Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

WAF1, a potential mediator of p53 tumor suppression

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321

p53 Mutations in Human Cancers

Hollstein, M., Sidransky, D., Vogelstein, B., & Harris, C. C. (1991) · Science · doi:10.1126/science.1905840 · Cited by 8,018

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063

Participation of p53 protein in the cellular response to DNA damage.

Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761

p21 is a universal inhibitor of cyclin kinases

Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691

Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint

Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,242

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864

Tumor Suppressor Activity of AP2α Mediated through a Direct Interaction with p53

McPherson, L. A., Loktev, A. V., & Weigel, R. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208924200 · Cited by 95

Expression of p21Cip1/Waf1/Sdi1 and p27Kip1Cyclin-Dependent Kinase Inhibitors During Human Hematopoiesis

Taniguchi, T., Endo, H., Chikatsu, N., Uchimaru, K., Asano, S., Fujita, T., Nakahata, T., & Motokura, T. (1999) · Blood · doi:10.1182/blood.v93.12.4167 · Cited by 96

Circadian regulation of cell cycle: Molecular connections between aging and the circadian clock

Khapre, R. V., Samsa, W. E., & Kondratov, R. V. (2010) · Annals of Medicine · doi:10.3109/07853890.2010.499134 · Cited by 96

Uncoupling Cancer Mutations Reveals Critical Timing of p53 Loss in Sarcomagenesis

Young, N. P., Crowley, D. G., & Jacks, T. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4563 · Cited by 91

Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle, and specific-related mortality of transformed cells.

Trielli, M. O., Andreassen, P. R., Lacroix, F., & Margolis, R. L. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.3.689 · Cited by 93

An overview of the cell cycle arrest protein, p21WAF1

Harada, K., & Ogden, G. R. (2000) · Oral Oncology · doi:10.1016/s1368-8375(99)00049-4 · Cited by 94

Cell-Cycle Inhibitors p27Kip1 and p21Cip1 Regulate Murine Sertoli Cell Proliferation1

Holsberger, D. R., Buchold, G. M., Leal, M. C., Kiesewetter, S. E., O’Brien, D. A., Hess, R. A., França, L. R., Kiyokawa, H., & Cooke, P. S. (2005) · Biology of Reproduction · doi:10.1095/biolreprod.105.040386 · Cited by 94

Antiproliferative B cell translocation gene 2 protein is down-regulated post-transcriptionally as an early event in prostate carcinogenesis

Ficazzola, M. (2001) · Carcinogenesis · doi:10.1093/carcin/22.8.1271 · Cited by 93

Radiation and the G 2 Phase of the Cell Cycle

Hwang, A., & Muschel, R. J. (1998) · Radiation Research · doi:10.2307/3579808 · Cited by 94

Early Increase in Cyclin-D1 Expression and Accelerated Entry of Mouse Hepatocytes into S Phase after Administration of the Mitogen 1,4-Bis[2-(3,5-Dichloropyridyloxy)] Benzene

Ledda-Columbano, G. M., Pibiri, M., Loi, R., Perra, A., Shinozuka, H., & Columbano, A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64709-8 · Cited by 94

Ubiquitin, E6-AP, and Their Role in p53 Inactivation

Scheffner, M. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00003-5 · Cited by 93

Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

Yao, H., Yang, S., Edirisinghe, I., Rajendrasozhan, S., Caito, S. W., Adenuga, D., O’Reilly, M. A., & Rahman, I. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0342oc · Cited by 96

Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb

Chau, B. N., Borges, H. L., Chen, T.-T., Masselli, A., Hunton, I. C., & Wang, J. Y. J. (2002) · Nature Cell Biology · doi:10.1038/ncb853 · Cited by 93

The p53 circuit board

Sullivan, K. D., Gallant‐Behm, C. L., Henry, R. E., Fraikin, J.-L., & Espinosa, J. M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.01.004 · Cited by 96

How the Other Half Lives: What p53 Does When It Is Not Being a Transcription Factor

Ho, T., Tan, B. X., & Lane, D. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010013 · Cited by 92

c-Jun NH2-Terminal Kinase 1 Plays a Critical Role in Intestinal Homeostasis and Tumor Suppression

Tong, C., Yin, Z., Song, Z., Dockendorff, A., Huang, C., Mariadason, J. M., Flavell, R. A., Davis, R. J., Augenlicht, L. H., & Yang, W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061036 · Cited by 92

A function of p21 during promyelocytic leukemia cell differentiation independent of CDK inhibition and cell cycle arrest

Casini, T., & Pelicci, P. G. (1999) · Oncogene · doi:10.1038/sj.onc.1202630 · Cited by 92

Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon

Poole, A. J., Heap, D., Carroll, R. E., & Tyner, A. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207994 · Cited by 90

Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control

Takahashi, A., Ohtani, N., & Hara, E. (2007) · Cell Division · doi:10.1186/1747-1028-2-10 · Cited by 101

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

Adnane, J., Jackson, R. J., Nicosia, S. V., Cantor, A. B., Pledger, W. J., & Sebti, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203956 · Cited by 91

Up-regulation of p27Kip1, p21WAF1/Cip1 and p16Ink4a is associated with, but not sufficient for, induction of squamous differentiation

Harvat, B. L., Wang, A., Seth, P. K., & Jetten, A. M. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.9.1185 · Cited by 91

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells

Wei, H.-J., Nickoloff, J. A., Chen, W.-H., Liu, H., Lo, W., Chang, Y.-T., Yang, P., Wu, C., Williams, D. F., Gelovani, J. G., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2413 · Cited by 87

Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits Smooth Muscle Cell Proliferation via Induction of p21WAF1

Okamoto, H., Fujioka, Y., Takahashi, A., Takahashi, T., Taniguchi, T., Ishikawa, Y., & Yokoyama, M. (2006) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.13.183 · Cited by 90

Cell‐cycle control and the cartilage growth plate

Beier, F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20111 · Cited by 90

The Raf-1/MEK/ERK Pathway Regulates the Expression of the p21Cip1/Waf1 Gene in Chondrocytes

Beier, F., Taylor, A. C., & Luvalle, P. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30273 · Cited by 90

Cellular Apoptosis and Organ Injury in Sepsis: A Review

Power, C. P., Fanning, N. F., & Redmond, H. P. (2002) · Shock · doi:10.1097/00024382-200209000-00001 · Cited by 90

Loss of p27Kip1 but not p21Cip1 decreases survival and synergizes with MYC in murine lymphomagenesis

Martins, C. P., & Berns, A. J. M. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf364 · Cited by 90

Cerebellar granule cells: Insights into proliferation, differentiation, and role in medulloblastoma pathogenesis

Behesti, H., & Marino, S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.017 · Cited by 89

Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde

Ji, C. (1998) · Carcinogenesis · doi:10.1093/carcin/19.7.1275 · Cited by 90

Evaluation of -Cell Replication in Mice Transgenic for Hepatocyte Growth Factor and Placental Lactogen: Comprehensive Characterization of the G1/S Regulatory Proteins Reveals Unique Involvement of p21cip

Cózar‐Castellano, I., Weinstock, M. T., Haught, M., Velázquez-García, S., Sipula, D., & Stewart, A. F. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0632 · Cited by 90

Long noncoding RNAs in the p53 network

Chaudhary, R., & Lal, A. (2016) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1410 · Cited by 88

Apoptosis of Late-Stage Erythroblasts in Megaloblastic Anemia: Association With DNA Damage and Macrocyte Production

Koury, M. J., Horne, D. W., Brown, Z. A., Pietenpol, J. A., Blount, B. C., Ames, B. N., Hard, R., & Koury, S. T. (1997) · Blood · doi:10.1182/blood.v89.12.4617 · Cited by 88

Apoptosis and the cell cycle

Fotedar, R., Diederich, L., & Fotedar, A. (1996) · Springer eBooks · doi:10.1007/978-1-4615-5873-6_15 · Cited by 91

p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest

Flatt, P. M., Polyák, K., Tang, L. J., Scatena, C. D., Westfall, M. D., Rubinstein, L. A., Yu, J., Kinzler, K. W., Vogelstein, B., Hill, D. E., et al. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00441-9 · Cited by 89

Dissociation of the recombination control and the sequence-specific transactivation function of P53

Dudenhöffer, C., Kurth, M., Janus, F., Deppert, W., & Wiesmüller, L. (1999) · Oncogene · doi:10.1038/sj.onc.1202964 · Cited by 89

Common Fragile Sites: Genomic Hotspots of DNA Damage and Carcinogenesis

Ma, K., Qiu, L., Mrasek, K., Zhang, J., Liehr, T., Quintana, L. G., & Li, Z. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911974 · Cited by 86

NAD+ Modulates p53 DNA Binding Specificity and Function

McLure, K. G., Takagi, M., & Kastan, M. B. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9958-9967.2004 · Cited by 89

AMPK inhibits myoblast differentiation through a PGC-1α-dependent mechanism

Williamson, D. L., Butler, D. C., & Alway, S. E. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91007.2008 · Cited by 91

The Protein SET Regulates the Inhibitory Effect of p21Cip1 on Cyclin E-Cyclin-dependent Kinase 2 Activity

Estanyol, J. M., Jaumot, M., Casanovas, O., Rodrı́guez-Vilarrupla, A., Agell, N., & Bachs, O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33161 · Cited by 88

The cyclin-dependent kinase inhibitor p57Kip2 mediates proliferative actions of PTHrP in chondrocytes

MacLean, H. E., Guo, J., Knight, M. C., Zhang, P., Cobrinik, D. E., & Kronenberg, H. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21252 · Cited by 88

Interleukin-6 Overcomes p21WAF1 Upregulation and G1 Growth Arrest Induced by Dexamethasone and Interferon-γ in Multiple Myeloma Cells

Urashima, M., Teoh, G., Chauhan, D., Hoshi, Y., Ogata, A., Treon, S. P., Schlossman, R. L., & Anderson, K. C. (1997) · Blood · doi:10.1182/blood.v90.1.279 · Cited by 88

Genetic Evidence for the Interactions of Cyclin D1 and p27Kip1 in Mice

Tong, W., & Pollard, J. W. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1319-1328.2001 · Cited by 88

CDK4: a master regulator of the cell cycle and its role in cancer

Baker, S. J., Poulikakos, P. I., Irie, H. Y., Parekh, S. S., & Reddy, E. P. (2022) · Genes & Cancer · doi:10.18632/genesandcancer.221 · Cited by 84

SENSITIVITY OF HUMAN PROSTATIC CARCINOMA CELL LINES TO LOW DOSE RATE RADIATION EXPOSURE

DeWeese, T. L., Shipman, J. M., Dillehay, L. E., & Nelson, W. G. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)63990-9 · Cited by 87

Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and -independent pathways

Fukuda, S., Mantel, C., & Pelus, L. M. (2003) · Blood · doi:10.1182/blood-2003-05-1756 · Cited by 89

Specific binding of protein kinase CK2 catalytic subunits to tubulin

Faust, M., Schuster, N., & Montenarh, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01492-1 · Cited by 87

Sp1 Inhibits Proliferation and Induces Apoptosis in Vascular Smooth Muscle Cells by Repressing p21WAF1/Cip1 Transcription and Cyclin D1-Cdk4-p21WAF1/Cip1 Complex Formation

Kavurma, M. M., & Khachigian, L. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305650200 · Cited by 87

Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy

Ullah, Z., Lee, C. Y., & Depamphilis, M. (2009) · Cell Division · doi:10.1186/1747-1028-4-10 · Cited by 87

The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy

Rupnow, B. A., & Knox, S. J. (1999) · APOPTOSIS · doi:10.1023/a:1009675028784 · Cited by 86

Features of replicative senescence induced by direct addition of antennapedia‐p16INK4A fusion protein to human diploid fibroblasts

Kato, D., Miyazawa, K., Ruas, M., Starborg, M., Wada, I., Oka, T., Sakai, T., Peters, G. G., & Hara, E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00426-8 · Cited by 89

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2

Jones, S. N., Sands, A., Hancock, A. R., Vogel, H. S., Donehower, L. A., Linke, S. P., Wahl, G. M., & Bradley, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14106 · Cited by 87

miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress

Lezina, L., Purmessur, N. S., Antonov, A. V., Ivanova, T., Karpova, E., Kumar, K., Ivan, M., Aksenova, V., Tentler, D., Garabadgiu, A. V., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.483 · Cited by 90

ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest

Todd, D. E., Densham, R. M., Molton, S. A., Balmanno, K., Newson, C., Weston, C. R., Garner, A. P., Scott, L. A., & Cook, S. J. (2004) · Oncogene · doi:10.1038/sj.onc.1207467 · Cited by 86

p53 Promotes Cell Survival due to the Reversibility of Its Cell-Cycle Checkpoints

Lukin, D. J., Carvajal, L. A., Liu, W.-J., Resnick‐Silverman, L., & Manfredi, J. J. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0177 · Cited by 86

Duplication of ATR inhibits MyoD, induces aneuploidy and eliminates radiation-induced G1 arrest

Smith, L. G., Liu, S. J., Goodrich, L., Jacobson, D. A., Degnin, C., Bentley, N., Carr, A. M., Flaggs, G., Keegan, K. S., Hoekstra, M. F., et al. (1998) · Nature Genetics · doi:10.1038/ng0598-39 · Cited by 86

C/EBPα triggers proteasome‐dependent degradation of cdk4 during growth arrest

Wang, H., Goode, T., Iakova, P. A., Albrecht, J. H., & Timchenko, N. A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.5.930 · Cited by 85

Posttranscriptional regulation of p21WAF1/CIP1 expression in human breast carcinoma cells.

Li, X. S., Rishi, A. K., Shao, Z. M., Dawson, M. I., Jong, L., Shroot, B., Reichert, U., Ordóñez, J. V., & Fontana, J. A. (1996) · PubMed · Cited by 85

Normal Development of Mice Lacking Metablastin (P19), a Phosphoprotein Implicated in Cell Cycle Regulation

Schubart, U. K., Yu, J., Amat, J., WANG, Z. Q., Hoffmann, M. K., & Edelmann, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14062 · Cited by 85

p21Cip1 and p27Kip1 Induce Distinct Cell Cycle Effects and Differentiation Programs in Myeloid Leukemia Cells

Muñoz-Alonso, M. J., Acosta, J. C., Richard, C., Delgado, M. D., Sedivy, J. M., & León, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500758200 · Cited by 85

Cell cycle profiles and expressions of p21CIP1 and p27KIP1 during myocyte development

Poolman, R. A., Gilchrist, R., & Brooks, G. (1998) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00320-9 · Cited by 85

Beyond the cell cycle: A new role for Cdk6 in differentiation

Grossel, M. J., & Hinds, P. W. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20712 · Cited by 84

Role of the RB Tumor Suppressor in Cancer

Yamasaki, L. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48158-8_9 · Cited by 88

A Multistep Model for Paclitaxel-Induced Apoptosis in Human Breast Cancer Cell Lines

Blajeski, A. L., Kottke, T. J., & Kaufmann, S. H. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5349 · Cited by 84

Myeloid Differentiation (MyD)/Growth Arrest DNA Damage (GADD) genes in tumor suppression, immunity and inflammation

Liebermann, D. A., & Hoffman‐Liebermann, B. (2002) · Leukemia · doi:10.1038/sj.leu.2402477 · Cited by 83

Can the cardiomyocyte cell cycle be reprogrammed?

Bicknell, K. A., Coxon, C. H., & Brooks, G. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.01.006 · Cited by 84

Killin is a p53-regulated nuclear inhibitor of DNA synthesis

Cho, Y., & Liang, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705410105 · Cited by 84

Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells

Cho, J.-H., Lee, J.-G., Yang, Y., Kim, J., Ahn, J., Baek, N., Lee, K., & Choi, J. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.04.019 · Cited by 85

The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light

Almohanna, M., Al‐Khalaf, H. H., Al‐Yousef, N., & Aboussekhra, A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl1075 · Cited by 84

PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells

Bowers, J. S., Majchrzak, K., Nelson, M. H., Aksoy, B. A., Wyatt, M. M., Smith, A. S., Bailey, S. R., Neal, L. R., Hammerbacher, J., & Paulos, C. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01221 · Cited by 87

Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and survival

Meinhardt, G., Wendtner, C.-M., & Hallek, M. J. (1999) · Journal of Molecular Medicine · doi:10.1007/s001090050351 · Cited by 84

Developmentally programmed endoreduplication in animals

Ullah, Z., Lee, C. Y., Lilly, M. A., & Depamphilis, M. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8325 · Cited by 83

Lipid Rafts and Caveolae in Signaling by Growth Factor Receptors

Laurentiis, A. D., Donovan, L., & Arcaro, A. (2007) · The Open Biochemistry Journal · doi:10.2174/1874091x00701010012 · Cited by 88

Rho Activity Can Alter the Translation of p27 mRNA and Is Important for RasV12-induced Transformation in a Manner Dependent on p27 Status

Vidal, A., Millard, S. S., Miller, J. P., & Koff, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112090200 · Cited by 86

The MDM2 C-terminal Region Binds to TAFII250 and Is Required for MDM2 Regulation of the Cyclin A Promoter

Léveillard, T., & Wasylyk, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30651 · Cited by 81

Role of Cyclin Kinase Inhibitor p21 in Systemic Autoimmunity

Santiago‐Raber, M., Lawson, B. R., Dummer, W., Barnhouse, M., Koundouris, S., Wilson, C. B., Kono, D. H., & Theofilopoulos, A. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.4067 · Cited by 83

Functional role of p21 during the cellular response to stress.

Gorospe, M., Wang, X., & Holbrook, N. J. (1999) · Europe PMC (PubMed Central) · Cited by 83

Coordinate Control of Muscle Cell Survival by Distinct Insulin-like Growth Factor Activated Signaling Pathways

Lawlor, M. A., & Rotwein, P. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1131 · Cited by 83

p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis

Allan, L. A., & Fried, M. (1999) · Oncogene · doi:10.1038/sj.onc.1202931 · Cited by 83

α‐Lipoic acid induces p27 Kip ‐dependent cell cycle arrest in non‐transformed cell lines and apoptosis in tumor cell lines

van de Mark, K., Chen, J. S., Steliou, K., Perrine, S. P., & Faller, D. V. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10205 · Cited by 82

A Dual Role of p21 in Stem Cell Aging

Ju, Z., Choudhury, A. R., & Rudolph, K. L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.036 · Cited by 84

DNA Cross-Linker–Induced G2/M Arrest in Group C Fanconi Anemia Lymphoblasts Reflects Normal Checkpoint Function

Heinrich, M. C., Hoatlin, M. E., Zigler, A. J., Silvey, K. V., Bakke, A. C., Keeble, W. W., Zhi, Y., Reifsteck, C. A., Grompe, M., Brown, M. G., et al. (1998) · Blood · doi:10.1182/blood.v91.1.275 · Cited by 82

The cell cycle and development: redundant roles of cell cycle regulators

Zhang, P. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00032-0 · Cited by 80

Hyperglycaemia in vitro alters the proliferation and mitochondrial activity of the choriocarcinoma cell lines BeWo, JAR and JEG-3 as models for human first-trimester trophoblast

Weiss, U., Cervar, M., Puerstner, P., Schmut, O., Haas, J., Mauschitz, R., Arikan, G., & Desoyé, G. (2001) · Diabetologia · doi:10.1007/s001250051601 · Cited by 82

Apoptosis and gastrointestinal pharmacology

Pritchard, D. M., & Watson, A. J. M. (1996) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00102-7 · Cited by 82

Small cell lung cancer: Subtypes and therapeutic implications

Wang, W., Shulman, A., Amann, J. M., Carbone, D. P., & Tsichlis, P. N. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.04.001 · Cited by 83

Minireview: Glucocorticoid Regulation of Lung Development: Lessons Learned From Conditional GR Knockout Mice

Bird, A. D., McDougall, A. R. A., Seow, B., Hooper, S. B., & Cole, T. J. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1362 · Cited by 88

Recent advances in Ca2+-dependent Ras regulation and cell proliferation

Cook, S. J., & Lockyer, P. J. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.10.014 · Cited by 83

p53--An Acrobat in Tumorigenesis

Moll, U. M., & Schramm, L. (1998) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411980090010101 · Cited by 81

Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death

Weng, L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.3.251 · Cited by 82

p53 and apoptosis

Bellamy, C. O. C. (1997) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011628 · Cited by 80

A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

Kokontis, J. M., Wagner, A. J., O'Leary, M., Liao, S., & Hay, N. (2001) · Oncogene · doi:10.1038/sj.onc.1204139 · Cited by 81

Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.

Westphal, C. H., Schmaltz, C., Rowan, S., Elson, A., Fisher, D. E., & Leder, P. (1997) · PubMed · Cited by 81

Proteasome inhibitors induce mitochondria‐independent apoptosis in human glioma cells

Kitagawa, H., Tani, E., Ikemoto, H., Ozaki, I., Nakano, A., & Ōmura, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01709-8 · Cited by 81

Genetic and Epigenetic Control of CDKN1C Expression: Importance in Cell Commitment and Differentiation, Tissue Homeostasis and Human Diseases

Stampone, E., Caldarelli, I., Zullo, A., Bencivenga, D., Mancini, F. P., Ragione, F. D., & Borriello, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041055 · Cited by 80

Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

Mühleder, S., Fernández-Chacón, M., García-Gónzalez, I., & Benedito, R. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03664-y · Cited by 84

Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ

Kiourtis, C., Terradas-Terradas, M., Gee, L., May, S., Γεωργακοπούλου, Α., Collins, A., O'Sullivan, E. D., Baird, D., Hassan, M., Shaw, R., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01543-3 · Cited by 91

Quercetin, a flavonoid, inhibits the proliferation, differentiation, and mineralization of osteoblasts in vitro

Notoya, M., Tsukamoto, Y., Nishimura, H., Woo, J., Nagai, K., Lee, I.-S., & Hagiwara, H. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.058 · Cited by 80

p53 Induced Growth Arrest versus Apoptosis and its Modulation by Survival Cytokines

Liebermann, D. A., Hoffman‐Liebermann, B., & Vesely, D. L. (2007) · Cell Cycle · doi:10.4161/cc.6.2.3789 · Cited by 80

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

Shaltiël, I. A., Aprelia, M., Saurin, A. T., Chowdhury, D., Kops, G. J. P. L., Voest, E. E., & Medema, R. H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322021111 · Cited by 82

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

Waldman, T. A., Kinzler, K. W., & Vogelstein, B. (1995) · PubMed · Cited by 1,188

p21WAF1/CIP1 may be a tumor suppressor after all

Gartel, A. L. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.8.4712 · Cited by 19

p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

Zhang, W., Grasso, L., McClain, C. D., Gambel, A. M., Cha, Y., Travali, S., Deisseroth, A., & Mercer, W. E. (1995) · PubMed · Cited by 253

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

El‐Deiry, W. S., Harper, J. W., O'Connor, P. M., Velculescu, V. E., Ce, C., Jackman, J., Pietenpol, J. A., Burrell, M., De, H., & Wang, Y. (1994) · PubMed · Cited by 2,021

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

El‐Deiry, W. S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-2055 · Cited by 268