Testing computational models of dopamine and noradrenaline dysfunction in attention deficit/hyperactivity disorder
Abstract
We test our neurocomputational model of fronto-striatal dopamine (DA) and noradrenaline (NA) function for understanding cognitive and motivational deficits in attention deficit/hyperactivity disorder (ADHD). Our model predicts that low striatal DA levels in ADHD should lead to deficits in 'Go' learning from positive reinforcement, which should be alleviated by stimulant medications, as observed with DA manipulations in other populations. Indeed, while nonmedicated adult ADHD participants were impaired at both positive (Go) and negative (NoGo) reinforcement learning, only the former deficits were ameliorated by medication. We also found evidence for our model's extension of the same striatal DA mechanisms to working memory, via interactions with prefrontal cortex. In a modified AX-continuous performance task, ADHD participants showed reduced sensitivity to working memory contextual information, despite no global performance deficits, and were more susceptible to the influence of distractor stimuli presented during the delay. These effects were reversed with stimulant medications. Moreover, the tendency for medications to improve Go relative to NoGo reinforcement learning was predictive of their improvement in working memory in distracting conditions, suggestive of common DA mechanisms and supporting a unified account of DA function in ADHD. However, other ADHD effects such as erratic trial-to-trial switching and reaction time variability are not accounted for by model DA mechanisms, and are instead consistent with cortical noradrenergic dysfunction and associated computational models. Accordingly, putative NA deficits were correlated with each other and independent of putative DA-related deficits. Taken together, our results demonstrate the usefulness of computational approaches for understanding cognitive deficits in ADHD.
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The Basal ganglia model predicts decreased positive but increased negative reward prediction errors.
“Ziegler et al. (2016) propose that the Basal ganglia model (Frank et al., 2007) predicts decreased positive but increased negative reward prediction errors”
From Are prediction error modifications domain specific in autism but domain general in ADHD? (2025) · cites this paper as Frank et al., 2007
Computational studies show low striatal dopamine levels in ADHD patients lead to deficits in goal-oriented learning with positive reinforcements, often enhanced exogenously with stimulant medications.
“There have been computational studies performed that also show low striatal dopamine levels in ADHD patients which leads to deficits in goal-oriented learning with positive reinforcements, which is often enhanced exogenously with stimulant medications [19].”
From The Impact of Social Media & Technology on Child and Adolescent Mental Health (2025) · cites this paper as [19]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472 · see citing works
Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.006 · Cited by 3,568 · see citing works
Separate neural systems value immediate and delayed monetary rewards
McClure, S. M., Laibson, D. I., Loewenstein, G., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1100907 · Cited by 3,089 · see citing works
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
By Carrot or by Stick: Cognitive Reinforcement Learning in Parkinsonism
Frank, M. J., Seeberger, L. C., & O'Reilly, R. C. (2004) · Science · doi:10.1126/science.1102941 · Cited by 1,964 · see citing works
MARTINUSSEN, R., HAYDEN, J., HOGG-JOHNSON, S., & TANNOCK, R. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000153228.72591.73 · Cited by 1,297 · cited 1× · see citing works
“…memory manipulationFwhich requires selective updating of some information while working on a subset of a problemFis typically more impaired in ADHD than maintenance (Martinussen et al, 2005); similar updating/manipulation-specific deficits are observed in Parkinson's disease (see Cools, 2006).”
BackgroundCharacterizing cognition in ADHD: beyond executive dysfunction
Castellanos, F. X., Sonuga-Barke, E. J. S., Milham, M. P., & Tannock, R. (2006) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2006.01.011 · Cited by 1,170 · see citing works
Attention-deficit hyperactivity disorder : a clinical workbook
Barkley, R. A., & Murphy, K. R. (1991) · Cited by 1,144 · see citing works
Bymaster, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00346-9 · Cited by 1,123 · see citing works
O’Reilly, R. C., & Frank, M. J. (2005) · Neural Computation · doi:10.1162/089976606775093909 · Cited by 1,066 · see citing works
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035 · see citing works
Sonuga-Barke, E. J. S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.008 · Cited by 962 · see citing works
Frank, M. J. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929052880093 · Cited by 925 · see citing works
Cools, R. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.12.1136 · Cited by 906 · see citing works
Cools, R. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.024 · Cited by 903 · see citing works
Interactions between frontal cortex and basal ganglia in working memory: A computational model
FRANK, M. J., LOUGHRY, B., & O'REILLY, R. C. (2001) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.1.2.137 · Cited by 879 · see citing works
Biochemical pathophysiology of Parkinson's disease.
Hornykiewicz, O., & Kish, S. J. (1987) · PubMed · Cited by 850 · see citing works
The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics
Sonuga-Barke, E. J. S. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.005 · Cited by 816 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gerasimov, M., Maynard, L., Ding, Y.-S., Gatley, S. J., Gifford, A., & Franceschi, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-j0001.2001 · Cited by 770 · see citing works
The role of locus coeruleus in the regulation of cognitive performance
Usher, M., Cohen, J. D., Servan-Schreiber, D., Rajkowski, J., & Aston-Jones, G. (1999) · Science · doi:10.1126/science.283.5401.549 · Cited by 715 · see citing works
Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making
Frank, M. J. (2006) · Neural Networks · doi:10.1016/j.neunet.2006.03.006 · Cited by 706 · see citing works
Attention-Deficit Hyperactivity Disorder
Barkley, R. A. (1998) · Scientific American · doi:10.1038/scientificamerican0998-66 · Cited by 688 · see citing works
Dopamine transporter density in patients with attention deficit hyperactivity disorder
Dougherty, D. D., Bonab, A. A., Spencer, T. J., Rauch, S. L., Madras, B. K., & Fischman, A. J. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04030-1 · Cited by 684 · see citing works
Michelson, D., Faries, D., Wernicke, J., Kelsey, D., Kendrick, K., Sallee, F. R., Spencer, T., & the Atomoxetine ADHD Study Group (2001) · Pediatrics · doi:10.1542/peds.108.5.e83 · Cited by 666 · see citing works
Solanto, M. V., Abikoff, H., Sonuga-Barke, E., Schachar, R., Logan, G. D., Wigal, T., Hechtman, L., Hinshaw, S., & Turkel, E. (2001) · Journal of Abnormal Child Psychology · doi:10.1023/a:1010329714819 · Cited by 639 · see citing works
Differential patterns of striatal activation in young children with and without ADHD
Durston, S., Tottenham, N. T., Thomas, K. M., Davidson, M. C., Eigsti, I.-M., Yang, Y., Ulug, A. M., & Casey, B. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01904-2 · Cited by 619 · see citing works
Berridge, C. W., Devilbiss, D. M., Andrzejewski, M. E., Arnsten, A. F. T., Kelley, A. E., Schmeichel, B., Hamilton, C., & Spencer, R. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.022 · Cited by 617 · see citing works
Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients With Schizophrenia
Barch, D. M., Carter, C. S., Braver, T. S., Sabb, F. W., MacDonald, A. W., Noll, D. C., & Cohen, J. D. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.280 · Cited by 615 · see citing works
Joel, D., & Weiner, I. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00575-8 · Cited by 614 · see citing works
Aron, A. R., & Poldrack, R. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.026 · Cited by 602 · see citing works
Drug addiction: bad habits add up
Robbins, T. W., & Everitt, B. J. (1999) · Nature · doi:10.1038/19208 · Cited by 599 · see citing works
NIGG, J. T., & CASEY, B. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050376 · Cited by 593 · see citing works
Lijffijt, M., Kenemans, J. L., Verbaten, M. N., & van Engeland, H. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.2.216 · Cited by 592 · see citing works
Dissociating working memory from task difficulty in human prefrontal cortex
Barch, D. M., Braver, T. S., Nystrom, L. E., Forman, S. D., Noll, D. C., & Cohen, J. D. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00072-9 · Cited by 591 · see citing works
Sesack, S. R., Hawrylak, V. A., Matus, C., Guido, M. A., & Levey, A. I. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02697.1998 · Cited by 582 · see citing works
Barkley, R. A. (1997) · Psychological Bulletin · doi:10.1037//0033-2909.121.1.65 · Cited by 580 · see citing works
Leth-Steensen, C., King Elbaz, Z., & Douglas, V. I. (2000) · Acta Psychologica · doi:10.1016/s0001-6918(00)00019-6 · Cited by 580 · see citing works
Frank, M. J., & Claus, E. D. (2006) · Psychological Review · doi:10.1037/0033-295x.113.2.300 · Cited by 578 · see citing works
Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans
Chamberlain, S. R., Müller, U., Blackwell, A. D., Clark, L., Robbins, T. W., & Sahakian, B. J. (2006) · Science · doi:10.1126/science.1121218 · Cited by 573 · see citing works
The impact of reinforcement contingencies on AD/HD: A review and theoretical appraisal
Luman, M., Oosterlaan, J., & Sergeant, J. A. (2005) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.11.001 · Cited by 541 · see citing works
Varieties of Attention-Deficit/Hyperactivity Disorder-Related Intra-Individual Variability
Castellanos, F. X., Sonuga-Barke, E. J. S., Scheres, A., Di Martino, A., Hyde, C., & Walters, J. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.005 · Cited by 540 · see citing works
Braver, T. S., Barch, D. M., Keys, B. A., Carter, C. S., Cohen, J. D., Kaye, J. A., Janowsky, J. S., Taylor, S. F., Yesavage, J. A., Mumenthaler, M. S., et al. (2001) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.130.4.746 · Cited by 528 · see citing works
Krause, K.-H., Dresel, S. H., Krause, J., Kung, H. F., & Tatsch, K. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01040-5 · Cited by 521 · see citing works
Is the short-latency dopamine response too short to signal reward error?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01373-3 · Cited by 506 · see citing works
Scheres, A., Milham, M. P., Knutson, B., & Castellanos, F. X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.042 · Cited by 499 · see citing works
Krain, A. L., & Castellanos, F. X. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.01.005 · Cited by 495 · see citing works
Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder.
Sagvolden, T., Aase, H., Zeiner, P., & Berger, D. (1998) · PubMed · Cited by 491 · see citing works
Cognitive function in Parkinson's disease: From description to theory
Brown, R. G., & Marsden, C. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90058-i · Cited by 475 · see citing works
Frank, M. J., & O'Reilly, R. C. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.3.497 · Cited by 472 · see citing works
Schizophrenic Deficits in the Processing of Context
Servan‐Schreiber, D. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830120037008 · Cited by 462 · see citing works
Arnsten, A. F. T. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050084013 · Cited by 458 · see citing works
Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research
Solanto, M. V. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00431-4 · Cited by 456 · see citing works
DIAMOND, A. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050388 · Cited by 428 · see citing works
Error-Related Negativity Predicts Reinforcement Learning and Conflict Biases
Frank, M. J., Woroch, B. S., & Curran, T. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.020 · Cited by 422 · see citing works
S., M., S., B., M.-Y., H., C., B., E., S., J., D., & I., A. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0983-0 · Cited by 409 · see citing works
The Dopamine Transporter and Attention-Deficit/Hyperactivity Disorder
Madras, B. K., Miller, G. M., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.011 · Cited by 393 · see citing works
Neurobiology of Attention Deficit Disorder With Hyperactivity: Where Have We Come in 50 Years?
Zametkin, A. J., & Rapoport, J. L. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198709000-00011 · Cited by 348 · see citing works
Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder
Sagvolden, T., Aase, H., Zeiner, P., & Berger, D. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00170-8 · Cited by 345 · see citing works
Scheres, A., Dijkstra, M., Ainslie, E., Balkan, J., Reynolds, B., Sonuga-Barke, E., & Castellanos, F. X. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.10.012 · Cited by 327 · see citing works
Toplak, M. E., Jain, U., & Tannock, R. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-8 · Cited by 303 · see citing works
Owen, A. M. (1998) · Brain · doi:10.1093/brain/121.5.949 · Cited by 299 · see citing works
Striatal contributions to working memory: a functional magnetic resonance imaging study in humans
Lewis, S. J. G., Dove, A., Robbins, T. W., Barker, R. A., & Owen, A. M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03108.x · Cited by 273 · see citing works
Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.009 · Cited by 236 · see citing works
Stimulant drugs and ADHD : basic and clinical neuroscience
Solanto, M. V., Arnsten, A. F. T., & Castellanos, F. X. (2001) · Cited by 223 · see citing works
Durston, S., Fossella, J., Casey, B. J., Pol, H. E. H., Galván, A., Schnack, H. G., Steenhuis, M., Minderaa, R. B., Buitelaar, J. K., Kahn, R. S., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001649 · Cited by 216 · see citing works
Swanson, C. J., Perry, K. W., Koch-Krueger, S., Katner, J., Svensson, K. A., & Bymaster, F. P. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.11.022 · Cited by 214 · see citing works
Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder
Biederman, J., & Faraone, S. V. (2002) · Journal of Attention Disorders · doi:10.1177/070674370200601s03 · Cited by 192 · see citing works
Frank, M. J., Scheres, A., & Sherman, S. J. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2058 · Cited by 164 · see citing works
Wu, Q., Reith, M. E. A., Walker, Q. D., Kuhn, C. M., Carroll, F. I., & Garris, P. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-06272.2002 · Cited by 151 · see citing works
Rinne, U. K., Laihinen, A., Rinne, J. O., Någren, K., Bergman, J., & Ruotsalainen, U. (1990) · Movement Disorders · doi:10.1002/mds.870050114 · Cited by 150 · see citing works
Mazei‐Robison, M. S., Pluto, C. P., Kirkbride, B., & Pehek, E. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02542-8 · Cited by 143 · see citing works
Chee, P., Logan, G. D., Schachar, R. J., Lindsay, P. H., & Wachsmuth, R. (1989) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00915033 · Cited by 138 · see citing works
Overtoom, C. C. E., Verbaten, M. N., Kemner, C., Kenemans, J. L., van Engeland, H., Buitelaar, J. K., van der Molen, M. W., van der Gugten, J., Westenberg, H. G. M., Maes, R. A. A., et al. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00097-4 · Cited by 138 · see citing works
Schiffer, W. K., Volkow, N. D., Fowler, J. S., Alexoff, D. L., Logan, J., & Dewey, S. L. (2006) · Synapse · doi:10.1002/syn.20235 · Cited by 134 · see citing works
Neuropsychological functioning in stimulant-naive boys with hyperkinetic disorder
RHODES, S. M., COGHILL, D. R., & MATTHEWS, K. (2005) · Psychological Medicine · doi:10.1017/s0033291705004599 · Cited by 126 · cited 1× · see citing works
“Although working memory is not always found to be impaired in ADHD (Willcutt et al, 2005; Rhodes et al, 2005), our models predict a more specific impairment in the gating (rather than maintenance per se) of working memory representations.”
Seeman, P. M., & Madras, B. K. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00435-1 · Cited by 125 · see citing works
Russell, V. A., Allie, S., & Wiggins, T. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00291-6 · Cited by 107 · see citing works
Qualitative and quantitative analysis of locus coeruleus neurons in Parkinson's disease.
Bertrand, E., Lechowicz, W., Szpak, G. M., & Dymecki, J. (1997) · PubMed · Cited by 95 · see citing works
Stimulant Drugs and ADHD: Basic and Clinical Neuroscience.
Faraone, S. V. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200203000-00012 · Cited by 92 · see citing works
Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypes.
Todd, R., Huang, H.-Y., Smalley, S., Nelson, S., Willcutt, E., Pennington, B., Smith, S. D., Faraone, S., & Neuman, R. J. (2005) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.2005.01517.x · Cited by 86 · see citing works
Yano, M., & Steiner, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.019 · Cited by 83 · see citing works
Slow Oscillatory Discharge in the Primate Basal Ganglia
Wichmann, T., Kliem, M. A., & Soares, J. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00427.2001 · Cited by 69 · see citing works
Cragg, S. J., Hille, C. J., & Greenfield, S. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05705.2002 · Cited by 66 · see citing works
An exploration-exploitation model based on norepinepherine and dopamine activity
McClure, S. M., Gilzenrat, M. S., & Cohen, J. D. (2005) · neural information processing systems · Cited by 61 · see citing works
Ruskin, D. N., Bergstrom, D. A., Shenker, A., Freeman, L. E., Baek, D., & Walters, J. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00987-2 · Cited by 57 · see citing works
Russell, V. A., & Wiggins, T. (2000) · Metabolic Brain Disease · doi:10.1023/a:1011175225512 · Cited by 54 · see citing works
Ruskin, D. N., Bergstrom, D. A., Tierney, P. L., & Walters, J. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00921-1 · Cited by 48 · see citing works
Yano, M., Beverley, J. A., & Steiner, H. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.017 · Cited by 46 · see citing works
Moment-to-moment dynamics of ADHD behaviour in South African children
Aase, H., Meyer, A., & Sagvolden, T. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-11 · Cited by 46 · see citing works
Weiner, I., & Joel, D. (2002) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-06765-9_13 · Cited by 38 · see citing works
Llorente, A. M., Voigt, R. G., Jensen, C. L., Berretta, M. C., Fraley, J. K., & Heird, W. C. (2006) · The Clinical Neuropsychologist · doi:10.1080/13854040490888495 · Cited by 25 · see citing works
Stryjer, R., Klein, C., Treves, T. A., & Rabey, J. M. (2005) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2005.00294.x · Cited by 16 · see citing works
Frank, M. J., Scheres, A., & Sherman, S. J. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511731525.019 · Cited by 7 · see citing works
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O’Reilly, R. C., & Frank, M. J. (2005) · Neural Computation · doi:10.1162/089976606775093909 · Cited by 1,066 · see citing works
Frank, M. J. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929052880093 · Cited by 925 · see citing works
From reinforcement learning models to psychiatric and neurological disorders
Maia, T. V., & Frank, M. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2723 · Cited by 715 · see citing works
Reaction time variability in ADHD: A meta-analytic review of 319 studies
Kofler, M. J., Rapport, M. D., Sarver, D. E., Raiker, J. S., Orban, S. A., Friedman, L. M., & Kolomeyer, E. G. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.06.001 · Cited by 648 · see citing works
Eagle, D. M., Bari, A., & Robbins, T. W. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1127-6 · Cited by 548 · see citing works
Tripp, G., & Wickens, J. R. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.026 · Cited by 492 · see citing works
Hazy, T. E., Frank, M. J., & O’Reilly, R. C. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2055 · Cited by 450 · see citing works
A computational model of inhibitory control in frontal cortex and basal ganglia.
Wiecki, T. V., & Frank, M. (2011) · Psychology Review · doi:10.1037/a0031542 · Cited by 401 · see citing works
Collins, A. G. E., & Frank, M. J. (2014) · Psychological Review · doi:10.1037/a0037015 · Cited by 395 · see citing works
Cools, R., Frank, M. J., Gibbs, S. E. B., Miyakawa, A., Jagust, W. J., & D’Esposito, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4467-08.2009 · Cited by 365 · see citing works
Luman, M., Tripp, G., & Scheres, A. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.021 · Cited by 335 · see citing works
Chatham, C. H., Frank, M. J., & Munakata, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810002106 · Cited by 333 · see citing works
The drift diffusion model as the choice rule in reinforcement learning
Pedersen, M. L., Frank, M. J., & Biele, G. (2016) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1199-y · Cited by 272 · see citing works
Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis
Ellison-Wright, I., Ellison-Wright, Z., & Bullmore, E. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-51 · Cited by 269 · see citing works
Cools, R., Sheridan, M. A., Jacobs, E. G., & D’Esposito, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0601-07.2007 · Cited by 278 · see citing works
Nash Unsworth, A., & Robison, M. K. (2017) · Psychonomic Bulletin & Review · doi:10.3758/s13423-016-1220-5 · Cited by 255 · see citing works
Neurocomputational models of basal ganglia function in learning, memory and choice
Cohen, M. X., & Frank, M. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.029 · Cited by 238 · see citing works
Strauss, G. P., Frank, M. J., Waltz, J. A., Kasanova, Z., Herbener, E. S., & Gold, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.015 · Cited by 232 · see citing works
Ghahremani, D. G., Lee, B., Robertson, C. L., Tabibnia, G., Morgan, A. T., De Shetler, N., Brown, A. K., Monterosso, J. R., Aron, A. R., Mandelkern, M. A., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4284-11.2012 · Cited by 227 · see citing works
Wavelet-Synchronization Methodology: A New Approach for EEG-Based Diagnosis of ADHD
Ahmadlou, M., & Adeli, H. (2010) · Clinical EEG and Neuroscience · doi:10.1177/155005941004100103 · Cited by 216 · see citing works
Instructional control of reinforcement learning: A behavioral and neurocomputational investigation
Doll, B. B., Jacobs, W. J., Sanfey, A. G., & Frank, M. J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.007 · Cited by 209 · see citing works
Stimulus-dependent dopamine release in attention-deficit/hyperactivity disorder.
Sikström, S., & Söderlund, G. (2007) · Psychological Review · doi:10.1037/0033-295x.114.4.1047 · Cited by 205 · see citing works
Subcortical Structures and Cognition
Koziol, L. F., & Budding, D. E. (2009) · Springer eBooks · doi:10.1007/978-0-387-84868-6 · Cited by 273 · see citing works
Recent Developments in Neuropsychological Models of Childhood Psychiatric Disorders
Willcutt, E. G., Sonuga-Barke, E. J. S., Nigg, J. T., & Sergeant, J. A. (2008) · Advances in Biological Psychiatry · doi:10.1159/000118526 · Cited by 193 · see citing works
Model-Based Cognitive Neuroscience Approaches to Computational Psychiatry
Wiecki, T. V., Poland, J. S., & Frank, M. J. (2015) · Clinical Psychological Science · doi:10.1177/2167702614565359 · Cited by 191 · see citing works
Paloyelis, Y., Asherson, P., Mehta, M. A., Faraone, S. V., & Kuntsi, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.124 · Cited by 180 · see citing works
Frank, M. J., Scheres, A., & Sherman, S. J. (2007) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2007.2058 · Cited by 164 · see citing works
A dopaminergic basis for working memory, learning and attentional shifting in Parkinsonism
Moustafa, A. A., Sherman, S. J., & Frank, M. J. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.07.011 · Cited by 192 · see citing works
Eagle, D. M., Wong, J. C. K., Allan, M. E., Mar, A. C., Theobald, D. E., & Robbins, T. W. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6182-10.2011 · Cited by 145 · see citing works
A Role for Dopamine in Temporal Decision Making and Reward Maximization in Parkinsonism
Moustafa, A. A., Cohen, M. X., Sherman, S. J., & Frank, M. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3116-08.2008 · Cited by 147 · see citing works
Distraction in Visual Working Memory: Resistance is Not Futile
Lorenc, E. S., Mallett, R., & Lewis‐Peacock, J. A. (2021) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.12.004 · Cited by 143 · see citing works
A Meta-Analysis of Decision-Making and Attention in Adults With ADHD
Mowinckel, A. M., Pedersen, M. L., Eilertsen, E., & Biele, G. (2015) · Journal of Attention Disorders · doi:10.1177/1087054714558872 · Cited by 158 · see citing works
The Neuromodulatory System: A Framework for Survival and Adaptive Behavior in a Challenging World
Krichmar, J. L. (2008) · Adaptive Behavior · doi:10.1177/1059712308095775 · Cited by 132 · see citing works
Learning to avoid in older age.
Frank, M. J., & Kong, L. L. (2008) · Psychology and Aging · doi:10.1037/0882-7974.23.2.392 · Cited by 130 · see citing works
Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder
Wilbertz, G., Tebartz van Elst, L., Delgado, M. R., Maier, S., Feige, B., Philipsen, A., & Blechert, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.011 · Cited by 125 · see citing works
A neural network model of individual differences in task switching abilities
Herd, S. A., O׳Reilly, R. C., Hazy, T. E., Chatham, C. H., Brant, A. M., & Friedman, N. P. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.04.014 · Cited by 128 · see citing works
Self-citationGriffiths, K. R., Morris, R. W., & Balleine, B. W. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00101 · Cited by 118 · see citing works
Ziegler, S., Pedersen, M. L., Mowinckel, A. M., & Biele, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.002 · Cited by 110 · see citing works
Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis
Hauser, T. U., Fiore, V. G., Moutoussis, M., & Dolan, R. J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2015.12.009 · Cited by 118 · see citing works
Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys
Seu, E., Lang, A., Rivera, R. J., & Jentsch, J. D. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1250-4 · Cited by 121 · see citing works
Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC)
Cheung, S. W., & Larson, P. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.007 · Cited by 120 · see citing works
van der Schaaf, M. E., van Schouwenburg, M. R., Geurts, D. E. M., Schellekens, A. F. A., Buitelaar, J. K., Verkes, R. J., & Cools, R. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs344 · Cited by 102 · see citing works
Bari, A., & Robbins, T. W. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3141-6 · Cited by 105 · see citing works
Sobel, L. J., Bansal, R., Maia, T. V., Sanchez, J., Mazzone, L., Durkin, K., Liu, J., Hao, X., Ivanov, I., Miller, A., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091259 · Cited by 105 · see citing works
Stress modulates reinforcement learning in younger and older adults.
Lighthall, N. R., Gorlick, M. A., Schoeke, A., Frank, M. J., & Mather, M. (2012) · Psychology and Aging · doi:10.1037/a0029823 · Cited by 103 · see citing works
Hauser, T. U., Iannaccone, R., Dolan, R. J., Ball, J., Hättenschwiler, J., Drechsler, R., Rufer, M., Brandeis, D., Walitza, S., & Brem, S. (2017) · Psychological Medicine · doi:10.1017/s0033291716003305 · Cited by 86 · see citing works
Vaidya, C. J., & Stollstorff, M. (2008) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.40 · Cited by 95 · see citing works
Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks.
Rivero, O., Sich, S., Popp, S., Schmitt, A., Franke, B., & Lesch, K. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.009 · Cited by 104 · see citing works
Holroyd, C. B., Baker, T. E., Kerns, K. A., & Müller, U. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.02.011 · Cited by 92 · see citing works
Social stress reactivity alters reward and punishment learning
Cavanagh, J. F., Frank, M. J., & Allen, J. J. B. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq041 · Cited by 90 · see citing works
Risk and learning in impulsive and nonimpulsive patients with Parkinson's disease
Djamshidian, A., Jha, A., O’Sullivan, S. S., Silveira‐Moriyama, L., Jacobson, C., Brown, P., Lees, A. J., & Averbeck, B. B. (2010) · Movement Disorders · doi:10.1002/mds.23247 · Cited by 90 · see citing works
Handbook of Reward and Decision Making
Dreher, J., & Tremblay, L. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374620-7.x0001-5 · Cited by 88 · see citing works
Genetic Variation of Serotonin Function and Cognitive Control
Strobel, A., Dreisbach, G., Müller, J., Goschke, T., Brocke, B., & Lesch, K. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.12.1923 · Cited by 88 · see citing works
Robertson, C. L., Ishibashi, K., Mandelkern, M. A., Brown, A. K., Ghahremani, D. G., Sabb, F. W., Bilder, R. M., Cannon, T. D., Borg, J., & London, E. D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4850-14.2015 · Cited by 85 · see citing works
ADHD related behaviors are associated with brain activation in the reward system
Stark, R., Bauer, E., Merz, C. J., Zimmermann, M., Reuter, M., Plichta, M. M., Kirsch, P., Lesch, K. P., Fallgatter, A. J., Vaitl, D., et al. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.12.012 · Cited by 82 · see citing works
Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD
Shephard, E., Tye, C., Ashwood, K. L., Azadi, B., Asherson, P. J., Bolton, P., & McLoughlin, G. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3300-4 · Cited by 81 · see citing works
Frank, M. J., D’Lauro, C. J., & Curran, T. (2007) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.7.4.297 · Cited by 79 · see citing works
Dopamine vs Noradrenaline: Inverted-U Effects and ADHD Theories
Lévy, F. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802607238 · Cited by 77 · see citing works
Serotonergic and dopaminergic modulation of attentional processes
Boulougouris, V., & Tsaltas, E. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00925-4 · Cited by 75 · see citing works
Working Memory Capacity Predicts Effects of Methylphenidate on Reversal Learning
van der Schaaf, M. E., Fallon, S. J., ter Huurne, N., Buitelaar, J. K., & Cools, R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.100 · Cited by 72 · see citing works
Wallace, J., Boers, E., Ouellet, J., Afzali, M. H., & Conrod, P. (2023) · Scientific Reports · doi:10.1038/s41598-023-44105-7 · Cited by 70 · see citing works
Imaging the genetics of executive function
Greene, C. M., Braet, W., Johnson, K. A., & Bellgrove, M. A. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2007.11.009 · Cited by 70 · see citing works
Value-free random exploration is linked to impulsivity
Dubois, M., & Hauser, T. U. (2022) · Nature Communications · doi:10.1038/s41467-022-31918-9 · Cited by 72 · see citing works
Massar, S. A. A., Rossi, V., Schutter, D. J. L. G., & Kenemans, J. L. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.03.005 · Cited by 67 · see citing works
Kieling, C., Genro, J. P., Hutz, M. H., & Rohde, L. A. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30636 · Cited by 65 · see citing works
Koziol, L. F., Budding, D. E., & Chidekel, D. (2010) · The Cerebellum · doi:10.1007/s12311-010-0192-7 · Cited by 65 · see citing works
The rat's not for turning: Dissociating the psychological components of cognitive inflexibility
Nilsson, S. R. O., Alsiö, J., Somerville, E. M., & Clifton, P. G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.015 · Cited by 58 · see citing works
CNTRICS Final Task Selection: Long-Term Memory
Ragland, J. D., Cools, R., Frank, M. J., Pizzagalli, D. A., Preston, A. R., Charan Ranganath, A., & Wagner, A. D. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn134 · Cited by 57 · see citing works
McCracken, J. T., McGough, J. J., Loo, S. K., Levitt, J., Del’Homme, M., Cowen, J., Sturm, A., Whelan, F., Hellemann, G., Sugar, C., et al. (2016) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2016.05.015 · Cited by 57 · see citing works
Norman, L. J., Carlisi, C. O., Christakou, A., Murphy, C. M., Chantiluke, K. C., Giampietro, V., Simmons, A., Brammer, M. J., Mataix‐Cols, D., & Rubia, K. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.03.009 · Cited by 57 · see citing works
Girard, B., Tabareau, N., Pham, Q., Berthoz, A., & Slotine, J.-J. E. (2008) · Neural Networks · doi:10.1016/j.neunet.2008.03.009 · Cited by 55 · see citing works
Amyloidosis and cardiac involvement.
Cacoub, P., Axler, O., de Zuttere, D., Hausfater, P., Amoura, Z., Walter, S., Wechsler, B., Godeau, P., & Pietté, J. C. (2000) · PubMed · Cited by 54 · see citing works
CDH13is associated with working memory performance in attention deficit/hyperactivity disorder
Vásquez, A. A., Altink, M. E., Rommelse, N. N. J., Slaats-Willemse, D. I. E., Buschgens, C. J. M., Fliers, E. A., Faraone, S. V., Sergeant, J. A., Oosterlaan, J., Franke, B., et al. (2011) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2011.00724.x · Cited by 54 · see citing works
Leroi, I., Barraclough, M. L., McKie, S., Hinvest, N. S., Evans, J., Elliott, R., & McDonald, K. R. (2013) · Journal of Neuropsychology · doi:10.1111/jnp.12026 · Cited by 51 · see citing works
Transdiagnostic computations of uncertainty: towards a new lens on intolerance of uncertainty
Sandhu, T. R., Xiao, B., & Lawson, R. P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105123 · Cited by 51 · see citing works
Modulation of Social Influence by Methylphenidate
Campbell-Meiklejohn, D. K., Simonsen, A., Jensen, M., Wohlert, V., Gjerløff, T., Scheel‐Krüger, J., Møller, A., Frith, C., & Roepstorff, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.337 · Cited by 51 · see citing works
ADHD and Sensory Processing Disorders: Placing the Diagnostic Issues in Context
Koziol, L. F., & Budding, D. E. (2012) · Applied Neuropsychology Child · doi:10.1080/21622965.2012.709422 · Cited by 49 · see citing works
The influence of emotions on cognitive control: feelings and beliefs—where do they meet?
Harlé, K. M., Shenoy, P., & Paulus, M. P. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00508 · Cited by 48 · see citing works
Halje, P., Brys, I., Mariman, J. J., Cunha, C. D., Fuentes, R., & Petersson, P. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00590.2018 · Cited by 49 · see citing works
Wiecki, T. V., Riedinger, K., von Ameln-Mayerhofer, A., Schmidt, W., & Frank, M. J. (2009) · Psychopharmacology · doi:10.1007/s00213-008-1457-4 · Cited by 46 · see citing works
Asl, M. M., Vahabie, A., & Valizadeh, A. (2018) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.10.125 · Cited by 48 · see citing works
Longo, F., Mancini, M., Ibraheem, P. L., Aryal, S., Mesini, C., Patel, J. C., Penhos, E., Rahman, N., Mamcarz, M., Santini, E., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01099-w · Cited by 47 · see citing works
van Hulst, B. M., de Zeeuw, P., Bos, D. J., Rijks, Y., Neggers, S. F. W., & Durston, S. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12643 · Cited by 45 · see citing works
Dopamine Modulation of the Prefrontal Cortex and Cognitive Function
Seamans, J. K., & Robbins, T. W. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-333-6_14 · Cited by 45 · see citing works
Stimulation of the vagus nerve reduces learning in a go/no-go reinforcement learning task
Kühnel, A., Teckentrup, V., Neuser, M. P., Huys, Q. J. M., Burrasch, C., Walter, M., & Kroemer, N. B. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.03.023 · Cited by 43 · see citing works
The impact of acute tryptophan depletion on attentional performance in adult patients with ADHD
Mette, C., Zimmermann, M., Grabemann, M., Abdel‐Hamid, M., UEKERMANN, J., Biskup, C. S., Wiltfang, J., Zepf, F. D., & Kis, B. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12090 · Cited by 43 · see citing works
The Impact of Social Media & Technology on Child and Adolescent Mental Health
Masri-zada, T., Martirosyan, S., Abdou, A., Barbar, R., Kades, S., Makki, H., Haley, G., & K Agrawal, D. (2025) · Journal of Psychiatry and Psychiatric Disorders · doi:10.26502/jppd.2572-519x0242 · Cited by 45 · see citing works
Attention-deficit/hyperactivity disorder and the explore/exploit trade-off
Addicott, M. A., Pearson, J. M., Schechter, J. C., Sapyta, J. J., Weiss, M. D., & Kollins, S. H. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00881-8 · Cited by 38 · see citing works
Cerebellar-Thalamic Connectivity in Schizophrenia
Barch, D. M. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu076 · Cited by 39 · see citing works
Hearne, L. J., Lin, H., Sanz‐Leon, P., Tseng, W. I., Gau, S. S., Roberts, J. A., & Cocchi, L. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0554-6 · Cited by 38 · see citing works
Neurobiological and psychophysiological correlates of emotional dysregulation in ADHD patients
Herrmann, M. J., Biehl, S. C., Jacob, C., & Deckert, J. (2010) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-010-0047-6 · Cited by 39 · see citing works
Nonhuman gamblers: lessons from rodents, primates, and robots
Fabio Paglieri, A., Addessi, E., Petrillo, F. D., Giovanni Laviola, A., Mirolli, M., Parisi, D., Petrosino, G., Ventricelli, M., Zoratto, F., & Adriani, W. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00033 · Cited by 39 · see citing works
Schizophrenia: A Computational Reinforcement Learning Perspective
Frank, M. J. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn123 · Cited by 37 · see citing works
Umemoto, A., Lukie, C. N., Kerns, K. A., Müller, U., & Holroyd, C. B. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0298-3 · Cited by 36 · see citing works
Sethi, A., Voon, V., Critchley, H. D., Cercignani, M., & Harrison, N. A. (2018) · Brain · doi:10.1093/brain/awy048 · Cited by 36 · see citing works
Emotional deficits in adult ADHD patients: an ERP study
Herrmann, M. J., Schreppel, T., Biehl, S. C., Jacob, C., Heine, M., Boreatti‐Hümmer, A., Mühlberger, A., & Fallgatter, A. J. (2009) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp033 · Cited by 34 · see citing works
Mental Illness from the Perspective of Theoretical Neuroscience
Thagard, P. R. (2008) · Perspectives in biology and medicine · doi:10.1353/pbm.0.0030 · Cited by 35 · see citing works
Prehn‐Kristensen, A., Krauel, K., Hinrichs, H., Fischer, J., Malecki, U., Schuetze, H., Wolff, S., Jansen, O., Düzel, E., & Baving, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.075 · Cited by 34 · see citing works
How initial confirmatory experience potentiates the detrimental influence of bad advice
Staudinger, M. R., & Büchel, C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.074 · Cited by 33 · see citing works
Reinforcement, Dopamine and Rodent Models in Drug Development for ADHD
Tripp, G., & Wickens, J. R. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0132-y · Cited by 33 · see citing works
- Authors
- Frank, M. J., Santamaria, A., O'Reilly, R. C., & Willcutt, E.
- Affiliations
- University of Arizona (US)
- Alion Science and Technology (United States) (US)
- University of Colorado Boulder (US)
- Corresponding author
- Frank, Michael J
- Venue
- Neuropsychopharmacology
- Published
- 2006-12-13
- Volume
- 32
- Issue
- 7
- Pages
- 1583-1599
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2114186661
- Cited by
- 227
- References
- 97
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 9 · 2023: 9 · 2022: 11 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 7 · 2014: 19 · 2013: 15 · 2012: 16
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH069597, MH 069597-01)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, dopamine, norepinephrine, neurocomputational model, frontostriatal circuits, reinforcement learning, positive reinforcement, stimulant medication, working memory, prefrontal cortex, distractor interference, reaction time variability, cognitive impairment, motivational deficits
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Brain Chemistry, Computer Simulation, Dopamine, Female, Humans, Learning, Male, Memory, Short-Term, Neural Pathways, Norepinephrine, Reinforcement, Psychology, Prefrontal Cortex
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