Cited by 989T-cell and B-cell ImmunologyDNA Repair MechanismsGenomics and Chromatin Dynamics

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Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

Gu, Hua, Zou, Yong-Rui, Rajewsky, Klaus·1993·Cell

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Abstract

We have employed a method based on the Cre-loxP recombination system of bacteriophage P1 to generate a mouse strain in which the JH segments and the intron enhancer in the IgH locus are deleted. By analysis of immunoglobulin isotype switch recombination in heterozygous mutant B cells activated by lipopolysaccharide plus interleukin-4, we show that, on the mutant chromosome, switch recombination at the mu gene switch region is strongly suppressed, whereas the switch region of the gamma 1 gene is efficiently rearranged. These data demonstrate an independent control of switch recombination at individual switch regions and suggest that, in the process of switch recombination, the alignment of the recombining strands occurs independently of and probably after the introduction of double-strand breaks into the switch regions involved.

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Authors: Gu, H., Zou, Y.-R., & Rajewsky, K.
Affiliations: University of Cologne (DE)
ORCID: Gu, Hua
Zou, Yong-Rui
Rajewsky, Klaus
Venue: Cell
Publisher: Elsevier BV
Published: 1993-06
Volume: 73
Issue: 6
Pages: 1155-1164
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(93)90644-6
OpenAlex: W2053200644
Cited by: 989
References: 57
Citations by year: 2026: 13 · 2025: 12 · 2024: 22 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 17 · 2013: 24 · 2012: 31
FWCI: 19.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: switch regions, Cre-loxP recombination, intron enhancer, IGH locus, B cells, lipopolysaccharide, IL-4, DNA double-strand breaks
MeSH terms: Animals, Base Sequence, Female, Genes, Immunoglobulin, Genes, Switch, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Recombination, Genetic, Tumor Cells, Cultured, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Mice

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Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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