The DOI matches its Crossref record; 55 of the 57 references it cites were found in a registry or an index.
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
Abstract
We have employed a method based on the Cre-loxP recombination system of bacteriophage P1 to generate a mouse strain in which the JH segments and the intron enhancer in the IgH locus are deleted. By analysis of immunoglobulin isotype switch recombination in heterozygous mutant B cells activated by lipopolysaccharide plus interleukin-4, we show that, on the mutant chromosome, switch recombination at the mu gene switch region is strongly suppressed, whereas the switch region of the gamma 1 gene is efficiently rearranged. These data demonstrate an independent control of switch recombination at individual switch regions and suggest that, in the process of switch recombination, the alignment of the recombining strands occurs independently of and probably after the introduction of double-strand breaks into the switch regions involved.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In JHT mice, functional B cells fail to develop due to deletion of the Ig JH locus, while μ MT mice lack B cells as a result of inactivation of the Ig heavy chain of the class M gene [112,113].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [112]
Citations
Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
A short amino acid sequence able to specify nuclear location
Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production
Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927
Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
Self-citationGeneration and Analysis of Interleukin-4 Deficient Mice
Kühn, R., Rajewsky, K., & Müller, W. (1991) · Science · doi:10.1126/science.1948049 · Cited by 1,229
Self-citationSite-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.
Sauer, B., & Henderson, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5166 · Cited by 1,213
Bacteriophage P1 site-specific recombination
Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 813
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.
Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796
Teratocarcinomas and embryonic stem cells: A practical approach
Krumlauf, R. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90286-1 · Cited by 779
Research works printed but not linked: 2
- Schüpple, 1987, Monoclonal anti-allotype antibodies towards Balbc IgM, Eur. J. Immunol., 17, 739
- Stavnezer, 1984, Ig H-chain switching in cultured 129 murine B lymphoma cells, commitment to an IgA or IgE switch, Curr. Topics Microbiol. Immunol., 113, 109
Cited by
Sorted by citations
Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
Self-citationConditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Self-citationEvidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809
Revy, P., Muto, T., Lévy, Y., Geissmann, F., Plebani, A., Sanal, Ö., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,645
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589
Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting
Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397
Self-citationβ-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352
Neural crest expression of Cre recombinase directed by the proximal Pax3 promoter in transgenic mice
Li, J., Chen, F., & Epstein, J. A. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 158
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Self-citationEfficient in vivo manipulation of mouse genomic sequences at the zygote stage.
Lakso, M., Pichel, J. G., Gorman, J. R., Sauer, B., Okamoto, Y., Lee, E., Alt, F. W., & Westphal, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5860 · Cited by 1,125
Lam, K., Kühn, R., & Rajewsky, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80373-6 · Cited by 1,101
Self-citationDNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068
He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978
Marino, S., Vooijs, M., van der Gulden, H., Jonkers, J., & Berns, A. (2000) · Genes & Development · doi:10.1101/gad.14.8.994 · Cited by 920
Ahlgren, U., Jönsson, J., Jönsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918
Branda, C., & Dymecki, S. M. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00399-x · Cited by 876
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.
Santo, J. P. D., Müller, W., Guy‐Grand, D., Fischer, A., & Rajewsky, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.2.377 · Cited by 866
Self-citationMoerlooze, L. D., Spencer‐Dene, B., Revest, J., Hajihosseini, M. K., Rosewell, I. R., & Dickson, C. (2000) · Development · doi:10.1242/dev.127.3.483 · Cited by 863
Conditional control of gene expression in the mouse
Lewandoski, M. (2001) · Nature reviews genetics · doi:10.1038/35093537 · Cited by 442
Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.
Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lübbert, H., & Bujard, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10933 · Cited by 780
Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772
Inducible gene targeting in mice using the Cre/lox system.
Sauer, B. (1998) · Methods · doi:10.1006/meth.1998.0593 · Cited by 858
Taniuchi, I., Osato, M., Egawa, T., Sunshine, M. J., Bae, S., Komori, T., Ito, Y., & Littman, D. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01111-x · Cited by 744
The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus
Monory, K., Massa, F., Egertová, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.006 · Cited by 706
Transgenic mice with hematopoietic and lymphoid specific expression of Cre
de Boer, J., Williams, A., Skavdis, G., Harker, N., Coles, M., Tolaini, M., Norton, T., Williams, K., Roderick, K., Potocnik, A. J., et al. (2003) · European Journal of Immunology · doi:10.1002/immu.200310005 · Cited by 739
B lymphocyte-specific, Cre-mediated mutagenesis in mice
Rickert, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1317 · Cited by 729
Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning
Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791
Olkhanud, P. B., Damdinsuren, B., Bodogai, M., Gress, R. E., Sen, R., Wejksza, K., Malchinkhuu, E., Wersto, R. P., & Biragyn, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4316 · Cited by 689
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival
Srinivasan, L., Sasaki, Y., Calado, D. P., Zhang, B., Paik, J. H., DePinho, R. A., Kutok, J. L., Kearney, J. F., Otipoby, K. L., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2009.08.041 · Cited by 680
Self-citationhGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo
Zhuo, L., Theis, M., Álvarez-Maya, I., Brenner, M., Willecke, K., & Messing, A. (2001) · genesis · doi:10.1002/gene.10008 · Cited by 661
Long, F., Zhang, X. M., Karp, S. J., Yang, Y., & McMahon, A. P. (2001) · Development · doi:10.1242/dev.128.24.5099 · Cited by 654
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
Chaudhuri, J., & Alt, F. W. (2004) · Nature reviews. Immunology · doi:10.1038/nri1395 · Cited by 657
Stetson, D. B., Mohrs, M., Reinhardt, R. L., Baron, J. L., Wang, Z., Gapin, L., Kronenberg, M., & Locksley, R. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030630 · Cited by 618
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500168 · Cited by 617
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2002) · Nature Immunology · doi:10.1038/ni876 · Cited by 635
Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I., & Furukawa, T. (2003) · Nature Neuroscience · doi:10.1038/nn1155 · Cited by 607
Kanegae, Y., Lee, G., Sato, Y., Tanaka, M., Nakal, M., Sakaki, T., Sugano, S., & Saito, I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.19.3816 · Cited by 606
Dosage requirement of Pitx2 for development of multiple organs
Gage, P. J., Suh, H., & Camper, S. A. (1999) · Development · doi:10.1242/dev.126.20.4643 · Cited by 600
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
Honjo, T., Kinoshita, K., & Muramatsu, M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.090501.112049 · Cited by 610
Brusa, R., Zimmermann, F., Koh, D., Feldmeyer, D., Gass, P., Seeburg, P. H., & Sprengel, R. (1995) · Science · doi:10.1126/science.270.5242.1677 · Cited by 594
Cytokine Regulation and Function in T Cells
Dong, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053702 · Cited by 625
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells
Loonstra, A., Vooijs, M., Beverloo, H. B., Allak, B. A., van Drunen, E., Kanaar, R., Berns, A. J. M., & Jonkers, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161269798 · Cited by 591
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
Suzuki, A., Tsukio, M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A. C., Higuchi, T., Fukumoto, M., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00134-0 · Cited by 589
Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584
Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer
Kraus, M., Alimzhanov, M. B., Rajewsky, N., & Rajewsky, K. (2004) · Cell · doi:10.1016/j.cell.2004.05.014 · Cited by 573
Self-citationFunctional analysis of Sox8 and Sox9 during sex determination in the mouse
Chaboissier, M.-C., Kobayashi, A., Vidal, V., Lützkendorf, S., van de Kant, H. V. D., Wegner, M., de Rooij, D., Behringer, R., & Schedl, A. (2004) · Development · doi:10.1242/dev.01087 · Cited by 568
Graus-Porta, D., Blaess, S., Senften, M., Littlewood-Evans, A., Damsky, C. H., Huang, Z., Orban, P. C., Klein, R., Schittny, J. C., & Müller, U. (2001) · Neuron · doi:10.1016/s0896-6273(01)00374-9 · Cited by 569
Disruption of Semaphorin III/D Gene Causes Severe Abnormality in Peripheral Nerve Projection
Taniguchi, M., Yuasa, S., Fujisawa, H., Naruse, I., Saga, S., Mishina, M., & Yagi, T. (1997) · Neuron · doi:10.1016/s0896-6273(00)80368-2 · Cited by 516
Fehling, H. J., Lacaud, G., Kubo, A., Kennedy, M., Robertson, S. M., Keller, G. M., & Kouskoff, V. (2003) · Development · doi:10.1242/dev.00589 · Cited by 506
Sakai, K., & Miyazaki, J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7111 · Cited by 494
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain
Hayashi, S., Lewis, P. M., Pevny, L., & McMahon, A. P. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(03)00099-6 · Cited by 492
Williams, M. R., Arthur, J. S. C., Balendran, A., KAAY, J. V. D., Poli, V., Cohen, P., & Alessi, D. R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00441-3 · Cited by 479
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
Kwon, C.-H., Zhu, X., Zhang, J., Knoop, L. L., Tharp, R., Smeyne, R. J., Eberhart, C. G., Burger, P. C., & Baker, S. J. (2001) · Nature Genetics · doi:10.1038/ng781 · Cited by 478
Rajewsky, K., Gu, H., Kühn, R., Betz, U. A. K., Müller, W., Roes, J., & Schwenk, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118828 · Cited by 461
Self-citationAnalysis of Type 2 Immunity In Vivo with a Bicistronic IL-4 Reporter
Mohrs, M., Shinkai, K., Mohrs, K., & Locksley, R. M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00186-8 · Cited by 460
Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K., & Woodgett, J. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.001 · Cited by 458
Ramiro, A. R., Stavropoulos, P., Janković, M., & Nussenzweig, M. C. (2003) · Nature Immunology · doi:10.1038/ni920 · Cited by 437
O’Gorman, S., Dagenais, N., Qian, M., & Marchuk, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14602 · Cited by 436
TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo
Cazac, B. B., & Roes, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)00044-3 · Cited by 430
Molnarfi, N., Schulze‐Topphoff, U., Weber, M. S., Patarroyo, J. C., Prod’homme, T., Varrin‐Doyer, M., Shetty, A., Linington, C., Slavin, A., Hidalgo, J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130699 · Cited by 422
Altered T cell development in mice with a targeted mutation of the CD3‐epsilon gene.
Malissen, M., Gillet, A., Ardouin, L., Bouvier, G., Trucy, J., Ferrier, P., Vivier, É., & MALISSEN, B. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00146.x · Cited by 405
Improved properties of FLP recombinase evolved by cycling mutagenesis
Buchholz, F., Angrand, P., & Stewart, A. F. (1998) · Nature Biotechnology · doi:10.1038/nbt0798-657 · Cited by 404
The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching
Rolink, A. G., Melchers, F., & Andersson, J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80258-7 · Cited by 404
Analysis of C-MYC Function in Normal Cells via Conditional Gene-Targeted Mutation
de Alborán, I. M., O’Hagan, R. C., Gärtner, F., Malynn, B. A., Davidson, L., Rickert, R. C., Rajewsky, K., DePinho, R. A., & Alt, F. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00088-7 · Cited by 398
Self-citationLallemand, Y., Luria, V. A., Haffner‐Krausz, R., & Lonai, P. (1998) · Transgenic Research · doi:10.1023/a:1008868325009 · Cited by 393
Mechanism and control of class-switch recombination
Manis, J. P., Tian, M., & Alt, F. W. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02111-1 · Cited by 395
Tkalcevic, J., Novelli, M. R., Phylactides, M., Iredale, J. P., Segal, A. W., & Roes, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)80173-9 · Cited by 384
Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice
Alimzhanov, M. B., Kuprash, D. V., Kosco‐Vilbois, M. H., Luz, A., Turetskaya, R. L., Tarakhovsky, A., Rajewsky, K., Nedospasov, S. A., & Pfeffer, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9302 · Cited by 370
Self-citationGiovannini, M., Robanus-Maandag, E. C., van der Valk, M., Niwa‐Kawakita, M., Abramowski, V., Goutebroze, L., Woodruff, J. M., Berns, A. J. M., & Thomas, G. D. (2000) · Genes & Development · doi:10.1101/gad.14.13.1617 · Cited by 369
Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer
Trimboli, A. J., Fukino, K., de Bruin, A., Guo, W., Shen, L., Tanner, S. M., Creasap, N., Rosol, T. J., Robinson, M. L., Eng, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2148 · Cited by 365
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice
Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., & Gustafsson, J.-Α. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9794 · Cited by 364
Generation of a germ cell‐specific mouse transgenic Cre line, Vasa‐Cre
Gallardo, T. D., Shirley, L. J., John, G. B., & Castrillón, D. H. (2007) · genesis · doi:10.1002/dvg.20310 · Cited by 366
Dymecki, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6191 · Cited by 361
Bon, A. L., Thompson, C., Kamphuis, E., Durand, V., Rossmann, C., Kalinke, U., & Tough, D. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2074 · Cited by 367
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
Harrison, K. A., Thaler, J. P., Pfaff, S. L., Gu, H., & Kehrl, J. H. (1999) · Nature Genetics · doi:10.1038/12674 · Cited by 358
Self-citationBile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1β
Coffinier, C., Gresh, L., Fiette, L., Tronche, F., Schütz, G., Babinet, C., Pontoglio, M., Yaniv, M., & Barra, J. (2002) · Development · doi:10.1242/dev.129.8.1829 · Cited by 354
Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission
Yılmaz, B., Portugal, S., Tran, T. M., Gozzelino, R., Ramos, S., Gomes, J., Regalado, A. P., Cowan, P. J., d’Apice, A. J. F., Chong, A. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.053 · Cited by 359
Vooijs, M., Jonkers, J., & Berns, A. J. M. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve064 · Cited by 354
CHD8 haploinsufficiency results in autistic-like phenotypes in mice
Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., & Nakayama, K. I. (2016) · Nature · doi:10.1038/nature19357 · Cited by 353
Site-specific recombinases: tools for genome engineering
Kilby, N. J., Snaith, M. R., & Murray, J. A. H. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90104-p · Cited by 349
Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes
Kim, H., Kim, M., Im, S., & Fang, S. (2018) · Laboratory Animal Research · doi:10.5625/lar.2018.34.4.147 · Cited by 414
Gene Therapy: Promises and Problems
Pfeifer, A., & Verma, I. M. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.177 · Cited by 345
Metzler, M., Gertz, A., Sarkar, M., Schachter, H., Schrader, J. W., & Marth, J. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06480.x · Cited by 339
Stranges, P. B., Watson, J., Cooper, C. J., Choisy-Rossi, C.-M., Stonebraker, A. C., Beighton, R. A., Hartig, H. M., Sundberg, J. P., Servick, S. V., Kaufmann, G. F., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.016 · Cited by 331
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
Schmidt, E. E., Taylor, D., Prigge, J. R., Barnett, S., & Capecchi, M. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240471297 · Cited by 335
In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE)
Dupé, V., Davenne, M., Brocard, J., Dollé, P., Mark, M. P., Dierich, A., Chambon, P., & Rijli, F. M. (1997) · Development · doi:10.1242/dev.124.2.399 · Cited by 335
Mice lacking all conventional MHC class II genes
Madsen, L. S., Labrecque, N., Engberg, J., Dierich, A., Svejgaard, A., Benoist, C. O., Mathis, D. J., & Fugger, L. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10338 · Cited by 331
Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination
Lee, G., & Saito, I. (1998) · Gene · doi:10.1016/s0378-1119(98)00325-4 · Cited by 326
Zhang, L., Huynh, K. D., & Lee, J. T. (2007) · Cell · doi:10.1016/j.cell.2007.03.036 · Cited by 317
Dudley, D. D., Chaudhuri, J., Bassing, C. H., & Alt, F. W. (2005) · Advances in immunology · doi:10.1016/s0065-2776(04)86002-4 · Cited by 347
Xiao, Y. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.2985 · Cited by 316
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
Mountford, P. S., Zevnik, B., Düwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I., & Smith, A. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4303 · Cited by 312
Neves, P., Lampropoulou, V., Calderón‐Gómez, E., Roch, T., Stervbo, U., Shen, P., Kühl, A. A., Loddenkemper, C., Haury, M., Nedospasov, S. A., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.016 · Cited by 327
Stanley, E. G., Biben, C., Elefanty, A. G., Barnett, L. D., Köentgen, F., Robb, L., & Harvey, R. P. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12141429 · Cited by 306
Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development
Saijo, K., Schmedt, C., Su, I.-H., Karasuyama, H., Lowell, C. A., Reth, M. G., Adachi, T., Patke, A., Santana, A., & Tarakhovsky, A. (2003) · Nature Immunology · doi:10.1038/ni893 · Cited by 307
Anastassiadis, K., Fu, J., Patsch, C., Hu, S., Weidlich, S., Duerschke, K., Buchholz, F., Edenhofer, F., & Stewart, A. F. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.003087 · Cited by 307
Mouse models of metastasis: progress and prospects
Gómez-Cuadrado, L., Tracey, N., Ma, R., Qian, B., & Brunton, V. G. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030403 · Cited by 316
Mouse models for human lung cancerPreprint
Meuwissen, R. L. J., & Berns, A. J. M. (2005) · Genes & Development · doi:10.1101/gad.1284505 · Cited by 307
Metadata
- Authors
- Gu, H., Zou, Y.-R., & Rajewsky, K.
- Affiliations
- University of Cologne (DE)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 73
- Issue
- 6
- Pages
- 1155-1164
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2053200644
- Cited by
- 989
- References
- 57
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 22 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 17 · 2013: 24 · 2012: 31
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- switch regions, Cre-loxP recombination, intron enhancer, IGH locus, B cells, lipopolysaccharide, IL-4, DNA double-strand breaks
- MeSH terms
- Animals, Base Sequence, Female, Genes, Immunoglobulin, Genes, Switch, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Recombination, Genetic, Tumor Cells, Cultured, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review