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Cited by 4,412

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Open access
Nobes, Catherine D, Hall, Alan·1995·Cell
DOI 10.1016/0092-8674(95)90370-4
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Abstract

Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia. In addition to stress fibers, rho controls the assembly of focal adhesion complexes. We now show that rac and cdc42 also stimulate the assembly of multimolecular focal complexes at the plasma membrane. These complexes, which are associated with lamellipodia and filopodia, contain vinculin, paxillin, and focal adhesion kinase, but are distinct from and formed independently of rho-induced focal adhesions. Activation of cdc42 in Swiss 3T3 cells leads to the sequential activation of rac and then rho, suggesting a molecular model for the coordinated control of cell motility by members of the rho family of GTPases.

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Metadata

Authors
Nobes, C. D., & Hall, A.
Venue
Cell
Publisher
Elsevier BV
Published
1995-04
Volume
81
Issue
1
Pages
53-62
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(95)90370-4
OpenAlex
W2027810531
Cited by
4,412
References
1
FWCI
83.25
Type
journal article
Language
en
Open access
bronze

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