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Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
Abstract
We have employed a method based on the Cre-loxP recombination system of bacteriophage P1 to generate a mouse strain in which the JH segments and the intron enhancer in the IgH locus are deleted. By analysis of immunoglobulin isotype switch recombination in heterozygous mutant B cells activated by lipopolysaccharide plus interleukin-4, we show that, on the mutant chromosome, switch recombination at the mu gene switch region is strongly suppressed, whereas the switch region of the gamma 1 gene is efficiently rearranged. These data demonstrate an independent control of switch recombination at individual switch regions and suggest that, in the process of switch recombination, the alignment of the recombining strands occurs independently of and probably after the introduction of double-strand breaks into the switch regions involved.
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“In JHT mice, functional B cells fail to develop due to deletion of the Ig JH locus, while μ MT mice lack B cells as a result of inactivation of the Ig heavy chain of the class M gene [112,113].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [112]
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Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
A short amino acid sequence able to specify nuclear location
Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production
Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927
Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
Self-citationGeneration and Analysis of Interleukin-4 Deficient Mice
Kühn, R., Rajewsky, K., & Müller, W. (1991) · Science · doi:10.1126/science.1948049 · Cited by 1,229
Self-citationSite-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.
Sauer, B., & Henderson, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5166 · Cited by 1,213
Bacteriophage P1 site-specific recombination
Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 813
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.
Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796
Teratocarcinomas and embryonic stem cells: A practical approach
Krumlauf, R. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90286-1 · Cited by 779
Research works printed but not linked: 2
- Schüpple, 1987, Monoclonal anti-allotype antibodies towards Balbc IgM, Eur. J. Immunol., 17, 739
- Stavnezer, 1984, Ig H-chain switching in cultured 129 murine B lymphoma cells, commitment to an IgA or IgE switch, Curr. Topics Microbiol. Immunol., 113, 109
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Widespread recombinase expression using FLPeR (Flipper) mice
Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602
IgH Chain Class Switch Recombination: Mechanism and Regulation
Stavnezer, J., & Schrader, C. E. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401849 · Cited by 339
Constien, R., Forde, A., Liliensiek, B., Gröne, H., Nawroth, P. P., Hämmerling, G. J., & Arnold, B. (2001) · genesis · doi:10.1002/gene.1030 · Cited by 294
A LIM-homeodomain combinatorial code for motor-neuron pathway selection
Thor, S., Andersson, S. G. E., Tomlinson, A., & Thomas, J. B. (1999) · Nature · doi:10.1038/16275 · Cited by 287
Pelanda, R., Schwers, S., Sonoda, E., Torres, R. M., Nemazee, D. A., & Rajewsky, K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80395-7 · Cited by 290
Self-citationACCESSIBILITY CONTROL OF ANTIGEN-RECEPTOR VARIABLE-REGION GENE ASSEMBLY: Role ofcis-Acting Elements
Sleckman, B. P., Gorman, J. R., & Alt, F. W. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.459 · Cited by 284
Reina‐San‐Martin, B., Difilippantonio, S., Hanitsch, L. G., Masilamani, R. F., Nussenzweig, A., & Nussenzweig, M. C. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030569 · Cited by 302
Alonzi, T., Maritano, D., Gorgoni, B., Rizzuto, G., Libert, C., & Poli, V. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1621-1632.2001 · Cited by 329
Araki, K., Araki, M., Miyazaki, J., & VASSALLI, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.1.160 · Cited by 284
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Bon, A. L., Durand, V., Kamphuis, E., Thompson, C., Bulfone‐Paus, S., Rossmann, C., Kalinke, U., & Tough, D. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.8.4682 · Cited by 283
Shai, S., Zemljic‐Harpf, A. E., Babbitt, C. J., Jordan, M. C., Fishbein, M. C., Chen, J., Omura, M. C., Leil, T. A., Becker, K., Jiang, M., et al. (2002) · Circulation Research · doi:10.1161/hh0402.105790 · Cited by 282
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Thor, S., & Thomas, J. B. (1997) · Neuron · doi:10.1016/s0896-6273(00)81241-6 · Cited by 271
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Ridder, K. D., Sevko, A., Heide, J., Dams, M., Rupp, A.-K., Macas, J., Starmann, J., Tjwa, M., Plate, K. H., Sültmann, H., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008371 · Cited by 283
Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling
Pasqual, G., Chudnovskiy, A., Tas, J. M. J., Agudelo, M., Schweitzer, L. D., Cui, A., Hacohen, N., & Victora, G. D. (2018) · Nature · doi:10.1038/nature25442 · Cited by 270
Lorenz, R. G., Chaplin, D., McDonald, K. G., McDonough, J. S., & Newberry, R. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5475 · Cited by 273
Boboilă, C., Alt, F. W., & Schwer, B. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00001-6 · Cited by 306
Regulation of Cre recombinase activity by the synthetic steroid RU 486
Kellendonk, C. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.8.1404 · Cited by 273
Hennet, T., Hagen, F. K., Tabak, L. A., & Marth, J. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12070 · Cited by 271
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Cogné, M., Lansford, R. D., Bottaro, A., Zhang, J., Gorman, J. R., Young, F. M., Cheng, H.-L., & Alt, F. W. (1994) · Cell · doi:10.1016/0092-8674(94)90057-4 · Cited by 269
Mutually exclusive expression of odorant receptor transgenes
Serizawa, S., Ishii, T., Nakatani, H., Tsuboi, A., Nagawa, F., Asano, M., Sudo, K., Sakagami, J., Sakano, H., Ijiri, T., et al. (2000) · Nature Neuroscience · doi:10.1038/76641 · Cited by 264
A Dual Role oferbB2in Myelination and in Expansion of the Schwann Cell Precursor Pool
Garratt, A. N., Voiculescu, O., Topilko, P., Charnay, P., & Birchmeier, C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.1035 · Cited by 264
Davenport, T. G., Jerome-Majewska, L. A., & Papaioannou, V. E. (2003) · Development · doi:10.1242/dev.00431 · Cited by 295
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
Chaudhuri, J., Basu, U., Zarrin, A. A., Yan, C. T., Franco, S., Perlot, T., Vuong, B. Q., Wang, J. H., Phan, R. T., Datta, A., et al. (2007) · Advances in immunology · doi:10.1016/s0065-2776(06)94006-1 · Cited by 289
Tarutani, M., Itami, S., Okabe, M., Ikawa, M., Tezuka, T., Yoshikawa, K., Kinoshita, T., & Takeda, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7400 · Cited by 263
Revest, J., Spencer‐Dene, B., Kerr, K., Moerlooze, L. D., Rosewell, I. R., & Dickson, C. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0144 · Cited by 262
The AID enzyme induces class switch recombination in fibroblasts
Okazaki, I., Kinoshita, K., Muramatsu, M., Yoshikawa, K., & Honjo, T. (2002) · Nature · doi:10.1038/nature727 · Cited by 260
A site–directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination
Smith, A. J. H., Sousa, M. A. D., Kwabi‐Addo, B., Heppell-Parton, A. C., Impey, H. L., & Rabbitts, P. H. (1995) · Nature Genetics · doi:10.1038/ng0495-376 · Cited by 254
Switch Transcripts in Immunoglobulin Class Switching
Lorenz, M. G. O., Jung, S., & Radbruch, A. (1995) · Science · doi:10.1126/science.7892607 · Cited by 252
Majeti, R., Xu, Z., Parslow, T. G., Olson, J. L., Daikh, D., Killeen, N. P., & Weiss, A. (2000) · Cell · doi:10.1016/s0092-8674(00)00209-9 · Cited by 250
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Matsuda, J. L., Gapin, L., Baron, J. L., Sidobre, S., Stetson, D. B., Mohrs, M., Locksley, R. M., & Kronenberg, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332805100 · Cited by 248
E-cadherin is a survival factor for the lactating mouse mammary gland
Boussadia, O., Kutsch, S., Hierholzer, A., Delmas, V., & Kemler, R. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00090-4 · Cited by 248
Mutations in the Mu Heavy-Chain Gene in Patients with Agammaglobulinemia
Yel, L., Minegishi, Y., Coustan‐Smith, E., Buckley, R. H., Trübel, H., Pachman, L. M., Kitchingman, G. R., Campana, D., Rohrer, J., & Conley, M. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611143352003 · Cited by 248
Ruuls, S. R., Hoek, R. M., Ngo, V. N., McNeil, T., Lucian, L. A., Janatpour, M. J., Körner, H., Scheerens, H., Hessel, E. M., Cyster, J. G., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00215-1 · Cited by 246
B Cell Development under the Condition of Allelic Inclusion
Sonoda, E., Pewzner‐Jung, Y., Schwers, S., Taki, S., Jung, S., Eilat, D., & Rajewsky, K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80325-8 · Cited by 243
Self-citationDevelopment of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb
Revest, J., Suniara, R. K., Kerr, K., Owen, J. J. T., & Dickson, C. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1954 · Cited by 242
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Setoguchi, R., Tachibana, M., Naoe, Y., Muroi, S., Akiyama, K., Tezuka, C., Okuda, T., & Taniuchi, I. (2008) · Science · doi:10.1126/science.1151844 · Cited by 240
Essential role for the homeoprotein vHNF1/HNF1β in visceral endoderm differentiation
Coffinier, C., Thépot, D., Babinet, C., Yaniv, M., & Barra, J. (1999) · Development · doi:10.1242/dev.126.21.4785 · Cited by 239
Utomo, A. R. H., Nikitin, A. Y., & Lee, W. (1999) · Nature Biotechnology · doi:10.1038/15073 · Cited by 237
Targeting genes for self-excision in the germ linePreprint
Bunting, M., Bernstein, K. E., Greer, J. M., Capecchi, M. R., & Thomas, K. R. (1999) · Genes & Development · doi:10.1101/gad.13.12.1524 · Cited by 234
Hobom, U., Brune, W., Messerle, M., Hahn, G., & Koszinowski, U. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.17.7720-7729.2000 · Cited by 232
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McBride, K. M., Barreto, V. M., Ramiro, A. R., Stavropoulos, P., & Nussenzweig, M. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040373 · Cited by 227
Gene Transpositions in the HoxD Complex Reveal a Hierarchy of Regulatory Controls
van der Hoeven, F., Zákány, J., & Duboule, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81303-3 · Cited by 226
Pfeifer, A., Brandon, E. P., Kootstra, N. A., Gage, F. H., & Verma, I. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201415498 · Cited by 224
Ehrenstein, M. R., O’Keefe, T. L., Davies, S. L., & Neuberger, M. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10089 · Cited by 224
AID Is Essential for Immunoglobulin V Gene Conversion in a Cultured B Cell Line
Harris, R. S., Sale, J. E., Petersen‐Mahrt, S. K., & Neuberger, M. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00717-0 · Cited by 223
Minokoshi, Y., Kahn, C. R., & Kahn, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300019200 · Cited by 224
Betz, U. A. K., Bloch, W., van den Broek, M. F., Yoshida, K., Taga, T., Kishimoto, T., Addicks, K., Rajewsky, K., & Müller, W. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1955 · Cited by 218
Self-citationATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions
Reina‐San‐Martin, B., Chen, H. T., Nussenzweig, A., & Nussenzweig, M. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041162 · Cited by 230
Unutmaz, D., Xiang, W., Sunshine, M. J., Campbell, J., Butcher, E., & Littman, D. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3284 · Cited by 217
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Danbolt, N. C., Furness, D. N., & Zhou, Y. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.05.009 · Cited by 224
The Immunoglobulin Class Switch: Beyond “Accessibility”
Snapper, C. M., Marcu, K. B., & Zelazowski, P. (1997) · Immunity · doi:10.1016/s1074-7613(00)80324-6 · Cited by 213
Bottaro, A., Lansford, R. D., Xu, L., Zhang, J., Rothman, P. B., & Alt, F. W. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06305.x · Cited by 212
Woelbing, F., Kostka, S. L., Moelle, K., Belkaid, Y., Sunderkötter, C. H., Verbeek, S. J., Waisman, A., Nigg, A. P., KNOP, J., Udey, M. C., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052288 · Cited by 211
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Dóka, É., Ida, T., Dagnell, M., Abiko, Y., Luong, N. C., Balog, N., Takata, T., Espinosa, B., Nishimura, A., Cheng, Q., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax8358 · Cited by 214
Lieber, A., He, C. Y., Kirillova, I., & Kay, M. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8944-8960.1996 · Cited by 211
Niewoehner, B., Single, F. N., Hvalby, Ø., Jensen, V., Borgloh, S. M. Z. A., SEEBURG, P. H., Rawlins, J. N. P., Sprengel, R., & Bannerman, D. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05312.x · Cited by 215
Synpolydactyly in mice with a targeted deficiency in the HoxD complex
Zákány, J., & Duboule, D. (1996) · Nature · doi:10.1038/384069a0 · Cited by 209
P0‐Cre Transgenic Mice for Inactivation of Adhesion Molecules in Schwann Cells
Feltri, M. L., D’Antonio, M., Previtali, S. C., Fasolini, M., Messing, A., & Wrabetz, L. G. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08574.x · Cited by 208
Altering mice by homologous recombination using embryonic stem cells.
Bronson, S. K., & Smithies, O. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46959-1 · Cited by 207
Boboilă, C., Janković, M., Yan, C. T., Wang, J. H., Wesemann, D. R., Zhang, T., Fazeli, A., Feldman, L., Nussenzweig, A., Nussenzweig, M. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915067107 · Cited by 206
Function of the TCRα Enhancer in αβ and γδ T Cells
Sleckman, B. P., Bardon, C. G., Ferrini, R., Davidson, L., & Alt, F. W. (1997) · Immunity · doi:10.1016/s1074-7613(00)80372-6 · Cited by 206
Hirrlinger, P. G., Scheller, A., Braun, C., Hirrlinger, J., & Kirchhoff, F. (2006) · Glia · doi:10.1002/glia.20342 · Cited by 200
Nakhai, H., Sel, S., Favor, J., Mendoza-Torres, L., Paulsen, F., Duncker, G. I. W., & Schmid, R. (2007) · Development · doi:10.1242/dev.02781 · Cited by 219
Buchholz, F. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4256 · Cited by 202
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
Constância, M., Dean, W., Lopes, S. M. C. D. S., Moore, T., Kelsey, G., & Reik, W. (2000) · Nature Genetics · doi:10.1038/79930 · Cited by 200
The STAT3 isoforms α and β have unique and specific functions
Maritano, D., Sugrue, M. L., Tininini, S., Dewilde, S., Strobl, B., Fu, X., Murray-Tait, V., Chiarle, R., & Poli, V. (2004) · Nature Immunology · doi:10.1038/ni1052 · Cited by 234
Feng, Y.-Q., Seibler, J., Alami, R., Eisen, A., Westerman, K. A., Leboulch, P., Fiering, S., & Bouhassira, E. E. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3113 · Cited by 197
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Auwerx, J. H., Avner, P. R., Chambon, P., Baldock, R., Davidson, D. R., Hastie, N. D., Jackson, I. J., Ballabio, A., Balling, R., Barbacid, M., et al. (2004) · Nature Genetics · doi:10.1038/ng0904-925 · Cited by 198
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215518 · Cited by 196
Chen, F., & Capecchi, M. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.541 · Cited by 191
Deussing, J. M. (2006) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2006.11.003 · Cited by 197
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Nagaoka, H., Muramatsu, M., Yamamura, N., Kinoshita, K., & Honjo, T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012144 · Cited by 189
Expression and regulation of steroid 5α-reductase in the genital tubercle of the fetal rat
Tian, H., & Russell, D. W. (1997) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199705)209:1 · Cited by 22
Schweizer, U., Gunnersen, J. M., Karch, C., Wiese, S., Holtmann, B., Takeda, K., Akira, S., & Sendtner, M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200107009 · Cited by 186
Anton, M., & Graham, F. L. (1995) · Journal of Virology · doi:10.1128/jvi.69.8.4600-4606.1995 · Cited by 184
Neurotrophin Regulation of the Developing Nervous System: Analyses of Knockout Mice
Conover, J. C., & Yancopoulos, G. D. (1997) · Reviews in the Neurosciences · doi:10.1515/revneuro.1997.8.1.13 · Cited by 184
Bypass of lethality with mosaic mice generated by Cre– loxP -mediated recombination
Betz, U. A. K., Vosshenrich, C. A. J., Rajewsky, K., & Müller, W. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70717-3 · Cited by 184
Self-citationEpner, E., Reik, A., Cimbora, D., Telling, A., Bender, M. A., Fiering, S., Enver, T., Martin, D. I. K., Kennedy, M., Keller, G., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80144-6 · Cited by 183
Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturation
Besseyrias, V., Fiorini, E., Strobl, L. J., Zimber‐Strobl, U., Dumortier, A., Koch, U., Arcangeli, M.-L., Ezine, S., MacDonald, H. R., & Radtke, F. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061442 · Cited by 181
Modulating skeletal muscle mass by postnatal, muscle‐specific inactivation of the myostatin gene
Grobet, L., Pirottin, D., Farnir, F., Poncelet, D. A., Royo, L. J., Brouwers, B., Christians, E., Desmecht, D. J.-M., Coignoul, F., Kahn, R., et al. (2003) · genesis · doi:10.1002/gene.10188 · Cited by 187
In vivo role of the PIF‐binding docking site of PDK1 defined by knock‐in mutation
Collins, B. J., Deak, M., Arthur, J. S. C., Armit, L. J., & Alessi, D. R. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg407 · Cited by 183
Of mice and models: improved animal models for biomedical research
Bockamp, E., Maringer, M., Spangenberg, C., Fees, S. A., Fraser, S. T., Eshkind, L. G., Oesch, F., & Zabel, B. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00067.2002 · Cited by 181
Wunderlich, C. M., Ackermann, P., Ostermann, A. L., Adams‐Quack, P., Vogt, M. C., Tran, M.-L., Nikolajev, A., Waisman, A., Garbers, C., Theurich, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03773-0 · Cited by 178
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.
Bouvier, G., Françoise Watrin, A., Naspetti, M., Verthuy, C., Naquet, P., & Ferrier, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7877 · Cited by 179
Site-specific recombination: developments and applications
Sauer, B. (1994) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(94)90068-x · Cited by 179
Onoyama, I., Tsunematsu, R., Matsumoto, A., Kimura, T., de Alborán, I. M., Nakayama, K., & Nakayama, K. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062299 · Cited by 186
Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
Callahan, C. A., Muralidhar, M. G., Lundgren, S. E., Scully, A. L., & Thomas, J. B. (1995) · Nature · doi:10.1038/376171a0 · Cited by 177
Löffert, D., Ehlich, A., Müller, W., & Rajewsky, K. (1996) · Immunity · doi:10.1016/s1074-7613(00)80678-0 · Cited by 176
Self-citationConditional gene targeting on the pure C57BL/6 genetic background
Mishina, M., & Sakimura, K. (2007) · Neuroscience Research · doi:10.1016/j.neures.2007.01.004 · Cited by 175
Pituitary-Specific Gata2 Knockout: Effects on Gonadotrope and Thyrotrope Function
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Metadata
- Authors
- Gu, H., Zou, Y.-R., & Rajewsky, K.
- Affiliations
- University of Cologne (DE)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 73
- Issue
- 6
- Pages
- 1155-1164
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2053200644
- Cited by
- 989
- References
- 57
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 22 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 17 · 2013: 24 · 2012: 31
- FWCI
- 19.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- switch regions, Cre-loxP recombination, intron enhancer, IGH locus, B cells, lipopolysaccharide, IL-4, DNA double-strand breaks
- MeSH terms
- Animals, Base Sequence, Female, Genes, Immunoglobulin, Genes, Switch, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Molecular Sequence Data, Recombination, Genetic, Tumor Cells, Cultured, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Mice
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