Cited by 2,113Cancer-related Molecular PathwaysDNA Repair MechanismsCell death mechanisms and regulation

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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Deng, Chuxia, Zhang, Pumin, Wade Harper, J., Elledge, Stephen J., Leder, Philip·1995·Cell

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Abstract

p21CIP1/WAF1 is a CDK inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21CIP1/WAF1. They develop normally and (unlike p53-/- mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21-/- embryonic fibroblasts are significantly deficient in their ability to arrest in G1 in response to DNA damage and nucleotide pool perturbation. p21-/- cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed in p53-/- cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the anti-apoptotic and the anti-oncogenic effects of p53 are more complex.

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WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
p53 Mutations in Human Cancers
Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864

Show all 70 references

Research works printed but not linked: 3

Jiang, 1994, Induction of differentiation in human promyelocytic HL60 leukemia cells activates p21WAF1/CIP1 expression in the absence of p53, Oncogene, 9, 3397
Steinman, 1994, Induction of p21 (WAFf1CIPl) during differentiation, Oncogene, 9, 3389
Strasser, 1993, Eubcl2 transgene facilitates spontaneaous transformation of early pre-B and Ig secreting cells but not T cells, Oncogene, 8, 1

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Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
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Tumor suppressor p53 and its mutants in cancer metabolism
Liu, J., Zhang, C., Hu, W., & Feng, Z. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.12.025 · Cited by 276
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Minn, A. J., Boise, L., & Thompson, C. B. (1996) · Genes & Development · doi:10.1101/gad.10.20.2621 · Cited by 263
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Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice.
Soonpaa, M. H., Koh, G. Y., Pajak, L., Jing, S., Wang, H., Franklin, M. T., Kim, K. K., & Field, L. J. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119453 · Cited by 253
p53 transcriptional activity is essential for p53‐dependent apoptosis following DNA damage
Chao, C., Saito, S., Kang, J., Anderson, C. W., Appella, E., & Xu, Y. (2000) · The EMBO Journal · doi:10.1093/emboj/19.18.4967 · Cited by 260
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Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis.
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Dutto, I., Tillhon, M., Cazzalini, O., Stivala, L. A., & Prosperi, E. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1430-4 · Cited by 242
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis
Zhang, Y., Fujita, N., & Tsuruo, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202426 · Cited by 238
p21Waf1/Cip1 as a therapeutic target in breast and other cancers
Weiss, R. H. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00308-8 · Cited by 232
Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.
Wu, H., Wade, M., Krall, L., Grisham, J., Xiong, Y., & Van Dyke, T. (1996) · Genes & Development · doi:10.1101/gad.10.3.245 · Cited by 234
Regulation of CDK/cyclin complexes during the cell cycle
Arellano, M., & Moreno, S. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00178-1 · Cited by 240
Hormonal Control of the Cell Cycle in Ovarian Cells: Proliferation Versus Differentiation
Robker, R. L., & Richards, J. S. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.3.476 · Cited by 236
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways
Weng, L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.3.237 · Cited by 234
Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death
Sandig, V., Brand, K., Herwig, S., Lukas, J., Bartek, J., & Strauss, M. (1997) · Nature Medicine · doi:10.1038/nm0397-313 · Cited by 232
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Stepniak, E., Ricci, R., Eferl, R., Sumara, G., Sumara, I., Rath, M., Hui, L., & Wagner, E. F. (2006) · Genes & Development · doi:10.1101/gad.390506 · Cited by 232
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Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis
Wilting, R. H., Yanover, E., Heideman, M. R., Jacobs, H., Horner, J. W., van der Torre, J., DePinho, R. A., & Dannenberg, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.136 · Cited by 229
Deconstructing networks of p53-mediated tumor suppression in vivo
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The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth
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Clinical implications of p53 mutations
Wallace-Brodeur, R. R., & Lowe, S. W. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050270 · Cited by 226
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Transcriptional Activation of the p21 Gene by Interleukin-6 Type Cytokines
Bellido, T., O’Brien, C. A., Roberson, P. K., & Manolagas, S. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21137 · Cited by 224
Cooperating oncogenes converge to regulate cyclin/cdk complexes.Preprint
Lloyd, A. C., Obermüller, F., Staddon, S., Barth, C. F., McMahon, M., & Land, H. (1997) · Genes & Development · doi:10.1101/gad.11.5.663 · Cited by 224
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1
Martín, A., Odajima, J., Hunt, S. L., Dubus, P. R., Ortega, S., Malumbres, M., & Barbacid, M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.006 · Cited by 223
The Cyclin-Dependent Kinase Inhibitor p21 WAF1 Is Required for Survival of Differentiating Neuroblastoma Cells
Poluha, W., Poluha, D. K., Chang, B. B., Crosbie, N. E., Schonhoff, C. M., Kilpatrick, D. L., & Ross, A. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1335 · Cited by 222
Wild-type p53 negatively regulates the expression of a microtubule-associated protein.Preprint
Murphy, M. E., Hinman, A. M., & Levine, A. J. (1996) · Genes & Development · doi:10.1101/gad.10.23.2971 · Cited by 221
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Labuschagne, C. F., Zani, F., & Vousden, K. H. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.001 · Cited by 227
Differential expression and regulation of chemokines JE, KC, and IP-10 gene in primary cultured murine hepatocytes
Wang, H., Gao, X., Fukumoto, S., Tademoto, S., Sato, K., & Hirai, K. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199911)181:2 · Cited by 45
A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.
Li, C.-L., Chen, L., Iwata, T., Kitagawa, M., Fu, X.-Y., & Deng, C.-X. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.1.35 · Cited by 227
Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis
Kennedy, A. L., Morton, J. P., Manoharan, I., Nelson, D. M., Jamieson, N. B., Pawlikowski, J. S., McBryan, T., Doyle, B., McKay, C., Oien, K. A., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.020 · Cited by 213
Role for c-Abl tyrosine kinase in growth arrest response to DNA damage
Yuan, Z.-M., Huang, Y., Whang, Y. E., Sawyers, C. L., Weichselbaum, R. R., Kharbanda, S. M., & Kufe, D. W. (1996) · Nature · doi:10.1038/382272a0 · Cited by 216
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
Lin, A. W., & Lowe, S. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091100298 · Cited by 215
The primate cranial base: Ontogeny, function, and integration
Lieberman, D. E., Ross, C. F., & Ravosa, M. J. (2000) · American Journal of Physical Anthropology · doi:10.1002/1096-8644(2000)43:31+ · Cited by 535
p53; from inductive signal to cellular effect
Hansen, R., & Oren, M. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80108-6 · Cited by 213
A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos.
Iwata, T., Chen, L., Li, C.-L., Ovchinnikov, D., Behringer, R., Francomano, C., & Deng, C.-X. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.11.1603 · Cited by 217
Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence
Fletcher-Sananikone, E., Kanji, S., Tomimatsu, N., Di Cristofaro, L. F. M., Kollipara, R. K., Saha, D., Floyd, J. R., Sung, P., Hromas, R., Burns, T. C., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-0752 · Cited by 212
Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis
Gervais, J., Seth, P. K., & Zhang, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.19207 · Cited by 212
Expression of BRC Repeats in Breast Cancer Cells Disrupts the BRCA2-Rad51 Complex and Leads to Radiation Hypersensitivity and Loss of G2/M Checkpoint Control
Chen, C.-F., Chen, P.-L., Zhong, Q., Sharp, Z. D., & Lee, W.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.32931 · Cited by 207
Competing memories of mitogen and p53 signalling control cell-cycle entry
Yang, H. W., Chung, M., Kudo, T., & Meyer, T. (2017) · Nature · doi:10.1038/nature23880 · Cited by 211
Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification
Majid, S., Kikuno, N., Nelles, J. L., Noonan, E. J., Tanaka, Y., Kawamoto, K., Hirata, H., Li, L. C., Zhao, H., Okino, S. T., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2290 · Cited by 209
p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53
Li, F., Igarashi, M., Leung, J., Sugrue, M. M., Lee, S. W., & Aaronson, S. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202615 · Cited by 213
A reassessment of the telomere hypothesis of senescence
Reddel, R. R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199812)20:12 · Cited by 65
Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor
El-Abaseri, T. B., Putta, S. K., & Hansen, L. A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi220 · Cited by 209
p53‐inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG‐1
Matsuzawa, S., Takayama, S., Froesch, B. A., Zapata, J. M., & Reed, J. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.10.2736 · Cited by 203
Size Control: The Regulation of Cell Numbers in Animal Development
RAFF, M. C. (1996) · Cell · doi:10.1016/s0092-8674(00)80087-2 · Cited by 203
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.
Pantoja, C., & Serrano, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202880 · Cited by 201
Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation
Kim, J., Yu, L., Chen, W., Xu, Y., Wu, M., Todorova, D., Tang, Q., Feng, B., Jiang, L., Chen, G., et al. (2019) · Cancer Cell · doi:10.1016/j.ccell.2018.12.012 · Cited by 205
p53 Signaling and Cell Cycle Checkpoints
Stewart, Z. A., & Pietenpol, J. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000199t · Cited by 204
The GADD45 Inhibition of Cdc2 Kinase Correlates with GADD45-mediated Growth Suppression
Jin, S., Antinore, M. J., Lung, F. T., Dong, X. Z., Zhao, H., Fan, F., Colchagie, A. B., Blanck, P., Roller, P. P., Fornace, A. J., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000284200 · Cited by 202
The cytostatic function of c‐Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products.
Wen, S.-T., Jackson, P. K., & Etten, R. A. V. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00503.x · Cited by 199
Silymarin and silibinin cause G1 and G2–M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin
Deep, G., Singh, R. P., Agarwal, C., Kroll, D. J., & Agarwal, R. (2005) · Oncogene · doi:10.1038/sj.onc.1209146 · Cited by 197
Intact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197
Life (and death) in a malignant tumour
Kinzler, K. W., & Vogelstein, B. (1996) · Nature · doi:10.1038/379019a0 · Cited by 197

Authors: Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P.
Affiliations: Baylor College of Medicine (US)
Howard Hughes Medical Institute (US)
ORCID: Zhang, Pumin
Elledge, Stephen J.
Venue: Cell
Publisher: Elsevier BV
Published: 1995-08
Volume: 82
Issue: 4
Pages: 675-684
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(95)90039-x
OpenAlex: W2044057392
Cited by: 2,113
References: 70
Citations by year: 2026: 20 · 2025: 20 · 2024: 32 · 2023: 32 · 2022: 34 · 2021: 40 · 2020: 38 · 2019: 40 · 2018: 43 · 2017: 36 · 2016: 37 · 2015: 34 · 2014: 57 · 2013: 39 · 2012: 65
FWCI: 61.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6560 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute on Aging (AG11085, R01AG011085)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: p21, p53, G1/S checkpoint, cyclin-dependent kinase inhibitors, DNA damage response, embryonic fibroblasts, cell growth, thymocyte apoptosis, mitotic spindle checkpoint, tumor suppression
MeSH terms: Animals, Base Sequence, Cell Differentiation, Cell Division, Cell Line, DNA, DNA Damage, Spindle Apparatus, Molecular Sequence Data, Neoplasms, Experimental, Genes, p53, Tumor Suppressor Protein p53, G1 Phase, Cyclins, Apoptosis, Cyclin-Dependent Kinase Inhibitor p21, Mice

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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