Habitual versus goal-directed action control in Parkinson disease

de Wit, Sanne; Barker, Roger A.; Dickinson, Anthony D.; Cools, Roshan

doi:10.1162/jocn.2010.21514

Cited by 116Neural and Behavioral Psychology StudiesParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Habitual versus goal-directed action control in Parkinson disease

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de Wit, Sanne, Barker, Roger A., Dickinson, Anthony D., Cools, Roshan·2011·Journal of Cognitive Neuroscience

DOI 10.1162/jocn.2010.21514

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Abstract

This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus-response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus-response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.

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In Parkinson's Disease, goal-directed learning appeared to be impaired, not S-R habit learning.
“one attempt to test this found results that indicated it was goal-directed learning that appeared to be impaired in patients with this neurodegenerative disease (Nelson and Killcross, 2006, de Wit et al., 2011).”
From The role of habit in compulsivity (2016) · cites this paper as de Wit et al., 2011
The instrumental learning task was developed to distinguish between goal-directed and habit-based learning and has been used successfully to establish habits in both animals and humans.
“Briefly, the instrumental learning task was developed to distinguish between goal-directed and habit-based learning,19 and has been used successfully in studies to establish habits in both animals and humans.24,41, 42, 43, 44”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
Both humans and animals adopt an S-R habitual learning strategy to solve the incongruent trial type.
“Indeed, previous studies have demonstrated that both humans and animals adopt an S–R habitual learning strategy to solve this incongruent trial type.19,41, 42, 43, 44”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
During incongruent trials, goal-directed learning is disadvantageous, and performance relies solely on habitual control via direct S-R associations.
“In these trials, goal-directed learning is disadvantageous, and performance relies solely on habitual control via direct S–R associations.”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]
Patients with Parkinson's disease show an imbalance between goal-directed and habit learning.
“For example, patients with Parkinson's disease show an imbalance between goal-directed and habit learning.42”
From Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients (2013) · cites this paper as [42]

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Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · International Conference on Neural Information Processing · doi:10.1109/iconip.2002.1202887 · Cited by 2 · see citing works
Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation
Faure, A., Haberland, U., Condé, F., & Massioui, N. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3894-04.2005 · Cited by 402 · see citing works
Modulation of Habit Formation by Levodopa in Parkinson's Disease
Marzinzik, F., Wotka, J., Wahl, M., Krugel, L. K., Kordsachia, C. C., & Klostermann, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027695 · Cited by 6 · see citing works

Authors: de Wit, S., Barker, R. A., Dickinson, A. D., & Cools, R.
Affiliations: 1University of Amsterdam, The Netherlands
University of Cambridge (GB)
Radboud University Medical Center (NL)
ORCID: Barker, Roger A.
Dickinson, Anthony D.
Cools, Roshan
Venue: Journal of Cognitive Neuroscience
Publisher: MIT Press - Journals
Published: 2011-05-01
Volume: 23
Issue: 5
Pages: 1218-1229
ISSN: 0898-929X (ISSN-L)
1530-8898
DOI: 10.1162/jocn.2010.21514
OpenAlex: W2136439930
Cited by: 116
References: 74
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 4 · 2018: 15 · 2017: 11 · 2016: 5 · 2015: 6 · 2014: 13 · 2013: 8 · 2012: 10
FWCI: 5.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Cognitive Neuroscience (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Radboud Repository (Radboud University) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Fast Grants
Parkinson's UK (K-0610)
Universiteit van Amsterdam
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: Parkinson's disease, habitual behavior, goal-directed behavior, dopamine depletion, dorsal striatum, stimulus-response associations, response conflict, disease severity, action control
MeSH terms: Aged, Analysis of Variance, Association Learning, Conditioning, Operant, Discrimination Learning, Dopamine, Goals, Habits, Humans, Male, Middle Aged, Parkinson Disease, Reaction Time, Reference Values, Severity of Illness Index, Dopamine Agents, Case-Control Studies, Matched-Pair Analysis, Neostriatum

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Habitual versus goal-directed action control in Parkinson disease

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