Cited by 2,113Cancer-related Molecular PathwaysDNA Repair MechanismsCell death mechanisms and regulation

The DOI matches its Crossref record; 65 of the 70 references it cites were found in a registry or an index.

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Open access

Deng, Chuxia, Zhang, Pumin, Wade Harper, J., Elledge, Stephen J., Leder, Philip·1995·Cell

Open this paper in CoChat — free account

Abstract

p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21CIP1/WAF1. They develop normally and (unlike p53-/- mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21-/- embryonic fibroblasts are significantly deficient in their ability to arrest in G1 in response to DNA damage and nucleotide pool perturbation. p21-/- cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed in p53-/- cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the anti-apoptotic and the anti-oncogenic effects of p53 are more complex.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(95)90039-x

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864

Show all 70 references

Research works printed but not linked: 3

Jiang, 1994, Induction of differentiation in human promyelocytic HL60 leukemia cells activates p21WAF1/CIP1 expression in the absence of p53, Oncogene, 9, 3397
Steinman, 1994, Induction of p21 (WAFf1CIPl) during differentiation, Oncogene, 9, 3389
Strasser, 1993, Eubcl2 transgene facilitates spontaneaous transformation of early pre-B and Ig secreting cells but not T cells, Oncogene, 8, 1

Sorted by citations

Items 501–600 of 1,008

Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity
Hahm, E., & Singh, S. V. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0217 · Cited by 114
Developmental Activation of the Capability to Undergo Checkpoint-Induced Apoptosis in the Early Zebrafish Embryo
Ikegami, R., Hunter, P., & Yager, T. D. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9243 · Cited by 113
Regulation of MyoD function in the dividing myoblast
Wei, Q., & Paterson, B. M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02120-2 · Cited by 113
Expansion of LTC‐ICs and Maintenance of p21 and BCL‐2 Expression in Cord Blood CD34+/CD38−Early Progenitors Cultured over Human MSCs as a Feeder Layer
Kadereit, S., Deeds, L., Haynesworth, S. E., Koç, O. N., Kozik, M. M., Szekely, E., Daum‐Woods, K., Goetchius, G. W., Fu, P., Welniak, L. A., et al. (2002) · Stem Cells · doi:10.1634/stemcells.20-6-573 · Cited by 113
Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality
Hopkins, K. M., Auerbach, W., Wang, X. Y., Hande, M. P., Hang, H., Wolgemuth, D. J., Joyner, A. L., & Lieberman, H. B. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7235-7248.2004 · Cited by 114
c-Myb is required for progenitor cell homeostasis in colonic crypts
Malaterre, J., Carpinelli, M. R., Ernst, M., Alexander, W. S., Cooke, M. P., Sutton, S. E., Dworkin, S., Heath, J. K., Frampton, J., McArthur, G. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610055104 · Cited by 113
Photodynamic therapy results in induction of WAF1/CIP1/P21 leading to cell cycle arrest and apoptosis
Ahmad, N., Feyes, D. K., Agarwal, R., & Mukhtar, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6977 · Cited by 113
A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis
Elledge, S. J., Winston, J. T., & Harper, J. W. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)10030-1 · Cited by 114
Self-citation
Neither p21WAF1 nor 14-3-3sigma prevents G2 progression to mitotic catastrophe in human colon carcinoma cells after DNA damage, but p21WAF1 induces stable G1 arrest in resulting tetraploid cells.
Andreassen, P. R., Lacroix, F., Lohez, O. D., & Margolis, R. L. (2001) · PubMed · Cited by 113
Deletion of 150 kb in the Minimal Digeorge/Velocardiofacial Syndrome Critical Region in Mouse
Kimber, W. L., Hsieh, P., Hirotsune, S., Yuva‐Paylor, L. A., Sutherland, H. F., Chen, A., Ruiz‐Lozano, P., Hoogstraten-Miller, S. L., Chien, K. R., Paylor, R. E., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.12.2229 · Cited by 113
LncRNA Meg3 protects endothelial function by regulating the DNA damage response
Ali, M. S. S. H., Cheng, X., Moran, M., Haemmig, S., Naldrett, M. J., Alvarez, S., Feinberg, M. W., & Sun, X. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1190 · Cited by 113
Smad pathway‐specific transcriptional regulation of the cell cycle inhibitor p21WAF1/Cip1
Pardali, K., Kowanetz, M., Heldin, C., & Moustakas, A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20304 · Cited by 112
Mécanismes moléculaires contrôlant le cycle cellulaire : aspects fondamentaux et implications en cancérologie
Viallard, J.-F., Lacombe, F., Belloc, F., Pellegrin, J., & Reiffers, J. J. (2001) · Cancer/Radiothérapie · doi:10.1016/s1278-3218(01)00087-7 · Cited by 123
Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
Blagosklonny, M. V., Robey, R. W., Bates, S. E., & Fojo, T. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8625 · Cited by 112
Mutations in the DNA-binding codons of TP53, which are associated with decreased expression of TRAILreceptor-2, predict for poor survival in diffuse large B-cell lymphoma
Young, K. H., Weisenburger, D. D., Davé, B. J., Smith, L. M., Sanger, W. G., Iqbal, J., Campo, E., Delabie, J., Gascoyne, R. D., Ott, G., et al. (2007) · Blood · doi:10.1182/blood-2007-02-072082 · Cited by 111
Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer
Attardi, L. D., de Vries, A., & Jacks, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207026 · Cited by 111
The Cyclin-Dependent Kinase Inhibitor p21 Protects the Lung from Oxidative Stress
O’Reilly, M. A., Staversky, R. J., Watkins, R. H., Reed, C. K., Jensen, K. L. D. M., Finkelstein, J. N., & Keng, P. C. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.6.4355 · Cited by 111
Inhibition of G 1 Cyclin-Dependent Kinase Activity during Growth Arrest of Human Breast Carcinoma Cells by Prostaglandin A 2
Gorospe, M., Liu, Y., Xu, Q., Chrest, F. J., & Holbrook, N. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.762 · Cited by 110
Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control
Pawlyn, C., Bright, M. D., Buros, A. F., Epstein, J., Walters, Z. S., Aronson, L. I., Mirabella, F., Jones, J. R., Kaiser, M., Walker, B. A., et al. (2017) · Blood Cancer Journal · doi:10.1038/bcj.2017.27 · Cited by 110
p21 delays tumor onset by preservation of chromosomal stability
Barboza, J., Liu, G., Ju, Z., El‐Naggar, A. K., & Lozano, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606343104 · Cited by 110
p21 is essential for normal myogenic progenitor cell function in regenerating skeletal muscle
Hawke, T. J., Meeson, A. P., Jiang, N., Graham, S. M., Hutcheson, K. A., DiMaio, J. M., & Garry, D. J. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00055.2003 · Cited by 110
The Molecular Basis of Canine Melanoma: Pathogenesis and Trends in Diagnosis and Therapy
Modiano, J. F., Ritt, M. G., & Wojcieszyn, J. W. (1999) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1999.tb02173.x · Cited by 110
A mouse model for cyclin E-dependent genetic instability and tumorigenesis
Loeb, K. R., Kostner, H., Firpo, E. J., Norwood, T. H., Tsuchiya, K. D., Clurman, B. E., & Roberts, J. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.06.010 · Cited by 109
Rac, membrane heterogeneity, caveolin and regulation of growth by integrins
del Pozo, M. Á., & Schwartz, M. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.03.001 · Cited by 109
Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle
Radhakrishnan, S. K., Feliciano, C. S., Najmabadi, F., Haegebarth, A., Kandel, E., Tyner, A. L., & Gartel, A. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207571 · Cited by 107
A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides
Agarwal, M. L., Agarwal, A. M., Taylor, W. R., Chernova, O. B., Sharma, Y., & Stark, G. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14775 · Cited by 110
HES-1 Repression of Differentiation and Proliferation in PC12 Cells: Role for the Helix 3-Helix 4 Domain in Transcription Repression
Castella, P., Sawai, S., Nakao, K., Wagner, J. A., & Caudy, M. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6170-6183.2000 · Cited by 109
RETRACTED: Growth Retardation, DNA Repair Defects, and Lack of Spermatogenesis in BRCA1-Deficient Mice
Cressman, V. L., Backlund, D. C., Avrutskaya, A. V., Leadon, S. A., Godfrey, V., & Koller, B. H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7061 · Cited by 108
Retracted
C/EBPα Regulates Formation of S-Phase-Specific E2F-p107 Complexes in Livers of Newborn Mice
Timchenko, N. A., Wilde, M., & Darlington, G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2936 · Cited by 106
p53-mediated protective responses to UV irradiation
Smith, M. L., & Fornace, A. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12255 · Cited by 109
p21CIP1 and Cdc25A: Competition between an Inhibitor and an Activator of Cyclin-Dependent Kinases
Saha, P., Eichbaum, Q. G., Silberman, E. D., Mayer, B. J., & Dutta, A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4338 · Cited by 108
Down‐regulation of microRNA 106b is involved in p21‐mediated cell cycle arrest in response to radiation in prostate cancer cells
Li, B., Shi, X.-B., Nori, D., Chao, C., Chen, A. M., Valicenti, R. K., & White, R. D. (2010) · The Prostate · doi:10.1002/pros.21272 · Cited by 110
Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells
Reinacher‐Schick, A. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.443 · Cited by 107
p21Waf1/Cip1 Is an Assembly Factor Required for Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Proliferation
Weiss, R. H., Joo, A., & Randour, C. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10285 · Cited by 107
p21Cip1 and p27Kip1Regulate Cell Cycle Reentry after Hypoxic Stress but Are Not Necessary for Hypoxia-Induced Arrest
Green, S., Freiberg, R. A., & Giaccia, A. J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1196-1206.2001 · Cited by 107
Cell cycle exit during terminal erythroid differentiation is associated with accumulation of p27Kip1 and inactivation of cdk2 kinase
Hsieh, F. F., Barnett, L. A., Green, W. F., Freedman, K. H., Matushansky, I., Skoultchi, A. I., & Kelley, L. L. (2000) · Blood · doi:10.1182/blood.v96.8.2746 · Cited by 107
p53-Dependent Association between Cyclin G and the B′ Subunit of Protein Phosphatase 2A
Okamoto, K., Kamibayashi, C., Serrano, M., Prives, C. L., Mumby, M. C., & Beach, D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6593 · Cited by 107
p57 Kip2 Stabilizes the MyoD Protein by Inhibiting Cyclin E-Cdk2 Kinase Activity in Growing Myoblasts
Reynaud, E. G., Pelpel, K., Guillier, M., Leibovitch, M.-P., & Leibovitch, S. A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7621 · Cited by 105
Double indemnity: p53, BRCA and cancer
Brugarolas, J., & Jacks, T. (1997) · Nature Medicine · doi:10.1038/nm0797-721 · Cited by 106
DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways
Du, F., Sun, L., Chu, Y., Li, T., Lei, C., Wang, X., Jiang, M., Min, Y., Lu, Y., Zhao, X., et al. (2018) · Cancer Communications · doi:10.1186/s40880-018-0315-y · Cited by 103
Stress sensor Gadd45 genes as therapeutic targets in cancer.
Cretu, A., Sha, X., Tront, J. S., Hoffman‐Liebermann, B., & Liebermann, D. A. (2009) · PubMed · Cited by 105
Loss of p53 Induces Tumorigenesis in p21-Deficient Mesenchymal Stem Cells
Rodrı́guez, R., Rubio, R., Masip, M., Catalina, P., Nieto, A., de la Cueva, T., Arriero, M., Martín, N. S., de la Cueva, E., Balomenos, D., et al. (2009) · Neoplasia · doi:10.1593/neo.81620 · Cited by 106
Stabilization of MyoD by Direct Binding to p57Kip2
Reynaud, E. G., Leibovitch, M.-P., Tintignac, L. A. J., Pelpel, K., Guillier, M., & Leibovitch, S. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m907412199 · Cited by 104
p53-Dependent S-Phase Damage Checkpoint and Pronuclear Cross Talk in Mouse Zygotes with X-Irradiated Sperm
Shimura, T., Inoue, M., Taga, M., Shiraishi, K., Uematsu, N., Takei, N., Yuan, Z.-M., Shinohara, T., & Niwa, O. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2220-2228.2002 · Cited by 107
Role of p53 in Apoptosis
Canman, C. E., & Kastan, M. B. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61068-6 · Cited by 106
Definition of the p53 Functional Domains Necessary for Inducing Apoptosis
Zhu, J., Zhang, S., Jiang, J., & Chen, X. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005676200 · Cited by 108
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
Lee, S. W., Li, F., Igarashi, M., Ouchi, T., Lu, K. P., & Aaronson, S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150024397 · Cited by 104
Direct inhibition of G1 cdk kinase activity by MyoD promotes myoblast cell cycle withdrawal and terminal differentiation
Zhang, J., Zhao, X., Wei, Q., & Paterson, B. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.6983 · Cited by 104
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts
Mei, J., Huang, X., & Zhang, P. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00325-6 · Cited by 104
Self-citation
p53-Dependent Elevation of p21 Waf1 Expression by UV Light Is Mediated through mRNA Stabilization and Involves a Vanadate-Sensitive Regulatory System
Gorospe, M., Wang, X., & Holbrook, N. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1400 · Cited by 104
Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo
Phesse, T. J., Myant, K., Cole, A. M., Ridgway, R. A., Pearson, H. B., Muncan, V., BRINK, G. R. V. D., Vousden, K. H., Sears, R. C., Vassilev, L. T., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.15 · Cited by 102
The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation
Li, M., Zhou, J.-Y., Ge, Y., Matherly, L. H., & Wu, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307149200 · Cited by 103
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
Khan, S. H., Moritsugu, J., & Wahl, G. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3266 · Cited by 103
High and low fluences of alpha-particles induce a G1 checkpoint in human diploid fibroblasts.
Azzam, E. I., de Toledo, S. M., Waker, A. J., & Little, J. B. (2000) · PubMed · Cited by 103
Altered expression of cyclin D1 and CDK4 genes in ovarian carcinomas
Masciullo, V., Scambia, G., Marone, M., Giannitelli, C., Ferrandina, G., Bellacosa, A., Panici, P. B., & Mancuso, S. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970822)74:4 · Cited by 72
Involvement of p53 and p21 in Cellular Defects and Tumorigenesis in Atm−/− Mice
Xu, Y., Yang, E. M., Brugarolas, J., Jacks, T., & Baltimore, D. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4385 · Cited by 103
Single-nucleotide Polymorphisms in the p53 Signaling PathwayPreprint
Grochola, L. F., Zeron-Medina, J., Meriaux, S., & Bond, G. L. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001032 · Cited by 105
The Role of the Apoptotic Machinery in Tumor SuppressionPreprint
Delbridge, A. R. D., Valente, L. J., & Strasser, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008789 · Cited by 106
CDK inhibitors, p21Cip1 and p27Kip1, participate in cell cycle exit of mammalian cardiomyocytes
Tane, S., Ikenishi, A., Okayama, H., Iwamoto, N., Nakayama, K. I., & Takeuchi, T. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.109 · Cited by 102
Role of Cyclin B1 Levels in DNA Damage and DNA Damage-Induced Senescence
Nakayama, Y., & Yamaguchi, N. (2013) · International review of cytology · doi:10.1016/b978-0-12-407695-2.00007-x · Cited by 101
Involvement of p21(WAF1/Cip1) and p27(Kip1) in intestinal epithelial cell differentiation
Tian, J. Q., & Quaroni, A. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.6.c1245 · Cited by 102
p21 Cip1 and p27 Kip1 Act in Synergy to Alter the Sensitivity of Naive T Cells to TGF-β-Mediated G1 Arrest through Modulation of IL-2 Responsiveness
Wolfraim, L. A., Walz, T. M., James, Z., Fernandez, T., & Letterio, J. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3093 · Cited by 102
Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo
Mantel, C., Luo, Z., Canfield, J., Braun, S. E., Deng, C., & Broxmeyer, H. (1996) · Blood · doi:10.1182/blood.v88.10.3710.bloodjournal88103710 · Cited by 102
Self-citation
A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster
Li, X. L., Hara, T., Choi, Y., Subramanian, M., Francis, P., Bilke, S., Walker, R. L., Pineda, M. A., Zhu, Y. J., Yang, Y.-A., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01043-13 · Cited by 103
Silymarin and Cancer: A Dual Strategy in Both in Chemoprevention and Chemosensitivity
Delmas, D., Xiao, J., Véjux, A., & Aires, V. (2020) · Molecules · doi:10.3390/molecules25092009 · Cited by 101
The hallmarks of CDKN1C (p57, KIP2) in cancer
Kavanagh, E. T., & Joseph, B. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.03.002 · Cited by 101
Gadd45 in the response of hematopoietic cells to genotoxic stress
Liebermann, D. A., & Hoffman‐Liebermann, B. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.06.006 · Cited by 99
The adult stem cell marker Musashi‐1 modulates endometrial carcinoma cell cycle progression and apoptosis via Notch‐1 and p21WAF1/CIP1
Götte, M., Greve, B., Kelsch, R., Müller‐Uthoff, H., Weiss, K. G., Masouleh, B. K., Sibrowski, W., Kiesel, L., & Buchweitz, O. (2010) · International Journal of Cancer · doi:10.1002/ijc.25856 · Cited by 101
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
Thomas, A., Kelly, G. L., & Strasser, A. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00996-z · Cited by 102
Regulation of p53 Sequence-specific DNA-binding by Covalent Poly(ADP-ribosyl)ation
Mendoza‐Alvarez, H., & Álvarez-González, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105215200 · Cited by 100
DNA damage response of A549 cells treated with particulate matter (PM 10 ) of urban air pollutants
Sánchez-Pérez, Y., Chirino, Y. I., Osornio-Vargas, Á. R., Morales‐Bárcenas, R., Gutiérrez‐Ruíz, M. C., Vázquez‐López, I., & García-Cuellar, C. M. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.01.010 · Cited by 100
Altered Expression of Cell Cycle Proteins and Prolonged Duration of Cardiac Myocyte Hyperplasia in p27 KIP1 Knockout Mice
Poolman, R. A., Li, J., Durand, B., & Brooks, G. (1999) · Circulation Research · doi:10.1161/01.res.85.2.117 · Cited by 100
Natural Compounds with Proteasome Inhibitory Activity for Cancer Prevention and Treatment
Yang, H., Landis‐Piwowar, K. R., Chen, D., Milacic, V., & Dou, Q. P. (2008) · Current Protein and Peptide Science · doi:10.2174/138920308784533998 · Cited by 99
Apoptosis and syncytial fusion in human placental trophoblast and skeletal muscle
Huppertz, B., Tews, D. S., & Kaufmann, P. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)05005-7 · Cited by 100
Molecular pathways of senescence regulate placental structure and function
Gal, H., Lysenko, M., Stroganov, S., Vadai, E., Youssef, S. A., Geffen, K. T., Rotkopf, R., Biron‐Shental, T., de Bruin, A., Neeman, M., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100849 · Cited by 103
Short Chain Fatty Acids and Colon Cancer
Augenlicht, L. H., Mariadason, J. M., Wilson, A., Arango, D., Yang, W., Heerdt, B. G., & Velcich, A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3804s · Cited by 99
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
Zheng, L., Dai, H., Zhou, M., Li, X., Liu, C., Guo, Z., Wu, X., Wu, J., Wang, C., Zhong, J., et al. (2012) · Nature Communications · doi:10.1038/ncomms1825 · Cited by 105
Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by p21
Masgras, I., Carrera, S., de Verdier, P. J., Brennan, P., Majid, A., Makhtar, W. R. W., Tulchinsky, E. M., Jones, G. D. D., Roninson, I. B., & Macip, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.250357 · Cited by 102
Cell death during development
Zakeri, Z. F., & Lockshin, R. A. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00067-4 · Cited by 99
Redox Activation of p21 Cip1/WAF1/Sdi1 : A Multifunctional Regulator of Cell Survival and Death
O’Reilly, M. A. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.108 · Cited by 98
Topographical Association Between the Cyclin-Dependent Kinases Inhibitor P21, p53 Accumulation, and Cellular Proliferation in Human Atherosclerotic Tissue
Ihling, C. H., Menzel, G., Wellens, E., Mönting, J. S., Schaefer, H. E., & Zeiher, A. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2218 · Cited by 99
Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development
Chellappan, S., Giordano, A., & Fisher, P. B. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-71941-7_4 · Cited by 99
Cell-cycle control and renal disease
Shankland, S. J. (1997) · Kidney International · doi:10.1038/ki.1997.335 · Cited by 99
p57Kip2, a Glucocorticoid-Induced Inhibitor of Cell Cycle Progression in HeLa Cells
Samuelsson, M. K. R., Pazirandeh, A., Davani, B., & Okret, S. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.11.0379 · Cited by 98
NF90 Regulates Cell Cycle Exit and Terminal Myogenic Differentiation by Direct Binding to the 3′-Untranslated Region of MyoD and p21WAF1/CIP1 mRNAs
Shi, L., Zhao, G., Qiu, D., Godfrey, W. R., Vogel, H. S., Rando, T. A., Hu, H., & Kao, P. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411034200 · Cited by 98
Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4+ T Cell Responses
Watanabe, M., Moon, K. D., Vacchio, M. S., Hathcock, K. S., & Hodes, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.006 · Cited by 101
The HDAC Inhibitor Trichostatin A Inhibits Growth of Small Cell Lung Cancer Cells
Platta, C. S., Greenblatt, D. Y., Kunnimalaiyaan, M., & Chen, H. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.12.555 · Cited by 98
MCG10, a Novel p53 Target Gene That Encodes a KH Domain RNA-Binding Protein, Is Capable of Inducing Apoptosis and Cell Cycle Arrest in G2-M
Zhu, J., & Chen, X. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5602-5618.2000 · Cited by 99
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis
Philipp, J., Vo, K., Gurley, K. E., Seidel, K. D., & Kemp, C. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202840 · Cited by 98
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis
Raderschall, E., Bazarov, A., Cao, J., Lurz, R., Smith, A., Mann, W., Ropers, H., Sedivy, J. M., Golub, E. I., Fritz, E., et al. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.153 · Cited by 97
Mirk/Dyrk1B Mediates Survival during the Differentiation of C2C12Myoblasts
Mercer, S. E., Ewton, D. Z., Deng, X., Lim, S., Mazur, T. R., & Friedman, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413594200 · Cited by 97
A novel p53‐inducible gene coding for a microtubule‐localized protein with G2‐phase‐specific expression
Utrera, R., Collavin, L., Lazarević, D., Delia, D., & Schneider, C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5015 · Cited by 98
Arresting developments in the cardiac myocyte cell cycle: Role of cyclin-dependent kinase inhibitors
Brooks, G. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00125-4 · Cited by 96
USP19 Deubiquitinating Enzyme Supports Cell Proliferation by Stabilizing KPC1, a Ubiquitin Ligase for p27Kip1
Yu, L., Adegoke, O. A. J., Nepveu, A., Nakayama, K. I., Bedard, N., Cheng, D., Peng, J., & Wing, S. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00329-08 · Cited by 97
Intercellular adhesions as determinants of tissue assembly and malignant invasion
Steinberg, M. S., & Foty, R. A. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199711)173:2 · Cited by 43
Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27 Kip1 and p57 Kip2 during mouse development
Nagahama, H., Hatakeyama, S., Nakayama, K., Nagata, M., Tomita, K., & Nakayama, K. (2001) · Anatomy and Embryology · doi:10.1007/s004290000146 · Cited by 98
Distinct Role of cAMP and cGMP in the Cell Cycle Control of Vascular Smooth Muscle Cells
Fukumoto, S., Koyama, H., Hosoi, M., Yamakawa, K., Tanaka, S., Morii, H., & Nishizawà, Y. (1999) · Circulation Research · doi:10.1161/01.res.85.11.985 · Cited by 97
Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression
Ishimura, A., Minehata, K., Terashima, M., Kondoh, G., Hara, T., & Suzuki, T. (2012) · Development · doi:10.1242/dev.074138 · Cited by 96
A proline-rich motif in p53 is required for transactivation- independent growth arrest as induced by Gas1
Ruaro, E. M., Collavin, L., Sal, G. D., Haffner, R., Oren, M., Levine, A. J., & Schneider, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4675 · Cited by 96
Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation
Katz, S., Lechel, A., Obenauf, A. C., Begus‐Nahrmann, Y., Kraus, J. M., Hoffmann, E. M., Duda, J., Eshraghi, P., Hartmann, D., Liss, B., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.009 · Cited by 96

Authors: Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P.
Affiliations: Baylor College of Medicine (US)
Howard Hughes Medical Institute (US)
ORCID: Zhang, Pumin
Elledge, Stephen J.
Venue: Cell
Publisher: Elsevier BV
Published: 1995-08
Volume: 82
Issue: 4
Pages: 675-684
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(95)90039-x
OpenAlex: W2044057392
Cited by: 2,113
References: 70
Citations by year: 2026: 20 · 2025: 20 · 2024: 32 · 2023: 32 · 2022: 34 · 2021: 40 · 2020: 38 · 2019: 40 · 2018: 43 · 2017: 36 · 2016: 37 · 2015: 34 · 2014: 57 · 2013: 39 · 2012: 65
FWCI: 61.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6560 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute on Aging (AG11085, R01AG011085)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p21, p53, G1/S checkpoint, cyclin-dependent kinase inhibitors, DNA damage response, embryonic fibroblasts, cell growth, thymocyte apoptosis, mitotic spindle checkpoint, tumor suppression
MeSH terms: Animals, Base Sequence, Cell Differentiation, Cell Division, Cell Line, DNA, DNA Damage, Spindle Apparatus, Molecular Sequence Data, Neoplasms, Experimental, Genes, p53, Tumor Suppressor Protein p53, G1 Phase, Cyclins, Apoptosis, Cyclin-Dependent Kinase Inhibitor p21, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks