., Bonewald, L. F., Harris, S. E., & Mishina, Y. M. (2008) · genesis · doi:10.1002/dvg.20370 · Cited by 21

All Known In Vivo Functions of the Oct-2 Transcription Factor Require the C-Terminal Protein Domain

Corcoran, L. M., Köentgen, F., Dietrich, W., Veale, M. F., & Humbert, P. O. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2962 · Cited by 21

System for Efficient Helper-Dependent Minimal Adenovirus Construction and Rescue

Hillgenberg, M., Schnieders, F., Löser, P., & Strauss, M. (2001) · Human Gene Therapy · doi:10.1089/104303401300057342 · Cited by 21

Large-scale mutational analysis for the annotation of the mouse genome

Beckers, J., & de Angelis, M. H. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(01)00277-0 · Cited by 21

Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance

Vielnascher, R. M., Hainzl, E., Leitner, N. R., Rammerstorfer, M., Popp, D., Witalisz‐Siepracka, A., Rom, R., Karaghiosoff, M., Kolbe, T., Müller, S., et al. (2014) · Transgenic Research · doi:10.1007/s11248-014-9795-y · Cited by 20

Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination

Nicolás, L., Cols, M., Choi, J. E., Chaudhuri, J., & Vuong, B. Q. (2018) · F1000Research · doi:10.12688/f1000research.13247.1 · Cited by 20

Redesign of the monomer–monomer interface of Cre recombinase yields an obligate heterotetrameric complex

Zhang, C., Myers, C. A., Qi, Z., Mitra, R. D., Corbo, J. C., & Havranek, J. J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv901 · Cited by 20

A Hoxa2 mutant conditional allele generated by Flp‐ and Cre‐mediated recombination

Ren, S., Pasqualetti, M., Dierich, A., LeMeur, M., & Rijli, F. M. (2002) · genesis · doi:10.1002/gene.10052 · Cited by 20

A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion

Li, F., & Eckhardt, L. A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081202 · Cited by 20

Inhibition of recombinant human immunodeficiency virus type 1 replication by a site-specific recombinase

Flowers, C. C., Woffendin, C., Petryniak, J., Yang, S., & Nabel, G. J. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.2685-2692.1997 · Cited by 20

Cre‐mediated transgene activation in the developing and adult mouse brain

Cinato, E., Mirotsou, M., & Sablitzky, F. (2001) · genesis · doi:10.1002/gene.10014 · Cited by 20

Genetic Engineering of Herpes Simplex Virus and Vector Genomes Carrying loxP Sites in Cells Expressing Cre Recombinase

Logvinoff, C., & Epstein, A. L. (2000) · Virology · doi:10.1006/viro.1999.0108 · Cited by 20

Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate

Fernex, C., Caillol, D. H., Capone, M., Krippl, B., & Ferrier, P. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.5.792 · Cited by 20

BCR signal through α4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation

Inui, S., Maeda, K., Hua, D. R., Yamashita, T., Yamamoto, H., Miyamoto, E., Aizawa, S., & Sakaguchi, N. (2002) · International Immunology · doi:10.1093/intimm/14.2.177 · Cited by 19

Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns

Hatoyama, Y., Islam, M., Bond, A. G., Hayashi, K., Ciulli, A., & Kanemaki, M. T. (2024) · EMBO Reports · doi:10.1038/s44319-024-00224-4 · Cited by 18

Recombinase mediated cassette exchange into genomic targets using an adenovirus vector

Sorrell, D. A., Robinson, C. J., Smith, J.-A., & Kolb, A. F. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq192 · Cited by 19

Studies on Conditional Gene Expression in the Brain

Jerecìć, J., Single, F. N., KRÜTH, U., Krestel, H. E., Kolhekar, R., Storck, T., Kask, K., Higuchi, M., Sprengel, R., & SEEBURG, P. H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11271.x · Cited by 19

Regulation of Class Switch Recombination

Cogné, M., & Birshtein, B. K. (2004) · Elsevier eBooks · doi:10.1016/b978-012053641-2/50020-4 · Cited by 19

Searching for Genes Involved in the Pathogenesis of Primary Immunodeficiency Diseases: Lessons from Mouse Knockouts

Kokron, C. M., Bonilla, F. A., Oettgen, H. C., Ramesh, N., Geha, R. S., & Pandolfi, F. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027322314256 · Cited by 19

Gene targeting: Things go better with Cre

Jiang, R., & Gridley, T. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00149-7 · Cited by 19

Molecular Mechanism of Immunoglobulin Class Switch RecombinationPreprint

KINOSHITA, K., Lee, C.-G., Tashiro, J., Muramatsu, M., CHEN, X.-C., Yoshikawa, K., & Honjo, T. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.217 · Cited by 19

Lateral olivocochlear neurons modulate cochlear responses to noise exposure

Sitko, A. A., Frank, M. M., Romero, G. E., Hunt, M., & Goodrich, L. V. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404558122 · Cited by 21

Base Editing in Human Cells to Produce Single‐Nucleotide‐Variant Clonal Cell Lines

Vásquez, C. A., Cowan, Q. T., & Komor, A. C. (2020) · Current Protocols in Molecular Biology · doi:10.1002/cpmb.129 · Cited by 20

The multifaceted roles of B lymphocytes in metabolic dysfunction–associated steatotic liver disease

Li, H., & Xia, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447391 · Cited by 23

The role of androgens and global and tissue-specific androgen receptor expression on body composition, exercise adaptation, and performance

Barsky, S. T., & Monks, D. A. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00707-6 · Cited by 20

Increased Targeting of Donor Switch Region and IgE in Sγ1-Deficient B Cells

Misaghi, S., Garris, C., Sun, Y., Nguyen, A., Zhang, J., Sebrell, A., Senger, K., Yan, D., Lorenzo, M. N., Heldens, S., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000515 · Cited by 18

Targeted mutagenesis tools for modelling psychiatric disorders

Deussing, J. M. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1708-5 · Cited by 20

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination

Misaghi, S., Senger, K., Sai, T., Yan, Q., Sun, Y., Hamidzadeh, K., Nguyen, A., Jin, Z., Zhou, M., Yan, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221661110 · Cited by 18

Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)

Vermot, J., Garnier, J., Dierich, A., Niederreither, K., Harvey, R. P., Chambon, P., & Dollé, P. (2006) · genesis · doi:10.1002/gene.20195 · Cited by 18

Cre recombinase specificity defined by the tau locus

Korets-Smith, E., Lindemann, L., Tucker, K. L., Jiang, C., Kabacs, N., Bélteki, G., Haigh, J. J., Gertsenstein, M., & Nagy, A. (2004) · genesis · doi:10.1002/gene.20074 · Cited by 18

Transgenic mice and their impact on kidney research

Rubera, I., Hümmler, E., & Beermann, F. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0624-0 · Cited by 16

Cellular and Molecular Analysis of Lymphoid Development Using RAG-Deficient Mice

Spanopoulou, E. (1996) · International Reviews of Immunology · doi:10.3109/08830189609061752 · Cited by 18

The Use of Transgenic and Knock-out Mice in the Investigation of Ocular Surface Cell Biology

Kao, W. W. ‐., & Liu, C. (2003) · The Ocular Surface · doi:10.1016/s1542-0124(12)70003-4 · Cited by 18

Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

Perruzza, L., Strati, F., Raneri, M., Li, H., Gargari, G., Rezzonico-Jost, T., Palatella, M., Kwee, I., Morone, D., Seehusen, F., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111112 · Cited by 17

Viral Cre-LoxP tools aid genome engineering in mammalian cells

Sengupta, R., Mendenhall, A., Sarkar, N., Mukherjee, C., Afshari, A., Huang, J. S., & Lü, B. (2017) · Journal of Biological Engineering · doi:10.1186/s13036-017-0087-y · Cited by 19

Pyruvate dehydrogenase deficiency: morphological and metabolic effects, creation of animal model to search for curative treatment

Ebertowska, A., Ludkiewicz, B., Klejbor, I., Melka, N., & Moryś, J. (2020) · Folia Morphologica · doi:10.5603/fm.a2020.0020 · Cited by 17

Cre-Mediated Cerebellum- and Hippocampus-Restricted Gene Mutation in Mouse Brain

Guo, H., Mao, C., Jin, X.-L., Wang, H., Tu, Y.-T., Avasthi, P. P., & Li, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2263 · Cited by 17

Insulin Receptor Knock-Out Mice

Accili, D. (1997) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(97)00031-3 · Cited by 16

Localization of splenic B cells activated for switch recombination by in situ hybridization with Igamma1 switch transcript and Rad51 probes.

Peakman, M., & Maizels, N. (1998) · PubMed · Cited by 17

Gene Targeting in Neuroendocrinology

Candlish, M., Angelis, R. D., Götz, V., & Boehm, U. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140079 · Cited by 20

ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis

Guo, C., Xiao, Y., Gu, J., Zhao, P., Hu, Z., Zheng, J., Hua, R., Hai, Z., Su, J., Zhang, J. V., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-05372-2 · Cited by 16

Loop extrusion promotes an alternate pathway for isotype switching

Shen, H. M., Wuerffel, R., Cantillo, J. F., Priyadarshi, S., Lei, X., Liang, J., Wu, Y. L., & Kenter, A. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110059 · Cited by 16

Astonishing advances in mouse genetic tools for biomedical research

Jackson, W. S., & Kaczmarczyk, L. (2015) · Swiss Medical Weekly · doi:10.4414/smw.2015.14186 · Cited by 15

Removal of selectable marker gene from fibroblast cells in transgenic cloned cattle by transient expression of Cre recombinase and subsequent effects on recloned embryo development

Wang, S., Sun, X., Ding, F., Zhang, K., Zhao, R., Li, S., Li, R., Tang, B., Zhang, L., Liu, Y., et al. (2009) · Theriogenology · doi:10.1016/j.theriogenology.2009.04.009 · Cited by 16

Target DNA Sequence Directly Regulates the Frequency of Activation-Induced Deaminase-Dependent Mutations

Chen, Z., Viboolsittiseri, S. S., O’Connor, B. P., & Wang, J. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200416 · Cited by 16

Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene

Hayasaka, H., Martin, K. H., Hershey, E. D., & Parsons, J. T. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21329 · Cited by 16

Genetic Modification of Human Embryonic Stem Cells

Xia, X., & Zhang, S. (2007) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2007.10648105 · Cited by 16

Efficient Sequential Gene Regulation via FLP‐ and Cre‐Recombinase Using Adenovirus Vector in Mammalian Cells Including Mouse ES Cells

Kondo, S., Takahashi, Y., Shiozawa, S., Ichise, H., Yoshida, N., Kanegae, Y., & Saito, I. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03850.x · Cited by 15

Proceedings of the Symposium ‘Angiotensin AT1 Receptors: From Molecular Physiology to Therapeutics’: TRANSGENIC RATS: TOOLS TO STUDY THE FUNCTION OF THE RENIN‐ANGIOTENSIN SYSTEM

Bäder, M., & Ganten, D. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb02818.x · Cited by 16

Advances in the use of embryonic stem cell technology

Ramírez‐Solis, R., & Bradley, A. (1994) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(94)90069-8 · Cited by 16

Chromosome Manipulation by Cre‐loxRecombination

Sauer, B. (2007) · Wiley eBooks · doi:10.1128/9781555817954.ch4 · Cited by 16

Adenovirus vector technology: An efficient method for constructing recombinant adenovirus and on/off switching of gene expression

Kanegae, Y., Miyake, S., Sato, Y., Lee, G., & Saito, I. (1996) · Pediatrics International · doi:10.1111/j.1442-200x.1996.tb03466.x · Cited by 16

NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection

Krapić, M., Kavazović, I., Mikašinović, S., Mladenić, K., Krstanović, F., Seyhan, G., Helmrath, S., Camerini, E., Brizić, I., Peters, F. S., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01273-2 · Cited by 16

Generating Conditional Mutations in Zebrafish Using Gene-trap Mutagenesis

Maddison, L. A., Lu, J., & Chen, W. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-374814-0.00001-x · Cited by 15

Independent recruitment of Igh alleles in V(D)J recombination

Pereira, C., de Freitas, R. M., Lopes, T., Gardner, R., Marta, F., Vieira, P., & Barreto, V. M. (2014) · Nature Communications · doi:10.1038/ncomms6623 · Cited by 15

Targeted integration of a dominant neoR marker into a 2- to 3-Mb human minichromosome and transfer between cells

Au, H. C., Mascarello, J. T., & Scheffler, I. E. (1999) · Cytogenetic and Genome Research · doi:10.1159/000015338 · Cited by 15

Genotype to phenotype: challenges and opportunities

Holschneider, D. P., & Shih, J. C. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00026-5 · Cited by 15

Genomic targeting of a bicistronic DNA fragment by Cre-mediated site-specific recombination

Kolb, A. F., & Siddell, S. G. (1997) · Gene · doi:10.1016/s0378-1119(97)00515-5 · Cited by 15

Localization of Splenic B Cells Activated for Switch Recombination by In Situ Hybridization with Iγ1 Switch Transcript and Rad51 Probes

Peakman, M., & Maizels, N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4008 · Cited by 15

Mucosal viral infection elicits long-lived IgA responses via type 1 follicular helper T cells

Haniuda, K., Edner, N. M., Makita, Y., Appiah, S., Watts, T. H., Wu, G. F., Dileepan, T., & Gommerman, J. L. (2025) · Cell · doi:10.1016/j.cell.2025.07.022 · Cited by 14

Roles of G4-DNA and G4-RNA in Class Switch Recombination and Additional Regulations in B-Lymphocytes

Dézé, O., Laffleur, B., & Cogné, M. (2023) · Molecules · doi:10.3390/molecules28031159 · Cited by 15

Degron tagging for rapid protein degradation in mice

Hernández-Morán, B. A., Taylor, G. C. A., Lorente‐Macías, Á., & Wood, A. J. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050613 · Cited by 14

Essential roles of B cell subsets in the progression of MASLD and HCC

Petriv, N., Suo, H., Hochnadel, I., Timrott, K., Bondarenko, N., Neubert, L., Reinhard, E., Jedicke, N., Kaufhold, P., Guzmán, C. A., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101189 · Cited by 17

Inducible and reversible regulation of endogenous gene in mouse

Sun, R., Zhao, K., Shen, R., Cai, L., Yang, X., Kuang, Y., Mao, J., Huang, F., Wang, Z., & Fei, J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks738 · Cited by 14

A neutrophil–B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4

Gawish, R., Maier, B. B., Obermayer, G., Watzenboeck, M. L., Gorki, A.-D., Quattrone, F., Farhat, A., Lakovits, K., Hladik, A., Korosec, A., et al. (2022) · eLife · doi:10.7554/elife.78291 · Cited by 14

Genome Engineering with Cre-loxP

Maizels, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301241 · Cited by 14

Retinoic Acid Receptor α (RARα) Mutations in Human Leukemia

Parrado, A., Chomienne, C., & Padua, R. A. (2000) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190009065826 · Cited by 14

Immunoglobulin Deficient Mice Generated by Gene Targeting as Models for Studying the Immune Response

Bot, A. I. (1996) · International Reviews of Immunology · doi:10.3109/08830189609061756 · Cited by 14

Analysis of Gene Function in Lymphocytes by RAG-2-Deficient Blastocyst Complementation

Chen, J. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60427-7 · Cited by 14

Cell death during lymphocyte development and activation

DEALBORAN, I. (2003) · Seminars in Immunology · doi:10.1016/s1044-5323(03)00032-0 · Cited by 14

An extrachromosomal switch recombination substrate reveals kinetics and substrate requirements of switch recombination in primary murine B cells

Petry, K., Siebenkotten, G., Christine, R., Hein, K., & Radbruch, A. (1999) · International Immunology · doi:10.1093/intimm/11.5.753 · Cited by 14

Targeting and Regulation of Immunoglobulin Gene Somatic Hypermutation and lsotype Switch Recombination

Hengstschläger, M., Maizels, N., & Leung, H. (1995) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60811-9 · Cited by 14

Development of high-titer retroviral producer cell lines by using Cre-mediated recombination

Vanin, E. F., Cerruti, L., Tran, N., Grosveld, G. C., Cunningham, J. M., & Jane, S. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.10.7820-7826.1997 · Cited by 14

Intracranial AAV administration dose-dependently recruits B cells to inhibit the AAV redosing

Xu, Y., Bai, X., Lin, J., Lu, K., Weng, S., Wu, Y., Liu, S., Li, H., Wu, Z., Chen, G., et al. (2025) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2025.101420 · Cited by 15

Construction of transgenic swine with induced expression of Cre recombinase

Chen, L., Li, L., Pang, D., Li, Z., Wang, T., Zhang, M., Song, N., Yan, S., Lai, L., & Ouyang, H. (2010) · animal · doi:10.1017/s1751731109991571 · Cited by 13

Flanking genomic region of Tyr::Cre mice, rapid genotyping for homozygous mice

Colombo, S., Petit, V., Kumasaka, M. Y., Delmas, V., & Larue, L. (2007) · Pigment Cell Research · doi:10.1111/j.1600-0749.2007.00387.x · Cited by 13

A novel mouse model of sporadic colon cancer induced by combination of conditional Apc genes and chemical carcinogen in the absence of Cre recombinase

Souris, J. S., Zhang, H. J., Dougherty, U., Chen, N., Waller, J. V., Lo, L., Hart, J. A. L., Chen, C.-T., & Bissonnette, M. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz050 · Cited by 13

Establishment of a reversibly immortalized human hepatocyte cell line by using cre/loxp site-specific recombination

Kobayashi, N., Noguchi, H., Fujiwara, T., & Tanaka, N. (2000) · Transplantation Proceedings · doi:10.1016/s0041-1345(00)01154-4 · Cited by 13

N1L Is an Ectromelia Virus Virulence Factor and Essential forIn VivoSpread upon Respiratory Infection

Gratz, M. S., Suezer, Y., Kremer, M., Volz, A., Majzoub, M., Hanschmann, K.-M. O., Kalinke, U., Schwantes, A., & Sutter, G. (2011) · Journal of Virology · doi:10.1128/jvi.01191-10 · Cited by 14

I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

Fenina, M., Simon‐Chazottes, D., Vandormael‐Pournin, S., Soueid, J., Vives, F. L., Cohen‐Tannoudji, M., Bernard, B. A., & Panthier, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039895 · Cited by 13

Novel pan-neuronal Cre-transgenic line for conditional ablation of genes in the nervous system

Banares, S., Zeh, K., Krajewska, M., Kermer, P., Baribault, H., Reed, J. C., & Krajewski, S. (2005) · genesis · doi:10.1002/gene.20117 · Cited by 13

Pillars Article: Independent Control of Immunoglobulin Switch Recombination at Individual Switch Regions Evidenced through Cre-loxP-Mediated Gene Targeting. Cell. 1993. 73: 1155-1164

Gu, H., Zou, Y.-R., & Rajewsky, K. (2013) · The Journal of Immunology · doi:10.1093/jimmunol/191.1.7 · Cited by 3

IgH joining region plus intronic enhancer

Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50318-5

Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

Leung, H., & Maizels, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4154 · Cited by 72

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

Jung, S., Rajewsky, K., & Radbruch, A. (1993) · Science · doi:10.1126/science.8438159 · Cited by 343

Regulation of Switch Recombination to the Murine γ 1 Gene

Dunnick, W. A., Elenich, L. A., Berry, J., Albrecht, D. W., Stavnezer, J., & Claflin, J. L. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77633-5_17 · Cited by 4