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Cited by 253Sleep and Wakefulness ResearchSleep and Work-Related FatigueCircadian rhythm and melatonin

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

Sleep deprivation in the rat by the disk-over-water method

Rechtschaffen, Allan, Bergmann, Bernard M.·1995·Behavioural Brain Research
DOI 10.1016/0166-4328(95)00020-t
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Abstract

Chronic sleep deprivation may be required to reveal the most serious physiological consequences of sleep loss, but it usually requires strong stimulation which can obscure the interpretation of effects. The disk-over-water method permits chronic sleep deprivation of rats with gentle physical stimulation that can be equally applied to yoked control rats. A series of studies with this method has revealed little or no pathology in the control rats. The deprived rats show a reliable syndrome that includes temperature changes (which vary with the sleep stages that are lost); heat seeking behavior; increased food intake; weight loss; increased metabolic rate; increased plasma norepinephrine; decreased plasma thyroxine; an increased triiodothyronine-thyroxine ratio; and an increase of an enzyme which mediates thermogenesis by brown adipose tissue. The temperature changes are attributable to excessive heat loss and an elevated thermoregulatory setpoint, both of which increase thermoregulatory load, and the other changes are interpretable as responses to this increased load. This pattern indicates that sleep serves a thermoregulatory function in the rat. The sleep deprived rats also show stereotypic ulcerative and hyperkeratotic lesions localized to the tail and plantar surfaces of the paws, and they die within a matter of weeks; the mediation of these changes is unresolved.

Overview

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Crossref · 10.1016/0166-4328(95)00020-t

Cites

35 of 35 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 36 references

Research works printed but not linked: 6

  1. Bergmann, 1994, Chronic total sleep deprivation in hyperthyroid rats, Sleep Res., 22, 322
  2. Gilliland, 1984, Pathology in sleep deprived rats is not reflected in histological abnormalities, Sleep Res., 13, 190
  3. Gilliland, 1994, Bacterial growth during short-term sleep deprivation in rats, Sleep Res., 23, 413
  4. Obermeyer, 1993, The effect of sleep deprivation on the thermoregulatory response of rats to phentolamine, Sleep Res., 22, 340
  5. Shaw, 1993, Hypothermia is probably not the proximal cause of death in sleep deprived rats, Sleep Res., 22, 345
  6. Zenko, 1993, The effects of naltrexone on the regulated rise in body temperature in sleep deprived rats, Sleep Res., 22, 351

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Metadata

Authors
Rechtschaffen, A., & Bergmann, B. M.
Affiliations
University of Chicago (US)
Corresponding author
Rechtschaffen, Allan
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
1995-07
Volume
69
Issue
1-2
Pages
55-63
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/0166-4328(95)00020-t
OpenAlex
W2123138830
Cited by
253
References
36
Citations by year
2026: 1 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 13 · 2015: 8 · 2014: 7 · 2013: 19 · 2012: 17
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Chicago
  • National Institutes of Health
  • U.S. Public Health Service (ME 18428)
  • National Institute of Mental Health (MH-4151)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
sleep deprivation, chronic sleep deprivation, thermoregulation, brown adipose tissue, thermogenesis, norepinephrine, thyroid hormones, dietary intake, weight loss, metabolic rate, ulcerative lesions, hyperkeratosis, sleep function
MeSH terms
Animals, Sleep Deprivation, Rats

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