Cited by 596Neurological disorders and treatmentsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

The specificity of the ‘nonspecific’ midline and intralaminar thalamic nuclei

Groenewegen, Henk J., Berendse, Henk W.·1994·Trends in Neurosciences

Abstract

The midline and intralaminar thalamic nuclei have long been considered to be a 'nonspecific' nuclear complex that relays the activity of the brain-stem reticular formation to widespread cerebral-cortical areas. Over the past decade, it has become clear that individual midline and intralaminar nuclei each receive specific sets of afferents and project to specific parts of the cerebral cortex and striatum. Moreover, the targets of the thalamocortical and thalamostriatal projections of a given nucleus are interconnected through corticostriatal projections. Therefore, the midline and intralaminar nuclei might have a dual role in corticosubcortical interactions in the forebrain. Through distinct sets of inputs to individual midline or intralaminar thalamic nuclei, these nuclei are in a position to interact selectively with particular, functionally segregated basal-ganglia-thalamocortical circuits. By way of nonselective inputs, in particular from cholinergic brain-stem nuclei, the midline and intralaminar nuclei might act in concert to modify the level of activity of the entire basal-ganglia-thalamocortical system.

Integrity signals

Registry

Crossref · 10.1016/0166-2236(94)90074-4

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57 of 57 references verified0 citation errors · 0 not checkable

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  • Different cortical areas project to different domains of striatum and thalamus with some degree of topography.

    “Different cortical areas project to different domains of striatum and thalamus with some degree of topography33–35.”

    From A mesoscale connectome of the mouse brain (2014) · cites this paper as [33]

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Authors
Groenewegen, H. J., & Berendse, H. W.
Affiliations
Vrije Universiteit Amsterdam (NL)
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1994-01
Volume
17
Issue
2
Pages
52-57
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1978906168
Cited by
596
References
57
Citations by year
2026: 7 · 2025: 18 · 2024: 15 · 2023: 19 · 2022: 11 · 2021: 15 · 2020: 16 · 2019: 17 · 2018: 25 · 2017: 13 · 2016: 15 · 2015: 20 · 2014: 23 · 2013: 20 · 2012: 15
FWCI
4.93
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
midline thalamic nuclei, intralaminar nuclei, thalamocortical connections, thalamostriatal projections, corticostriatal projections, basal ganglia-thalamocortical circuit, brainstem reticular formation, cholinergic input, striatum, cerebral cortex
MeSH terms
Animals, Humans, Neural Pathways, Thalamic Nuclei

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