Cited by 2,113Cancer-related Molecular PathwaysDNA Repair MechanismsCell death mechanisms and regulation

The DOI matches its Crossref record; 65 of the 70 references it cites were found in a registry or an index.

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Open access

Deng, Chuxia, Zhang, Pumin, Wade Harper, J., Elledge, Stephen J., Leder, Philip·1995·Cell

Open this paper in CoChat — free account

Abstract

p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21CIP1/WAF1. They develop normally and (unlike p53-/- mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21-/- embryonic fibroblasts are significantly deficient in their ability to arrest in G1 in response to DNA damage and nucleotide pool perturbation. p21-/- cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed in p53-/- cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the anti-apoptotic and the anti-oncogenic effects of p53 are more complex.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(95)90039-x

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864

Show all 70 references

Research works printed but not linked: 3

Jiang, 1994, Induction of differentiation in human promyelocytic HL60 leukemia cells activates p21WAF1/CIP1 expression in the absence of p53, Oncogene, 9, 3397
Steinman, 1994, Induction of p21 (WAFf1CIPl) during differentiation, Oncogene, 9, 3389
Strasser, 1993, Eubcl2 transgene facilitates spontaneaous transformation of early pre-B and Ig secreting cells but not T cells, Oncogene, 8, 1

Sorted by citations

Items 701–800 of 1,008

Heme oxygenase‐1 protects against apoptosis induced by tumor necrosis factor‐α and cycloheximide in papillary thyroid carcinoma cells
Chen, G. Y., Liu, Z. M., Vlantis, A. C., Tse, G. M.-K., Leung, B. C. H., & van Hasselt, C. A. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20157 · Cited by 80
ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development
Shen, K. C., Heng, H. H., Wang, Y., Lu, S., Liu, G., Deng, C., Brooks, S. C., & Wang, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1471 · Cited by 82
Self-citation
Regulation of smooth muscle cell migration and integrin expression by the Gax transcription factor
Witzenbichler, B., Kureishi, Y., Luo, Z., Roux, A. L., Branellec, D., & Walsh, K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7251 · Cited by 80
Overexpression of p21 waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2
de la Fuente, C., Santiago, F., Chong, S. Y., Deng, L., Mayhood, T., Fu, P., Stein, D., Denny, T. N., Coffman, F. D., Azimi, N., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.16.7270-7283.2000 · Cited by 80
WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium.
Lukas, J. L., Groshen, S. G., Saffari, B., Niu, N., Reles, A., Wen, W., Felix, J. C., Jones, L. A., Hall, F. L., & Press, M. F. (1997) · Europe PMC (PubMed Central) · Cited by 80
Cell differentiation and proliferation—simultaneous but independent?
Brown, G., Hughes, P., & Michell, R. H. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00393-8 · Cited by 79
p53 and p21 Determine the Sensitivity of Noscapine-Induced Apoptosis in Colon Cancer Cells
Aneja, R., Ghaleb, A. M., Zhou, J., Yang, V. W., & Joshi, H. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4282 · Cited by 79
Antagonistic pleiotropy and p53
Ungewitter, E. K., & Scrable, H. J. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.06.002 · Cited by 88
Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein
Tokumoto, Y. M., Tang, D. G., & RAFF, M. C. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5261 · Cited by 79
Genetic Cooperation between the Werner Syndrome Protein and Poly(ADP-Ribose) Polymerase-1 in Preventing Chromatid Breaks, Complex Chromosomal Rearrangements, and Cancer in Mice
Lebel, M., Lavoie, J., Gaudreault, I., Bronsard, M., & Drouin, R. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64290-3 · Cited by 79
Tumorigenic activity of p21Waf1/Cip1 in thymic lymphoma
de la Cueva, E., Garcı́a-Cao, I., Herranz, M., López, P., Garcı́a, P., Flores, J. M., Serrano, M., Fernández‐Piqueras, J., & Martín‐Caballero, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209432 · Cited by 77
Cyclin-Dependent Kinase Inhibitor p21 Modulates the DNA Primer-Template Recognition Complex
Waga, S., & Stillman, B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4177 · Cited by 77
Cell cycle proteins in epithelial cell differentiation: Implications for breast cancer
Caldon, C. E., Sutherland, R. L., & Musgrove, E. A. (2010) · Cell Cycle · doi:10.4161/cc.9.10.11474 · Cited by 78
p53 in Tumor Progression: Life, Death, and Everything
Mowat, M. R. A. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60764-2 · Cited by 78
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Hagopian, G. S., Mills, G. B., Khokhar, A. R., Bast, R. C., & Siddik, Z. H. (1999) · PubMed · Cited by 78
Loss of the cell cycle inhibitors p21Cip1 and p27Kip1 enhances tumorigenesis in knockout mouse models
Jackson, R. J., Adnane, J., Coppola, D., Cantor, A. B., Sebti, S. M., & Pledger, W. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205946 · Cited by 77
The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition.
Tong, W., Kiyokawa, H., Soos, T. J., Park, M. S., Soares, V. C., Manova, K., Pollard, J. W., & Koff, A. (1998) · PubMed · Cited by 77
Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation
DeWeese, T. L., Walsh, J. C., Dillehay, L. E., Kessis, T. D., Hedrick, L., Cho, K. R., & Nelson, W. G. (1997) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00448-8 · Cited by 77
Inhibition of Human Umbilical Vein Endothelial Cell Proliferation by the CXC Chemokine, Platelet Factor 4 (PF4), Is Associated With Impaired Downregulation of p21Cip1/WAF1
Gentilini, G., Kirschbaum, N. E., Augustine, J. A., Aster, R. H., & Visentin, G. P. (1999) · Blood · doi:10.1182/blood.v93.1.25 · Cited by 77
p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
Timofeev, O. N., Schlereth, K., Wanzel, M., Braun, A., Nieswandt, B., Pagenstecher, A., Rosenwald, A., Elsässer, H., & Stiewe, T. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.008 · Cited by 82
An Overexpression Screen in Drosophila for Genes That Restrict Growth or Cell-Cycle Progression in the Developing Eye
Tseng, A.-S. K., & Hariharan, I. K. (2002) · Genetics · doi:10.1093/genetics/162.1.229 · Cited by 76
Ki-67 Contributes to Normal Cell Cycle Progression and Inactive X Heterochromatin in p21 Checkpoint-Proficient Human Cells
Sun, X., Bizhanova, A., Matheson, T. D., Yu, J., Zhu, L. J., & Kaufman, P. D. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00569-16 · Cited by 76
Current status of gene therapy for lung cancer and head and neck cancer.
Moon, C., Oh, Y. W., & Roth, J. A. (2003) · PubMed · Cited by 75
The Tal1 Oncoprotein Inhibits E47-mediated Transcription
Park, S. T., & Sun, X.-H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7030 · Cited by 77
What have animal models taught us about the p53 pathway?
Lozano, G., & Zambetti, G. P. (2005) · The Journal of Pathology · doi:10.1002/path.1704 · Cited by 78
Death in the Life of a Tooth
Matalová, E., Tucker, A. S., & Sharpe, P. T. (2004) · Journal of Dental Research · doi:10.1177/154405910408300103 · Cited by 76
Overexpression of c-Myc Alters G 1 /S Arrest following Ionizing Radiation
Sheen, J.-H., & Dickson, R. B. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1819-1833.2002 · Cited by 76
Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells
O’Rourke, D. M., Kao, G. D., Singh, N., Park, B., Muschel, R. J., Wu, C.-J., & Greene, M. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10842 · Cited by 76
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage: version 3
Friedberg, E. C., & Meira, L. B. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00068-8 · Cited by 76
Visualizing the dynamics of p21 Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706949104 · Cited by 73
Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells
Kang, D. Y., Sp, N., Lee, J., & Jang, K. (2021) · Biomedicines · doi:10.3390/biomedicines9030297 · Cited by 75
Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated.
McKenzie, P., Guichard, S. M., Middlemas, D. S., Ashmun, R. A., Danks, M. K., & Harris, L. C. (1999) · PubMed · Cited by 75
Osteoblasts are “educated” by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
Kolb, A. D., Shupp, A. B., Mukhopadhyay, D., Marini, F. C., & Bussard, K. M. (2019) · Breast Cancer Research · doi:10.1186/s13058-019-1117-0 · Cited by 77
Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53
Martinez-Rivera, M., & Siddik, Z. H. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.026 · Cited by 80
Loss of the ssecks/gravin/akap12 Gene Results in Prostatic Hyperplasia
Akakura, S., Changhui, H., Nelson, P. J., Foster, B. A., & Gelman, I. H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5619 · Cited by 74
Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis
Ahmad, I., Patel, R., Liu, Y., Singh, L. B., Taketo, M. M., Wu, X., Leung, H. Y., & Sansom, O. J. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.7 · Cited by 74
p53 Mediates Senescence-Like Arrest Induced by Chronic Replicational Stress
Marusyk, A., Wheeler, L. J., Mathews, C. K., & DeGregori, J. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01316-06 · Cited by 74
Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4
Ding, Q.-M., Ko, T. C., & Evers, B. M. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.5.c1193 · Cited by 74
Sp1 and Sp3 activate p21 (WAF1/CIP1) gene transcription in the Caco-2 colon adenocarcinoma cell line
Gartel, A. L., Goufman, E., Najmabadi, F., & Tyner, A. L. (2000) · Oncogene · doi:10.1038/sj.onc.1203900 · Cited by 74
The p53 tumor suppressor: Critical regulator of life & death in cancer
Fisher, D. E. (2001) · APOPTOSIS · doi:10.1023/a:1009659708549 · Cited by 74
Aberrant Expression of Apoptosis-Related Molecules in Endometriosis: A Possible Mechanism Underlying the Pathogenesis of Endometriosis
Nasu, K., Nishida, M., Kawano, Y., Tsuno, A., Abe, W., Yuge, A., Takai, N., & Narahara, H. (2011) · Reproductive Sciences · doi:10.1177/1933719110392059 · Cited by 73
Understanding the non-canonical pathways involved in p53-mediated tumor suppression
Hager, K. M., & Gu, W. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt487 · Cited by 74
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma
Chen, Q., Cai, D., Li, M., & Wu, X. (2017) · Oncology Reports · doi:10.3892/or.2017.5724 · Cited by 73
Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway
Cheng, L., Zhang, X., Huang, Y., Zhu, Y., Xu, L.-Y., Li, Z., Dai, X., Shi, L., Zhou, S., Wei, J., et al. (2021) · Oncogenesis · doi:10.1038/s41389-020-00290-y · Cited by 73
p27 in Cell Cycle Control and Cancer
Møller, M. B. (2000) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190009053535 · Cited by 76
Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.
Chávez‐Reyes, A., Parant, J. M., Amelse, L. L., Luna, R. M. D. O., Korsmeyer, S. J., & Lozano, G. (2003) · PubMed · Cited by 73
The role of circadian clock genes in tumors
Li, H.-X. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s203144 · Cited by 80
CDKS and CKIS: Molecular targets for tissue remodelling
Nabel, E. G. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd869 · Cited by 73
The molecular control of DNA damage-induced cell death
Coultas, L., & Strasser, A. (2000) · APOPTOSIS · doi:10.1023/a:1009617727938 · Cited by 72
A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1
Rozenfeld-Granot, G., Krishnamurthy, J., Kannan, K., Toren, A., Amariglio, N., Givol, D., & Rechavi, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205218 · Cited by 72
Differential sensitivity of normal and malignant breast epithelial cells to genistein is partly mediated by p21(WAF1).
Upadhyay, S. K., Neburi, M., Chinni, S. R., Alhasan, S., Miller, F. W., & Sarkar, F. H. (2001) · PubMed · Cited by 72
Molecular pathology of primary and metastatic ductal pancreatic lesions
Ruggeri, B., Huang, L., Berger, D., Chang, H., Klein–Szanto, A. J., Goodrow, T. L., Wood, M., Obara, T., Heath, C. W., & Lynch, H. T. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970215)79:4 · Cited by 71
CDKN1A/p21 in Breast Cancer: Part of the Problem, or Part of the Solution?
Manousakis, E., Miralles, C. M., Esquerda, M. G., & Wright, R. H. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417488 · Cited by 73
The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.
Sun, S., Yue, P., Chen, X., Hong, W. K., & Lotan, R. (2002) · PubMed · Cited by 71
SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer
Han, F., Liu, W., JIANG, X. H., Shi, X. A., Yin, L., Ao, L., Cui, Z., Li, Y., Huang, C., Cao, J., et al. (2014) · Oncogene · doi:10.1038/onc.2014.370 · Cited by 71
EGFR, HER-2/neu, Cyclin D1, p21 and p53 in Correlation to Cell Proliferation and Steroid Hormone Receptor Status in Ductal Carcinoma in situ of the Breast
Lebeau, A., Unholzer, A., Amann, G., Kronawitter, M., Bauerfeind, I., Sendelhofert, A., Iff, A., & Löhrs, U. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1023958324448 · Cited by 72
p27Kip1 is an inducer of intestinal epithelial cell differentiation
Quaroni, A., Tian, J. Q., Seth, P. K., & Rhys, C. M. J. A. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.4.c1045 · Cited by 71
Accumulation of recombinant chromosomes and low fidelity of transmission of chromosome X DNA markers in ?-ray-induced lymphomas lacking p53
Koide, N., Matsumoto, Y., Kosugi, S., Chou, D., Sakai∞, K., Hatakeyama, K., Niwa, O., & Kominami, R. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199901)24:1 · Cited by 4
Self-citation
Alterations of INK4A and INK4B Genes in Adult Soft Tissue Sarcomas: Effect on Survival
Orlow, I., Drobnjak, M., Zhang, Z., Lewis, J., Woodruff, J. M., Brennan, M. F., & Cordon‐Cardo, C. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.1.73 · Cited by 69
Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure
Megyesi, J. K., Andrade, L., Vieira, J. M., Safirstein, R. L., & Price, P. M. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00078.2002 · Cited by 71
Different Responses of Epidermal and Hair Follicular Cells to Radiation Correlate with Distinct Patterns of p53 and p21 Induction
Song, S., & Lambert, P. F. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65215-7 · Cited by 71
The p21WAF1/CIP1 Promoter Is Methylated in Rat-1 Cells: Stable Restoration of p53-Dependent p21WAF1/CIP1 Expression after Transfection of a Genomic Clone Containing the p21WAF1/CIP1 Gene
Allan, L. A., Duhig, T., Read, M., & Fried, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1291-1298.2000 · Cited by 71
The proto-oncogene Bcl6 inhibits apoptotic cell death in differentiation-induced mouse myogenic cells
Kumagai, T., Miki, T., Kikuchi, M., Fukuda, T., Miyasaka, N., Kamiyama, R., & Hirosawa, S. (1999) · Oncogene · doi:10.1038/sj.onc.1202306 · Cited by 71
The p53-regulated Cyclin-dependent Kinase Inhibitor, p21 (cip1, waf1, sdi1), Is Not Required for Global Genomic and Transcription-coupled Nucleotide Excision Repair of UV-induced DNA Photoproducts
Adimoolam, S., Lin, C., & Ford, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102240200 · Cited by 71
Functional Versatility of the CDK Inhibitor p57Kip2
Creff, J., & Besson, A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.584590 · Cited by 70
Critical Role for FoxO3a-Dependent Regulation of p21 CIP1/WAF1 in Response to Statin Signaling in Cardiac Myocytes
Hauck, L., Harms, C., Grothe, D., An, J., Gertz, K. R., Kronenberg, G., Dietz, R., Endres, M., & von Harsdorf, R. (2006) · Circulation Research · doi:10.1161/01.res.0000254704.92532.b9 · Cited by 70
p53 Loss Increases the Osteogenic Differentiation of Bone Marrow Stromal Cells
He, Y., de Castro, L. F., Shin, M. H., Dubois, W., Yang, H. H., Jiang, S., Mishra, P. J., Ren, L., Gou, H., Lal, A., et al. (2014) · Stem Cells · doi:10.1002/stem.1925 · Cited by 72
BRCA1-associated tumorigenesis: what have we learned from knockout mice?
Brodie, S. G., & Deng, C. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02451-9 · Cited by 70
Self-citation
Induction of p21 Mediated by Reactive Oxygen Species Formed during the Metabolism of Aziridinylbenzoquinones by HCT116 Cells
Qiu, X., Forman, H. J., Schönthal, A. H., & Cadenas, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31915 · Cited by 70
Loss of CCAAT/enhancer binding protein δ promotes chromosomal instability
Huang, A., Montagna, C., Sharan, S., Ni, Y., Ried, T., & Sterneck, E. (2004) · Oncogene · doi:10.1038/sj.onc.1207285 · Cited by 70
E2F Mediates Sustained G2 Arrest and Down-regulation of Stathmin and AIM-1 Expression in Response to Genotoxic Stress
Polager, S., & Ginsberg, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210327200 · Cited by 70
Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells
Timms, J. F., White, S. L., O’Hare, M. J., & Waterfield, M. D. (2002) · Oncogene · doi:10.1038/sj.onc.1205847 · Cited by 70
Absence of p21 Waf1/Cip1/Sdi1 Modulates Macrophage Differentiation and Inflammatory Response and Protects Against Atherosclerosis
Merched, A. J., & Chan, L. (2004) · Circulation · doi:10.1161/01.cir.0000148681.01282.89 · Cited by 70
Microenvironmental Regulation of Proliferation in Multicellular Spheroids Is Mediated through Differential Expression of Cyclin-Dependent Kinase Inhibitors
LaRue, K. E., Khalil, M., & Freyer, J. P. (2004) · Cancer Research · doi:10.1158/0008-5472.can-2902-2 · Cited by 69
An antisense oligodeoxynucleotide to p21(Waf1/Cip1) causes apoptosis in human breast cancer cells.
Fan, Y., Borowsky, A. D., & Weiss, R. H. (2003) · PubMed · Cited by 68
The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19 ARF
Seavey, S. E., Holubar, M. K., Saucedo, L. J., & Perry, M. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7590-7598.1999 · Cited by 69
Constitutive Expression of the Cyclin-dependent Kinase Inhibitor p21 Is Transcriptionally Regulated by the Tumor Suppressor Protein p53
Tang, H.-Y. J., Zhao, K., Pizzolato, J. F., Fonarev, M., Langer, J., & Manfredi, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29156 · Cited by 70
p53-Dependent Signal Transduction Induced by Stress.
Wang, X., & Ohnishi, T. (1997) · Journal of Radiation Research · doi:10.1269/jrr.38.179 · Cited by 70
Review: The molecular regulation of apoptosis and implications for radiation oncology
K. R. BLANK, M. S. R. (1997) · International Journal of Radiation Biology · doi:10.1080/095530097143789 · Cited by 70
Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network
Derry, W. B., Bierings, R., van Iersel, M., Satkunendran, T., Reinke, V., & Rothman, J. H. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402075 · Cited by 70
Changes in skeletal muscle gene expression following clenbuterol administration
Spurlock, D. M., McDaneld, T. G., & McIntyre, L. M. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-320 · Cited by 69
Coordinated changes in cell cycle machinery occur during keratinocyte terminal differentiation
Martinez, L. A., Chen, Y., Fischer, S. M., & Conti, C. J. (1999) · Oncogene · doi:10.1038/sj.onc.1202300 · Cited by 69
The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis
Kim, Y.-G., Alpers, C. E., Brugarolas, J., Johnson, R. J., Couser, W. G., & Shankland, S. J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00504.x · Cited by 69
Use of Normal and Transgenic Mice to Examine the Relationship between Terminal Differentiation of Intestinal Epithelial Cells and Accumulation of Their Cell Cycle Regulators
Chandrasekaran, C., Coopersmith, C. M., & Gordon, J. I. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.28414 · Cited by 69
Loss of G 1 /S Checkpoint in Human Immunodeficiency Virus Type 1-Infected Cells Is Associated with a Lack of Cyclin-Dependent Kinase Inhibitor p21/Waf1
Clark, E., Santiago, F., Deng, L., Chong, S. Y., de la Fuente, C., Wang, L., Fu, P., Stein, D., Denny, T. N., Lanka, V. K., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.11.5040-5052.2000 · Cited by 68
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis
Carr, M. I., & Jones, S. N. (2016) · Translational Cancer Research · doi:10.21037/tcr.2016.11.75 · Cited by 71
Role of induced genetic instability in the mutagenic effects of chemicals and radiation
Murname, J. P. (1996) · Mutation Research/Genetic Toxicology · doi:10.1016/s0165-1218(96)90017-8 · Cited by 68
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
Lebel, M., Cardiff, R. D., & Leder, P. (2001) · PubMed · Cited by 68
Self-citation
Genotoxic Drugs Induce Interaction of the c-Abl Tyrosine Kinase and the Tumor Suppressor Protein p53
Yuan, Z.-M., Huang, Y., Fan, M.-M., Sawyers, C. L., Kharbanda, S. M., & Kufe, D. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.43.26457 · Cited by 68
Differentiation-Related Changes in the Cell Cycle Traverse
Studzinski, G. P., & Harrison, L. E. (1999) · International review of cytology · doi:10.1016/s0074-7696(08)61384-4 · Cited by 67
The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis
Yonish-Rouach, E. (1996) · Cellular and Molecular Life Sciences · doi:10.1007/bf01920109 · Cited by 68
Induction of apoptotic cell death by phytoestrogens by up-regulating the levels of phospho-p53 and p21 in normal and malignant estrogen receptor α–negative breast cells
Seo, H., Ju, J., Jang, K., & Shin, I. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.01.011 · Cited by 67
p27Kip1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA Damage
Cuadrado, M., Gutierrez‐Martinez, P., Swat, A., Nebreda, Á. R., & Fernández-Capetillo, Ó. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0729 · Cited by 67
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence
Yang, D., McCrann, D. J., Nguyen, H. G., Hilaire, C. S., DePinho, R. A., Jones, M. R., & Ravid, K. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00274.x · Cited by 67
Mediation of Nerve Growth Factor-driven Cell Cycle Arrest in PC12 Cells by p53
Hughes, A. L., Gollapudi, L. A., Sladek, T. L., & Neet, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003146200 · Cited by 67
GADD45A and CDKN1A are involved in apoptosis and cell cycle modulatory effects of viscumTT with further inactivation of the STAT3 pathway
Kleinsimon, S., Longmuss, E., Rolff, J., Jäger, S., Eggert, A., Delebinski, C. I., & Seifert, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-24075-x · Cited by 67
Expression of p27Kip1 in Osteoblast-Like Cells during Differentiation with Parathyroid Hormone
Onishi, T., & Hruska, K. A. (1997) · Endocrinology · doi:10.1210/en.138.5.1995 · Cited by 67
Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells
Yamamoto, H., Soh, J., Shirin, H., Xing, W.-Q., Lim, J. T., Yao, Y., Slosberg, E. D., Tomita, N., Schieren, I., & Weinstein, I. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202269 · Cited by 67
Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites
Kivinen, L., Tsubari, M., Haapajärvi, T., Datto, M., Wang, X.-F., & Laiho, M. (1999) · Oncogene · doi:10.1038/sj.onc.1203000 · Cited by 68
RNA‐binding proteins Rbm38 and Rbm24 regulate myogenic differentiation via p21‐dependent and ‐independent regulatory pathways
Miyamoto, S., Hidaka, K., Jin, D., & Morisaki, T. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01347.x · Cited by 64

Authors: Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P.
Affiliations: Baylor College of Medicine (US)
Howard Hughes Medical Institute (US)
ORCID: Zhang, Pumin
Elledge, Stephen J.
Venue: Cell
Publisher: Elsevier BV
Published: 1995-08
Volume: 82
Issue: 4
Pages: 675-684
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(95)90039-x
OpenAlex: W2044057392
Cited by: 2,113
References: 70
Citations by year: 2026: 20 · 2025: 20 · 2024: 32 · 2023: 32 · 2022: 34 · 2021: 40 · 2020: 38 · 2019: 40 · 2018: 43 · 2017: 36 · 2016: 37 · 2015: 34 · 2014: 57 · 2013: 39 · 2012: 65
FWCI: 61.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6560 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute on Aging (AG11085, R01AG011085)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p21, p53, G1/S checkpoint, cyclin-dependent kinase inhibitors, DNA damage response, embryonic fibroblasts, cell growth, thymocyte apoptosis, mitotic spindle checkpoint, tumor suppression
MeSH terms: Animals, Base Sequence, Cell Differentiation, Cell Division, Cell Line, DNA, DNA Damage, Spindle Apparatus, Molecular Sequence Data, Neoplasms, Experimental, Genes, p53, Tumor Suppressor Protein p53, G1 Phase, Cyclins, Apoptosis, Cyclin-Dependent Kinase Inhibitor p21, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks