The DOI matches its Crossref record; 65 of the 70 references it cites were found in a registry or an index.
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Open accessAbstract
p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21CIP1/WAF1. They develop normally and (unlike p53-/- mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21-/- embryonic fibroblasts are significantly deficient in their ability to arrest in G1 in response to DNA damage and nucleotide pool perturbation. p21-/- cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed in p53-/- cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the anti-apoptotic and the anti-oncogenic effects of p53 are more complex.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“p21 is required for p53-mediated G1/S146, 147, 148 and also for G2/M cell cycle arrest.149”
From Census and evaluation of p53 target genes (2017) · cites this paper as [148]
Citations
Cites
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Research works printed but not linked: 3
- Jiang, 1994, Induction of differentiation in human promyelocytic HL60 leukemia cells activates p21WAF1/CIP1 expression in the absence of p53, Oncogene, 9, 3397
- Steinman, 1994, Induction of p21 (WAFf1CIPl) during differentiation, Oncogene, 9, 3389
- Strasser, 1993, Eubcl2 transgene facilitates spontaneaous transformation of early pre-B and Ig secreting cells but not T cells, Oncogene, 8, 1
Cited by
Sorted by citations
Items 101–200 of 1,008
p21 and p27: roles in carcinogenesis and drug resistance
Abukhdeir, A. M., & Park, B. H. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000744 · Cited by 465
High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21 Cip1
Sewing, A., Wiseman, B. S., Lloyd, A. C., & Land, H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5588 · Cited by 457
Maddika, S., Ande, S. R., Panigrahi, S., Paranjothy, T., Węglarczyk, K., Zuse, A., ESHRAGHI, M., Manda, K., Wiecheć, E., & Łoś, M. (2007) · Drug Resistance Updates · doi:10.1016/j.drup.2007.01.003 · Cited by 473
Genetic determinants of p53-induced apoptosis and growth arrest.Preprint
Polyák, K., Waldman, T. A., He, T., Kinzler, K. W., & Vogelstein, B. (1996) · Genes & Development · doi:10.1101/gad.10.15.1945 · Cited by 458
Dimitrova, N., Zamudio, J. R., Jong, R. M., Soukup, D., Resnick, R., Sarma, K., Ward, A. J., Raj, A., Lee, J. T., Sharp, P. A., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.025 · Cited by 445
Bhunia, A. K., Piontek, K., Boletta, A., Liu, L., Qian, F., Xu, P.-N., Germino, F. J., & Germino, G. G. (2002) · Cell · doi:10.1016/s0092-8674(02)00716-x · Cited by 454
Robker, R. L., & Richards, J. S. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.7.0138 · Cited by 453
Roninson, I. B. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00847-3 · Cited by 443
Chen, Q. M., Bartholomew, J. C., Campisi, J., Acosta, M., REAGAN, J. D., & Ames, B. N. (1998) · Biochemical Journal · doi:10.1042/bj3320043 · Cited by 442
Jernvall, J., Åberg, T., Kettunen, P. J., Keränen, S. V. E., & Thesleff, I. (1998) · Development · doi:10.1242/dev.125.2.161 · Cited by 445
Aladjem, M. I., Spike, B. T., Rodewald, L. W., Hope, T. J., Klemm, M., Jaenisch, R., & Wahl, G. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70061-2 · Cited by 453
Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription
Takai, H., Naka, K., Okada, Y., Watanabe, M., Harada, N., Saito, S., Anderson, C. W., Appella, E., Nakanishi, M., Suzuki, H., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf506 · Cited by 441
Rouault, J.-P., Falette, N., Guéhenneux, F., Guillot, C., Rimokh, R., Wang, Q., Berthet, C., Moyret-Lalle, C., Savatier, P., Pain, B., et al. (1996) · Nature Genetics · doi:10.1038/ng1296-482 · Cited by 434
Altered control of cellular proliferation in the absence of mammalian brahma (SNF2α)
Reyes, J. C., Barra, J., Muchardt, C., Camus, A., Babinet, C., & Yaniv, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6979 · Cited by 433
Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Cazzalini, O., Scovassi, A. I., Savio, M., Stivala, L. A., & Prosperi, E. (2010) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2010.01.009 · Cited by 445
DNA damage checkpoints in mammals
Niida, H., & Nakanishi, M. (2005) · Mutagenesis · doi:10.1093/mutage/gei063 · Cited by 447
Smith, M. L., Ford, J. M., Hollander, M. C., Bortnick, R. A., Amundson, S. A., Seo, Y. R., Deng, C., Hanawalt, P. C., & Fornace, A. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3705-3714.2000 · Cited by 438
Self-citationCell-cycle inhibitors: three families united by a common cause
Vidal, A., & Koff, A. (2000) · Gene · doi:10.1016/s0378-1119(00)00092-5 · Cited by 439
Homologous recombinational repair of DNA ensures mammalian chromosome stability
Thompson, L. H., & Schild, D. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00115-4 · Cited by 435
Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1937 · Cited by 426
Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms
Li, N., & Karin, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13012 · Cited by 429
Senescence-associated inflammatory responses: aging and cancer perspectives
Lasry, A., & Ben-Neriah, Y. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.009 · Cited by 408
Mechanism of Action for Leflunomide in Rheumatoid Arthritis
Fox, R. I., Herrmann, M. L., Frangou, C. G., Wahl, G. M., Morris, R. E., Strand, V., & Kirschbaum, B. J. (1999) · Clinical Immunology · doi:10.1006/clim.1999.4777 · Cited by 425
ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53
Tang, D., Wu, D., Hirao, A., Lahti, J. M., Liu, L., Mazza, B., Kidd, V. J., Mak, T. W., & Ingram, A. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111598200 · Cited by 432
Examination of the expanding pathways for the regulation of p21 expression and activity
Jung, Y.-S., Qian, Y., & Chen, X. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.013 · Cited by 428
An overview of Cdk1-controlled targets and processes
Enserink, J. M., & Kolodner, R. D. (2010) · Cell Division · doi:10.1186/1747-1028-5-11 · Cited by 409
Ellisen, L. W., Ramsayer, K. D., Johannessen, C. M., Yang, A., Beppu, H., Minda, K., Oliner, J. D., McKeon, F., & Haber, D. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00706-2 · Cited by 474
Drosophila p53 Is a Structural and Functional Homolog of the Tumor Suppressor p53
Ollmann, M. M., Young, L. M., Como, C. J. D., Karim, F. D., Belvin, M. P., Robertson, S., Whittaker, K. L., Demsky, M., Fisher, W. W., Buchman, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80626-1 · Cited by 420
Franklin, D. S., Godfrey, V., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., & Xiong, Y. (1998) · Genes & Development · doi:10.1101/gad.12.18.2899 · Cited by 409
p21CIP1 and p57KIP2 control muscle differentiation at the myogenin stepPreprint
Zhang, P., Wong, C., Liu, D., Finegold, M. J., Harper, J. W., & Elledge, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.2.213 · Cited by 409
Self-citationHirao, A., Cheung, A., Duncan, G. S., Girard, P.-M., Elia, A., Wakeham, A. C., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.18.6521-6532.2002 · Cited by 410
Self-citationDual roles of ATM in the cellular response to radiation and in cell growth control.Preprint
Xu, Y., & Baltimore, D. (1996) · Genes & Development · doi:10.1101/gad.10.19.2401 · Cited by 407
Cooperative effects of INK4a and ras in melanoma susceptibility in vivoPreprint
Chin, L., Pomerantz, J. H., Polsky, D., Jacobson, M., Cohen, C., Cordon‐Cardo, C., Horner, J. W., & DePinho, R. A. (1997) · Genes & Development · doi:10.1101/gad.11.21.2822 · Cited by 407
Regulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 406
Simonen, M., Pedersen, V., Weinmann, O., Schnell, L., Buss, A., Ledermann, B., Christ, F., Sansig, G., van der Putten, H., & Schwab, M. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00226-5 · Cited by 405
Cdk inhibitors in development and cancer
Harper, J. W., & Elledge, S. J. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)90011-8 · Cited by 402
Self-citationPERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 familyPreprint
Attardi, L. D., Reczek, E. E., Cosmas, C., Demicco, E. G., McCurrach, M. E., Lowe, S. W., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.14.6.704 · Cited by 397
Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
Carreira, S., GOODALL, J. C., Aksan, I., Rocca, S. A. L., Galibert, M., Denat, L., Larue, L., & Goding, C. R. (2005) · Nature · doi:10.1038/nature03269 · Cited by 393
NF-κB and cell-cycle regulation: the cyclin connection
JOYCE, D., ALBANESE, C., Steer, J. H., Fu, M., Bouzahzah, B., & Pestell, R. G. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00018-6 · Cited by 390
The retinoblastoma protein pathway and the restriction point
Bartek, J., Bártková, J., & Lukas, J. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80081-0 · Cited by 390
Cell-cycle arrest versus cell death in cancer therapy
Waldman, T. A., Zhang, Y., Dillehay, L. E., Yu, J., Kinzler, K. W., Vogelstein, B., & Williams, J. (1997) · Nature Medicine · doi:10.1038/nm0997-1034 · Cited by 388
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
Edgar, B. A., & Lehner, C. F. (1996) · Science · doi:10.1126/science.274.5293.1646 · Cited by 390
Chen, B., Yu, P., Chan, W. N., Xie, F., Zhang, Y., Liang, L., Leung, K. T., Lo, K. W., Yu, J., Tse, G. M. K., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01679-y · Cited by 420
Apoptosis in the development and treatment of cancer
Gerl, R. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh283 · Cited by 390
Redox Control of the Cell Cycle in Health and Disease
Sarsour, E. H., Kumar, M. G., Chaudhuri, L., Kalen, A. L., & Goswami, P. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2513 · Cited by 393
Links between Tumor Suppressors
Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., & Piccolo, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00308-8 · Cited by 386
Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence
Macip, S., Igarashi, M., Fang, L., Chen, A., Pan, Z., Lee, S. W., & Aaronson, S. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2180 · Cited by 374
Pestell, R. G., Albanese, C., Reutens, A. T., Segall, J. E., Lee, R. J., & Arnold, A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.4.0373 · Cited by 376
Xu, X., Qiao, W., Linke, S. P., Cao, L., Li, W., Furth, P. A., Harris, C. C., & Deng, C. (2001) · Nature Genetics · doi:10.1038/90108 · Cited by 376
Self-citationSignaling Pathways that Control Cell ProliferationPreprint
Duronio, R. J., & Xiong, Y. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008904 · Cited by 395
Amati, B. B. (1998) · Frontiers in bioscience · doi:10.2741/a239 · Cited by 370
McCurrach, M. E., Connor, T. M. F., Knudson, C. M., Korsmeyer, S. J., & Lowe, S. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2345 · Cited by 368
Kolluri, S. K., Weiss, C., Koff, A., & Göttlicher, M. (1999) · Genes & Development · doi:10.1101/gad.13.13.1742 · Cited by 364
Guidelines for minimal information on cellular senescence experimentation in vivo
Ogrodnik, M., Carlos Acosta, J., Adams, P. D., d’Adda di Fagagna, F., Baker, D. J., Bishop, C. L., Chandra, T., Collado, M., Gil, J., Gorgoulis, V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.059 · Cited by 376
Fifteen-year quest for microphthalmia-associated transcription factor target genes
Chéli, Y., Ohanna, M., Ballotti, R., & Bertolotto, C. (2009) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2009.00653.x · Cited by 362
Galipeau, P. C., Cowan, D., Sanchez, C. A., Barrett, M. T., Emond, M. J., Levine, D. S., Rabinovitch, P. S., & Reid, B. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7081 · Cited by 360
Fredersdorf, S., Burns, J. S., Milne, A. M., Packham, G., Fallis, L., Gillett, C., Royds, J. A., Peston, D., Hall, P. A., Hanby, A. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6380 · Cited by 357
Checking out the G2/M transition
Smits, V. A. J., & Medema, R. H. (2001) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(01)00204-4 · Cited by 359
Stress Signals Utilize Multiple Pathways To Stabilize p53
Ashcroft, M. A., Taya, Y., & Vousden, K. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.3224-3233.2000 · Cited by 360
Zhang, X., Liu, S., Hu, T., Liu, S., He, Y., & Sun, S. (2009) · Hepatology · doi:10.1002/hep.23008 · Cited by 357
Weiss, M. J., Yu, C., & Orkin, S. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1642 · Cited by 349
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.
Martín‐Caballero, J., Flores, J. M., Garcı́a, P., & Serrano, M. (2001) · PubMed · Cited by 352
C/EBPα Arrests Cell Proliferation through Direct Inhibition of Cdk2 and Cdk4
Wang, H., Iakova, P. A., Wilde, M., Welm, A. L., Goode, T., Roesler, W. J., & Timchenko, N. A. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00366-5 · Cited by 354
Nuclear Accumulation of p21 Cip1 at the Onset of Mitosis: a Role at the G 2 /M-Phase Transition
Dulić, V., Stein, G. H., Far, D. F., & Reed, S. I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.546 · Cited by 352
Vairapandi, M., Balliet, A. G., Hoffman‐Liebermann, B., & Liebermann, D. A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10140 · Cited by 343
The role of p53 in chemosensitivity and radiosensitivity
El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206949 · Cited by 337
Jackson, J. G., Pant, V., Li, Q., Chang, L. L., Quintás-Cardama, A., Garza, D., Tavana, O., Yang, P., Manshouri, T., Li, Y., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.027 · Cited by 329
Chinery, R., Brockman, J. A., Peeler, M. O., Shyr, Y., Beauchamp, R. D., & Coffey, R. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1233 · Cited by 334
p53 in signaling checkpoint arrest or apoptosis
Bates, S., & Vousden, K. H. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)90004-0 · Cited by 331
Tumor-Suppressor Functions of the TP53 PathwayPreprint
Aubrey, B. J., Strasser, A., & Kelly, G. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026062 · Cited by 352
The p53 tumor suppressor participates in multiple cell cycle checkpoints
Giono, L. E., & Manfredi, J. J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20689 · Cited by 342
p53, p21, pRB, and p16 Expression Predict Clinical Outcome in Cystectomy With Bladder Cancer
Shariat, S. F., Tokunaga, H., Zhou, J.-H., Kim, J.-H., Ayala, G. E., Benedict, W. F., & Lerner, S. P. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.03.118 · Cited by 329
Dacapo, a Cyclin-Dependent Kinase Inhibitor, Stops Cell Proliferation during Drosophila Development
Lane, M. E., Sauer, K., Wallace, K. N., Jan, Y. N., Lehner, C. F., & Vaessin, H. (1996) · Cell · doi:10.1016/s0092-8674(00)81818-8 · Cited by 327
How does radiation kill cells?
Cohen–Jonathan, E., Bernhard, E. J., & McKenna, W. G. (1999) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(99)80014-3 · Cited by 328
Dent, P., Reardon, D. B., Park, J. S., Bowers, G. D., Logsdon, C. D., Valerie, K. C., & Schmidt‐Ullrich, R. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.8.2493 · Cited by 326
Liu, G., Parant, J. M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A. K., Multani, A., Chang, S., & Lozano, G. (2004) · Nature Genetics · doi:10.1038/ng1282 · Cited by 325
DNA damage checkpoint kinases in cancer
Smith, H. L., Southgate, H. E. D., Tweddle, D. A., & Curtin, N. J. (2020) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2020.3 · Cited by 328
Cell cycle exit upon myogenic differentiation
Walsh, K., & Perlman, H. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80005-6 · Cited by 325
Cyclin-Binding Motifs Are Essential for the Function of p21 CIP1
Chen, J., Saha, P., Kornbluth, S., Dynlacht, B. D., & Dutta, A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4673 · Cited by 320
Macleod, K. F., Hu, Y., & Jacks, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01006.x · Cited by 321
Croix, B. S., Flørenes, V. A., Rak, J. W., Flanagan, M., Bhattacharya, N., Slingerland, J. M., & Kerbel, R. S. (1996) · Nature Medicine · doi:10.1038/nm1196-1204 · Cited by 322
Pattern formation by local self-activation and lateral inhibition
Meinhardt, H., & Gierer, A. (2000) · BioEssays · doi:10.1002/1521-1878(200008)22:8 · Cited by 629
Self-citationde Nooij, J. C., Letendre, M. A., & Hariharan, I. K. (1996) · Cell · doi:10.1016/s0092-8674(00)81819-x · Cited by 318
The Guardian's Little Helper: MicroRNAs in the p53 Tumor Suppressor Network
He, X., He, L., & Hannon, G. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2672 · Cited by 319
E2F Repression by C/EBPα Is Required for Adipogenesis and Granulopoiesis In Vivo
Porse, B. T., Pedersen, T. Å., Xu, X., Lindberg, B. G., Wewer, U. M., Friis-Hansen, L. J., & Nerlov, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00516-5 · Cited by 318
Signal Transduction and Cellular Radiation Responses
Schmidt‐Ullrich, R., Dent, P., Grant, S., Mikkelsen, R. B., & Valerie, K. C. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)153[0245:stacrr]2.0.co;2 · Cited by 311
Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., & Marine, J.-C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5527-5538.2002 · Cited by 313
Negative Regulation of Tumor Suppressor p53 by MicroRNA miR-504
Hu, W., Chan, C. S., Wu, R., Zhang, C., Sun, Y., Song, J. S., Tang, L. H., Levine, A. J., & Feng, Z. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.027 · Cited by 321
Missero, C., Cunto, F. D., Kiyokawa, H., Koff, A., & Dotto, G. P. (1996) · Genes & Development · doi:10.1101/gad.10.23.3065 · Cited by 311
Zhang, P., Wong, C., DePinho, R. A., Harper, J. W., & Elledge, S. J. (1998) · Genes & Development · doi:10.1101/gad.12.20.3162 · Cited by 309
Self-citationUbiquitination of p53 and p21 Is Differentially Affected by Ionizing and UV Radiation
Maki, C. G., & Howley, P. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.355 · Cited by 308
Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1
Herold, S., Wanzel, M., Beuger, V., Frohme, C., Beul, D., Hillukkala, T., Syväoja, J. E., Saluz, H., Haenel, F., & Eilers, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00633-0 · Cited by 305
Mechanisms of p53-mediated apoptosis
Bates, S., & Vousden, K. H. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050267 · Cited by 304
Lebel, M., & Leder, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13097 · Cited by 304
Self-citationZacksenhaus, E., Jiang, Z., Chung, D., Marth, J. D., Phillips, R. A., & Gallie, B. L. (1996) · Genes & Development · doi:10.1101/gad.10.23.3051 · Cited by 302
The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
Kreis, N., Louwen, F., & Yuan, J. (2019) · Cancers · doi:10.3390/cancers11091220 · Cited by 309
Specific loss of apoptotic but not cell‐cycle arrest function in a human tumor derived p53 mutant.
Rowan, S., Ludwig, R., Haupt, Y., Bates, S., Lü, X., Oren, M., & Vousden, K. H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00418.x · Cited by 300
Matsuoka, S., Thompson, J. S., Edwards, M. C., Bartletta, J. M., Grundy, P. E., Kalikin, L. M., Harper, J. W., Elledge, S. J., & Feinberg, A. P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3026 · Cited by 301
Self-citationFoundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
Morgan, S. E., & Kastan, M. B. (1997) · Advances in cancer research · doi:10.1016/s0065-230x(08)60095-0 · Cited by 301
Regulation of Mammalian Tooth Cusp Patterning by Ectodin
Kassai, Y., Munne, P., Hotta, Y., Penttilä, E., Kavanagh, K. D., Ohbayashi, N., Takada, S., Thesleff, I., Jernvall, J., & Itoh, N. (2005) · Science · doi:10.1126/science.1116848 · Cited by 298
Metadata
- Authors
- Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P.
- Affiliations
- Baylor College of Medicine (US)
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 82
- Issue
- 4
- Pages
- 675-684
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2044057392
- Cited by
- 2,113
- References
- 70
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 32 · 2023: 32 · 2022: 34 · 2021: 40 · 2020: 38 · 2019: 40 · 2018: 43 · 2017: 36 · 2016: 37 · 2015: 34 · 2014: 57 · 2013: 39 · 2012: 65
- FWCI
- 61.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Aging (AG11085, R01AG011085)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- p21, p53, G1/S checkpoint, cyclin-dependent kinase inhibitors, DNA damage response, embryonic fibroblasts, cell growth, thymocyte apoptosis, mitotic spindle checkpoint, tumor suppression
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cell Division, Cell Line, DNA, DNA Damage, Spindle Apparatus, Molecular Sequence Data, Neoplasms, Experimental, Genes, p53, Tumor Suppressor Protein p53, G1 Phase, Cyclins, Apoptosis, Cyclin-Dependent Kinase Inhibitor p21, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review