Responses of monkey midbrain dopamine neurons during delayed alternation performance
Abstract
Cognitive deficits are important components of the parkinsonian syndrome. In order to investigate the role of dopamine (DA) neurons in cognitive functions, we recorded the electrical activity of midbrain DA neurons in a monkey performing in a spatial delayed alternation task. Triggered by a light, the animal reached toward one of two levers to receive a drop of liquid reward. The lever associated with reward was alternated after each correct movement. Of 88 DA neurons, 65% and 52% showed phasic responses to the trigger light and reward, respectively. By contrast, sustained delay-related activity described for striatum and frontal cortex was not observed, suggesting that the activity of DA neurons does not reflect mnemonic or preparatory representational task components. Rather, DA neurons respond to the salient attentional and motivating stimuli guiding task performance.
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Dopamine responses in elaborate tasks constitute standard reward prediction-error signals.
“However, on closer inspection, dopamine responses in such elaborate tasks constitute standard reward prediction-error signals2,33,59,66,69,75,151–153.”
From Dopamine reward prediction-error signalling: A two-component response (2016) · cites this paper as [69]
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Meeter, M., Veldkamp, R., & Jin, Y. (2008) · Brain and Cognition · doi:10.1016/j.bandc.2008.07.007 · Cited by 3 · see citing works
Schimmel, L. P., Banasikowski, T. J., Hawken, E. R., Dumont, É. C., & Beninger, R. J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.06.041 · Cited by 3 · see citing works
Reward responses of dopamine neurons: A biological reinforcement signal
Schultz, W. (1997) · Lecture notes in computer science · doi:10.1007/bfb0020125 · Cited by 3 · see citing works
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- Authors
- Ljungberg, T., Apicella, P., & Schultz, W.
- Affiliations
- University of Fribourg (CH)
- Corresponding author
- Schultz, Wolfram
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1991-12
- Volume
- 567
- Issue
- 2
- Pages
- 337-341
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2000148387
- Cited by
- 128
- References
- 21
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 5 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 4 · 2012: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopaminergic neurons, midbrain, delayed alternation, spatial working memory, parkinsonism, cognitive impairment, attention, reward, primate behavior
- MeSH terms
- Animals, Cognition, Conditioning, Operant, Dopamine, Macaca fascicularis, Mesencephalon, Neurons, Photic Stimulation
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